LOCUS       NM_010818               2363 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus CD200 molecule (Cd200), transcript variant 1, mRNA.
ACCESSION   NM_010818 XM_358839
VERSION     NM_010818.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2363)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2363)
  AUTHORS   Misrani,A., Ngwa,C., Mamun,A.A., Sharmeen,R., Manyam,K.V.,
            Ritzel,R.M., McCullough,L. and Liu,F.
  TITLE     Brain endothelial CD200 signaling protects brain against ischemic
            damage
  JOURNAL   Brain Res Bull 207, 110864 (2024)
   PUBMED   38157992
  REMARK    GeneRIF: Brain endothelial CD200 signaling protects brain against
            ischemic damage.
REFERENCE   3  (bases 1 to 2363)
  AUTHORS   Qian,H., Gao,F., Wu,X., Lin,D., Huang,Y., Chen,A., Deng,J.,
            Gong,C., Chen,X. and Zheng,X.
  TITLE     Activation of the CD200/CD200R1 axis attenuates neuroinflammation
            and improves postoperative cognitive dysfunction via the
            PI3K/Akt/NF-kappaB signaling pathway in aged mice
  JOURNAL   Inflamm Res 72 (12), 2127-2144 (2023)
   PUBMED   37902837
  REMARK    GeneRIF: Activation of the CD200/CD200R1 axis attenuates
            neuroinflammation and improves postoperative cognitive dysfunction
            via the PI3K/Akt/NF-kappaB signaling pathway in aged mice.
REFERENCE   4  (bases 1 to 2363)
  AUTHORS   Pfeifer,C.W., Walsh,J.T., Santeford,A., Lin,J.B., Beatty,W.L.,
            Terao,R., Liu,Y.A., Hase,K., Ruzycki,P.A. and Apte,R.S.
  TITLE     Dysregulated CD200-CD200R signaling in early diabetes modulates
            microglia-mediated retinopathy
  JOURNAL   Proc Natl Acad Sci U S A 120 (45), e2308214120 (2023)
   PUBMED   37903272
  REMARK    GeneRIF: Dysregulated CD200-CD200R signaling in early diabetes
            modulates microglia-mediated retinopathy.
REFERENCE   5  (bases 1 to 2363)
  AUTHORS   van der Vlist,M., Raoof,R., Willemen,H.L.D.M., Prado,J.,
            Versteeg,S., Martin Gil,C., Vos,M., Lokhorst,R.E., Pasterkamp,R.J.,
            Kojima,T., Karasuyama,H., Khoury-Hanold,W., Meyaard,L. and
            Eijkelkamp,N.
  TITLE     Macrophages transfer mitochondria to sensory neurons to resolve
            inflammatory pain
  JOURNAL   Neuron 110 (4), 613-626 (2022)
   PUBMED   34921782
REFERENCE   6  (bases 1 to 2363)
  AUTHORS   Hoek,R.M., Ruuls,S.R., Murphy,C.A., Wright,G.J., Goddard,R.,
            Zurawski,S.M., Blom,B., Homola,M.E., Streit,W.J., Brown,M.H.,
            Barclay,A.N. and Sedgwick,J.D.
  TITLE     Down-regulation of the macrophage lineage through interaction with
            OX2 (CD200)
  JOURNAL   Science 290 (5497), 1768-1771 (2000)
   PUBMED   11099416
REFERENCE   7  (bases 1 to 2363)
  AUTHORS   Schafer,K. and Braun,T.
  TITLE     Early specification of limb muscle precursor cells by the homeobox
            gene Lbx1h
  JOURNAL   Nat Genet 23 (2), 213-216 (1999)
   PUBMED   10508520
REFERENCE   8  (bases 1 to 2363)
  AUTHORS   Borriello,F., Tizard,R., Rue,E. and Reeves,R.
  TITLE     Characterization and localization of Mox2, the gene encoding the
            murine homolog of the rat MRC OX-2 membrane glycoprotein
  JOURNAL   Mamm Genome 9 (2), 114-118 (1998)
   PUBMED   9457671
REFERENCE   9  (bases 1 to 2363)
  AUTHORS   Chen,Z., Zeng,H. and Gorczynski,R.M.
  TITLE     Cloning and characterization of the murine homologue of the
            rat/human MRC OX-2 gene
  JOURNAL   Biochim Biophys Acta 1362 (1), 6-10 (1997)
   PUBMED   9434094
REFERENCE   10 (bases 1 to 2363)
  AUTHORS   Preston,S., Wright,G.J., Starr,K., Barclay,A.N. and Brown,M.H.
  TITLE     The leukocyte/neuron cell surface antigen OX2 binds to a ligand on
            macrophages
  JOURNAL   Eur J Immunol 27 (8), 1911-1918 (1997)
   PUBMED   9295026
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CN665640.1 and BC054759.1.
            
            On Aug 11, 2006 this sequence version replaced NM_010818.2.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC054759.1, SRR1660813.153544.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-542               CN665640.1         1-542
            543-2363            BC054759.1         476-2296
FEATURES             Location/Qualifiers
     source          1..2363
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 29.53 cM"
     gene            1..2363
                     /gene="Cd200"
                     /gene_synonym="Mox2; OX2"
                     /note="CD200 molecule"
                     /db_xref="GeneID:17470"
                     /db_xref="MGI:MGI:1196990"
     exon            1..198
                     /gene="Cd200"
                     /gene_synonym="Mox2; OX2"
                     /inference="alignment:Splign:2.1.0"
     exon            199..280
                     /gene="Cd200"
                     /gene_synonym="Mox2; OX2"
                     /inference="alignment:Splign:2.1.0"
     exon            281..607
                     /gene="Cd200"
                     /gene_synonym="Mox2; OX2"
                     /inference="alignment:Splign:2.1.0"
     exon            608..880
                     /gene="Cd200"
                     /gene_synonym="Mox2; OX2"
                     /inference="alignment:Splign:2.1.0"
     exon            881..1024
                     /gene="Cd200"
                     /gene_synonym="Mox2; OX2"
                     /inference="alignment:Splign:2.1.0"
     exon            1025..2347
                     /gene="Cd200"
                     /gene_synonym="Mox2; OX2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggcgtggtt ggttggtcgt ctcttcctcc acactagagg agctgtagag tctgcctgtg
       61 cagtggaggg ggctctctct acggcgaata gtagtgtccc tgctcacagg tgttgcggag
      121 atatcctcca tcgtggaaga gctcagaccc cgagaagctg gtgtctagct gcggcccaga
      181 gcaaggatgg gcagtctggt attcaggaga cctttctgcc atctctccac ctacagcctg
      241 atttggggca tggcagcagt agcgctgagc acagctcaag tggaagtggt gacccaggat
      301 gaaagaaagg cgctgcacac aactgcatcc ttacgatgtt ctctaaaaac atcccaggaa
      361 cccttgattg tgacatggca gaaaaagaaa gccgtgagcc cagaaaacat ggtcacctac
      421 agcaaaaccc atggggttgt aatccagcct gcctacaaag acaggataaa tgtcacagag
      481 ctgggactct ggaactcaag catcaccttc tggaacacaa cattggaaga tgagggctgc
      541 tacatgtgtc tcttcaacac gtttggttct cagaaggtct caggaacagc ttgccttacc
      601 ctctatgtac agcccatagt acaccttcac tacaactatt ttgaagacca cctaaacatc
      661 acttgctctg cgactgcccg tccagcccct gccatctcct ggaagggtac tgggacagga
      721 attgagaata gtaccgagag tcacttccat tcaaatggga ctacatctgt caccagcatc
      781 ctccgggtca aagaccccaa aactcaagtt gggaaggaag tgatctgcca ggttttatac
      841 ctggggaatg tgattgacta caagcagagt ctggacaaag gattttggtt ttcagttcca
      901 ctgttgctaa gcattgtttc tctggtaatt cttctgatct tgatctccat cttactatac
      961 tggaaacgtc accgaaatca ggagcggggt gaatcatcac aggggatgca aagaatgaaa
     1021 taagagctct aaagaaatta tacagaaccc tgaacgtgtt tccctggtct acttgaatct
     1081 gatgtgaaag aaaagcagga gggaaaaggc cattctccat aggacctaag gagagcaaaa
     1141 gaccagacac gagcctgtga gggatttgac tttttgctgt tgtcccaggt cctcggtgtt
     1201 tgcattccaa gaggaagtcg agtgcctcgg gtctgttgta ggacttgatt tttttttttt
     1261 ttgtagagca atgcagtgcc atgctgttag aaaggctcca gacttagaac caccagtgcc
     1321 aagccagctc tcagaccgac tagggctccc atcggaggaa caaatcgtag tcaacttacc
     1381 tcacagagct ctctggtcct tacacaaagt agaaaggagt gggaccagaa aattggccat
     1441 gtctgaaatc tgatggaatt tttaggaaga aaactgaaga ataagcaaaa gaagaaagaa
     1501 cacagaaggg tccaaagagc ttctgagagt accttttgcc tttctgttgg tgtcccagct
     1561 ctggttttgt tcttaggtcc gccagtgtgt ttccctgttg tttgagtatc tagttgacta
     1621 cctgctactg ttctgctgat ggttggcctt gctagaatcc ctgactcccc tgccgttctc
     1681 tatgtgcttc tatgagggtt actatgatga aaatagagca gaagatagtg tgaagtaaca
     1741 ttggcaactg taatgtgtcc atttaactta tttttatagc acttaggcaa tattgttagt
     1801 cttagtgagt agttcacatc tttacaaaag catgctctcc ctatccattg ggcccacaat
     1861 aacactctct ttgaggccat tctgaatcct gtctcgtgta atgataatat attatgaaaa
     1921 cagatacttt aagaatttcc tgtacagcag tcagttgttt attctctctc tctctctctc
     1981 tctctctctc cctcccccac cccagcttct ttttctgtga ctttgttttt cataaagaga
     2041 aggcatctcc tgaatacaat cgctttgttc tgaagacatc gtgaactatt aattcttaac
     2101 cctttgacaa aactagtgaa gttgttttct gtatcttttg cttcatctgt ctttatagag
     2161 tgacctagga attcaagtgt aagttgtttc cattgttgaa ctggatattt atatacttgg
     2221 tatgcttttc acgtgttatt taattctgta taatttccta tatttgtatt aaaatattga
     2281 gcaattaaaa gtgtcaacta aatatttgat gtggcattcc cttgagaaat atagaaataa
     2341 agaataaaaa aaaaaaaaaa aaa
//
