LOCUS       NM_013486               1144 bp    mRNA    linear   ROD 05-AUG-2024
DEFINITION  Mus musculus CD2 antigen (Cd2), mRNA.
ACCESSION   NM_013486
VERSION     NM_013486.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1144)
  AUTHORS   Li,R., Galindo,C.C., Davidson,D., Guo,H., Zhong,M.C., Qian,J.,
            Li,B., Ruzsics,Z., Lau,C.M., O'Sullivan,T.E., Vidal,S.M., Sun,J.C.
            and Veillette,A.
  TITLE     Suppression of adaptive NK cell expansion by macrophage-mediated
            phagocytosis inhibited by 2B4-CD48
  JOURNAL   Cell Rep 43 (3), 113800 (2024)
   PUBMED   38386559
REFERENCE   2  (bases 1 to 1144)
  AUTHORS   Li,B., Lu,Y., Zhong,M.C., Qian,J., Li,R., Davidson,D., Tang,Z.,
            Zhu,K., Argenty,J., de Peredo,A.G., Malissen,B., Roncagalli,R. and
            Veillette,A.
  TITLE     Cis interactions between CD2 and its ligands on T cells are
            required for T cell activation
  JOURNAL   Sci Immunol 7 (74), eabn6373 (2022)
   PUBMED   35930657
REFERENCE   3  (bases 1 to 1144)
  AUTHORS   Fernandez Lahore,G., Forster,M., Johannesson,M., Sabatier,P.,
            Lonnblom,E., Aoun,M., He,Y., Nandakumar,K.S., Zubarev,R.A. and
            Holmdahl,R.
  TITLE     Polymorphic estrogen receptor binding site causes Cd2-dependent sex
            bias in the susceptibility to autoimmune diseases
  JOURNAL   Nat Commun 12 (1), 5565 (2021)
   PUBMED   34552089
  REMARK    GeneRIF: Polymorphic estrogen receptor binding site causes
            Cd2-dependent sex bias in the susceptibility to autoimmune
            diseases.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1144)
  AUTHORS   Kanatsu-Shinohara,M., Chen,G., Morimoto,H. and Shinohara,T.
  TITLE     CD2 is a surface marker for mouse and rat spermatogonial stem cells
  JOURNAL   J Reprod Dev 66 (4), 341-349 (2020)
   PUBMED   32213736
  REMARK    GeneRIF: CD2 is a surface marker for mouse and rat spermatogonial
            stem cells.
REFERENCE   5  (bases 1 to 1144)
  AUTHORS   Hashem,T., Kammala,A.K., Thaxton,K., Griffin,R.M., Mullany,K.,
            Panettieri,R.A. Jr., Subramanian,H. and Das,R.
  TITLE     CD2 Regulates Pathogenesis of Asthma Induced by House Dust Mice
            Extract
  JOURNAL   Front Immunol 11, 881 (2020)
   PUBMED   32477356
  REMARK    GeneRIF: CD2 Regulates Pathogenesis of Asthma Induced by House Dust
            Mice Extract.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1144)
  AUTHORS   Killeen,N., Stuart,S.G. and Littman,D.R.
  TITLE     Development and function of T cells in mice with a disrupted CD2
            gene
  JOURNAL   EMBO J 11 (12), 4329-4336 (1992)
   PUBMED   1358605
REFERENCE   7  (bases 1 to 1144)
  AUTHORS   Morse,H.C. 3rd.
  TITLE     Genetic nomenclature for loci controlling surface antigens of mouse
            hemopoietic cells
  JOURNAL   J Immunol 149 (10), 3129-3134 (1992)
   PUBMED   1431091
  REMARK    Review article
            Erratum:[J Immunol 1993 Mar 15;150(6):2563]
REFERENCE   8  (bases 1 to 1144)
  AUTHORS   Kato,K., Koyanagi,M., Okada,H., Takanashi,T., Wong,Y.W.,
            Williams,A.F., Okumura,K. and Yagita,H.
  TITLE     CD48 is a counter-receptor for mouse CD2 and is involved in T cell
            activation
  JOURNAL   J Exp Med 176 (5), 1241-1249 (1992)
   PUBMED   1383383
REFERENCE   9  (bases 1 to 1144)
  AUTHORS   Dower,N.A., Seldin,M.F., Pugh,S. and Stone,J.C.
  TITLE     Organization and chromosomal locations of Rap1a/Krev sequences in
            the mouse
  JOURNAL   Mamm Genome 3 (3), 162-167 (1992)
   PUBMED   1617222
REFERENCE   10 (bases 1 to 1144)
  AUTHORS   Oakey,R.J., Howard,T.A., Hogarth,P.M., Tani,K. and Seldin,M.F.
  TITLE     Chromosomal mapping of the high affinity Fc gamma receptor gene
  JOURNAL   Immunogenetics 35 (4), 279-282 (1992)
   PUBMED   1347284
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC131184.4 and
            AL645930.15.
            
            On Nov 17, 2006 this sequence version replaced NM_013486.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: Y00023.1, AF065908.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849383, SAMN00849388
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-115               AC131184.4         179142-179256
            116-424             AC131184.4         179366-179674
            425-655             AC131184.4         183820-184050
            656-778             AC131184.4         187171-187293
            779-863             AC131184.4         190808-190892
            864-1144            AL645930.15        227713-227993       c
FEATURES             Location/Qualifiers
     source          1..1144
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 44.17 cM"
     gene            1..1144
                     /gene="Cd2"
                     /gene_synonym="LFA-2; Ly-37; Ly37"
                     /note="CD2 antigen"
                     /db_xref="GeneID:12481"
                     /db_xref="MGI:MGI:88320"
     exon            1..115
                     /gene="Cd2"
                     /gene_synonym="LFA-2; Ly-37; Ly37"
                     /inference="alignment:Splign:2.1.0"
     CDS             61..1095
                     /gene="Cd2"
                     /gene_synonym="LFA-2; Ly-37; Ly37"
                     /note="T-cell surface antigen CD2; LFA-3 receptor;
                     lymphocyte antigen 37; T-cell surface antigen T11/Leu-5"
                     /codon_start=1
                     /product="T-cell surface antigen CD2 precursor"
                     /protein_id="NP_038514.1"
                     /db_xref="CCDS:CCDS17681.1"
                     /db_xref="GeneID:12481"
                     /db_xref="MGI:MGI:88320"
                     /translation="MKCKFLGSFFLLFSLSGKGADCRDNETIWGVLGHGITLNIPNFQ
                     MTDDIDEVRWVRRGTLVAEFKRKKPPFLISETYEVLANGSLKIKKPMMRNDSGTYNVM
                     VYGTNGMTRLEKDLDVRILERVSKPMIHWECPNTTLTCAVLQGTDFELKLYQGETLLN
                     SLPQKNMSYQWTNLNAPFKCEAINPVSKESKMEVVNCPEKGLSFYVTVGVGAGGLLLV
                     LLVALFIFCICKRRKRNRRRKDEELEIKASRTSTVERGPKPHSTPAAAAQNSVALQAP
                     PPPGHHLQTPGHRPLPPGHRTREHQQKKRPPPSGTQIHQQKGPPLPRPRVQPKPPCGS
                     GDGVSLPPPN"
     exon            116..424
                     /gene="Cd2"
                     /gene_synonym="LFA-2; Ly-37; Ly37"
                     /inference="alignment:Splign:2.1.0"
     exon            425..655
                     /gene="Cd2"
                     /gene_synonym="LFA-2; Ly-37; Ly37"
                     /inference="alignment:Splign:2.1.0"
     exon            656..778
                     /gene="Cd2"
                     /gene_synonym="LFA-2; Ly-37; Ly37"
                     /inference="alignment:Splign:2.1.0"
     exon            779..1144
                     /gene="Cd2"
                     /gene_synonym="LFA-2; Ly-37; Ly37"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1118..1123
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cd2"
                     /gene_synonym="LFA-2; Ly-37; Ly37"
                     /note="hexamer: AATAAA"
     polyA_site      1144
                     /gene="Cd2"
                     /gene_synonym="LFA-2; Ly-37; Ly37"
                     /note="major polyA site"
ORIGIN      
        1 gcctcaccac agtcctgaca gaaagaactc agagtcaccc ctgggaaaag aactctaaag
       61 atgaaatgta aattcctggg tagcttcttt ctgctcttca gcctttccgg caaaggggcg
      121 gactgcagag acaatgagac catctggggt gtcttgggtc atggcatcac cctgaacatc
      181 cccaactttc aaatgactga tgatattgat gaggtgcgat gggtaaggag gggcaccctg
      241 gtcgcagagt ttaaaaggaa gaagccacct tttttgatat cagaaacgta tgaggtctta
      301 gcaaacggat ccctgaagat aaagaagccg atgatgagaa acgacagtgg cacctataat
      361 gtaatggtgt atggcacaaa tgggatgact aggctggaga aggacctgga cgtgaggatt
      421 ctggagaggg tctcaaagcc catgatccac tgggaatgcc ccaacacaac cctgacctgt
      481 gcggtcttgc aagggacaga ttttgaactg aagctgtatc aaggggaaac actactcaat
      541 agtctccccc agaagaacat gagttaccag tggaccaacc tgaacgcacc attcaagtgt
      601 gaggcgataa acccggtcag caaggagtct aagatggaag ttgttaactg tccagagaaa
      661 ggtctgtcct tctatgtcac agtgggggtc ggtgcaggag gactcctctt ggtgctcttg
      721 gtggcgcttt ttattttctg tatctgcaag aggagaaaac ggaacaggag gagaaaagat
      781 gaagagctgg aaataaaagc ttccagaaca agcactgtgg aaaggggccc caagccgcac
      841 tcaaccccag ccgcagcagc gcagaattca gtggcgctcc aagctcctcc tccacctggc
      901 catcacctcc agacacctgg ccatcgtccc ttgcctccag gccaccgtac ccgtgagcac
      961 cagcagaaga agagacctcc tccatcaggc acacagattc accagcagaa aggccctcct
     1021 ttacccagac cccgagttca gccaaaacct ccctgtggga gtggagatgg tgtttcactg
     1081 ccgcccccta attaagaagg cagagttcgt catttccaat aaaaagctgt gtggatttat
     1141 cttc
//
