LOCUS       NM_009844               2438 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Mus musculus CD19 antigen (Cd19), transcript variant 1, mRNA.
ACCESSION   NM_009844
VERSION     NM_009844.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2438)
  AUTHORS   Kabrani,E., Rahjouei,A., Berruezo-Llacuna,M., Ebeling,S., Saha,T.,
            Altwasser,R., Delgado-Benito,V., Pavri,R. and Di Virgilio,M.
  TITLE     RIF1 integrates DNA repair and transcriptional requirements during
            the establishment of humoral immune responses
  JOURNAL   Nat Commun 16 (1), 777 (2025)
   PUBMED   39824820
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2438)
  AUTHORS   Cunha,D.M., Hernandez-Perez,S. and Mattila,P.K.
  TITLE     Enhanced antibody responses in CD19-Cre mice
  JOURNAL   Sci Rep 15 (1), 1348 (2025)
   PUBMED   39779739
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2438)
  AUTHORS   He,K., Xiao,H., MacDonald,W.A., Mehta,I., Kishore,A., Vincent,A.,
            Xu,Z., Ray,A., Chen,W., Weaver,C.T., Lambrecht,B.N., Das,J. and
            Poholek,A.C.
  TITLE     Spatial microniches of IL-2 combine with IL-10 to drive lung
            migratory TH2 cells in response to inhaled allergen
  JOURNAL   Nat Immunol 25 (11), 2124-2139 (2024)
   PUBMED   39394532
REFERENCE   4  (bases 1 to 2438)
  AUTHORS   Rakhymzhan,A., Fiedler,A.F., Gunther,R., Domingue,S.R.,
            Wooldridge,L., Leben,R., Cao,Y., Bias,A., Roodselaar,J., Kohler,R.,
            Ulbricht,C., Heidelin,J., Andresen,V., Beckers,I., Haibel,A.,
            Duda,G., Hauser,A.E. and Niesner,R.A.
  TITLE     Optimized intravital three-photon imaging of intact mouse tibia
            links plasma cell motility to functional states
  JOURNAL   iScience 27 (10), 110985 (2024)
   PUBMED   39391739
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2438)
  AUTHORS   Lee,D., Jo,M.G., Min,K.Y., Choi,M.Y., Kim,Y.M., Kim,H.S. and
            Choi,W.S.
  TITLE     IL-10+ regulatory B cells mitigate atopic dermatitis by suppressing
            eosinophil activation
  JOURNAL   Sci Rep 14 (1), 18164 (2024)
   PUBMED   39107352
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2438)
  AUTHORS   Kozmik,Z., Wang,S., Dorfler,P., Adams,B. and Busslinger,M.
  TITLE     The promoter of the CD19 gene is a target for the B-cell-specific
            transcription factor BSAP
  JOURNAL   Mol Cell Biol 12 (6), 2662-2672 (1992)
   PUBMED   1375324
REFERENCE   7  (bases 1 to 2438)
  AUTHORS   Zhou,L.J., Ord,D.C., Omori,S.A. and Tedder,T.F.
  TITLE     Structure of the genes encoding the CD19 antigen of human and mouse
            B lymphocytes
  JOURNAL   Immunogenetics 35 (2), 102-111 (1992)
   PUBMED   1370948
REFERENCE   8  (bases 1 to 2438)
  AUTHORS   Zhou,L.J., Ord,D.C., Hughes,A.L. and Tedder,T.F.
  TITLE     Structure and domain organization of the CD19 antigen of human,
            mouse, and guinea pig B lymphocytes. Conservation of the extensive
            cytoplasmic domain
  JOURNAL   J Immunol 147 (4), 1424-1432 (1991)
   PUBMED   1714482
REFERENCE   9  (bases 1 to 2438)
  AUTHORS   Tedder,T.F. and Isaacs,C.M.
  TITLE     Isolation of cDNAs encoding the CD19 antigen of human and mouse B
            lymphocytes. A new member of the immunoglobulin superfamily
  JOURNAL   J Immunol 143 (2), 712-717 (1989)
   PUBMED   2472450
REFERENCE   10 (bases 1 to 2438)
  AUTHORS   Nadler,L.M., Anderson,K.C., Marti,G., Bates,M., Park,E., Daley,J.F.
            and Schlossman,S.F.
  TITLE     B4, a human B lymphocyte-associated antigen expressed on normal,
            mitogen-activated, and malignant B lymphocytes
  JOURNAL   J Immunol 131 (1), 244-250 (1983)
   PUBMED   6408173
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC125322.4.
            
            On Sep 26, 2022 this sequence version replaced NM_009844.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK089835.1, AK172008.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-124               AC125322.4         73306-73429         c
            125-391             AC125322.4         72818-73084         c
            392-586             AC125322.4         72348-72542         c
            587-865             AC125322.4         71948-72226         c
            866-976             AC125322.4         70628-70738         c
            977-1025            AC125322.4         70339-70387         c
            1026-1114           AC125322.4         69998-70086         c
            1115-1216           AC125322.4         69576-69677         c
            1217-1318           AC125322.4         69354-69455         c
            1319-1387           AC125322.4         69197-69265         c
            1388-1444           AC125322.4         69042-69098         c
            1445-1501           AC125322.4         68894-68950         c
            1502-1588           AC125322.4         68141-68227         c
            1589-1695           AC125322.4         67914-68020         c
            1696-2438           AC125322.4         67005-67747         c
FEATURES             Location/Qualifiers
     source          1..2438
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 69.01 cM"
     gene            1..2438
                     /gene="Cd19"
                     /note="CD19 antigen"
                     /db_xref="GeneID:12478"
                     /db_xref="MGI:MGI:88319"
     exon            1..124
                     /gene="Cd19"
                     /inference="alignment:Splign:2.1.0"
     CDS             37..1680
                     /gene="Cd19"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; B-lymphocyte antigen CD19; differentiation
                     antigen CD19"
                     /codon_start=1
                     /product="B-lymphocyte antigen CD19 isoform 1 precursor"
                     /protein_id="NP_033974.2"
                     /db_xref="CCDS:CCDS21828.1"
                     /db_xref="GeneID:12478"
                     /db_xref="MGI:MGI:88319"
                     /translation="MPSPLPVSFLLFLTLVGGRPQKSLLVEVEEGGNVVLPCLPDSSP
                     VSSEKLAWYRGNQSTPFLELSPGSPGLGLHVGSLGILLVIVNVSDHMGGFYLCQKRPP
                     FKDIWQPAWTVNVEDSGEMFRWNASDVRDLDCDLRNRSSGSHRSTSGSQLYVWAKDHP
                     KVWGTKPVCAPRGSSLNQSLINQDLTVAPGSTLWLSCGVPPVPVAKGSISWTHVHPRR
                     PNVSLLSLSLGGEHPVREMWVWGSLLLLPQATALDEGTYYCLRGNLTIERHVKVIARS
                     AVWLWLLRTGGWIVPVVTLVYVIFCMVSLVAFLYCQRAFILRRKRKRMTDPARRFFKV
                     TPPSGNGTQNQYGNVLSLPTSTSGQAHAQRWAAGLGSVPGSYGNPRIQVQDTGAQSHE
                     TGLEEEGEAYEEPDSEEGSEFYENDSNLGQDQVSQDGSGYENPEDEPMGPEEEDSFSN
                     AESYENADEELAQPVGRMMDFLSPHGSAWDPSREASSLGSQSYEDMRGILYAAPQLHS
                     IQSGPSHEEDADSYENMDKSDDLEPAWEGEGHMGTWGTT"
     exon            125..391
                     /gene="Cd19"
                     /inference="alignment:Splign:2.1.0"
     exon            392..586
                     /gene="Cd19"
                     /inference="alignment:Splign:2.1.0"
     exon            587..865
                     /gene="Cd19"
                     /inference="alignment:Splign:2.1.0"
     exon            866..976
                     /gene="Cd19"
                     /inference="alignment:Splign:2.1.0"
     exon            977..1025
                     /gene="Cd19"
                     /inference="alignment:Splign:2.1.0"
     exon            1026..1114
                     /gene="Cd19"
                     /inference="alignment:Splign:2.1.0"
     exon            1115..1216
                     /gene="Cd19"
                     /inference="alignment:Splign:2.1.0"
     exon            1217..1318
                     /gene="Cd19"
                     /inference="alignment:Splign:2.1.0"
     exon            1319..1387
                     /gene="Cd19"
                     /inference="alignment:Splign:2.1.0"
     exon            1388..1444
                     /gene="Cd19"
                     /inference="alignment:Splign:2.1.0"
     exon            1445..1501
                     /gene="Cd19"
                     /inference="alignment:Splign:2.1.0"
     exon            1502..1588
                     /gene="Cd19"
                     /inference="alignment:Splign:2.1.0"
     exon            1589..1695
                     /gene="Cd19"
                     /inference="alignment:Splign:2.1.0"
     exon            1696..2438
                     /gene="Cd19"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2413..2418
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cd19"
                     /note="hexamer: AATAAA"
     polyA_site      2438
                     /gene="Cd19"
                     /note="major polyA site"
ORIGIN      
        1 acgcagaagc cgggtgcccc agggagcctg gctaccatgc catctcctct ccctgtctcc
       61 ttcctcctct ttcttacctt agtaggaggc aggccccaga agtccttact ggtggaggta
      121 gaagagggag gcaatgttgt gctgccatgc ctcccggact cctcacctgt ctcttctgag
      181 aagctggctt ggtatcgagg taaccagtca acacccttcc tggagctgag ccccgggtcc
      241 cctggcctgg gattgcacgt ggggtccctg ggcatcttgc tagtgattgt caatgtctca
      301 gaccatatgg ggggcttcta cctgtgccag aagaggcccc ctttcaagga catctggcag
      361 cctgcctgga cagtgaacgt ggaggatagt ggggagatgt tccggtggaa tgcttcagac
      421 gtcagggacc tggactgtga cctaaggaac aggtcctctg ggagccacag gtccacttct
      481 ggttcccagc tgtatgtgtg ggctaaagac catcctaagg tctggggaac aaagcctgta
      541 tgtgcccctc gggggagcag tttgaatcag agtctaatca accaagatct cactgtggca
      601 cccggctcca cactttggct gtcctgtggg gtaccccctg tcccagtggc caaaggctcc
      661 atctcctgga cccatgtgca tcctaggaga cctaatgttt cactactgag cctaagcctt
      721 gggggagagc acccggtcag agagatgtgg gtttgggggt ctcttctgct tctgccccaa
      781 gccacagctt tagatgaagg cacctattat tgtctccgag gaaacctgac catcgagagg
      841 cacgtgaagg tcattgcaag gtcagcagtg tggctctggc tgttgagaac tggtggatgg
      901 atagtcccag tggtgacttt agtatatgtc atcttctgta tggtttctct ggtggctttt
      961 ctctattgtc aaagagcctt tatcctgaga aggaaaagga agcgaatgac tgaccccgcc
     1021 aggagattct tcaaagtgac gcctccctcg ggaaacggga cccagaacca gtacgggaat
     1081 gtgctctccc ttcctacatc tacctctggc caggcccatg ctcagcgttg ggctgctggc
     1141 ctagggagtg tccctgggtc ctatggaaat ccacgcattc aagtccagga tactggagct
     1201 cagagccatg aaacaggact ggaagaagaa ggggaggcct atgaagagcc agacagcgag
     1261 gagggctctg aattctatga gaacgactcc aaccttgggc aggaccaggt ttcccaggat
     1321 gggagtggct atgagaaccc cgaggatgag cccatgggtc cagaggaaga agactccttc
     1381 tccaatgctg agtcttatga aaatgcagat gaggagctgg cccaaccagt tggcaggatg
     1441 atggacttcc tgagccccca tgggtctgcg tgggacccca gccgggaagc atcctcgctt
     1501 gggtcccagt cctatgaaga tatgagaggg atcctctatg cagctcctca gctccactca
     1561 attcagtccg gtcccagtca tgaagaagat gcagactctt atgaaaacat ggataagtct
     1621 gacgacctag aaccagcatg ggaaggagag ggccacatgg ggacttgggg aaccacgtga
     1681 ctcccaagtg actagcctgg acttcgttag gtcccaagaa ccacatctga ttctgaaatc
     1741 tggagatccc agatggtgtc agtcagtgaa atgaccttga tcaggatgtg tgcatgctga
     1801 cacacacaca ctcatatgca tgttcaagca aagcttcctt ttgacccttt gctttcccca
     1861 aataaaccca attagccact caaattctct gaagccggcc cttgtgtggg ataggaaggg
     1921 aagatggggt tgaatccagc cctgagtcac ccagaggaag gagaactgag gtctgagtac
     1981 atcctggctc tagccttccc atggcctggc atttagccac ctaacatcca gtgatgcaaa
     2041 tatgtccagc cgctacattc catggtgtcc cacaagggag agacagtgat gggactagca
     2101 gactgtttgg ttgtaaccca tccctgctca ccctgcacaa actgggaaac actgtctgcc
     2161 tctcttttaa tcctgcctgc tccaggctaa caggccagta ccctcacctt cgagtttctg
     2221 gcaacactac ctgagtgcct gctcaggggg ttcagcttct gaccatatgt agacaccacc
     2281 ccagctctga gtttacacat catcacccct tgcctaagac ctgaaacccc cctttacctt
     2341 cgcccaggtg tgccatttcc ctgctccctc ctgcatcctt gggacctgtg aacctactca
     2401 agtgctgctc tcaataaatc tgcctttata ctttctaa
//
