LOCUS       NM_008533               2326 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Mus musculus CD180 antigen (Cd180), transcript variant 1, mRNA.
ACCESSION   NM_008533
VERSION     NM_008533.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2326)
  AUTHORS   Kani,K., Kasai,K., Tada,Y., Ishibashi,R., Takano,S., Igarashi,N.,
            Ichimura-Shimizu,M., Tsuneyama,K., Furusawa,Y. and Nagai,Y.
  TITLE     The innate immune receptor RP105 promotes metabolic syndrome by
            altering gut microbiota composition and intestinal barrier function
  JOURNAL   Biochem Biophys Res Commun 664, 77-85 (2023)
   PUBMED   37146560
REFERENCE   2  (bases 1 to 2326)
  AUTHORS   Donovan,M.L., Bielefeldt-Ohmann,H., Rollo,R.F., McPherson,S.J.,
            Schultz,T.E., Mori,G., Kling,J.C. and Blumenthal,A.
  TITLE     Distinct contributions of the innate immune receptors TLR2 and
            RP105 to formation and architecture of structured lung granulomas
            in mice infected with Mycobacterium tuberculosis
  JOURNAL   Immunology 169 (1), 13-26 (2023)
   PUBMED   36370035
  REMARK    GeneRIF: Distinct contributions of the innate immune receptors TLR2
            and RP105 to formation and architecture of structured lung
            granulomas in mice infected with Mycobacterium tuberculosis.
REFERENCE   3  (bases 1 to 2326)
  AUTHORS   Zhu,J., Zhang,Y., Shi,L., Xia,Y., Zha,H., Li,H. and Song,Z.
  TITLE     RP105 protects against ischemic and septic acute kidney injury via
            suppressing TLR4/NF-kappaB signaling pathways
  JOURNAL   Int Immunopharmacol 109, 108904 (2022)
   PUBMED   35696803
  REMARK    GeneRIF: RP105 protects against ischemic and septic acute kidney
            injury via suppressing TLR4/NF-kappaB signaling pathways.
REFERENCE   4  (bases 1 to 2326)
  AUTHORS   Chan,C.C., Harley,I.T.W., Pfluger,P.T., Trompette,A.,
            Stankiewicz,T.E., Allen,J.L., Moreno-Fernandez,M.E.,
            Damen,M.S.M.A., Oates,J.R., Alarcon,P.C., Doll,J.R., Flick,M.J.,
            Flick,L.M., Sanchez-Gurmaches,J., Mukherjee,R., Karns,R.,
            Helmrath,M., Inge,T.H., Weisberg,S.P., Pamp,S.J., Relman,D.A.,
            Seeley,R.J., Tschop,M.H., Karp,C.L. and Divanovic,S.
  TITLE     A BAFF/APRIL axis regulates obesogenic diet-driven weight gain
  JOURNAL   Nat Commun 12 (1), 2911 (2021)
   PUBMED   34006859
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2326)
  AUTHORS   Sakaguchi,T., Okumura,R., Ono,C., Okuzaki,D., Kawai,T., Okochi,Y.,
            Tanimura,N., Murakami,M., Kayama,H., Umemoto,E., Kioka,H.,
            Ohtani,T., Sakata,Y., Miyake,K., Okamura,Y., Baba,Y. and Takeda,K.
  TITLE     TRPM5 Negatively Regulates Calcium-Dependent Responses in
            Lipopolysaccharide-Stimulated B Lymphocytes
  JOURNAL   Cell Rep 31 (10), 107755 (2020)
   PUBMED   32521253
REFERENCE   6  (bases 1 to 2326)
  AUTHORS   Wang,W., Soto,H., Oldham,E.R., Buchanan,M.E., Homey,B., Catron,D.,
            Jenkins,N., Copeland,N.G., Gilbert,D.J., Nguyen,N., Abrams,J.,
            Kershenovich,D., Smith,K., McClanahan,T., Vicari,A.P. and
            Zlotnik,A.
  TITLE     Identification of a novel chemokine (CCL28), which binds CCR10
            (GPR2)
  JOURNAL   J Biol Chem 275 (29), 22313-22323 (2000)
   PUBMED   10781587
REFERENCE   7  (bases 1 to 2326)
  AUTHORS   Corcoran,L.M. and Metcalf,D.
  TITLE     IL-5 and Rp105 signaling defects in B cells from commonly used 129
            mouse substrains
  JOURNAL   J Immunol 163 (11), 5836-5842 (1999)
   PUBMED   10570267
REFERENCE   8  (bases 1 to 2326)
  AUTHORS   Miyake,K., Shimazu,R., Kondo,J., Niki,T., Akashi,S., Ogata,H.,
            Yamashita,Y., Miura,Y. and Kimoto,M.
  TITLE     Mouse MD-1, a molecule that is physically associated with RP105 and
            positively regulates its expression
  JOURNAL   J Immunol 161 (3), 1348-1353 (1998)
   PUBMED   9686597
REFERENCE   9  (bases 1 to 2326)
  AUTHORS   Miura,Y., Miyake,K., Yamashita,Y., Shimazu,R., Copeland,N.G.,
            Gilbert,D.J., Jenkins,N.A., Inazawa,J., Abe,T. and Kimoto,M.
  TITLE     Molecular cloning of a human RP105 homologue and chromosomal
            localization of the mouse and human RP105 genes (Ly64 and LY64)
  JOURNAL   Genomics 38 (3), 299-304 (1996)
   PUBMED   8975706
REFERENCE   10 (bases 1 to 2326)
  AUTHORS   Miyake,K., Yamashita,Y., Ogata,M., Sudo,T. and Kimoto,M.
  TITLE     RP105, a novel B cell surface molecule implicated in B cell
            activation, is a member of the leucine-rich repeat protein family
  JOURNAL   J Immunol 154 (7), 3333-3340 (1995)
   PUBMED   7897216
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY222876.1, AK089255.1 and BY529039.1.
            
            On Nov 2, 2006 this sequence version replaced NM_008533.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK156548.1, AK089255.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-10                BY222876.1         2-11
            11-2166             AK089255.1         2-2157
            2167-2326           BY529039.1         229-388
FEATURES             Location/Qualifiers
     source          1..2326
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="NOD"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 54.92 cM"
     gene            1..2326
                     /gene="Cd180"
                     /gene_synonym="F630107B15; Ly-78; Ly78; RP105"
                     /note="CD180 antigen"
                     /db_xref="GeneID:17079"
                     /db_xref="MGI:MGI:1194924"
     exon            1..232
                     /gene="Cd180"
                     /gene_synonym="F630107B15; Ly-78; Ly78; RP105"
                     /inference="alignment:Splign:2.1.0"
     CDS             143..2128
                     /gene="Cd180"
                     /gene_synonym="F630107B15; Ly-78; Ly78; RP105"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; lymphocyte antigen 78; radioprotective 105 kDa
                     protein"
                     /codon_start=1
                     /product="CD180 antigen isoform 1 precursor"
                     /protein_id="NP_032559.2"
                     /db_xref="CCDS:CCDS26741.1"
                     /db_xref="GeneID:17079"
                     /db_xref="MGI:MGI:1194924"
                     /translation="MAPDISCFFLVALFLASCRATTSSDQKCIEKEVNKTYNCENLGL
                     NEIPGTLPNSTECLEFSFNVLPTIQNTTFSRLINLTFLDLTRCQIYWIHEDTFQSQHR
                     LDTLVLTANPLIFMAETALSGPKALKHLFFIQTGISSIDFIPLHNQKTLESLYLGSNH
                     ISSIKLPKGFPTEKLKVLDFQNNAIHYLSKEDMSSLQQATNLSLNLNGNDIAGIELGA
                     FDSAVFQSLNFGGTQNLLVIFKGLKNSTIQSLWLGTFEDMDDEDISPAVFEGLCEMSV
                     ESINLQKHYFFNISSNTFHCFSGLQELDLTATHLSELPSGLVGLSTLKKLVLSANKFE
                     NLCQISASNFPSLTHLSIKGNTKRLELGTGCLENLENLRELDLSHDDIETSDCCNLQL
                     RNLSHLQSLNLSYNEPLSLKTEAFKECPQLELLDLAFTRLKVKDAQSPFQNLHLLKVL
                     NLSHSLLDISSEQLFDGLPALQHLNLQGNHFPKGNIQKTNSLQTLGRLEILVLSFCDL
                     SSIDQHAFTSLKMMNHVDLSHNRLTSSSIEALSHLKGIYLNLASNRISIILPSLLPIL
                     SQQRTINLRQNPLDCTCSNIYFLEWYKENMQKLEDTEDTLCENPPLLRGVRLSDVTLS
                     CSMAAVGIFFLIVFLLVFAILLIFAVKYFLRWKYQHI"
     exon            233..399
                     /gene="Cd180"
                     /gene_synonym="F630107B15; Ly-78; Ly78; RP105"
                     /inference="alignment:Splign:2.1.0"
     exon            400..2326
                     /gene="Cd180"
                     /gene_synonym="F630107B15; Ly-78; Ly78; RP105"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agctcccagc atttcggttc taagatcgac cttctgagca cttcattgcc tgccaaattg
       61 ccagggctat tagagtgtga ttagattgct tggctctgag cattagataa tcctacgcag
      121 ctgggcttgc tctggacctg ggatggctcc ggacatcagc tgcttctttt tagtggccct
      181 cttcttggcc agttgccgag ccaccacatc ctcagatcag aagtgcattg agaaagaagt
      241 caacaaaaca tacaactgtg aaaatttagg tctcaatgaa attcctggca ctttaccaaa
      301 ctcaacagaa tgtttggagt tcagctttaa tgtcttgcct accattcaaa acacgacctt
      361 cagcagactt atcaatctca ccttcctgga tttaaccagg tgccagattt actggataca
      421 tgaagatact ttccaaagcc aacatcggtt agacacactt gtactaaccg caaatcccct
      481 gatatttatg gcagagacag cacttagtgg gcctaaggca ttgaagcatc tgttcttcat
      541 ccaaacagga atatccagta ttgattttat cccactgcac aatcaaaaaa ccttggaaag
      601 tctctatctc ggaagcaacc atatttcctc cattaagctc cccaaaggtt tcccaacaga
      661 gaagctgaag gtcctggatt ttcagaataa tgctatccat tacctgtcta aagaagatat
      721 gagctctctc cagcaagcca ctaatctgag ccttaactta aatggaaatg acattgcagg
      781 aatagagctg ggggctttcg actcagctgt cttccaaagt ttaaactttg gagggactca
      841 gaacttgcta gttatcttca agggtttgaa gaactctacg atccagtctc tttggctggg
      901 gacatttgag gacatggatg acgaagatat tagtcctgcc gtgtttgagg gtctctgtga
      961 aatgtctgtg gagagcatca acctacagaa gcattatttc ttcaacattt cctccaacac
     1021 attccattgc ttcagtggcc tccaggaact ggacctaaca gccactcacc tgagtgaatt
     1081 gccttctgga cttgtgggac taagcacact taagaaatta gttctcagtg caaataagtt
     1141 tgagaatttg tgccaaatca gtgcttccaa tttcccctcc cttactcacc tttccatcaa
     1201 gggcaacacg aagagacttg agctcggtac tggctgttta gaaaacctag aaaatctccg
     1261 cgaacttgac ctcagccatg atgacattga aacttctgat tgttgcaacc tgcaactccg
     1321 aaacctgtct cacttacaga gcctgaactt gagctacaat gaacccctga gcctcaagac
     1381 ggaggcattc aaagaatgcc ctcagctaga actcctagat ttggcattta ctcgactaaa
     1441 ggtgaaagat gcacagagtc ccttccagaa cctccatctt ttgaaggtgc tgaatctctc
     1501 ccacagcctc cttgacatca gcagtgagca gctcttcgat ggcctgccag cactccagca
     1561 tttgaactta cagggaaatc actttccaaa agggaatatt caaaagacca actcacttca
     1621 gacactggga agactagaaa tcctggtttt atccttttgt gatctctcct ccattgacca
     1681 gcacgccttc accagtctga agatgatgaa tcatgtagac ctgagtcaca acaggctgac
     1741 atccagtagc attgaggctc ttagtcatct taaggggatc tacctcaatc tggcctccaa
     1801 tcgcatcagc atcatcctac ccagtctcct ccccatcttg tcccagcaga ggaccattaa
     1861 tttaagacaa aatccccttg actgcacttg ctcaaacatt tactttttag aatggtacaa
     1921 agaaaacatg caaaaactcg aggacacaga ggacactctt tgcgaaaatc ccccattgct
     1981 gaggggagtc aggctctccg atgtcacgct atcctgtagt atggcagctg tgggcatttt
     2041 ctttcttatt gtattcttgc tcgtgtttgc tattttgctg atttttgcag tgaaatattt
     2101 tctcagatgg aaataccaac acatttagct caagatttcc agagaaggca gataaatgtg
     2161 tttagcaaaa ttgtcccaag tgaagaaact gtcatccttg agtgaccaga cttttctatt
     2221 agttcctagg gctgggctgg gggttcactg agcttttctg aacatatgtc ttactcatat
     2281 gagtcttcca tggtactgtg gttggaggac cagacatggc tgtgag
//
