LOCUS       NM_026862               2724 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus CD177 antigen (Cd177), mRNA.
ACCESSION   NM_026862
VERSION     NM_026862.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2724)
  AUTHORS   Wu,B., Meng,L., Zhao,Y., Li,J., Tian,Q., Pang,Y., Ren,C. and
            Dong,Z.
  TITLE     Meningeal neutrophil immune signaling influences behavioral
            adaptation following threat
  JOURNAL   Neuron 113 (2), 260-276 (2025)
   PUBMED   39561768
REFERENCE   2  (bases 1 to 2724)
  AUTHORS   Meng,L., Zhou,M., Wang,Y., Pan,Y., Chen,Z., Wu,B. and Zhao,Y.
  TITLE     CD177 on neutrophils engages stress-related behavioral changes in
            male mice
  JOURNAL   Brain Behav Immun 120, 403-412 (2024)
   PUBMED   38871062
  REMARK    GeneRIF: CD177 on neutrophils engages stress-related behavioral
            changes in male mice.
REFERENCE   3  (bases 1 to 2724)
  AUTHORS   Li,J., Fang,Z., Xu,S., Rao,H., Liu,J., Lei,K., Yang,L., Wang,C. and
            Zeng,Z.
  TITLE     The link between neutrophils, NETs, and NLRP3 inflammasomes: The
            dual effect of CD177 and its therapeutic potential in acute
            respiratory distress syndrome/acute lung injury
  JOURNAL   Biomol Biomed 24 (4), 798-812 (2024)
   PUBMED   38226808
  REMARK    GeneRIF: The link between neutrophils, NETs, and NLRP3
            inflammasomes: The dual effect of CD177 and its therapeutic
            potential in acute respiratory distress syndrome/acute lung injury.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2724)
  AUTHORS   Chen,H., Wu,X., Sun,R., Lu,H., Lin,R., Gao,X., Li,G., Feng,Z.,
            Zhu,R., Yao,Y., Feng,B. and Liu,Z.
  TITLE     Dysregulation of CD177+ neutrophils on intraepithelial lymphocytes
            exacerbates gut inflammation via decreasing microbiota-derived DMF
  JOURNAL   Gut Microbes 15 (1), 2172668 (2023)
   PUBMED   36729914
REFERENCE   5  (bases 1 to 2724)
  AUTHORS   Kim,M.C., Borcherding,N., Ahmed,K.K., Voigt,A.P., Vishwakarma,A.,
            Kolb,R., Kluz,P.N., Pandey,G., De,U., Drashansky,T., Helm,E.Y.,
            Zhang,X., Gibson-Corley,K.N., Klesney-Tait,J., Zhu,Y., Lu,J.,
            Lu,J., Huang,X., Xiang,H., Cheng,J., Wang,D., Wang,Z., Tang,J.,
            Hu,J., Wang,Z., Liu,H., Li,M., Zhuang,H., Avram,D., Zhou,D.,
            Bacher,R., Zheng,S.G., Wu,X., Zakharia,Y. and Zhang,W.
  TITLE     CD177 modulates the function and homeostasis of tumor-infiltrating
            regulatory T cells
  JOURNAL   Nat Commun 12 (1), 5764 (2021)
   PUBMED   34599187
  REMARK    GeneRIF: CD177 modulates the function and homeostasis of
            tumor-infiltrating regulatory T cells.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2724)
  AUTHORS   Zhou,G., Yu,L., Fang,L., Yang,W., Yu,T., Miao,Y., Chen,M., Wu,K.,
            Chen,F., Cong,Y. and Liu,Z.
  TITLE     CD177+ neutrophils as functionally activated neutrophils negatively
            regulate IBD
  JOURNAL   Gut 67 (6), 1052-1063 (2018)
   PUBMED   28468761
REFERENCE   7  (bases 1 to 2724)
  AUTHORS   Zhou,G., Peng,K., Song,Y., Yang,W., Shu,W., Yu,T., Yu,L., Lin,M.,
            Wei,Q., Chen,C., Yin,L., Cong,Y. and Liu,Z.
  TITLE     CD177+ neutrophils suppress epithelial cell tumourigenesis in
            colitis-associated cancer and predict good prognosis in colorectal
            cancer
  JOURNAL   Carcinogenesis 39 (2), 272-282 (2018)
   PUBMED   29228136
REFERENCE   8  (bases 1 to 2724)
  AUTHORS   Loughner,C.L., Bruford,E.A., McAndrews,M.S., Delp,E.E.,
            Swamynathan,S. and Swamynathan,S.K.
  TITLE     Organization, evolution and functions of the human and mouse
            Ly6/uPAR family genes
  JOURNAL   Hum Genomics 10, 10 (2016)
   PUBMED   27098205
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   9  (bases 1 to 2724)
  AUTHORS   Xie,Q., Klesney-Tait,J., Keck,K., Parlet,C., Borcherding,N.,
            Kolb,R., Li,W., Tygrett,L., Waldschmidt,T., Olivier,A., Chen,S.,
            Liu,G.H., Li,X. and Zhang,W.
  TITLE     Characterization of a novel mouse model with genetic deletion of
            CD177
  JOURNAL   Protein Cell 6 (2), 117-126 (2015)
   PUBMED   25359465
  REMARK    GeneRIF: Herein we established a novel genetic mouse model to study
            the role of CD177 and found that CD177 plays an important role in
            neutrophils.
REFERENCE   10 (bases 1 to 2724)
  AUTHORS   Iwama,A., Zhang,P., Darlington,G.J., McKercher,S.R., Maki,R. and
            Tenen,D.G.
  TITLE     Use of RDA analysis of knockout mice to identify myeloid genes
            regulated in vivo by PU.1 and C/EBPalpha
  JOURNAL   Nucleic Acids Res 26 (12), 3034-3043 (1998)
   PUBMED   9611252
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC161488.7.
            
            On Feb 25, 2022 this sequence version replaced NM_026862.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC027283.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-87                AC161488.7         64556-64642
            88-231              AC161488.7         64735-64878
            232-417             AC161488.7         65091-65276
            418-537             AC161488.7         66428-66547
            538-654             AC161488.7         66765-66881
            655-795             AC161488.7         68155-68295
            796-981             AC161488.7         68542-68727
            982-1101            AC161488.7         70205-70324
            1102-1227           AC161488.7         70479-70604
            1228-1362           AC161488.7         72480-72614
            1363-1548           AC161488.7         72728-72913
            1549-1668           AC161488.7         74182-74301
            1669-1788           AC161488.7         74452-74571
            1789-1935           AC161488.7         78614-78760
            1936-2121           AC161488.7         79623-79808
            2122-2253           AC161488.7         79912-80043
            2254-2724           AC161488.7         80424-80894
FEATURES             Location/Qualifiers
     source          1..2724
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 12.58 cM"
     gene            1..2724
                     /gene="Cd177"
                     /gene_synonym="1190003K14Rik; Pdp3"
                     /note="CD177 antigen"
                     /db_xref="GeneID:68891"
                     /db_xref="MGI:MGI:1916141"
     exon            1..87
                     /gene="Cd177"
                     /gene_synonym="1190003K14Rik; Pdp3"
                     /inference="alignment:Splign:2.1.0"
     CDS             36..2489
                     /gene="Cd177"
                     /gene_synonym="1190003K14Rik; Pdp3"
                     /codon_start=1
                     /product="CD177 antigen precursor"
                     /protein_id="NP_081138.2"
                     /db_xref="CCDS:CCDS20962.1"
                     /db_xref="GeneID:68891"
                     /db_xref="MGI:MGI:1916141"
                     /translation="MNSIPVLTLLGVTALLPCVPALTCQKSSAQAVRNVAELPLRWWG
                     AGEKTCEVSEGCQDLIMLLYNGPKVNLVIIKGCTEVEDQEPKVIWLRTGPGLSVVSYT
                     RVCRHGDLCNDVNSTKILEELPTPTVPGSLRCPLCLSNDSCENAPEQVCPVGSTHCYD
                     GVLRLRGDGIRTNLKVQGCMAQPDCNLLNGTQAIGTLYMSENCDLIGPQALDCNSGSL
                     ETVRNVSDLHLSWTTGWQTCEAGEGCYETVMLIQNGHEFHMVLTKGCTRDMNKKARLT
                     RHRTGPGISIVSYVHVCRDRDFCNDLSTTDPLWTPPPDTELGTLRCRHCLSTGSCVSA
                     SELVCPAGSTHCYSGVLSLRGGGVISDLKVQGCISQSQPGCNLLNGTQTIGPVDVRED
                     CGLQLDALKCQHGTLKTIQDISKLPLQWTAGQKICNVGEGCQDTLMLIENGEQVNLVL
                     TKGCTTAKDQEAKVTEHRTGPGLSVTSYTRVCRKKDFCNDLSTTAPLWAPPPVTAPGT
                     TRCPLCFSEQACENAPEQVCPAGSTHCYSGVLSLRGGGIISDLKVQGCMSQPGCNLLN
                     GTQTIGPVDVSERCSPPSETTELSCYRGVMFELGNGFAEEPVKWTAPGSQVCAPDEIC
                     QETLLLIDVGQKSAFLGSKGCSSPGAQDNIGVSIFSRLPGMLVASYTKFCSSHLCNGA
                     DSSSVLLSILPRPDVPPPGDVQCPMCVELFGSCKSTDSVTCPRGATHCYKGDIALQGG
                     GLTTRVSIQGCMAPPIKPLLGDSKTIGIFSAEESSNYRHEDDVTSAPSLAWTLRLSAW
                     MLGLSALLSSLYAGICPLC"
     exon            88..231
                     /gene="Cd177"
                     /gene_synonym="1190003K14Rik; Pdp3"
                     /inference="alignment:Splign:2.1.0"
     exon            232..417
                     /gene="Cd177"
                     /gene_synonym="1190003K14Rik; Pdp3"
                     /inference="alignment:Splign:2.1.0"
     exon            418..537
                     /gene="Cd177"
                     /gene_synonym="1190003K14Rik; Pdp3"
                     /inference="alignment:Splign:2.1.0"
     exon            538..654
                     /gene="Cd177"
                     /gene_synonym="1190003K14Rik; Pdp3"
                     /inference="alignment:Splign:2.1.0"
     exon            655..795
                     /gene="Cd177"
                     /gene_synonym="1190003K14Rik; Pdp3"
                     /inference="alignment:Splign:2.1.0"
     exon            796..981
                     /gene="Cd177"
                     /gene_synonym="1190003K14Rik; Pdp3"
                     /inference="alignment:Splign:2.1.0"
     exon            982..1101
                     /gene="Cd177"
                     /gene_synonym="1190003K14Rik; Pdp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1102..1227
                     /gene="Cd177"
                     /gene_synonym="1190003K14Rik; Pdp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1228..1362
                     /gene="Cd177"
                     /gene_synonym="1190003K14Rik; Pdp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1363..1548
                     /gene="Cd177"
                     /gene_synonym="1190003K14Rik; Pdp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1549..1668
                     /gene="Cd177"
                     /gene_synonym="1190003K14Rik; Pdp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1669..1788
                     /gene="Cd177"
                     /gene_synonym="1190003K14Rik; Pdp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1789..1935
                     /gene="Cd177"
                     /gene_synonym="1190003K14Rik; Pdp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1936..2121
                     /gene="Cd177"
                     /gene_synonym="1190003K14Rik; Pdp3"
                     /inference="alignment:Splign:2.1.0"
     exon            2122..2253
                     /gene="Cd177"
                     /gene_synonym="1190003K14Rik; Pdp3"
                     /inference="alignment:Splign:2.1.0"
     exon            2254..2724
                     /gene="Cd177"
                     /gene_synonym="1190003K14Rik; Pdp3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agcactggag aaatttccag ccacagactg gtatcatgaa ttctatacca gtgctgaccc
       61 ttctgggggt cacggccttg ctaccctgtg tcccagctct gacctgccag aaaagcagcg
      121 cacaggctgt gaggaatgtg gcagagctgc ccctcaggtg gtggggagct ggtgagaaaa
      181 cctgcgaggt tagcgagggt tgccaagact tgataatgct cctgtataat ggacccaagg
      241 tcaacttggt gatcatcaag ggctgcaccg aggttgagga ccaagagccg aaggtgatct
      301 ggctcaggac aggccctggg ctctctgtgg tgtcctacac ccgtgtgtgt cgccatggtg
      361 acctctgcaa tgatgtgaac agcactaaga tccttgagga gctacctaca cccacagttc
      421 cagggtccct gcgctgccca ctctgccttt ctaatgacag ctgtgagaat gcaccggagc
      481 aggtctgccc tgtgggaagc acacactgct acgatggagt cctcaggctc aggggagatg
      541 gcatcaggac caatctcaag gtgcagggct gcatggccca gccagactgc aacctgctta
      601 atggcaccca ggcgattggg accttgtata tgagcgaaaa ctgtgatctt ataggtccac
      661 aggctctgga ttgcaatagt gggagcttgg aaactgtgag gaatgtatca gatctgcact
      721 tgagctggac gactggctgg caaacctgtg aggctggcga ggggtgttat gaaacagtga
      781 tgctaataca aaatggacat gaatttcaca tggttctcac taagggatgt actagggata
      841 tgaacaaaaa ggctcggctc accaggcata gaacaggccc agggatctcc atcgtctcct
      901 acgtgcatgt gtgccgcgac agggacttct gtaatgacct gtctacaaca gaccctcttt
      961 ggaccccgcc ccctgacaca gagctaggga ccctgcgctg ccgacactgc ctttcaaccg
     1021 gcagctgtgt gagtgcatcc gagctggtct gccccgcagg cagcacacac tgctacagtg
     1081 gagtcctcag cctcagggga ggaggggtca tttctgatct gaaggtacag ggatgcatat
     1141 cgcagtccca gccaggatgc aacctgctca acggtaccca gacaatcgga cccgtggatg
     1201 tgcgtgagga ctgcggtctt cagttagatg ctctgaaatg ccagcatggg acgctgaaga
     1261 ccatccagga tatatcgaag ctgcctctcc agtggacggc tggccagaaa atctgtaatg
     1321 tgggtgaagg ctgccaagac acactgatgt tgatagagaa cggagagcag gtgaacttgg
     1381 ttctcacgaa aggctgcact accgcaaagg accaagaggc caaagtcacg gagcacagaa
     1441 ctggaccagg gctgtctgtc acctcctaca cccgagtgtg ccgtaaaaaa gacttctgca
     1501 atgacctgtc taccacagcc cctctctggg ctccacctcc agtgacagcc ccagggacca
     1561 ctcgctgccc tctctgcttt tctgaacaag cctgtgagaa tgcaccggag caggtctgcc
     1621 ctgcaggcag cacacactgc tacagtggag tcctcagcct caggggagga gggatcatct
     1681 ctgatctgaa ggtgcagggc tgtatgtccc agccaggatg caacctgctc aacggtaccc
     1741 agacaatcgg acccgtggat gtgagcgagc gctgcagtcc tccgtcagaa acaacagagt
     1801 tgtcctgtta caggggtgtg atgtttgagc ttggcaatgg ctttgcggag gaacctgtca
     1861 agtggacggc accagggtct caggtgtgtg cacctgatga gatttgtcaa gagacgctgc
     1921 tgctcataga cgtaggacaa aaatcagcct tcctggggag taaaggctgc agcagtcctg
     1981 gggcgcagga caatattggt gtctccatat tctcccggct ccctgggatg ctggtagctt
     2041 cctataccaa attctgttct tcccacctgt gcaatggagc cgacagcagc agtgtccttc
     2101 taagcatcct ccctcgtcca gatgttcctc ccccaggaga tgtgcagtgc cccatgtgtg
     2161 tagagttatt tggatcctgc aagagcactg actctgtcac ctgccctagg ggtgccactc
     2221 actgttataa aggtgacatt gcactacagg gaggtggact gactaccaga gtgagcattc
     2281 aggggtgcat ggccccacct atcaaacctt tactgggtga ctccaaaaca atcggtatct
     2341 tctcggcaga ggagagctct aactatcgac atgaggatga tgttacctcg gccccttccc
     2401 tggcctggac cttacggcta tcggcctgga tgttagggct atcggctctt ctcagctctt
     2461 tgtatgctgg gatctgtcct ctctgctgaa cccatttcct gaccattctt aatccctctt
     2521 ggccacccag acccagccct cctctgactt caaagacctg aggctgggcg ctgtcggcct
     2581 gcgctgtcgg gcgccctcat ccctcaccca cacacctctg cccctcatgc ttagacttgg
     2641 gagccactga acccagccgg ctccagagca gacaagcaca cgttgaccac gtgtggaaaa
     2701 ataaagttgc tgttgtttgt ccaa
//
