LOCUS       NP_081138                817 aa            linear   ROD 28-JAN-2025
DEFINITION  CD177 antigen precursor [Mus musculus].
ACCESSION   NP_081138
VERSION     NP_081138.2
DBSOURCE    REFSEQ: accession NM_026862.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 817)
  AUTHORS   Wu,B., Meng,L., Zhao,Y., Li,J., Tian,Q., Pang,Y., Ren,C. and
            Dong,Z.
  TITLE     Meningeal neutrophil immune signaling influences behavioral
            adaptation following threat
  JOURNAL   Neuron 113 (2), 260-276 (2025)
   PUBMED   39561768
REFERENCE   2  (residues 1 to 817)
  AUTHORS   Meng,L., Zhou,M., Wang,Y., Pan,Y., Chen,Z., Wu,B. and Zhao,Y.
  TITLE     CD177 on neutrophils engages stress-related behavioral changes in
            male mice
  JOURNAL   Brain Behav Immun 120, 403-412 (2024)
   PUBMED   38871062
  REMARK    GeneRIF: CD177 on neutrophils engages stress-related behavioral
            changes in male mice.
REFERENCE   3  (residues 1 to 817)
  AUTHORS   Li,J., Fang,Z., Xu,S., Rao,H., Liu,J., Lei,K., Yang,L., Wang,C. and
            Zeng,Z.
  TITLE     The link between neutrophils, NETs, and NLRP3 inflammasomes: The
            dual effect of CD177 and its therapeutic potential in acute
            respiratory distress syndrome/acute lung injury
  JOURNAL   Biomol Biomed 24 (4), 798-812 (2024)
   PUBMED   38226808
  REMARK    GeneRIF: The link between neutrophils, NETs, and NLRP3
            inflammasomes: The dual effect of CD177 and its therapeutic
            potential in acute respiratory distress syndrome/acute lung injury.
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 817)
  AUTHORS   Chen,H., Wu,X., Sun,R., Lu,H., Lin,R., Gao,X., Li,G., Feng,Z.,
            Zhu,R., Yao,Y., Feng,B. and Liu,Z.
  TITLE     Dysregulation of CD177+ neutrophils on intraepithelial lymphocytes
            exacerbates gut inflammation via decreasing microbiota-derived DMF
  JOURNAL   Gut Microbes 15 (1), 2172668 (2023)
   PUBMED   36729914
REFERENCE   5  (residues 1 to 817)
  AUTHORS   Kim,M.C., Borcherding,N., Ahmed,K.K., Voigt,A.P., Vishwakarma,A.,
            Kolb,R., Kluz,P.N., Pandey,G., De,U., Drashansky,T., Helm,E.Y.,
            Zhang,X., Gibson-Corley,K.N., Klesney-Tait,J., Zhu,Y., Lu,J.,
            Lu,J., Huang,X., Xiang,H., Cheng,J., Wang,D., Wang,Z., Tang,J.,
            Hu,J., Wang,Z., Liu,H., Li,M., Zhuang,H., Avram,D., Zhou,D.,
            Bacher,R., Zheng,S.G., Wu,X., Zakharia,Y. and Zhang,W.
  TITLE     CD177 modulates the function and homeostasis of tumor-infiltrating
            regulatory T cells
  JOURNAL   Nat Commun 12 (1), 5764 (2021)
   PUBMED   34599187
  REMARK    GeneRIF: CD177 modulates the function and homeostasis of
            tumor-infiltrating regulatory T cells.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 817)
  AUTHORS   Zhou,G., Yu,L., Fang,L., Yang,W., Yu,T., Miao,Y., Chen,M., Wu,K.,
            Chen,F., Cong,Y. and Liu,Z.
  TITLE     CD177+ neutrophils as functionally activated neutrophils negatively
            regulate IBD
  JOURNAL   Gut 67 (6), 1052-1063 (2018)
   PUBMED   28468761
REFERENCE   7  (residues 1 to 817)
  AUTHORS   Zhou,G., Peng,K., Song,Y., Yang,W., Shu,W., Yu,T., Yu,L., Lin,M.,
            Wei,Q., Chen,C., Yin,L., Cong,Y. and Liu,Z.
  TITLE     CD177+ neutrophils suppress epithelial cell tumourigenesis in
            colitis-associated cancer and predict good prognosis in colorectal
            cancer
  JOURNAL   Carcinogenesis 39 (2), 272-282 (2018)
   PUBMED   29228136
REFERENCE   8  (residues 1 to 817)
  AUTHORS   Loughner,C.L., Bruford,E.A., McAndrews,M.S., Delp,E.E.,
            Swamynathan,S. and Swamynathan,S.K.
  TITLE     Organization, evolution and functions of the human and mouse
            Ly6/uPAR family genes
  JOURNAL   Hum Genomics 10, 10 (2016)
   PUBMED   27098205
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   9  (residues 1 to 817)
  AUTHORS   Xie,Q., Klesney-Tait,J., Keck,K., Parlet,C., Borcherding,N.,
            Kolb,R., Li,W., Tygrett,L., Waldschmidt,T., Olivier,A., Chen,S.,
            Liu,G.H., Li,X. and Zhang,W.
  TITLE     Characterization of a novel mouse model with genetic deletion of
            CD177
  JOURNAL   Protein Cell 6 (2), 117-126 (2015)
   PUBMED   25359465
  REMARK    GeneRIF: Herein we established a novel genetic mouse model to study
            the role of CD177 and found that CD177 plays an important role in
            neutrophils.
REFERENCE   10 (residues 1 to 817)
  AUTHORS   Iwama,A., Zhang,P., Darlington,G.J., McKercher,S.R., Maki,R. and
            Tenen,D.G.
  TITLE     Use of RDA analysis of knockout mice to identify myeloid genes
            regulated in vivo by PU.1 and C/EBPalpha
  JOURNAL   Nucleic Acids Res 26 (12), 3034-3043 (1998)
   PUBMED   9611252
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC161488.7.
            
            On Aug 28, 2003 this sequence version replaced NP_081138.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC027283.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..817
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 12.58 cM"
     Protein         1..817
                     /product="CD177 antigen precursor"
                     /calculated_mol_wt=84987
     sig_peptide     1..21
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2123
     Region          21..120
                     /region_name="TFP_LU_ECD_CD177_rpt1"
                     /note="first extracellular domain (ECD) found in CD177
                     antigen and similar proteins; cd23623"
                     /db_xref="CDD:467143"
     mat_peptide     22..817
                     /product="CD177 antigen. /id=PRO_0000378449"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8R2S8.1)"
                     /calculated_mol_wt=84987
     Site            115
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q8R2S8.1)"
     Region          129..204
                     /region_name="TFP_LU_ECD_CD177_rpt2"
                     /note="second extracellular domain (ECD) found in CD177
                     antigen and similar proteins; cd23636"
                     /db_xref="CDD:467800"
     Site            189
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q8R2S8.1)"
     Region          210..309
                     /region_name="TFP_LU_ECD_CD177_rpt1"
                     /note="first extracellular domain (ECD) found in CD177
                     antigen and similar proteins; cd23623"
                     /db_xref="CDD:467143"
     Region          317..393
                     /region_name="TFP_LU_ECD_CD177_rpt2"
                     /note="second extracellular domain (ECD) found in CD177
                     antigen and similar proteins; cd23636"
                     /db_xref="CDD:467800"
     Site            379
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q8R2S8.1)"
     Region          399..498
                     /region_name="TFP_LU_ECD_CD177_rpt1"
                     /note="first extracellular domain (ECD) found in CD177
                     antigen and similar proteins; cd23623"
                     /db_xref="CDD:467143"
     Region          506..580
                     /region_name="TFP_LU_ECD_CD177_rpt2"
                     /note="second extracellular domain (ECD) found in CD177
                     antigen and similar proteins; cd23636"
                     /db_xref="CDD:467800"
     Site            566
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q8R2S8.1)"
     Region          589..689
                     /region_name="TFP_LU_ECD_CD177_rpt3"
                     /note="third extracellular domain (ECD) found in CD177
                     antigen and similar proteins; cd23624"
                     /db_xref="CDD:467144"
     Region          700..776
                     /region_name="TFP_LU_ECD_CD177_rpt4"
                     /note="fourth extracellular domain (ECD) found in CD177
                     antigen and similar proteins; cd23637"
                     /db_xref="CDD:467801"
     Site            797..817
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8R2S8.1)"
     CDS             1..817
                     /gene="Cd177"
                     /gene_synonym="1190003K14Rik; Pdp3"
                     /coded_by="NM_026862.4:36..2489"
                     /db_xref="CCDS:CCDS20962.1"
                     /db_xref="GeneID:68891"
                     /db_xref="MGI:MGI:1916141"
ORIGIN      
        1 mnsipvltll gvtallpcvp altcqkssaq avrnvaelpl rwwgagektc evsegcqdli
       61 mllyngpkvn lviikgctev edqepkviwl rtgpglsvvs ytrvcrhgdl cndvnstkil
      121 eelptptvpg slrcplclsn dscenapeqv cpvgsthcyd gvlrlrgdgi rtnlkvqgcm
      181 aqpdcnllng tqaigtlyms encdligpqa ldcnsgslet vrnvsdlhls wttgwqtcea
      241 gegcyetvml iqnghefhmv ltkgctrdmn kkarltrhrt gpgisivsyv hvcrdrdfcn
      301 dlsttdplwt pppdtelgtl rcrhclstgs cvsaselvcp agsthcysgv lslrgggvis
      361 dlkvqgcisq sqpgcnllng tqtigpvdvr edcglqldal kcqhgtlkti qdisklplqw
      421 tagqkicnvg egcqdtlmli engeqvnlvl tkgcttakdq eakvtehrtg pglsvtsytr
      481 vcrkkdfcnd lsttaplwap ppvtapgttr cplcfseqac enapeqvcpa gsthcysgvl
      541 slrgggiisd lkvqgcmsqp gcnllngtqt igpvdvserc sppsettels cyrgvmfelg
      601 ngfaeepvkw tapgsqvcap deicqetlll idvgqksafl gskgcsspga qdnigvsifs
      661 rlpgmlvasy tkfcsshlcn gadsssvlls ilprpdvppp gdvqcpmcve lfgsckstds
      721 vtcprgathc ykgdialqgg glttrvsiqg cmappikpll gdsktigifs aeessnyrhe
      781 ddvtsapsla wtlrlsawml glsallssly agicplc
//
