LOCUS       NM_053094               4409 bp    mRNA    linear   ROD 05-DEC-2024
DEFINITION  Mus musculus CD163 antigen (Cd163), transcript variant 2, mRNA.
ACCESSION   NM_053094 XM_981067
VERSION     NM_053094.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4409)
  AUTHORS   Mori,M., Sakamoto,A., Kawakami,R., Guo,L., Slenders,L.,
            Mosquera,J.V., Ghosh,S.K.B., Wesseling,M., Shiraki,T.,
            Bellissard,A., Shah,P., Weinkauf,C.C., Konishi,T., Sato,Y.,
            Cornelissen,A., Kawai,K., Jinnouchi,H., Xu,W., Vozenilek,A.E.,
            Williams,D., Tanaka,T., Sekimoto,T., Kelly,M.C., Fernandez,R.,
            Grogan,A., Coslet,A.J., Fedotova,A., Kurse,A., Mokry,M.,
            Romero,M.E., Kolodgie,F.D., Pasterkamp,G., Miller,C.L., Virmani,R.
            and Finn,A.V.
  TITLE     CD163+ Macrophages Induce Endothelial-to-Mesenchymal Transition in
            Atheroma
  JOURNAL   Circ Res 135 (2), e4-e23 (2024)
   PUBMED   38860377
  REMARK    GeneRIF: CD163[+] Macrophages Induce Endothelial-to-Mesenchymal
            Transition in Atheroma.
REFERENCE   2  (bases 1 to 4409)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 4409)
  AUTHORS   Ferreira,S.A., Li,C., Klaestrup,I.H., Vitic,Z., Rasmussen,R.K.,
            Kirkegaard,A., Toft,G.U., Betzer,C., Svendsen,P., Jensen,P.H.,
            Luo,Y., Etzerodt,A., Moestrup,S.K. and Romero-Ramos,M.
  TITLE     Sex-dimorphic neuroprotective effect of CD163 in an alpha-synuclein
            mouse model of Parkinson's disease
  JOURNAL   NPJ Parkinsons Dis 9 (1), 164 (2023)
   PUBMED   38092806
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4409)
  AUTHORS   Ren,Y., Zhang,S., Weeks,J., Moreno,J.R., He,B., Xue,T.,
            Rainbolt,J., Morita,Y., Shu,Y., Liu,Y., Kates,S.L., Schwarz,E.M.
            and Xie,C.
  TITLE     Reduced angiogenesis and delayed endochondral ossification in
            CD163-/- mice highlights a role of M2 macrophages during bone
            fracture repair
  JOURNAL   J Orthop Res 41 (11), 2384-2393 (2023)
   PUBMED   36970754
REFERENCE   5  (bases 1 to 4409)
  AUTHORS   Shaw,T.M., Maloney,S.M., Nennig,K., Ramuta,M.D., Norton,A.,
            Ibarra,R., Kuehnert,P., Brinton,M., Faaberg,K., Kuhn,J.H.,
            O'Connor,D.H., Warren,C.J. and Bailey,A.L.
  TITLE     Ectopic expression of murine CD163 enables cell-culture isolation
            of lactate dehydrogenase-elevating virus 63 years after its
            discovery
  JOURNAL   J Virol 97 (10), e0093023 (2023)
   PUBMED   37792000
REFERENCE   6  (bases 1 to 4409)
  AUTHORS   Fujisaka,S., Usui,I., Kanatani,Y., Ikutani,M., Takasaki,I.,
            Tsuneyama,K., Tabuchi,Y., Bukhari,A., Yamazaki,Y., Suzuki,H.,
            Senda,S., Aminuddin,A., Nagai,Y., Takatsu,K., Kobayashi,M. and
            Tobe,K.
  TITLE     Telmisartan improves insulin resistance and modulates adipose
            tissue macrophage polarization in high-fat-fed mice
  JOURNAL   Endocrinology 152 (5), 1789-1799 (2011)
   PUBMED   21427223
  REMARK    GeneRIF: Data show that telmisartan reduced the mRNA expression of
            CD11c and TNF-alpha, M1 macrophage markers, and significantly
            increased the expressions of M2 markers, such as CD163, CD209.
REFERENCE   7  (bases 1 to 4409)
  AUTHORS   Calvert,J.G., Slade,D.E., Shields,S.L., Jolie,R., Mannan,R.M.,
            Ankenbauer,R.G. and Welch,S.K.
  TITLE     CD163 expression confers susceptibility to porcine reproductive and
            respiratory syndrome viruses
  JOURNAL   J Virol 81 (14), 7371-7379 (2007)
   PUBMED   17494075
REFERENCE   8  (bases 1 to 4409)
  AUTHORS   Ghazalpour,A., Wang,X., Lusis,A.J. and Mehrabian,M.
  TITLE     Complex inheritance of the 5-lipoxygenase locus influencing
            atherosclerosis in mice
  JOURNAL   Genetics 173 (2), 943-951 (2006)
   PUBMED   16624897
REFERENCE   9  (bases 1 to 4409)
  AUTHORS   Schaer,D.J., Schoedon,G. and Schaffner,A.
  TITLE     Assignment of the CD163 antigen (CD163) to mouse chromosome 6 band
            F2 by radiation hybrid mapping
  JOURNAL   Cytogenet Genome Res 98 (2-3), 231B (2002)
   PUBMED   12698011
  REMARK    GeneRIF: Assignment of the CD163 antigen to mouse chromosome 6 band
            F2.
REFERENCE   10 (bases 1 to 4409)
  AUTHORS   Schaer,D.J., Boretti,F.S., Hongegger,A., Poehler,D., Linnscheid,P.,
            Staege,H., Muller,C., Schoedon,G. and Schaffner,A.
  TITLE     Molecular cloning and characterization of the mouse CD163
            homologue, a highly glucocorticoid-inducible member of the
            scavenger receptor cysteine-rich family
  JOURNAL   Immunogenetics 53 (2), 170-177 (2001)
   PUBMED   11345593
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC124470.4.
            
            On Dec 18, 2009 this sequence version replaced NM_053094.1.
            
            Transcript Variant: This variant (2) lacks an alternate segment in
            the 3' coding region, compared to variant 1. The resulting protein
            (isoform 2) is shorter than isoform 1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF274883.1, BC145793.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-135               AC124470.4         123649-123783       c
            136-219             AC124470.4         122554-122637       c
            220-540             AC124470.4         121113-121433       c
            541-864             AC124470.4         119167-119490       c
            865-1185            AC124470.4         116727-117047       c
            1186-1506           AC124470.4         115693-116013       c
            1507-1821           AC124470.4         110818-111132       c
            1822-2136           AC124470.4         110409-110723       c
            2137-2232           AC124470.4         109685-109780       c
            2233-2547           AC124470.4         109278-109592       c
            2548-2871           AC124470.4         107756-108079       c
            2872-3183           AC124470.4         102862-103173       c
            3184-3213           AC124470.4         102289-102318       c
            3214-3321           AC124470.4         101826-101933       c
            3322-3411           AC124470.4         100447-100536       c
            3412-3464           AC124470.4         99337-99389         c
            3465-4409           AC124470.4         97907-98851         c
FEATURES             Location/Qualifiers
     source          1..4409
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 59.13 cM"
     gene            1..4409
                     /gene="Cd163"
                     /gene_synonym="CD163v2; CD163v3"
                     /note="CD163 antigen"
                     /db_xref="GeneID:93671"
                     /db_xref="MGI:MGI:2135946"
     exon            1..135
                     /gene="Cd163"
                     /gene_synonym="CD163v2; CD163v3"
                     /inference="alignment:Splign:2.1.0"
     CDS             90..3455
                     /gene="Cd163"
                     /gene_synonym="CD163v2; CD163v3"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2; scavenger receptor cysteine-rich type 1 protein
                     M130"
                     /codon_start=1
                     /product="scavenger receptor cysteine-rich type 1 protein
                     M130 isoform 2 precursor"
                     /protein_id="NP_444324.2"
                     /db_xref="CCDS:CCDS20516.1"
                     /db_xref="GeneID:93671"
                     /db_xref="MGI:MGI:2135946"
                     /translation="MGGHRMVLLGGAGSPGCKRFVHLGFFVVAVSSLLSASAVTNAPG
                     EMKKELRLAGGENNCSGRVELKIHDKWGTVCSNGWSMNEVSVVCQQLGCPTSIKALGW
                     ANSSAGSGYIWMDKVSCTGNESALWDCKHDGWGKHNCTHEKDAGVTCSDGSNLEMRLV
                     NSAGHRCLGRVEIKFQGKWGTVCDDNFSKDHASVICKQLGCGSAISFSGSAKLGAGSG
                     PIWLDDLACNGNESALWDCKHRGWGKHNCDHAEDVGVICLEGADLSLRLVDGVSRCSG
                     RLEVRFQGEWGTVCDDNWDLRDASVVCKQLGCPTAISAIGRVNASEGSGQIWLDNISC
                     EGHEATLWECKHQEWGKHYCHHREDAGVTCSDGADLELRLVGGGSRCAGIVEVEIQKL
                     TGKMCSRGWTLADADVVCRQLGCGSALQTQAKIYSKTGATNTWLFPGSCNGNETTFWQ
                     CKNWQWGGLSCDNFEEAKVTCSGHREPRLVGGEIPCSGRVEVKHGDVWGSVCDFDLSL
                     EAASVVCRELQCGTVVSILGGAHFGEGSGQIWGEEFQCSGDESHLSLCSVAPPLDRTC
                     THSRDVSVVCSRYIDIRLAGGESSCEGRVELKTLGAWGPLCSSHWDMEDAHVLCQQLK
                     CGVAQSIPEGAHFGKGAGQVWSHMFHCTGTEEHIGDCLMTALGAPTCSEGQVASVICS
                     GNQSQTLLPCSSLSPVQTTSSTIPKESEVPCIASGQLRLVGGGGRCAGRVEVYHEGSW
                     GTVCDDNWDMTDANVVCKQLDCGVAINATGSAYFGEGAGAIWLDEVICTGKESHIWQC
                     HSHGWGRHNCRHKEDAGVICSEFMSLRLTNEAHKENCTGRLEVFYNGTWGSIGSSNMS
                     PTTVGVVCRQLGCADNGTVKPIPSDKTPSRPMWVDRVQCPKGVDTLWQCPSSPWKQRQ
                     ASPSSQESWIICDNKIRLQEGHTDCSGRVEIWHKGSWGTVCDDSWDLNDAKVVCKQLG
                     CGQAVKALKEAAFGPGTGPIWLNEIKCRGNESSLWDCPAKPWSHSDCGHKEDASIQCL
                     PKMTSESHHGTGHPTLTALLVCGAILLVLLIVFLLWTLKRRQIQRLTVSSRGEVLIHQ
                     VQYQEMDSKADDLDLLKSSGVIQRHTEKENDNL"
     exon            136..219
                     /gene="Cd163"
                     /gene_synonym="CD163v2; CD163v3"
                     /inference="alignment:Splign:2.1.0"
     exon            220..540
                     /gene="Cd163"
                     /gene_synonym="CD163v2; CD163v3"
                     /inference="alignment:Splign:2.1.0"
     exon            541..864
                     /gene="Cd163"
                     /gene_synonym="CD163v2; CD163v3"
                     /inference="alignment:Splign:2.1.0"
     exon            865..1185
                     /gene="Cd163"
                     /gene_synonym="CD163v2; CD163v3"
                     /inference="alignment:Splign:2.1.0"
     exon            1186..1506
                     /gene="Cd163"
                     /gene_synonym="CD163v2; CD163v3"
                     /inference="alignment:Splign:2.1.0"
     exon            1507..1821
                     /gene="Cd163"
                     /gene_synonym="CD163v2; CD163v3"
                     /inference="alignment:Splign:2.1.0"
     exon            1822..2136
                     /gene="Cd163"
                     /gene_synonym="CD163v2; CD163v3"
                     /inference="alignment:Splign:2.1.0"
     exon            2137..2232
                     /gene="Cd163"
                     /gene_synonym="CD163v2; CD163v3"
                     /inference="alignment:Splign:2.1.0"
     exon            2233..2547
                     /gene="Cd163"
                     /gene_synonym="CD163v2; CD163v3"
                     /inference="alignment:Splign:2.1.0"
     exon            2548..2871
                     /gene="Cd163"
                     /gene_synonym="CD163v2; CD163v3"
                     /inference="alignment:Splign:2.1.0"
     exon            2872..3183
                     /gene="Cd163"
                     /gene_synonym="CD163v2; CD163v3"
                     /inference="alignment:Splign:2.1.0"
     exon            3184..3213
                     /gene="Cd163"
                     /gene_synonym="CD163v2; CD163v3"
                     /inference="alignment:Splign:2.1.0"
     exon            3214..3321
                     /gene="Cd163"
                     /gene_synonym="CD163v2; CD163v3"
                     /inference="alignment:Splign:2.1.0"
     exon            3322..3411
                     /gene="Cd163"
                     /gene_synonym="CD163v2; CD163v3"
                     /inference="alignment:Splign:2.1.0"
     exon            3412..3464
                     /gene="Cd163"
                     /gene_synonym="CD163v2; CD163v3"
                     /inference="alignment:Splign:2.1.0"
     exon            3465..4409
                     /gene="Cd163"
                     /gene_synonym="CD163v2; CD163v3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4390..4395
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cd163"
                     /gene_synonym="CD163v2; CD163v3"
                     /note="hexamer: AATAAA"
     polyA_site      4409
                     /gene="Cd163"
                     /gene_synonym="CD163v2; CD163v3"
                     /note="major polyA site"
ORIGIN      
        1 cctccgtggt catccacttt ctacagagaa cacgtctatg aaatagtatc aggagacaca
       61 cggagccatc aaaatcatca agctttggaa tgggtggaca cagaatggtt cttcttggag
      121 gtgctggatc tcctggttgt aaaaggtttg tccatctagg tttctttgtt gtggctgtga
      181 gctcacttct cagtgcctct gctgtcacta acgctcctgg agaaatgaag aaggaactga
      241 gactggcggg tggtgaaaac aactgtagtg ggagagtgga acttaagatc catgacaagt
      301 ggggcacagt gtgcagtaac ggctggagca tgaatgaagt gtccgtggtt tgccagcagc
      361 tgggatgccc aacttctatt aaagcccttg gatgggctaa ctccagcgcc ggctctggat
      421 atatctggat ggacaaagtt tcttgtacag ggaatgagtc agctctttgg gactgcaaac
      481 atgatgggtg gggaaagcat aactgtaccc atgaaaaaga tgctggagtg acctgctcag
      541 atggatctaa tttggagatg agactggtga acagtgcggg ccaccgatgc ttaggaagag
      601 tagaaataaa gttccaggga aagtggggga cggtgtgtga cgacaacttc agcaaagatc
      661 acgcttctgt gatttgtaaa cagcttggat gtggaagtgc cattagtttc tctggctcag
      721 ctaaattggg agctggttct ggaccaatct ggctcgatga cctggcatgc aatggaaatg
      781 agtcagctct ctgggactgc aaacaccggg gatggggcaa gcataactgt gaccatgctg
      841 aggatgtcgg tgtgatttgc ttagagggag cagatctgag cctgagacta gtggatggag
      901 tgtccagatg ttcaggaaga ttggaagtga gattccaagg agaatggggg accgtgtgtg
      961 atgataactg ggatctccgg gatgcttctg tggtgtgcaa gcaactggga tgtccaactg
     1021 ccatcagtgc cattggtcga gttaatgcca gtgagggatc tggacagatt tggcttgaca
     1081 acatttcatg cgaaggacat gaggcaactc tttgggagtg taaacaccaa gagtggggaa
     1141 agcattactg tcatcataga gaagacgctg gtgtgacatg ttctgatgga gcagatctgg
     1201 aacttagact tgtaggtgga ggcagtcgct gtgctggcat tgtggaggtg gagattcaga
     1261 agctgactgg gaagatgtgt agccgaggct ggacactggc agatgcggat gtggtttgca
     1321 gacagcttgg atgtggatct gcgcttcaaa cccaggctaa gatctactct aaaactgggg
     1381 caacaaatac gtggctcttt cctggatctt gtaatggaaa tgaaactact ttttggcaat
     1441 gcaaaaactg gcagtggggc ggcctttcct gtgataattt cgaagaagcc aaagttacct
     1501 gctcaggcca cagggaaccc agactggttg gaggagaaat cccatgctct ggtcgtgtgg
     1561 aagtgaaaca cggagacgtg tggggctccg tctgtgattt tgacttgtct ctggaagctg
     1621 ccagtgtggt gtgcagggaa ttacaatgtg gaacagtcgt ctctatccta gggggagcac
     1681 attttggaga aggaagtgga cagatctggg gtgaagaatt ccagtgtagt ggggatgagt
     1741 cccatctttc actatgctca gtggcgcccc cgctagacag aacttgtacc cacagcaggg
     1801 atgtcagcgt agtctgctca cgatacatag atattcgtct ggcaggcggc gagtcctcct
     1861 gtgagggaag agtggagctc aagacactcg gagcctgggg tcccctctgc agttctcatt
     1921 gggacatgga agatgctcat gtcttatgtc agcagctgaa gtgtggggtt gcccaatcta
     1981 ttccagaagg agcacatttt gggaaaggag ctggtcaggt ctggagtcac atgttccact
     2041 gcactggaac tgaggaacat ataggagatt gcctcatgac tgctctgggt gcgccgacgt
     2101 gttccgaagg acaggtggcc tctgtcatct gctcaggaaa ccaatcccag acactattgc
     2161 catgtagttc attgtctcca gtccaaacaa caagctctac aattccaaag gagagtgaag
     2221 ttccctgcat agcaagtggc cagcttcgct tggtaggtgg aggtggtcgc tgcgctggaa
     2281 gagtggaggt ctaccacgag ggctcttggg gcaccgtctg tgatgacaat tgggatatga
     2341 ctgatgccaa tgtggtgtgc aagcagctgg actgtggcgt ggcaattaac gccactggct
     2401 ctgcttactt cggggaagga gcaggagcta tctggctaga cgaagtcatc tgcactggga
     2461 aagagtctca tatttggcag tgccattcac atggctgggg acgccataac tgcaggcaca
     2521 aagaagatgc aggtgttatc tgctccgagt tcatgtctct gaggctgacc aacgaagccc
     2581 acaaagaaaa ctgcacaggt cgccttgaag tgttttacaa tggtacatgg ggcagtattg
     2641 gcagtagcaa tatgtctcca accactgtgg gggtggtgtg ccgtcagctg ggctgtgcag
     2701 acaacgggac tgtgaaaccc ataccttcag acaagacacc atccaggccc atgtgggtag
     2761 atcgtgtgca gtgtccaaaa ggagttgaca ctttgtggca gtgcccctcg tcaccttgga
     2821 aacagagaca ggccagcccc tcctcccagg agtcctggat catctgtgac aacaaaataa
     2881 gactccagga agggcataca gactgttctg gacgtgtgga gatctggcac aaaggttcct
     2941 ggggaacagt gtgtgatgac tcctgggatc ttaatgatgc taaggttgta tgtaagcagt
     3001 tgggctgtgg ccaagctgtg aaggcactaa aagaagcagc atttggtcca ggaactgggc
     3061 ccatatggct caatgaaatt aagtgtagag ggaatgagtc ttccctgtgg gattgtcctg
     3121 ccaaaccgtg gagtcacagc gactgtgggc acaaagaaga tgcttccatc cagtgcctcc
     3181 caaaaatgac ttcagaatca catcatggca caggtcaccc caccctcacg gcactcttgg
     3241 tttgtggagc cattctattg gtcctcctca ttgtcttcct cctgtggact ctgaagcgac
     3301 gacagattca gcgacttaca gtttcctcaa gaggagaggt cttgatacat caagttcagt
     3361 accaagagat ggattcaaag gcggatgatc tggacttgct gaaatcctcg ggggtcattc
     3421 agaggcacac tgagaaggaa aatgataatt tataatccac tgaggttgga gtttaagaag
     3481 ccttgacagg acagccagct aaatggaaca agagcccagg caacgcacgg atgaccacag
     3541 ctgcatcttc atgcagtcct ttgtttcctg gaactctgct gaacctgcaa aaaccatatt
     3601 tgtgaatgtg accacttaat agagatggga gacttttgag ggaattaaac aatattgcta
     3661 ttggtttgct tgttcgcaat agggtctcat tatgtatagc cctggagatg gcgatagaga
     3721 gcaggcaagc ctagaattca cagagatctg cttgtctctg cttcccaaat gctgggatca
     3781 aatatgtgga ccaccacatg tggtttaaca attgtgtctt gattttataa atttctggtt
     3841 ggtttttctg acgtttttag ggtttcgtga atataaaata atgtcttttc ggttggcatg
     3901 ctaattttta aatattatac acttccttgt agtgagttta agaataattt cttataacca
     3961 agtcaattca ttttcacttt gaattattta ataaaggaat atggtcattg tgaccacaca
     4021 cacagcagtt gtgaccacct gtatgaggcc ttcaaaaaat attttaaaaa tagagggctg
     4081 gagaaatggc tcagagatcc tgagttcaat tcctagcaac cacatggtgg ctcacaacca
     4141 tctgtaatgg gaatccgatg ccctcttcca gtgtatctga agatagtgac actgtcctca
     4201 ttaacataaa ataaataaat aaatctttaa aaaaagaaaa gacaatagag gaggggaggg
     4261 gcgtgagagt aggagtgagg actgattgag aagaaggttg gaggaagtgg ggggaggtga
     4321 aaagctagtt gggaacttat gtgatcacag tgcatcatgt ccaaatatga catgtccaaa
     4381 aatgttatta ataaagaaac ggaaaacaa
//
