LOCUS       NM_018767               2513 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus CD160 antigen (Cd160), transcript variant 2, mRNA.
ACCESSION   NM_018767
VERSION     NM_018767.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2513)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2513)
  AUTHORS   Pawlak,M., DeTomaso,D., Schnell,A., Meyer Zu Horste,G., Lee,Y.,
            Nyman,J., Dionne,D., Regan,B.M.L., Singh,V., Delorey,T.,
            Schramm,M.A., Wang,C., Wallrapp,A., Burkett,P.R., Riesenfeld,S.J.,
            Anderson,A.C., Regev,A., Xavier,R.J., Yosef,N. and Kuchroo,V.K.
  TITLE     Induction of a colitogenic phenotype in Th1-like cells depends on
            interleukin-23 receptor signaling
  JOURNAL   Immunity 55 (9), 1663-1679 (2022)
   PUBMED   36070768
REFERENCE   3  (bases 1 to 2513)
  AUTHORS   Seo,G.Y., Takahashi,D., Wang,Q., Mikulski,Z., Chen,A., Chou,T.F.,
            Marcovecchio,P., McArdle,S., Sethi,A., Shui,J.W., Takahashi,M.,
            Surh,C.D., Cheroutre,H. and Kronenberg,M.
  TITLE     Epithelial HVEM maintains intraepithelial T cell survival and
            contributes to host protection
  JOURNAL   Sci Immunol 7 (73), eabm6931 (2022)
   PUBMED   35905286
REFERENCE   4  (bases 1 to 2513)
  AUTHORS   Del Rio,M.L., Nguyen,T.H., Tesson,L., Heslan,J.M.,
            Gutierrez-Adan,A., Fernandez-Gonzalez,R., Gutierrez-Arroyo,J.,
            Buhler,L., Perez-Simon,J.A., Anegon,I. and Rodriguez-Barbosa,J.I.
  TITLE     The impact of CD160 deficiency on alloreactive CD8 T cell responses
            and allograft rejection
  JOURNAL   Transl Res 239, 103-123 (2022)
   PUBMED   34461306
  REMARK    GeneRIF: The impact of CD160 deficiency on alloreactive CD8 T cell
            responses and allograft rejection.
REFERENCE   5  (bases 1 to 2513)
  AUTHORS   Zhang,L., Zhang,A., Xu,J., Qiu,C., Zhu,L., Qiu,C., Fu,W., Wang,Y.,
            Ye,L., Fu,Y.X., Zhao,C., Zhang,X. and Xu,J.
  TITLE     CD160 Plays a Protective Role During Chronic Infection by Enhancing
            Both Functionalities and Proliferative Capacity of CD8+ T Cells
  JOURNAL   Front Immunol 11, 2188 (2020)
   PUBMED   33072082
  REMARK    GeneRIF: CD160 Plays a Protective Role During Chronic Infection by
            Enhancing Both Functionalities and Proliferative Capacity of CD8+ T
            Cells.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2513)
  AUTHORS   Tsujimura,K., Obata,Y., Matsudaira,Y., Nishida,K., Akatsuka,Y.,
            Ito,Y., Demachi-Okamura,A., Kuzushima,K. and Takahashi,T.
  TITLE     Characterization of murine CD160+ CD8+ T lymphocytes
  JOURNAL   Immunol Lett 106 (1), 48-56 (2006)
   PUBMED   16764942
  REMARK    GeneRIF: CD160 is expressed on the majority of CD8(+) memory T
            cells as well as recently activated CD8(+) T cells
REFERENCE   7  (bases 1 to 2513)
  AUTHORS   Maeda,M., Carpenito,C., Russell,R.C., Dasanjh,J., Veinotte,L.L.,
            Ohta,H., Yamamura,T., Tan,R. and Takei,F.
  TITLE     Murine CD160, Ig-like receptor on NK cells and NKT cells,
            recognizes classical and nonclassical MHC class I and regulates NK
            cell activation
  JOURNAL   J Immunol 175 (7), 4426-4432 (2005)
   PUBMED   16177084
  REMARK    GeneRIF: Knockout Mice BALB C Mice C3H Mice F344 Rats K562 Cells
            Cultured Cells
REFERENCE   8  (bases 1 to 2513)
  AUTHORS   Bodnar,J.S., Chatterjee,A., Castellani,L.W., Ross,D.A., Ohmen,J.,
            Cavalcoli,J., Wu,C., Dains,K.M., Catanese,J., Chu,M., Sheth,S.S.,
            Charugundla,K., Demant,P., West,D.B., de Jong,P. and Lusis,A.J.
  TITLE     Positional cloning of the combined hyperlipidemia gene Hyplip1
  JOURNAL   Nat Genet 30 (1), 110-116 (2002)
   PUBMED   11753387
REFERENCE   9  (bases 1 to 2513)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   10 (bases 1 to 2513)
  AUTHORS   Anumanthan,A., Bensussan,A., Boumsell,L., Christ,A.D.,
            Blumberg,R.S., Voss,S.D., Patel,A.T., Robertson,M.J., Nadler,L.M.
            and Freeman,G.J.
  TITLE     Cloning of BY55, a novel Ig superfamily member expressed on NK
            cells, CTL, and intestinal intraepithelial lymphocytes
  JOURNAL   J Immunol 161 (6), 2780-2790 (1998)
   PUBMED   9743336
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK042093.1 and AK139789.1.
            
            On Jul 22, 2009 this sequence version replaced NM_018767.2.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1 and 2 both encode isoform a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC021596.1, AK042093.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1028              AK042093.1         2-1029
            1029-2513           AK139789.1         1107-2591
FEATURES             Location/Qualifiers
     source          1..2513
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 41.99 cM"
     gene            1..2513
                     /gene="Cd160"
                     /gene_synonym="By55"
                     /note="CD160 antigen"
                     /db_xref="GeneID:54215"
                     /db_xref="MGI:MGI:1860383"
     exon            1..52
                     /gene="Cd160"
                     /gene_synonym="By55"
                     /inference="alignment:Splign:2.1.0"
     exon            53..197
                     /gene="Cd160"
                     /gene_synonym="By55"
                     /inference="alignment:Splign:2.1.0"
     CDS             116..673
                     /gene="Cd160"
                     /gene_synonym="By55"
                     /note="isoform a precursor is encoded by transcript
                     variant 2; natural killer cell receptor BY55; natural
                     killer cell BY55"
                     /codon_start=1
                     /product="CD160 antigen isoform a precursor"
                     /protein_id="NP_061237.3"
                     /db_xref="CCDS:CCDS17648.1"
                     /db_xref="GeneID:54215"
                     /db_xref="MGI:MGI:1860383"
                     /translation="MQRILMAPGQSCCALAILLAIVNFQHGGCIHVTSSASQKGGRLD
                     LTCTLWHKKDEAEGLILFWCKDNPWNCSPETNLEQLRVKRDPETDGITEKSSQLVFTI
                     EQATPSDSGTYQCCARSQKPEIYIHGHFLSVLVTGNHTEIRQRQRSHPDFSHINGTLS
                     SGFLQVKAWGMLVTSLVALQALYTL"
     exon            198..524
                     /gene="Cd160"
                     /gene_synonym="By55"
                     /inference="alignment:Splign:2.1.0"
     exon            525..656
                     /gene="Cd160"
                     /gene_synonym="By55"
                     /inference="alignment:Splign:2.1.0"
     exon            657..2513
                     /gene="Cd160"
                     /gene_synonym="By55"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1010..1015
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cd160"
                     /gene_synonym="By55"
                     /note="hexamer: AATAAA"
     regulatory      1014..1019
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cd160"
                     /gene_synonym="By55"
                     /note="hexamer: AAGAAA"
     polyA_site      1027
                     /gene="Cd160"
                     /gene_synonym="By55"
                     /note="major polyA site"
     polyA_site      1031
                     /gene="Cd160"
                     /gene_synonym="By55"
     regulatory      1101..1106
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cd160"
                     /gene_synonym="By55"
                     /note="hexamer: AATAAA"
     polyA_site      1124
                     /gene="Cd160"
                     /gene_synonym="By55"
ORIGIN      
        1 acactcagcg tgagccccca gcttgagagc aaggaagaac atctgtcctg aggagtgtgc
       61 agccacagac cagcaaagtc aacatttccg tgaaattcct ggggctgaca acagcatgca
      121 aagaatcctg atggcccctg gccaaagctg ctgtgccctg gccatcctgc tggcaattgt
      181 gaacttccaa catggtggat gtattcatgt caccagctca gcatcccaga aaggagggcg
      241 actggacctc acctgtactt tgtggcacaa gaaagacgaa gctgaggggc taatactctt
      301 ctggtgcaaa gacaatcctt ggaactgttc ccctgagacc aacttagaac agcttagggt
      361 taaaagggat cctgagacag atggcatcac tgaaaagtca tctcagttgg tgttcaccat
      421 agaacaagct acaccatcag acagtgggac ctaccagtgc tgtgccagaa gccagaaacc
      481 agaaatctac attcatggcc actttctctc cgttctagtc acagggaacc acacagagat
      541 aagacagaga caaaggtcac accctgactt cagccatatc aacggcactc tcagttcagg
      601 cttcctgcaa gtaaaggctt gggggatgtt ggtcaccagc ctggtggccc ttcaagctct
      661 atataccttg tgacagagag aaaaaaagac ttcagaggaa ggtacagcga ggtaaatctg
      721 acaatgcgca gagaagccgg gtccataaaa cggatatact ctgaacactg gggccggcca
      781 gacggtcaag ggtaaaggtg tttgcctgcc acattgcagg tccaacccgt gcacccacat
      841 ggtggaggga gagaactgac tcccacaggc tgtcctctga tctccactgg gtgccgtgcc
      901 tccaccccag gcaacaaaaa aatcccaaga atctagcaga acagttggta tacctctgga
      961 tctccttcct gactgccaga gcgaggttgg cttctcccac ctcggtgcca ataaagaaaa
     1021 cgttttgcaa atgttgctga tgtatagtcc ttgaatgcca ggtatgtttt ataccacaga
     1081 ataatgtttc ccctccacac aataaaataa gcaagtttta attgtatgtg tgtgcatgag
     1141 gcatttgtga gagcactgca cacacacgga ggtcagagga aactcttggg agttagctct
     1201 cttctaccat ggggtctgga gatcaaactt aggcgtcctg gcttgtgcaa gtgctttcag
     1261 ctgctgagct gtctcgccag ccccaaataa gcacgttttt aaaagataag aggaaaggag
     1321 ctgaagagat ggcttagagg gagcgtgcag tcataacact ggtgtttgca tctcagcacc
     1381 catgtaacaa gccaacagtt cccataagcc tcagcttcaa agggccagag acaggattgc
     1441 tggggctcgc tagcttccag tgtagtggag aaaaatgtga gaccctactc aaaggagtag
     1501 gtagagaaca agaggaaacc caacaccctc ttcaggcctc tatgagcaca tgcatctgca
     1561 ctcacgcact cactcgcatc ccccgacaca cacacacaca ctaaataaat ctttaaaaag
     1621 gaaaatgcca ttcttaaaaa gaactgttta tttaatactg taaaaaatat aaaatgagca
     1681 aatatgggga agaaagagag caagagaatc aggtgtagtg actggcttgc aaggaaaaca
     1741 aaaatatctt taggtaagtg aaacttactt ttattttatg tgttgagtgt atgcctgcac
     1801 atgtgtgcac cacatgaata cctggtgccc agacaagggc atcagatccc ctggaactgc
     1861 agttacatca gtgtaaagga gacgtcaccc acagtgtttt tctaagaatc aaataagacc
     1921 ctatattcgg aaccaaaaga gatatctgaa ttttgactcc aaagtctccg aaactttctc
     1981 cactatatta catcctctat aatcttttct acccgtttgt aactttaagt aaatgttaag
     2041 ctcacatgaa cagagaagtc atttgccttt tactcttcag agaatcttct ggaattactc
     2101 agaccacagt catctcaaca ccacatccaa atacagggaa ggttccatat agcatattgt
     2161 attaactgaa gtgcacacac aaatctacac acaagacata tgatctctgc tcgtttaaca
     2221 agacattcac aggcactgaa ctaagcagaa taaataagca accataaagc aaaggtctaa
     2281 aacaatcttg tttctaatgc tcatttcaag attcagttaa gcagaaatgg gaaatactgt
     2341 cttgggttta aaatgtgttg atacaatcaa tttcaatttt aaataagccc gtgaactttc
     2401 gtgtatgaag cccaaaatct atatgaataa ttcacaattt gtgaagccac tgagctatta
     2461 caaagaacct acaaacccat ttccttctgt tcaaataaat attttacata tgt
//
