LOCUS       NM_001111049            1791 bp    mRNA    linear   ROD 06-JUN-2024
DEFINITION  Mus musculus CD151 antigen (Cd151), transcript variant 2, mRNA.
ACCESSION   NM_001111049
VERSION     NM_001111049.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1791)
  AUTHORS   Jankovicova,J., Frolikova,M., Palenikova,V., Valaskova,E.,
            Cerny,J., Secova,P., Bartokova,M., Horovska,L.,
            Manaskova-Postlerova,P., Antalikova,J. and Komrskova,K.
  TITLE     Expression and distribution of CD151 as a partner of alpha6
            integrin in male germ cells
  JOURNAL   Sci Rep 10 (1), 4374 (2020)
   PUBMED   32152440
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1791)
  AUTHORS   Li,H., Li,J., Han,R., Deng,X., Shi,J., Huang,H., Hamad,N.,
            McCaughley,A., Liu,J., Wang,C., Chen,K., Wei,D., Qiang,J.,
            Thatcher,S., Wu,Y., Liu,C., Thibault,O., Wei,X., Chen,S., Qian,H.,
            Zhou,B.P., Xu,P. and Yang,X.H.
  TITLE     Deletion of tetraspanin CD151 alters the Wnt oncogene-induced
            mammary tumorigenesis: A cell type-linked function and signaling
  JOURNAL   Neoplasia 21 (12), 1151-1163 (2019)
   PUBMED   31783316
  REMARK    GeneRIF: our study suggests that CD151 is a key player in the Wnt
            oncogene-driven tumorigenesis and impacts breast cancer malignancy
            in a cell type-dependent manner.
REFERENCE   3  (bases 1 to 1791)
  AUTHORS   Tao,Y., Zhang,H., Huang,S., Pei,L., Feng,M., Zhao,X., Ouyang,Z.,
            Yao,S., Jiang,R. and Wei,K.
  TITLE     miR-199a-3p promotes cardiomyocyte proliferation by inhibiting
            Cd151 expression
  JOURNAL   Biochem Biophys Res Commun 516 (1), 28-36 (2019)
   PUBMED   31186138
  REMARK    GeneRIF: Overexpression of Cd151 blocks the activating effect of
            miR-199a-3p on cardiomyocyte proliferation, suggesting Cd151 is a
            functional target of miR-199a-3p in cardiomyocytes.
REFERENCE   4  (bases 1 to 1791)
  AUTHORS   Qiao,Y., Yan,Y., Tan,K.S., Tan,S.S.L., Seet,J.E., Arumugam,T.V.,
            Chow,V.T.K., Wang,Y. and Tran,T.
  TITLE     CD151, a novel host factor of nuclear export signaling in influenza
            virus infection
  JOURNAL   J Allergy Clin Immunol 141 (5), 1799-1817 (2018)
   PUBMED   29274410
  REMARK    GeneRIF: CD151 is a critical novel host factor of nuclear export
            signaling.
REFERENCE   5  (bases 1 to 1791)
  AUTHORS   Naudin,C., Smith,B., Bond,D.R., Dun,M.D., Scott,R.J., Ashman,L.K.,
            Weidenhofer,J. and Roselli,S.
  TITLE     Characterization of the early molecular changes in the glomeruli of
            Cd151 -/- mice highlights induction of mindin and MMP-10
  JOURNAL   Sci Rep 7 (1), 15987 (2017)
   PUBMED   29167507
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1791)
  AUTHORS   Lammerding,J., Kazarov,A.R., Huang,H., Lee,R.T. and Hemler,M.E.
  TITLE     Tetraspanin CD151 regulates alpha6beta1 integrin adhesion
            strengthening
  JOURNAL   Proc Natl Acad Sci U S A 100 (13), 7616-7621 (2003)
   PUBMED   12805567
  REMARK    GeneRIF: CD151 plays a key role in selectively strengthening
            alpha6beta1 integrin-mediated adhesion to laminin-1
REFERENCE   7  (bases 1 to 1791)
  AUTHORS   Ashman,L.K.
  TITLE     CD151.
  JOURNAL   J Biol Regul Homeost Agents 16 (3), 223-226 (2002)
   PUBMED   12456024
  REMARK    GeneRIF: CD151 may be involved in the interaction of platelets with
            the subendothelial matrix at sites of vascular damage [review]
            Review article
REFERENCE   8  (bases 1 to 1791)
  AUTHORS   Nelson,P.S., Pritchard,C., Abbott,D. and Clegg,N.
  TITLE     The human (PEDB) and mouse (mPEDB) Prostate Expression Databases
  JOURNAL   Nucleic Acids Res 30 (1), 218-220 (2002)
   PUBMED   11752298
REFERENCE   9  (bases 1 to 1791)
  AUTHORS   Fitter,S., Seldin,M.F. and Ashman,L.K.
  TITLE     Characterisation of the mouse homologue of CD151 (PETA-3/SFA-1);
            genomic structure, chromosomal localisation and identification of 2
            novel splice forms
  JOURNAL   Biochim Biophys Acta 1398 (1), 75-85 (1998)
   PUBMED   9602068
REFERENCE   10 (bases 1 to 1791)
  AUTHORS   Hasegawa,H., Watanabe,H., Nomura,T., Utsunomiya,Y., Yanagisawa,K.
            and Fujita,S.
  TITLE     Molecular cloning and expression of mouse homologue of SFA-1/PETA-3
            (CD151), a member of the transmembrane 4 superfamily
  JOURNAL   Biochim Biophys Acta 1353 (2), 125-130 (1997)
   PUBMED   9294006
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BQ896459.1, DV063036.1, U89772.1, AW539552.1 and AI155754.1.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1, 2 and 3 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BI665501.1, BI647457.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-28                BQ896459.1         19-46
            29-733              DV063036.1         56-760
            734-1275            U89772.1           576-1117
            1276-1779           AW539552.1         1-504               c
            1780-1791           AI155754.1         335-346
FEATURES             Location/Qualifiers
     source          1..1791
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 86.82 cM"
     gene            1..1791
                     /gene="Cd151"
                     /gene_synonym="PETA-3; SFA-1; Tspan24"
                     /note="CD151 antigen"
                     /db_xref="GeneID:12476"
                     /db_xref="MGI:MGI:1096360"
     exon            1..105
                     /gene="Cd151"
                     /gene_synonym="PETA-3; SFA-1; Tspan24"
                     /inference="alignment:Splign:2.1.0"
     exon            106..233
                     /gene="Cd151"
                     /gene_synonym="PETA-3; SFA-1; Tspan24"
                     /inference="alignment:Splign:2.1.0"
     exon            234..324
                     /gene="Cd151"
                     /gene_synonym="PETA-3; SFA-1; Tspan24"
                     /inference="alignment:Splign:2.1.0"
     CDS             241..1002
                     /gene="Cd151"
                     /gene_synonym="PETA-3; SFA-1; Tspan24"
                     /note="GP27; membrane glycoprotein SFA-1;
                     platelet-endothelial tetraspan antigen 3"
                     /codon_start=1
                     /product="CD151 antigen"
                     /protein_id="NP_001104519.1"
                     /db_xref="CCDS:CCDS22017.1"
                     /db_xref="GeneID:12476"
                     /db_xref="MGI:MGI:1096360"
                     /translation="MGEFNEKKATCGTVCLKYLLFTYNCCFWLAGLAVMAVGIWTLAL
                     KSDYISLLASSTYLATAYILVVAGVVVMVTGVLGCCATFKERRNLLRLYFILLLIIFL
                     LEIIAGILAYVYYQQLNTELKENLKDTMVKRYHQSGHEGVSSAVDKLQQEFHCCGSNN
                     SQDWQDSEWIRSGEADSRVVPDSCCKTMVAGCGKRDHASNIYKVEGGCITKLETFIQE
                     HLRVIGAVGIGIACVQVFGMIFTCCLYRSLKLEHY"
     exon            325..516
                     /gene="Cd151"
                     /gene_synonym="PETA-3; SFA-1; Tspan24"
                     /inference="alignment:Splign:2.1.0"
     exon            517..591
                     /gene="Cd151"
                     /gene_synonym="PETA-3; SFA-1; Tspan24"
                     /inference="alignment:Splign:2.1.0"
     exon            592..696
                     /gene="Cd151"
                     /gene_synonym="PETA-3; SFA-1; Tspan24"
                     /inference="alignment:Splign:2.1.0"
     exon            697..855
                     /gene="Cd151"
                     /gene_synonym="PETA-3; SFA-1; Tspan24"
                     /inference="alignment:Splign:2.1.0"
     exon            856..1786
                     /gene="Cd151"
                     /gene_synonym="PETA-3; SFA-1; Tspan24"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1759..1764
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cd151"
                     /gene_synonym="PETA-3; SFA-1; Tspan24"
                     /note="hexamer: AATAAA"
     polyA_site      1780
                     /gene="Cd151"
                     /gene_synonym="PETA-3; SFA-1; Tspan24"
                     /note="major polyA site"
ORIGIN      
        1 tcgcgcgcag ggcgtgtcct cgcaggcccc gggccgagcg ttctctgtac tccgagtgat
       61 cgctcctacc gtggctgccg gggctggtat ttcaaagcgt ggttgatctg gtggctctga
      121 gaaccatttt gaccactgct taagcttctg tagttggagt ggcaagatcc cacctgctag
      181 gtgaagggca gagagtgact tttgacctgt acctgctggt cctgacttga gaggcccagg
      241 atgggtgaat tcaatgagaa gaaggcaaca tgtggcacag tctgcctcaa gtacctgctc
      301 tttacctaca actgctgctt ctggctggcc ggcctggctg tcatggcagt gggcatctgg
      361 acactggccc tcaagagtga ctacattagt ctgctggcct caagcactta cctagccacg
      421 gcctacatct tagtggtggc tggtgttgtt gtcatggtga ctggagtcct gggctgctgt
      481 gccactttca aggagcgacg gaacctgtta cgcttgtact tcatcctgct cctcatcatc
      541 ttcctcctgg agatcattgc tggcatcctg gcctatgtct attatcagca gctgaacaca
      601 gagctcaagg agaatctgaa ggacaccatg gtcaagagat accaccagtc aggccacgag
      661 ggtgtgagca gcgctgtcga caagctgcag caagagttcc actgttgtgg cagcaacaac
      721 tctcaagact ggcaagacag cgagtggatc cgctctggtg aggcagacag ccgcgtggtt
      781 cctgacagct gctgtaagac tatggtagct ggctgtggta agcgggacca tgcctccaac
      841 atctataaag tggagggtgg ctgtatcact aagctggaga ccttcattca ggagcacctg
      901 cgggtcattg gggcggtggg cattggcatc gcctgtgtgc aggtcttcgg catgatcttc
      961 acctgctgct tgtaccgaag cctcaagctg gaacactact gaccacgatg atgtcaggcc
     1021 gggcggccag ccttgcacta ctgaccacga tgatgccagg ctgggcggcc agccttgcac
     1081 tatgtcccag ccccactact gaacactact gacttagact gctgactgcc agaggtagct
     1141 accctcatgc catcgccatg accccccctg gcatgccacc tcaggggcat gcaccttcaa
     1201 gtgcctttca ctgcacacca aagtcccaaa gctcgaagca gcgtacttgc cccagcatta
     1261 agaagggggg ggggggtggg gggttcaaat gccagtgttg ggctaggcct ggctagtaga
     1321 atagggttta gattatttga cagaagtgcc tcttatgcag actgcttccc tttgggtagc
     1381 tgtgatctgc agtaagtctg gggagaacct gagtacacca ctacacgttg ggtaaaagca
     1441 ggtggggcct ttctggttgg attaggcacc cttcatgcct gctaccagga actctcagat
     1501 ctgcttgccc caaacaaatg gtgtaagctg agggaaactc caaccccaca cttgatgctc
     1561 tgtcctctcc acacaggcct cttgctccta acagctcagc cctggccttt tctcactact
     1621 gatagcatca tgtaaatgct ccatgttcct gtacactgtc tccttttgga gcatctctga
     1681 atggagcatg gctgttttca tctcactgct gtattccaga tgctgcccac aaatgctcct
     1741 gctatgtaac aggtgctcaa taaatgtaaa tgtataagca ctcgaaaaaa a
//
