LOCUS       NM_009841               1681 bp    mRNA    linear   ROD 26-JUN-2024
DEFINITION  Mus musculus CD14 antigen (Cd14), mRNA.
ACCESSION   NM_009841
VERSION     NM_009841.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1681)
  AUTHORS   Lai,Y., Guo,Y., Liao,C., Mao,C., Liu,J., Ren,C., Yang,W., Luo,L.
            and Chen,W.
  TITLE     Osteoclast differentiation and dynamic mRNA expression during mice
            embryonic palatal bone development
  JOURNAL   Sci Rep 13 (1), 15170 (2023)
   PUBMED   37704707
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1681)
  AUTHORS   Zezulin,A.U., Yen,D., Ye,D., Howell,E.D., Bresciani,E., Diemer,J.,
            Ren,J.G., Ahmad,M.H., Castilla,L.H., Touw,I.P., Minn,A.J., Tong,W.,
            Liu,P.P., Tan,K., Yu,W. and Speck,N.A.
  TITLE     RUNX1 is required in granulocyte-monocyte progenitors to attenuate
            inflammatory cytokine production by neutrophils
  JOURNAL   Genes Dev 37 (13-14), 605-620 (2023)
   PUBMED   37536952
REFERENCE   3  (bases 1 to 1681)
  AUTHORS   Sharma,A., Wang,J. and Gandhi,C.R.
  TITLE     CD14 is not required for carbon tetrachloride-induced hepatic
            inflammation and fibrosis with or without lipopolysaccharide
            challenge
  JOURNAL   J Cell Physiol 238 (7), 1530-1541 (2023)
   PUBMED   37098757
  REMARK    GeneRIF: CD14 is not required for carbon tetrachloride-induced
            hepatic inflammation and fibrosis with or without
            lipopolysaccharide challenge.
REFERENCE   4  (bases 1 to 1681)
  AUTHORS   Elias-Oliveira,J., Prado,M.K.B., Souza,C.O.S., Pastore,M.R.,
            Ramos,S.G., Costa Darini,A.L., Gardinassi,L.G. and Faccioli,L.H.
  TITLE     CD14 signaling mediates lung immunopathology and mice mortality
            induced by Achromobacter xylosoxidans
  JOURNAL   Inflamm Res 71 (12), 1535-1546 (2022)
   PUBMED   36280620
  REMARK    GeneRIF: CD14 signaling mediates lung immunopathology and mice
            mortality induced by Achromobacter xylosoxidans.
REFERENCE   5  (bases 1 to 1681)
  AUTHORS   Song,S., Regan,B., Ereifej,E.S., Chan,E.R. and Capadona,J.R.
  TITLE     Neuroinflammatory Gene Expression Analysis Reveals Pathways of
            Interest as Potential Targets to Improve the Recording Performance
            of Intracortical Microelectrodes
  JOURNAL   Cells 11 (15), 2348 (2022)
   PUBMED   35954192
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1681)
  AUTHORS   Fearns,C., Kravchenko,V.V., Ulevitch,R.J. and Loskutoff,D.J.
  TITLE     Murine CD14 gene expression in vivo: extramyeloid synthesis and
            regulation by lipopolysaccharide
  JOURNAL   J Exp Med 181 (3), 857-866 (1995)
   PUBMED   7532683
REFERENCE   7  (bases 1 to 1681)
  AUTHORS   Pugin,J., Heumann,I.D., Tomasz,A., Kravchenko,V.V., Akamatsu,Y.,
            Nishijima,M., Glauser,M.P., Tobias,P.S. and Ulevitch,R.J.
  TITLE     CD14 is a pattern recognition receptor
  JOURNAL   Immunity 1 (6), 509-516 (1994)
   PUBMED   7534618
REFERENCE   8  (bases 1 to 1681)
  AUTHORS   Ferrero,E., Hsieh,C.L., Francke,U. and Goyert,S.M.
  TITLE     CD14 is a member of the family of leucine-rich proteins and is
            encoded by a gene syntenic with multiple receptor genes
  JOURNAL   J Immunol 145 (1), 331-336 (1990)
   PUBMED   1694207
REFERENCE   9  (bases 1 to 1681)
  AUTHORS   Setoguchi,M., Nasu,N., Yoshida,S., Higuchi,Y., Akizuki,S. and
            Yamamoto,S.
  TITLE     Mouse and human CD14 (myeloid cell-specific leucine-rich
            glycoprotein) primary structure deduced from cDNA clones
  JOURNAL   Biochim Biophys Acta 1008 (2), 213-222 (1989)
   PUBMED   2472171
REFERENCE   10 (bases 1 to 1681)
  AUTHORS   Matsuura,K., Setoguchi,M., Nasu,N., Higuchi,Y., Yoshida,S.,
            Akizuki,S. and Yamamoto,S.
  TITLE     Nucleotide and amino acid sequences of the mouse CD14 gene
  JOURNAL   Nucleic Acids Res 17 (5), 2132 (1989)
   PUBMED   2467257
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC027740.11, AK149744.1,
            AK151139.1, BY498446.1 and EH108279.1.
            
            On Jul 29, 2014 this sequence version replaced NM_009841.3.
            
            Summary: This gene encodes a protein that plays an important role
            in the innate immune response and is expressed in
            monocyte/macrophage cells. This gene product acts as a co-receptor
            that binds several microbial and fungal molecules, including
            lipopolysaccharides (LPS). This proteins LPS-binding activity is
            enhanced by the LPS binding protein (LBP) to allow binding to the
            TLR4-MD-2 co-receptor complex. The product of this gene is found in
            two forms, either as a soluble protein or attached to the cell
            surface by a glycosylphosphatidylinositol anchor. [provided by
            RefSeq, Jul 2014].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK149744.1, BC057889.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-77                AC027740.11        183286-183362       c
            78-834              AK149744.1         5-761
            835-1581            AK151139.1         133-879
            1582-1659           BY498446.1         363-440
            1660-1681           EH108279.1         6-27                c
FEATURES             Location/Qualifiers
     source          1..1681
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 19.46 cM"
     gene            1..1681
                     /gene="Cd14"
                     /note="CD14 antigen"
                     /db_xref="GeneID:12475"
                     /db_xref="MGI:MGI:88318"
     exon            1..327
                     /gene="Cd14"
                     /inference="alignment:Splign:2.1.0"
     CDS             325..1425
                     /gene="Cd14"
                     /note="monocyte differentiation antigen CD14; myeloid
                     cell-specific leucine-rich glycoprotein"
                     /codon_start=1
                     /product="monocyte differentiation antigen CD14 precursor"
                     /protein_id="NP_033971.1"
                     /db_xref="CCDS:CCDS29159.1"
                     /db_xref="GeneID:12475"
                     /db_xref="MGI:MGI:88318"
                     /translation="MERVLGLLLLLLVHASPAPPEPCELDEESCSCNFSDPKPDWSSA
                     FNCLGAADVELYGGGRSLEYLLKRVDTEADLGQFTDIIKSLSLKRLTVRAARIPSRIL
                     FGALRVLGISGLQELTLENLEVTGTAPPPLLEATGPDLNILNLRNVSWATRDAWLAEL
                     QQWLKPGLKVLSIAQAHSLNFSCEQVRVFPALSTLDLSDNPELGERGLISALCPLKFP
                     TLQVLALRNAGMETPSGVCSALAAARVQLQGLDLSHNSLRDAAGAPSCDWPSQLNSLN
                     LSFTGLKQVPKGLPAKLSVLDLSYNRLDRNPSPDELPQVGNLSLKGNPFLDSESHSEK
                     FNSGVVTAGAPSSQAVALSGTLALLLGDRLFV"
     exon            328..1661
                     /gene="Cd14"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1638..1643
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cd14"
                     /note="hexamer: AATAAA"
     polyA_site      1658
                     /gene="Cd14"
                     /note="major polyA site"
ORIGIN      
        1 taggtcatcc tcctggcaca gaatgcccta atgccactct gaattcttcc tgtttttcgt
       61 cccttcctaa aaaacacttc gttgcaatat ttactagaag tgagtagggc tgttaggagg
      121 aagagaagtg gagacgcaat tagaattcac agaggaaggg acagggtgac accccaggat
      181 tacataaatt tacaggggct gccaaattgg tcgaacaagc ccgtggaacc tggaagccag
      241 agaacaccac cgctgtaaag gaaagaaact gaagcctttc tcggagccta tctgggctgc
      301 tcaaactttc agaatctacc gaccatggag cgtgtgcttg gcttgttgct gttgcttctg
      361 gtgcacgcct ctcccgcccc accagagccc tgcgagctag acgaggaaag ttgttcctgc
      421 aacttctcag atccgaagcc agattggtcc agcgctttca attgtttggg ggcggcagat
      481 gtggaattgt acggcggcgg ccgcagcctg gaataccttc taaagcgtgt ggacacggaa
      541 gcagatctgg ggcagttcac tgatattatc aagtctctgt ccttaaagcg gcttacggtg
      601 cgggccgcgc ggattcctag tcggattcta ttcggagccc tgcgtgtgct cgggatttcc
      661 ggcctccagg aactgactct tgaaaatctc gaggtaaccg gcaccgcgcc gccaccgctt
      721 ctggaagcca ccggacccga tctcaacatc ttgaacctcc gcaacgtgtc gtgggcaaca
      781 agggatgcct ggctcgcaga actgcagcag tggctaaagc ctggactcaa ggtactgagt
      841 attgcccaag cacactcgct caacttttcc tgcgaacagg tccgcgtctt ccctgccctc
      901 tccaccttag acctgtctga caatcctgaa ttgggcgaga gaggactgat ctcagccctc
      961 tgtcccctca agttcccgac cctccaagtt ttagcgctgc gtaacgcggg gatggagacg
     1021 cccagcggcg tgtgctctgc gctggccgca gcaagggtac agctgcaagg actagacctt
     1081 agtcacaatt cactgcggga tgctgcaggc gctccgagtt gtgactggcc cagtcagcta
     1141 aactcgctca atctgtcttt cactgggctg aagcaggtac ctaaagggct gccagccaag
     1201 ctcagcgtgc tggatctcag ttacaacagg ctggatagga accctagccc agatgagctg
     1261 ccccaagtgg ggaacctgtc acttaaagga aatccctttt tggactctga atcccactcg
     1321 gagaagttta actctggcgt agtcaccgcc ggagctccat catcccaagc agtggccttg
     1381 tcaggaactc tggctttgct cctaggagat cgcctctttg tttaaggaac atttgcatcc
     1441 tcctggtttc tgagggtcct cgtcaacgaa tcctctgctt taaatttatt aaaatcttaa
     1501 tccacgatgt aaggaaagaa aggcagtcaa gatggttcag tgggtaaaag ccagcaaact
     1561 tgacccctga ttttaaccct caggatccac acggaagggg aaaactcact cctgaaagtt
     1621 gtccatctgt gctcacaaat aaatattttt taaaataaca aaaaaaaaaa aaaaaaaaaa
     1681 a
//
