LOCUS       NM_001167906            4636 bp    mRNA    linear   ROD 09-JUN-2024
DEFINITION  Mus musculus CD101 antigen (Cd101), mRNA.
ACCESSION   NM_001167906
VERSION     NM_001167906.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4636)
  AUTHORS   Chetty,A., Darby,M.G., Pillaye,J., Taliep,A., Cunningham,A.F.,
            O'Shea,M.K., Katawa,G., Layland,L.E., Ritter,M. and Horsnell,W.G.C.
  TITLE     Induction of Siglec-FhiCD101hi eosinophils in the lungs following
            murine hookworm Nippostrongylus brasiliensis infection
  JOURNAL   Front Immunol 14, 1170807 (2023)
   PUBMED   37251384
  REMARK    GeneRIF: Induction of Siglec-F[hi]CD101[hi] eosinophils in the
            lungs following murine hookworm Nippostrongylus brasiliensis
            infection.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4636)
  AUTHORS   Mattner,J., Mohammed,J.P., Fusakio,M.E., Giessler,C.,
            Hackstein,C.P., Opoka,R., Wrage,M., Schey,R., Clark,J.,
            Fraser,H.I., Rainbow,D.B. and Wicker,L.S.
  TITLE     Genetic and functional data identifying Cd101 as a type 1 diabetes
            (T1D) susceptibility gene in nonobese diabetic (NOD) mice
  JOURNAL   PLoS Genet 15 (6), e1008178 (2019)
   PUBMED   31199784
  REMARK    GeneRIF: ur results connect the Cd101 haplotype-dependent
            protection from T1D to an anti-diabetogenic function of
            CD101-expressing Tregs and Gr1-positive myeloid cells and confirm
            the identity of Cd101 as Idd10.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4636)
  AUTHORS   Schey,R., Dornhoff,H., Baier,J.L., Purtak,M., Opoka,R.,
            Koller,A.K., Atreya,R., Rau,T.T., Daniel,C., Amann,K., Bogdan,C.
            and Mattner,J.
  TITLE     CD101 inhibits the expansion of colitogenic T cells
  JOURNAL   Mucosal Immunol 9 (5), 1205-1217 (2016)
   PUBMED   26813346
  REMARK    GeneRIF: CD101 inhibits the expansion of colitogenic T cells.
REFERENCE   4  (bases 1 to 4636)
  AUTHORS   Mohammed,J.P., Fusakio,M.E., Rainbow,D.B., Moule,C., Fraser,H.I.,
            Clark,J., Todd,J.A., Peterson,L.B., Savage,P.B., Wills-Karp,M.,
            Ridgway,W.M., Wicker,L.S. and Mattner,J.
  TITLE     Identification of Cd101 as a susceptibility gene for
            Novosphingobium aromaticivorans-induced liver autoimmunity
  JOURNAL   J Immunol 187 (1), 337-349 (2011)
   PUBMED   21613619
  REMARK    GeneRIF: A gene region (Idd10) previously shown to influence
            susceptibility to type 1 diabetes in the NOD mouse also influences
            an autoimmune disease involving a different tissue, the liver,
            which follows an infection with Novosphingobium aromaticivorans.
REFERENCE   5  (bases 1 to 4636)
  AUTHORS   Rainbow,D.B., Moule,C., Fraser,H.I., Clark,J., Howlett,S.K.,
            Burren,O., Christensen,M., Moody,V., Steward,C.A., Mohammed,J.P.,
            Fusakio,M.E., Masteller,E.L., Finger,E.B., Houchins,J.P., Naf,D.,
            Koentgen,F., Ridgway,W.M., Todd,J.A., Bluestone,J.A.,
            Peterson,L.B., Mattner,J. and Wicker,L.S.
  TITLE     Evidence that Cd101 is an autoimmune diabetes gene in nonobese
            diabetic mice
  JOURNAL   J Immunol 187 (1), 325-336 (2011)
   PUBMED   21613616
  REMARK    GeneRIF: Further support is provided for the hypothesis that Cd101
            is insulin-dependent diabetes susceptibility region 10 (Idd10);
            haplotype and expression analyses of novel Idd10 congenic strains
            are coupled to the development of a CD101 knockout mouse.
REFERENCE   6  (bases 1 to 4636)
  AUTHORS   Yamaji,K., Ikegami,H., Fujisawa,T., Noso,S., Nojima,K., Babaya,N.,
            Itoi-Babaya,M., Makino,S., Sakamoto,T. and Ogihara,T.
  TITLE     Evidence for Cd101 but not Fcgr1 as candidate for type 1 diabetes
            locus, Idd10
  JOURNAL   Biochem Biophys Res Commun 331 (2), 536-542 (2005)
   PUBMED   15850792
  REMARK    GeneRIF: Cd101, but not Fcgr1, is responsible for the Idd10 effect
REFERENCE   7  (bases 1 to 4636)
  AUTHORS   Penha-Goncalves,C., Moule,C., Smink,L.J., Howson,J., Gregory,S.,
            Rogers,J., Lyons,P.A., Suttie,J.J., Lord,C.J., Peterson,L.B.,
            Todd,J.A. and Wicker,L.S.
  TITLE     Identification of a structurally distinct CD101 molecule encoded in
            the 950-kb Idd10 region of NOD mice
  JOURNAL   Diabetes 52 (6), 1551-1556 (2003)
   PUBMED   12765969
  REMARK    GeneRIF: of the eight genes found in the Idd10 region, the CD101
            gene was selected as a candidate for Idd10 based on its function in
            humans and its polymorphism in the NOD strain of mice
REFERENCE   8  (bases 1 to 4636)
  AUTHORS   Robles,D.T., Eisenbarth,G.S., Dailey,N.J., Peterson,L.B. and
            Wicker,L.S.
  TITLE     Insulin autoantibodies are associated with islet inflammation but
            not always related to diabetes progression in NOD congenic mice
  JOURNAL   Diabetes 52 (3), 882-886 (2003)
   PUBMED   12606534
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL669872.8.
            
            On Jun 20, 2019 this sequence version replaced NM_001167906.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AM849328.1, AM849329.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849387 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-101               AL669872.8         178931-179031       c
            102-482             AL669872.8         169830-170210       c
            483-899             AL669872.8         168051-168467       c
            900-1286            AL669872.8         166372-166758       c
            1287-1664           AL669872.8         162466-162843       c
            1665-2069           AL669872.8         161264-161668       c
            2070-2480           AL669872.8         157318-157728       c
            2481-2930           AL669872.8         152959-153408       c
            2931-4636           AL669872.8         141667-143372       c
FEATURES             Location/Qualifiers
     source          1..4636
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 43.9 cM"
     gene            1..4636
                     /gene="Cd101"
                     /gene_synonym="EWI-101; Gm1016; Gm734; Igsf2"
                     /note="CD101 antigen"
                     /db_xref="GeneID:630146"
                     /db_xref="MGI:MGI:2685862"
     exon            1..101
                     /gene="Cd101"
                     /gene_synonym="EWI-101; Gm1016; Gm734; Igsf2"
                     /inference="alignment:Splign:2.1.0"
     CDS             59..3160
                     /gene="Cd101"
                     /gene_synonym="EWI-101; Gm1016; Gm734; Igsf2"
                     /note="immunoglobulin superfamily, member 2; leukocyte
                     surface protein; EWI immunoglobulin subfamily member
                     EWI-101; glu-Trp-Ile EWI motif-containing protein 101"
                     /codon_start=1
                     /product="immunoglobulin superfamily member 2 precursor"
                     /protein_id="NP_001161378.1"
                     /db_xref="CCDS:CCDS51020.1"
                     /db_xref="GeneID:630146"
                     /db_xref="MGI:MGI:2685862"
                     /translation="MACILCVASLFLSLTKFSIGQREVKIQEGPLYRAEGYPVSIRCT
                     VSGHQGPSTQDFRWSIYLPSAPTKEVQIISTKDAGFSYAVYAQRVQSKEIYIERLQGD
                     SVLLHISKLQMKDAGEYECHTPNTDGKYFGSYSAKTNLTVVPDTLSATMPSQTLSKKE
                     GEPLELTCETTKATVQHTHLSLTWYLMQEGGGSQATEIVSLSKDFVLTPGSSYADRFV
                     AGDVRLDKLGATSFRLSVGKLQPSDQGQVFCEATEWIQDPDETWTLITRKQTDQTALR
                     IQPAARDFTVSITASSSPDEGKPLELVCLAVGRDGNPQLQGVWFLNGKEIAQTDAGGV
                     LDLKRDYRDRASQGQLQVSKLSAQTFSLKIFSVGPEDVGTYSCEVAEVARTQMGSWQV
                     LQRKQSPGYRVQLREPAARSVTVSAEQRTVWEGETLTLLCKAAGDVSALSVSWWLTPQ
                     DQSTPVFVAGMGQDGTVQLGVSSPGPAHRGNRRLEKVDWATFRLEIASAMVTDSGTYE
                     CRVSERLQNQAKGLQSTQKISVTVKSLKSSLRVNLMSRQPQVMLAHTFHLSCVVRANY
                     SDLKLPFSVTWQFQPAGSGAFHRLIRIAHNGTVEWGDVLSQIHRKTKVSQSFFRSQLQ
                     IYDAAMEETGVYRCTVEVYDRDSICTSGPARVSATSNLLMITVTFPESKLSVNSSSQV
                     QELSISSSTQIECAILSRSAGNLPLSIIWYFSSVSANASYLKILEMDQSSVVKYGDEF
                     QTPRSKQKFYSEKVSQDLFLLNILSVEDSDQGHYHCAVEEWLLSTNDTWQKLERKTSG
                     LTELKLRPTGSQVHVSKVNWTGNATEYGEAGFSCSLDGSGSTASLYSVTWYRGRGTAT
                     ATAAAVANATATITAPAGSQMLVHLQYDGLLQYGREGSRRLQHCYRSSPTDFVLKLHR
                     VEMEDAGIYWCRVTEWQQHGHPGKWINQASGESQRMVLRVLRSEPTVSSLICSSGPLL
                     HFLIVCPFVMLLLLATSFLCLYRKARKLSQLSLSAKKEKALWVGMRKTSLQKEAGEES
                     GHY"
     exon            102..482
                     /gene="Cd101"
                     /gene_synonym="EWI-101; Gm1016; Gm734; Igsf2"
                     /inference="alignment:Splign:2.1.0"
     exon            483..899
                     /gene="Cd101"
                     /gene_synonym="EWI-101; Gm1016; Gm734; Igsf2"
                     /inference="alignment:Splign:2.1.0"
     exon            900..1286
                     /gene="Cd101"
                     /gene_synonym="EWI-101; Gm1016; Gm734; Igsf2"
                     /inference="alignment:Splign:2.1.0"
     exon            1287..1664
                     /gene="Cd101"
                     /gene_synonym="EWI-101; Gm1016; Gm734; Igsf2"
                     /inference="alignment:Splign:2.1.0"
     exon            1665..2069
                     /gene="Cd101"
                     /gene_synonym="EWI-101; Gm1016; Gm734; Igsf2"
                     /inference="alignment:Splign:2.1.0"
     exon            2070..2480
                     /gene="Cd101"
                     /gene_synonym="EWI-101; Gm1016; Gm734; Igsf2"
                     /inference="alignment:Splign:2.1.0"
     exon            2481..2930
                     /gene="Cd101"
                     /gene_synonym="EWI-101; Gm1016; Gm734; Igsf2"
                     /inference="alignment:Splign:2.1.0"
     exon            2931..4636
                     /gene="Cd101"
                     /gene_synonym="EWI-101; Gm1016; Gm734; Igsf2"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      3296
                     /gene="Cd101"
                     /gene_synonym="EWI-101; Gm1016; Gm734; Igsf2"
                     /note="major polyA site"
     regulatory      4614..4619
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cd101"
                     /gene_synonym="EWI-101; Gm1016; Gm734; Igsf2"
                     /note="hexamer: AATAAA"
     polyA_site      4636
                     /gene="Cd101"
                     /gene_synonym="EWI-101; Gm1016; Gm734; Igsf2"
                     /note="major polyA site"
ORIGIN      
        1 gtcactcagc ctctgagcaa gttcagtgac gctgcccgaa aaagctgtgc cggtccagat
       61 ggcatgcatc ctgtgtgtgg catctctctt tctctctcta actaagttca gcatcggcca
      121 gagggaagta aaaattcaag aaggccctct gtacagagcc gaaggttacc ctgtcagcat
      181 caggtgcacc gtaagtggtc atcagggtcc ttccacgcag gatttccggt ggtctattta
      241 cctgccaagc gccccgacca aggaagtcca gatcatcagt accaaggatg ccggcttctc
      301 ttacgcagtg tatgcccaga gggtgcaaag caaggagatc tacatagaga ggctgcaggg
      361 tgactcggtc ctgctgcata tctcaaaact ccagatgaaa gatgctggcg agtacgagtg
      421 ccacacaccc aacacggatg ggaagtactt tggaagttac agtgcaaaga caaatcttac
      481 tgtggttccc gacaccctgt ctgccaccat gccctcccag acgctcagta agaaggaagg
      541 tgagcccttg gaactcacct gtgagacaac caaagccacc gtgcaacaca cccatctctc
      601 tctcacctgg tacctgatgc aggaaggagg agggagccaa gccactgaga tcgtttctct
      661 ctccaaggac tttgtattga cccctgggtc ctcctatgca gacaggtttg tggccggtga
      721 tgtacggctg gacaagcttg gagccacttc cttcaggctg tctgtaggca agctccagcc
      781 ctcagatcag ggccaggtgt tctgtgaggc cacagaatgg attcaggatc cagatgaaac
      841 gtggactttg atcacaagaa agcagacaga tcaaacagct ctgaggatcc agccggcagc
      901 aagagatttt acagtgagca tcacagccag tagctcacct gatgaaggaa aacccttgga
      961 actggtttgc ctggctgttg gcagagatgg taacccgcag cttcagggtg tgtggtttct
     1021 caatgggaag gaaattgccc agactgatgc tggtggggtc ctggacctga agagagacta
     1081 cagagacaga gcgagccaag gccagctgca ggtgtcaaag ttaagtgccc agacgttctc
     1141 tctcaagatc ttctccgtgg gtccagagga tgtaggcacc tacagttgtg aagtggcaga
     1201 ggtggcgagg actcagatgg gctcctggca ggtacttcag agaaagcagt caccaggcta
     1261 ccgggtgcag ctgagggagc cagcagcaag aagtgtgacc gtgtctgccg agcagcgtac
     1321 tgtgtgggaa ggagagacgc ttacccttct ctgcaaggca gctggggatg tgagtgctct
     1381 atctgtgagt tggtggctca ccccacagga ccagtccaca cccgtgtttg tggctggcat
     1441 ggggcaagat ggtactgtgc agctgggagt ctcttctccg ggccctgcgc accgtggtaa
     1501 caggaggctg gagaaagtgg actgggccac ctttcggctg gagattgcct ctgccatggt
     1561 cacagacagc ggtacctatg aatgcagggt gtcagagaga ctccagaacc aggccaaagg
     1621 tttgcagtca acccagaaga tttcagtcac tgtaaaatct ctgaagtcaa gtttacgagt
     1681 taatctgatg agccgtcagc cacaagtgat gctagcccat accttccacc tgtcctgtgt
     1741 agtgagggcc aactactcgg atctcaagct gccgttctcg gtaacgtggc agttccagcc
     1801 agcgggctct ggagcctttc atcggcttat tcgaattgcc cacaatggca ccgttgaatg
     1861 gggggacgtc ctctcccaga tccacaggaa gacgaaggtg tcacagtctt tctttcgttc
     1921 tcaactccaa atctacgatg cagctatgga ggagacaggg gtgtatcggt gtacagtgga
     1981 ggtttatgac agagattcca tatgcacaag tggcccagcc agagtatctg ccacctctaa
     2041 cctattaatg attactgtca cctttccaga gagcaaactg agcgtgaact caagcagtca
     2101 ggtccaagag ctatccatca gctccagcac tcagatagaa tgtgccatct tgtcccgatc
     2161 tgctggaaac cttccgttat ccatcatttg gtacttctct tccgtttctg caaatgcatc
     2221 ctatctgaaa atcctagaaa tggaccaaag cagtgttgta aaatatgggg acgaatttca
     2281 aacccctcgg agcaagcaaa aattttattc tgagaaagtt tctcaagact tatttctgct
     2341 gaacattctg agtgtggagg acagtgacca gggccactac cactgtgctg tagaggaatg
     2401 gctcttatct acaaatgaca cttggcaaaa gcttgaaaga aagacttcag gactcacaga
     2461 attgaaactc aggcccacag gaagccaggt ccatgtctcc aaagtgaatt ggacaggaaa
     2521 cgctaccgag tatggagagg cgggcttcag ctgcagccta gatggctcag gcagcacagc
     2581 ttccctatac tctgtgacat ggtaccgggg cagaggaact gccacggcta ctgctgccgc
     2641 agttgccaat gccactgcca ccatcactgc ccccgcaggg agtcaaatgc tggtgcacct
     2701 gcagtatgac ggcttgctgc agtatggcag agaggggagc aggaggctcc agcactgcta
     2761 ccgatcctct cccacagact tcgtcctgaa gctgcatcgg gtggaaatgg aggatgctgg
     2821 gatatattgg tgcagggtga ctgagtggca gcaacatggc cacccaggca agtggatcaa
     2881 ccaagcctca ggcgagtcgc aacgaatggt gctcagggtg ctgcgctcag agcccacggt
     2941 ctcctccctg atctgctcct cggggccctt gctccacttc ctcatcgtct gccccttcgt
     3001 catgctgctc cttctggcca cgtccttcct ctgcttgtac cggaaggcca ggaagttgtc
     3061 acagctgagt ctcagtgcaa agaaagaaaa ggctctctgg gtgggcatga gaaagacatc
     3121 acttcagaag gaagctggag aggagagtgg acactactga ggagcacctg ggctggagaa
     3181 aggagcgtgg agggattggg ttggagcgtg gaggatgaat gaattctgtt ttagaccttg
     3241 gccaagttac caagggacca gaagggatgt gccatggaca tagattgtta accatatctt
     3301 gtcgagtgtt tctttgtgta gcaaccattt ttttttcttt gcatccttca gaagcagata
     3361 gtgtcattgt ccccactcac acagacctca cctcctggag gtccagcctc atctggaaag
     3421 agaggaacac cagctgtcga gccttccttc ctctctcatt cctctcccac tcatctattc
     3481 ccttggcaac atcagcttgg cccagtcaca agggaaatca tttttctcta gataagaaat
     3541 gtaggaaaaa ccgggtgtcg gcaaagccgg agggattgag agcatggact ggcttgcctg
     3601 aaatcggact cccccaatca ttatgtaatt ttttctaggc agaaatccga tgttttttct
     3661 ccaacccccc tttacaaatg cccgctgaaa agtgtaagag tcgttgtcta atcaatatcg
     3721 gcgctttgac aaaagggtaa tgtgttacag ccttttggaa gttttcattt ggcttcctgc
     3781 ttttataatt ggggatgctt tttgtttctg tttttatgat gtcaaggaaa ggccttggga
     3841 tacagcccta ggccagcctt gaacttgatc tcactgtcta gccctacact gtacagtctg
     3901 gaccgtcctc caccttacag ccctcttccc cccaccaagg ccagcctcca agggctggga
     3961 ttcaaagcat gcattggcac tggtcggtgc tgtgcatgtc tttaatccca gcactcagga
     4021 gatagaagtg tatgaatctc tacactcaag gccagcctgg tctacagact gagttccagg
     4081 aaacccaggc agggctacac cgagaaaccc tctcttggaa aaagaaggag gaagaagaaa
     4141 aggaggagga ggaggaagag gaaagggagg gtgaggagag caggggcatt ggcatgcttg
     4201 gtttaagaga tagtaagtca tcgttgaaga gcatccttct tcccatacaa cagtgttcta
     4261 ctcagccccc aaggcctcct atctccttca cacacacaca cacacacaca cacacacaca
     4321 cacacacaca cacaccagcc taccaccata gtgctaggcc ttggccagtg cctttgttga
     4381 aagcactgag tcggaggaaa gagcctcggt agaacttggg agacggctct gcagtaatgc
     4441 ccctgtctca tggtactgga gtgtgggttc aagggaagaa gagggtcaag tctgactcct
     4501 gagtttccta atctcaccct agaaatccca agggcgaggt gtgatggttt aaggctttca
     4561 agagctgttt ccactgagca ggcctggctg tagccagaat tgaaaatcaa tcaaataaag
     4621 gacctcagat aacaca
//
