LOCUS       NP_001161378            1033 aa            linear   ROD 09-JUN-2024
DEFINITION  immunoglobulin superfamily member 2 precursor [Mus musculus].
ACCESSION   NP_001161378
VERSION     NP_001161378.1
DBSOURCE    REFSEQ: accession NM_001167906.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 1033)
  AUTHORS   Chetty,A., Darby,M.G., Pillaye,J., Taliep,A., Cunningham,A.F.,
            O'Shea,M.K., Katawa,G., Layland,L.E., Ritter,M. and Horsnell,W.G.C.
  TITLE     Induction of Siglec-FhiCD101hi eosinophils in the lungs following
            murine hookworm Nippostrongylus brasiliensis infection
  JOURNAL   Front Immunol 14, 1170807 (2023)
   PUBMED   37251384
  REMARK    GeneRIF: Induction of Siglec-F[hi]CD101[hi] eosinophils in the
            lungs following murine hookworm Nippostrongylus brasiliensis
            infection.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 1033)
  AUTHORS   Mattner,J., Mohammed,J.P., Fusakio,M.E., Giessler,C.,
            Hackstein,C.P., Opoka,R., Wrage,M., Schey,R., Clark,J.,
            Fraser,H.I., Rainbow,D.B. and Wicker,L.S.
  TITLE     Genetic and functional data identifying Cd101 as a type 1 diabetes
            (T1D) susceptibility gene in nonobese diabetic (NOD) mice
  JOURNAL   PLoS Genet 15 (6), e1008178 (2019)
   PUBMED   31199784
  REMARK    GeneRIF: ur results connect the Cd101 haplotype-dependent
            protection from T1D to an anti-diabetogenic function of
            CD101-expressing Tregs and Gr1-positive myeloid cells and confirm
            the identity of Cd101 as Idd10.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 1033)
  AUTHORS   Schey,R., Dornhoff,H., Baier,J.L., Purtak,M., Opoka,R.,
            Koller,A.K., Atreya,R., Rau,T.T., Daniel,C., Amann,K., Bogdan,C.
            and Mattner,J.
  TITLE     CD101 inhibits the expansion of colitogenic T cells
  JOURNAL   Mucosal Immunol 9 (5), 1205-1217 (2016)
   PUBMED   26813346
  REMARK    GeneRIF: CD101 inhibits the expansion of colitogenic T cells.
REFERENCE   4  (residues 1 to 1033)
  AUTHORS   Mohammed,J.P., Fusakio,M.E., Rainbow,D.B., Moule,C., Fraser,H.I.,
            Clark,J., Todd,J.A., Peterson,L.B., Savage,P.B., Wills-Karp,M.,
            Ridgway,W.M., Wicker,L.S. and Mattner,J.
  TITLE     Identification of Cd101 as a susceptibility gene for
            Novosphingobium aromaticivorans-induced liver autoimmunity
  JOURNAL   J Immunol 187 (1), 337-349 (2011)
   PUBMED   21613619
  REMARK    GeneRIF: A gene region (Idd10) previously shown to influence
            susceptibility to type 1 diabetes in the NOD mouse also influences
            an autoimmune disease involving a different tissue, the liver,
            which follows an infection with Novosphingobium aromaticivorans.
REFERENCE   5  (residues 1 to 1033)
  AUTHORS   Rainbow,D.B., Moule,C., Fraser,H.I., Clark,J., Howlett,S.K.,
            Burren,O., Christensen,M., Moody,V., Steward,C.A., Mohammed,J.P.,
            Fusakio,M.E., Masteller,E.L., Finger,E.B., Houchins,J.P., Naf,D.,
            Koentgen,F., Ridgway,W.M., Todd,J.A., Bluestone,J.A.,
            Peterson,L.B., Mattner,J. and Wicker,L.S.
  TITLE     Evidence that Cd101 is an autoimmune diabetes gene in nonobese
            diabetic mice
  JOURNAL   J Immunol 187 (1), 325-336 (2011)
   PUBMED   21613616
  REMARK    GeneRIF: Further support is provided for the hypothesis that Cd101
            is insulin-dependent diabetes susceptibility region 10 (Idd10);
            haplotype and expression analyses of novel Idd10 congenic strains
            are coupled to the development of a CD101 knockout mouse.
REFERENCE   6  (residues 1 to 1033)
  AUTHORS   Yamaji,K., Ikegami,H., Fujisawa,T., Noso,S., Nojima,K., Babaya,N.,
            Itoi-Babaya,M., Makino,S., Sakamoto,T. and Ogihara,T.
  TITLE     Evidence for Cd101 but not Fcgr1 as candidate for type 1 diabetes
            locus, Idd10
  JOURNAL   Biochem Biophys Res Commun 331 (2), 536-542 (2005)
   PUBMED   15850792
  REMARK    GeneRIF: Cd101, but not Fcgr1, is responsible for the Idd10 effect
REFERENCE   7  (residues 1 to 1033)
  AUTHORS   Penha-Goncalves,C., Moule,C., Smink,L.J., Howson,J., Gregory,S.,
            Rogers,J., Lyons,P.A., Suttie,J.J., Lord,C.J., Peterson,L.B.,
            Todd,J.A. and Wicker,L.S.
  TITLE     Identification of a structurally distinct CD101 molecule encoded in
            the 950-kb Idd10 region of NOD mice
  JOURNAL   Diabetes 52 (6), 1551-1556 (2003)
   PUBMED   12765969
  REMARK    GeneRIF: of the eight genes found in the Idd10 region, the CD101
            gene was selected as a candidate for Idd10 based on its function in
            humans and its polymorphism in the NOD strain of mice
REFERENCE   8  (residues 1 to 1033)
  AUTHORS   Robles,D.T., Eisenbarth,G.S., Dailey,N.J., Peterson,L.B. and
            Wicker,L.S.
  TITLE     Insulin autoantibodies are associated with islet inflammation but
            not always related to diabetes progression in NOD congenic mice
  JOURNAL   Diabetes 52 (3), 882-886 (2003)
   PUBMED   12606534
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL669872.8.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AM849328.1, AM849329.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849387 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1033
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 43.9 cM"
     Protein         1..1033
                     /product="immunoglobulin superfamily member 2 precursor"
                     /note="immunoglobulin superfamily, member 2; leukocyte
                     surface protein; EWI immunoglobulin subfamily member
                     EWI-101; glu-Trp-Ile EWI motif-containing protein 101"
                     /calculated_mol_wt=112106
     sig_peptide     1..20
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2118
     mat_peptide     21..1033
                     /product="Immunoglobulin superfamily member 2.
                     /id=PRO_0000363951"
                     /note="propagated from UniProtKB/Swiss-Prot (A8E0Y8.1)"
                     /calculated_mol_wt=112106
     Region          26..143
                     /region_name="V-set"
                     /note="Immunoglobulin V-set domain; pfam07686"
                     /db_xref="CDD:462230"
     Site            139
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (A8E0Y8.1)"
     Region          150..254
                     /region_name="IgV"
                     /note="Immunoglobulin variable domain (IgV); cd00099"
                     /db_xref="CDD:409355"
     Region          150..169
                     /region_name="FR1"
                     /note="FR1 [structural motif]"
                     /db_xref="CDD:409355"
     Region          156..158
                     /region_name="Ig strand A'"
                     /note="Ig strand A' [structural motif]"
                     /db_xref="CDD:409355"
     Region          162..170
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409355"
     Region          170..180
                     /region_name="CDR1"
                     /note="CDR1 [structural motif]"
                     /db_xref="CDD:409355"
     Site            order(180..181,183,252)
                     /site_type="other"
                     /note="antigen binding site [polypeptide binding]"
                     /db_xref="CDD:409355"
     Region          181..195
                     /region_name="FR2"
                     /note="FR2 [structural motif]"
                     /db_xref="CDD:409355"
     Region          181..187
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409355"
     Region          193..196
                     /region_name="Ig strand C'"
                     /note="Ig strand C' [structural motif]"
                     /db_xref="CDD:409355"
     Region          196..217
                     /region_name="CDR2"
                     /note="CDR2 [structural motif]"
                     /db_xref="CDD:409355"
     Region          217..227
                     /region_name="Ig strand D"
                     /note="Ig strand D [structural motif]"
                     /db_xref="CDD:409355"
     Region          218..251
                     /region_name="FR3"
                     /note="FR3 [structural motif]"
                     /db_xref="CDD:409355"
     Region          231..237
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409355"
     Region          245..252
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409355"
     Region          253..255
                     /region_name="EWI motif"
                     /note="propagated from UniProtKB/Swiss-Prot (A8E0Y8.1)"
     Region          287..379
                     /region_name="Ig_3"
                     /note="Immunoglobulin domain; pfam13927"
                     /db_xref="CDD:464046"
     Region          412..512
                     /region_name="Ig_3"
                     /note="Immunoglobulin domain; pfam13927"
                     /db_xref="CDD:464046"
     Region          676..781
                     /region_name="Ig"
                     /note="Immunoglobulin domain; cl11960"
                     /db_xref="CDD:472250"
     Site            677
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (A8E0Y8.1)"
     Region          691..695
                     /region_name="Ig strand B"
                     /note="Ig strand B [structural motif]"
                     /db_xref="CDD:409353"
     Region          708..712
                     /region_name="Ig strand C"
                     /note="Ig strand C [structural motif]"
                     /db_xref="CDD:409353"
     Region          759..763
                     /region_name="Ig strand E"
                     /note="Ig strand E [structural motif]"
                     /db_xref="CDD:409353"
     Region          773..778
                     /region_name="Ig strand F"
                     /note="Ig strand F [structural motif]"
                     /db_xref="CDD:409353"
     Region          830..927
                     /region_name="V-set"
                     /note="Immunoglobulin V-set domain; pfam07686"
                     /db_xref="CDD:462230"
     Site            971..991
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (A8E0Y8.1)"
     CDS             1..1033
                     /gene="Cd101"
                     /gene_synonym="EWI-101; Gm1016; Gm734; Igsf2"
                     /coded_by="NM_001167906.2:59..3160"
                     /db_xref="CCDS:CCDS51020.1"
                     /db_xref="GeneID:630146"
                     /db_xref="MGI:MGI:2685862"
ORIGIN      
        1 macilcvasl flsltkfsig qrevkiqegp lyraegypvs irctvsghqg pstqdfrwsi
       61 ylpsaptkev qiistkdagf syavyaqrvq skeiyierlq gdsvllhisk lqmkdageye
      121 chtpntdgky fgsysaktnl tvvpdtlsat mpsqtlskke gepleltcet tkatvqhthl
      181 sltwylmqeg ggsqateivs lskdfvltpg ssyadrfvag dvrldklgat sfrlsvgklq
      241 psdqgqvfce atewiqdpde twtlitrkqt dqtalriqpa ardftvsita ssspdegkpl
      301 elvclavgrd gnpqlqgvwf lngkeiaqtd aggvldlkrd yrdrasqgql qvsklsaqtf
      361 slkifsvgpe dvgtysceva evartqmgsw qvlqrkqspg yrvqlrepaa rsvtvsaeqr
      421 tvwegetltl lckaagdvsa lsvswwltpq dqstpvfvag mgqdgtvqlg vsspgpahrg
      481 nrrlekvdwa tfrleiasam vtdsgtyecr vserlqnqak glqstqkisv tvkslksslr
      541 vnlmsrqpqv mlahtfhlsc vvranysdlk lpfsvtwqfq pagsgafhrl iriahngtve
      601 wgdvlsqihr ktkvsqsffr sqlqiydaam eetgvyrctv evydrdsict sgparvsats
      661 nllmitvtfp esklsvnsss qvqelsisss tqiecailsr sagnlplsii wyfssvsana
      721 sylkilemdq ssvvkygdef qtprskqkfy sekvsqdlfl lnilsvedsd qghyhcavee
      781 wllstndtwq klerktsglt elklrptgsq vhvskvnwtg nateygeagf scsldgsgst
      841 aslysvtwyr grgtatataa avanatatit apagsqmlvh lqydgllqyg regsrrlqhc
      901 yrssptdfvl klhrvemeda giywcrvtew qqhghpgkwi nqasgesqrm vlrvlrsept
      961 vsslicssgp llhflivcpf vmllllatsf lclyrkarkl sqlslsakke kalwvgmrkt
     1021 slqkeagees ghy
//
