LOCUS       NM_177682               1802 bp    mRNA    linear   ROD 22-SEP-2024
DEFINITION  Mus musculus CCZ1 vacuolar protein trafficking and biogenesis
            associated (Ccz1), transcript variant 1, mRNA.
ACCESSION   NM_177682
VERSION     NM_177682.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1802)
  AUTHORS   Wu,M.Y., Liu,L., Wang,E.J., Xiao,H.T., Cai,C.Z., Wang,J., Su,H.,
            Wang,Y., Tan,J., Zhang,Z., Wang,J., Yao,M., Ouyang,D.F., Yue,Z.,
            Li,M., Chen,Y., Bian,Z.X. and Lu,J.H.
  TITLE     PI3KC3 complex subunit NRBF2 is required for apoptotic cell
            clearance to restrict intestinal inflammation
  JOURNAL   Autophagy 17 (5), 1096-1111 (2021)
   PUBMED   32160108
REFERENCE   2  (bases 1 to 1802)
  AUTHORS   Kinchen,J.M. and Ravichandran,K.S.
  TITLE     Identification of two evolutionarily conserved genes regulating
            processing of engulfed apoptotic cells
  JOURNAL   Nature 464 (7289), 778-782 (2010)
   PUBMED   20305638
  REMARK    GeneRIF: data identify SAND-1 (Mon1) and CCZ-1 (Ccz1) as critical
            and evolutionarily conserved components regulating the processing
            of ingested apoptotic cell corpses [ccz1]
REFERENCE   3  (bases 1 to 1802)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   4  (bases 1 to 1802)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   5  (bases 1 to 1802)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC121917.2.
            
            On Mar 15, 2023 this sequence version replaced NM_177682.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK152576.1, AK152328.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-190               AC121917.2         66777-66966
            191-288             AC121917.2         68574-68671
            289-382             AC121917.2         68769-68862
            383-460             AC121917.2         70136-70213
            461-508             AC121917.2         70587-70634
            509-592             AC121917.2         72379-72462
            593-768             AC121917.2         77447-77622
            769-850             AC121917.2         80207-80288
            851-912             AC121917.2         83060-83121
            913-1024            AC121917.2         83391-83502
            1025-1058           AC121917.2         88406-88439
            1059-1176           AC121917.2         89039-89156
            1177-1335           AC121917.2         90035-90193
            1336-1463           AC121917.2         90900-91027
            1464-1802           AC121917.2         93416-93754
FEATURES             Location/Qualifiers
     source          1..1802
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 82.85 cM"
     gene            1..1802
                     /gene="Ccz1"
                     /note="CCZ1 vacuolar protein trafficking and biogenesis
                     associated"
                     /db_xref="GeneID:231874"
                     /db_xref="MGI:MGI:2141070"
     exon            1..190
                     /gene="Ccz1"
                     /inference="alignment:Splign:2.1.0"
     CDS             77..1519
                     /gene="Ccz1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     vacuolar fusion protein CCZ1 homolog; CCZ1 vacuolar
                     protein trafficking and biogenesis associated homolog"
                     /codon_start=1
                     /product="vacuolar fusion protein CCZ1 homolog isoform 1"
                     /protein_id="NP_808350.1"
                     /db_xref="CCDS:CCDS19846.1"
                     /db_xref="GeneID:231874"
                     /db_xref="MGI:MGI:2141070"
                     /translation="MAAAAAGPGAWAAQEKQFPPALLSFFIYNPRFGPREGEEENKIL
                     FYHPNEVEKNEKIRNVGLCEAIVQFTRTFSPSKPAKSLHTQKNRQFFNEPEENFWMVM
                     VVRNPIIEKQSKDGKAVVEYQEEELLDKVYSSVLQQCYSMYKLFNGTFLKAMEDGGVK
                     LLKERLEKFFHRYLQTLHLQSCDLLDIFGGISFFPLDKMTYLKIQSFINRMEESLSVV
                     KYTAFLYNDQLIWSGLEQDDMRILYKYLTTSLFPRHIEPELAGRDSPVRAEMPGNLQH
                     YGRFLTGPLNLNDPEAKCRFPKIFVNTDDTYEELHLIVYKAMSAAVCFMIDASTPLTL
                     DFCRRLDSIVGPQLTVLASDICEQFNINKRISGSEKEPQFKFIYFNHMNLAEKSTIHM
                     RKTPSVSLTSVHPDLMKILGDINSDFTRADEDEEIIVKAMSDYWVVGKKSDQRELYVI
                     LSQKNANLIEVNEEVKKLCATQFNNIFFLD"
     exon            191..288
                     /gene="Ccz1"
                     /inference="alignment:Splign:2.1.0"
     exon            289..382
                     /gene="Ccz1"
                     /inference="alignment:Splign:2.1.0"
     exon            383..460
                     /gene="Ccz1"
                     /inference="alignment:Splign:2.1.0"
     exon            461..508
                     /gene="Ccz1"
                     /inference="alignment:Splign:2.1.0"
     exon            509..592
                     /gene="Ccz1"
                     /inference="alignment:Splign:2.1.0"
     exon            593..768
                     /gene="Ccz1"
                     /inference="alignment:Splign:2.1.0"
     exon            769..850
                     /gene="Ccz1"
                     /inference="alignment:Splign:2.1.0"
     exon            851..912
                     /gene="Ccz1"
                     /inference="alignment:Splign:2.1.0"
     exon            913..1024
                     /gene="Ccz1"
                     /inference="alignment:Splign:2.1.0"
     exon            1025..1058
                     /gene="Ccz1"
                     /inference="alignment:Splign:2.1.0"
     exon            1059..1176
                     /gene="Ccz1"
                     /inference="alignment:Splign:2.1.0"
     exon            1177..1335
                     /gene="Ccz1"
                     /inference="alignment:Splign:2.1.0"
     exon            1336..1463
                     /gene="Ccz1"
                     /inference="alignment:Splign:2.1.0"
     exon            1464..1802
                     /gene="Ccz1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1778..1783
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ccz1"
                     /note="hexamer: AATAAA"
     polyA_site      1802
                     /gene="Ccz1"
                     /note="major polyA site"
ORIGIN      
        1 ggaagtgcgg tgttccctaa ggctgctgcc tcggagcggg cggaggggag cctcccgaaa
       61 cgggggccgg gccgggatgg cggcagccgc ggccgggccg ggtgcttggg cggcccagga
      121 gaagcagttc ccgccagcgc tgctgagctt cttcatctac aacccccgtt tcgggccgcg
      181 cgagggagag gaagaaaata aaattctgtt ttaccatcca aatgaagtag aaaagaatga
      241 aaaaattaga aatgttggat tatgtgaagc aattgtacag tttacaagga cttttagccc
      301 atcgaaacct gcaaaatctt tacacacaca gaagaacaga cagttcttca atgaaccaga
      361 agaaaatttc tggatggtta tggttgttcg gaatcctatc atcgagaagc aaagtaaaga
      421 tggcaaggcg gtagtggagt accaagagga ggagctgttg gacaaggtgt acagctcagt
      481 gctgcagcag tgctacagca tgtacaagct tttcaatggg acgtttctga aagccatgga
      541 agatggaggc gtcaagctcc taaaggaaag attagagaaa ttcttccatc ggtatttgca
      601 gacactacat ttgcagtcat gtgacctact tgatattttt ggtggaatca gcttcttccc
      661 attggataaa atgacttact tgaaaatcca gtcctttatt aaccgaatgg aagaaagcct
      721 aagtgtagtc aaatatacag cattcctcta caatgaccaa cttatctgga gtggactaga
      781 gcaagatgac atgagaattt tgtacaaata cctcaccacc tcactgttcc ccaggcacat
      841 cgaacctgag ttggcgggaa gggactcccc agtcagggca gagatgcctg ggaatcttca
      901 gcactatgga agatttctta ctggaccctt gaaccttaat gatccagaag caaaatgcag
      961 attccccaaa atttttgtaa atacagatga cacgtatgaa gagctccatt taattgttta
     1021 taaggccatg agtgcagccg tgtgcttcat gattgacgcc tccacgccgc tcacgctgga
     1081 tttctgccga agactggaca gcatcgttgg gccccagctt acggtgctgg catctgacat
     1141 ctgtgagcag tttaatatca acaagaggat ctctgggtct gaaaaggagc cccagtttaa
     1201 gttcatctac ttcaaccaca tgaatttagc agagaaaagt acaattcaca tgaggaaaac
     1261 gcccagtgtg tcactcacat ccgtccaccc agatctaatg aagatattag gggacatcaa
     1321 cagtgacttt accagagcag atgaagatga agaaatcatt gtgaaggcca tgagcgacta
     1381 ctgggttgtt gggaagaagt ctgaccagcg ggagctgtac gtgattctca gtcagaagaa
     1441 tgcgaacctg atcgaggtca atgaagaggt gaagaaactg tgtgccacgc agttcaacaa
     1501 catcttcttc ttggattgac tccactggct cagcagaaca tctttaaaaa cctcaacaac
     1561 ctttgtgttt accattacaa cttactggtc atgctagtga ctgggttagg gacacagtaa
     1621 agcaatacct gcttggaaaa ccacatttct acttggtctg atgattccct gaggtttcta
     1681 gatgttaaat atttatgtga aattaattaa atgtagtcag ctgaatacca ttccattctg
     1741 ctgacattgt atgggtattt tactgggaaa taagactaat aaattgttaa agtttttaaa
     1801 aa
//
