LOCUS       NM_009840               2391 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus chaperonin containing TCP1 subunit 8 (Cct8), mRNA.
ACCESSION   NM_009840
VERSION     NM_009840.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2391)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2391)
  AUTHORS   Kragness,S., Clark,Z., Mullin,A., Guidry,J. and Earls,L.R.
  TITLE     An Rtn4/Nogo-A-interacting micropeptide modulates synaptic
            plasticity with age
  JOURNAL   PLoS One 17 (6), e0269404 (2022)
   PUBMED   35771867
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2391)
  AUTHORS   Oftedal,B.E., Maio,S., Handel,A.E., White,M.P.J., Howie,D.,
            Davis,S., Prevot,N., Rota,I.A., Deadman,M.E., Kessler,B.M.,
            Fischer,R., Trede,N.S., Sezgin,E., Maizels,R.M. and Hollander,G.A.
  TITLE     The chaperonin CCT8 controls proteostasis essential for T cell
            maturation, selection, and function
  JOURNAL   Commun Biol 4 (1), 681 (2021)
   PUBMED   34083746
  REMARK    GeneRIF: The chaperonin CCT8 controls proteostasis essential for T
            cell maturation, selection, and function.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2391)
  AUTHORS   Tarkar,A., Loges,N.T., Slagle,C.E., Francis,R., Dougherty,G.W.,
            Tamayo,J.V., Shook,B., Cantino,M., Schwartz,D., Jahnke,C.,
            Olbrich,H., Werner,C., Raidt,J., Pennekamp,P., Abouhamed,M.,
            Hjeij,R., Kohler,G., Griese,M., Li,Y., Lemke,K., Klena,N., Liu,X.,
            Gabriel,G., Tobita,K., Jaspers,M., Morgan,L.C., Shapiro,A.J.,
            Letteboer,S.J., Mans,D.A., Carson,J.L., Leigh,M.W., Wolf,W.E.,
            Chen,S., Lucas,J.S., Onoufriadis,A., Plagnol,V., Schmidts,M.,
            Boldt,K., Roepman,R., Zariwala,M.A., Lo,C.W., Mitchison,H.M.,
            Knowles,M.R., Burdine,R.D., Loturco,J.J. and Omran,H.
  CONSRTM   UK10K
  TITLE     DYX1C1 is required for axonemal dynein assembly and ciliary
            motility
  JOURNAL   Nat Genet 45 (9), 995-1003 (2013)
   PUBMED   23872636
REFERENCE   5  (bases 1 to 2391)
  AUTHORS   Slater,L.H., Hett,E.C., Clatworthy,A.E., Mark,K.G. and Hung,D.T.
  TITLE     CCT chaperonin complex is required for efficient delivery of
            anthrax toxin into the cytosol of host cells
  JOURNAL   Proc Natl Acad Sci U S A 110 (24), 9932-9937 (2013)
   PUBMED   23716698
REFERENCE   6  (bases 1 to 2391)
  AUTHORS   Kubota,H., Hynes,G. and Willison,K.
  TITLE     The chaperonin containing t-complex polypeptide 1 (TCP-1).
            Multisubunit machinery assisting in protein folding and assembly in
            the eukaryotic cytosol
  JOURNAL   Eur J Biochem 230 (1), 3-16 (1995)
   PUBMED   7601114
  REMARK    Review article
REFERENCE   7  (bases 1 to 2391)
  AUTHORS   Kubota,H., Hynes,G. and Willison,K.
  TITLE     The eighth Cct gene, Cctq, encoding the theta subunit of the
            cytosolic chaperonin containing TCP-1
  JOURNAL   Gene 154 (2), 231-236 (1995)
   PUBMED   7890169
REFERENCE   8  (bases 1 to 2391)
  AUTHORS   Hynes,G., Kubota,H. and Willison,K.R.
  TITLE     Antibody characterisation of two distinct conformations of the
            chaperonin-containing TCP-1 from mouse testis
  JOURNAL   FEBS Lett 358 (2), 129-132 (1995)
   PUBMED   7828721
REFERENCE   9  (bases 1 to 2391)
  AUTHORS   Kubota,H., Hynes,G., Carne,A., Ashworth,A. and Willison,K.
  TITLE     Identification of six Tcp-1-related genes encoding divergent
            subunits of the TCP-1-containing chaperonin
  JOURNAL   Curr Biol 4 (2), 89-99 (1994)
   PUBMED   7953530
REFERENCE   10 (bases 1 to 2391)
  AUTHORS   O'Bryan,J.P., Frye,R.A., Cogswell,P.C., Neubauer,A., Kitch,B.,
            Prokop,C., Espinosa,R. 3rd, Le Beau,M.M., Earp,H.S. and Liu,E.T.
  TITLE     axl, a transforming gene isolated from primary human myeloid
            leukemia cells, encodes a novel receptor tyrosine kinase
  JOURNAL   Mol Cell Biol 11 (10), 5016-5031 (1991)
   PUBMED   1656220
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK147038.1, AK075880.1, AK075711.1 and AV335786.1.
            
            On Mar 8, 2007 this sequence version replaced NM_009840.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK147038.1, AK075880.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164137, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-12                AK147038.1         4-15
            13-555              AK075880.1         2-544
            556-1840            AK075711.1         537-1821
            1841-2389           AK075880.1         1830-2378
            2390-2391           AV335786.1         239-240
FEATURES             Location/Qualifiers
     source          1..2391
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 49.57 cM"
     gene            1..2391
                     /gene="Cct8"
                     /gene_synonym="Cctq; Tcpq"
                     /note="chaperonin containing TCP1 subunit 8"
                     /db_xref="GeneID:12469"
                     /db_xref="MGI:MGI:107183"
     exon            1..141
                     /gene="Cct8"
                     /gene_synonym="Cctq; Tcpq"
                     /inference="alignment:Splign:2.1.0"
     exon            142..232
                     /gene="Cct8"
                     /gene_synonym="Cctq; Tcpq"
                     /inference="alignment:Splign:2.1.0"
     exon            233..312
                     /gene="Cct8"
                     /gene_synonym="Cctq; Tcpq"
                     /inference="alignment:Splign:2.1.0"
     exon            313..462
                     /gene="Cct8"
                     /gene_synonym="Cctq; Tcpq"
                     /inference="alignment:Splign:2.1.0"
     exon            463..643
                     /gene="Cct8"
                     /gene_synonym="Cctq; Tcpq"
                     /inference="alignment:Splign:2.1.0"
     exon            644..705
                     /gene="Cct8"
                     /gene_synonym="Cctq; Tcpq"
                     /inference="alignment:Splign:2.1.0"
     exon            706..843
                     /gene="Cct8"
                     /gene_synonym="Cctq; Tcpq"
                     /inference="alignment:Splign:2.1.0"
     exon            844..1022
                     /gene="Cct8"
                     /gene_synonym="Cctq; Tcpq"
                     /inference="alignment:Splign:2.1.0"
     exon            1023..1089
                     /gene="Cct8"
                     /gene_synonym="Cctq; Tcpq"
                     /inference="alignment:Splign:2.1.0"
     exon            1090..1177
                     /gene="Cct8"
                     /gene_synonym="Cctq; Tcpq"
                     /inference="alignment:Splign:2.1.0"
     exon            1178..1293
                     /gene="Cct8"
                     /gene_synonym="Cctq; Tcpq"
                     /inference="alignment:Splign:2.1.0"
     exon            1294..1365
                     /gene="Cct8"
                     /gene_synonym="Cctq; Tcpq"
                     /inference="alignment:Splign:2.1.0"
     exon            1366..1530
                     /gene="Cct8"
                     /gene_synonym="Cctq; Tcpq"
                     /inference="alignment:Splign:2.1.0"
     exon            1531..1650
                     /gene="Cct8"
                     /gene_synonym="Cctq; Tcpq"
                     /inference="alignment:Splign:2.1.0"
     exon            1651..2391
                     /gene="Cct8"
                     /gene_synonym="Cctq; Tcpq"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1823..1828
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cct8"
                     /gene_synonym="Cctq; Tcpq"
                     /note="hexamer: AATAAA"
     polyA_site      1841
                     /gene="Cct8"
                     /gene_synonym="Cctq; Tcpq"
                     /note="major polyA site"
     regulatory      2303..2308
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cct8"
                     /gene_synonym="Cctq; Tcpq"
                     /note="hexamer: AATAAA"
     polyA_site      2329
                     /gene="Cct8"
                     /gene_synonym="Cctq; Tcpq"
     regulatory      2362..2367
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cct8"
                     /gene_synonym="Cctq; Tcpq"
                     /note="hexamer: AATAAA"
     polyA_site      2390
                     /gene="Cct8"
                     /gene_synonym="Cctq; Tcpq"
ORIGIN      
        1 ttcccagcag gcagtgcgcg gcgccccttg cttcctcggc gtctcggagc gagcgcgtga
       61 gcggtggact gcggccgagc catggcgctt cacgtcccca aggccccggg ctttgcccag
      121 atgctcaagg atggagccaa acatttctcg ggattagaag aggctgtgta tagaaatata
      181 caggcctgca aggagcttgc tcagactact cgcacagcgt acggaccaaa tggaatgaat
      241 aaaatggtca tcaatcgcct ggagaagttg tttgtgacaa acgatgcagc gactatttta
      301 agagagctag aagtgcagca tcctgctgca aagatgatag tgatggcctc tcatatgcaa
      361 gaacaagagg ttggtgatgg cacaaacttc gttctggtgt tcgctggggc tcttctggaa
      421 ctagctgaag aacttctgag gattggcctg tcagtatcag aggtaatatc ggggtatgaa
      481 atagcttgca aaaaagctca tgagatcctt cctgagttgg tatgttgttc tgccaaaaac
      541 cttcgagatg ttgatgaagt gtcctctctg cttcgaacct ccatcatgag taagcagtac
      601 ggcagcgaga cgtttttggc caagcttatt gctcaggctt gtgtttctat ctttcctgat
      661 tctggcaatt tcaatgttga taacatcaga gtatgtaaga ttctgggctc tggtatttat
      721 tcatcctcag tattacatgg catggttttt aagaaggaaa ctgaaggtga tgtgacatct
      781 gtcaaagatg caaagatagc tgtgtactct tgtccgtttg atggcatgat aacagagaca
      841 aaggggaccg tgctgattaa gactgccgag gagctaatga acttcagtaa gggagaggag
      901 aacctcatgg atgctcaggt gaaggccatt gcaggcactg gtgcaaatgt catagtaaca
      961 ggcggcaaag tggcggacat agctcttcat tatgctaaca agtacaatat catgttggtg
     1021 agactgaact caaagtggga tctcagacga ctctgtaaaa cagttggtgc cacagctctt
     1081 ccaaaattga ctcctcccgt ccaagaagaa atgggacatt gtgacagtgt ttacctctca
     1141 gaagttggag atacacaagt ggttgttttt aagcatgaaa aagaagatgg tgccatttct
     1201 actatagttc ttcgaggttc tacagacaat ctgatggatg acatagaaag ggcagtagat
     1261 gatggagtta atactttcaa agttctcaca agggataagc gtcttgtacc tggaggtgga
     1321 gctaccgaaa ttgaattggc taaacaaatc acatcatatg gagagacgtg tcctgggctt
     1381 gaacagtatg ctattaagaa gtttgctgaa gcgtttgaag cgattccacg ggcactggca
     1441 gaaaattctg gcgtgaaggc caatgaagtt atctctaaac tttattccgt acaccaagaa
     1501 ggaaacaaaa atgtggggtt ggatatcgag gctgaagtcc ctgctgtaaa ggatatgtta
     1561 gaagccagta ttttagatac ttacttggga aaatactggg ctattaaact ggccactaat
     1621 gctgcagtca ctgtactaag agtggatcag atcatcatgg caaaaccagc tggtgggccc
     1681 aaacctccaa gtgggaagaa ggactgggat gacgaccaga atgactgagg aacttgtcat
     1741 aggttaagag ttgtgtttgt agagtagaac ttgcccagtg ttttattttt cttatttgtg
     1801 tttgtactct gctgggtggt acaataaatg tgttactgtt atggccgtct gtttaatcac
     1861 tcacatgact gttctcattg tatacttgac catatctatt gggaaagaca ctttctagtc
     1921 tgttgtttat ctcatttcca aagttgttcc cccaatccca tggccttgaa agtctggctt
     1981 ctaaatgttt gttgtttatc ccatagcaaa caaaaaaagt tcagacagtg tcctaattaa
     2041 tataaggctt ttcaatagtg gctgggccag agtttatgcg cacacactga caccaagatt
     2101 tcacattgct cccaatccta atctcagcac tagaatagtg aaacatggtg ttgccagtag
     2161 tgggtacagt aaataacaac ttaaactcta ataaaacaag ttttgggaat atcagtttat
     2221 tgatgtgtca agcactacca cccagtcaga gtaagcacag aacttagtta ttcaaatcct
     2281 tcctaaagtt gaaactagaa ggaataaaaa ccagtatgct aatacaaaac cgctgtaaat
     2341 tattttgcct gtatttaaat aaataaacat gatttttttt ctgtcattta c
//
