LOCUS       NM_007638               2452 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus chaperonin containing TCP1 subunit 7 (Cct7), mRNA.
ACCESSION   NM_007638
VERSION     NM_007638.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2452)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2452)
  AUTHORS   Slater,L.H., Hett,E.C., Clatworthy,A.E., Mark,K.G. and Hung,D.T.
  TITLE     CCT chaperonin complex is required for efficient delivery of
            anthrax toxin into the cytosol of host cells
  JOURNAL   Proc Natl Acad Sci U S A 110 (24), 9932-9937 (2013)
   PUBMED   23716698
REFERENCE   3  (bases 1 to 2452)
  AUTHORS   Dun,M.D., Smith,N.D., Baker,M.A., Lin,M., Aitken,R.J. and Nixon,B.
  TITLE     The chaperonin containing TCP1 complex (CCT/TRiC) is involved in
            mediating sperm-oocyte interaction
  JOURNAL   J Biol Chem 286 (42), 36875-36887 (2011)
   PUBMED   21880732
REFERENCE   4  (bases 1 to 2452)
  AUTHORS   Hanafy,K.A., Martin,E. and Murad,F.
  TITLE     CCTeta, a novel soluble guanylyl cyclase-interacting protein
  JOURNAL   J Biol Chem 279 (45), 46946-46953 (2004)
   PUBMED   15347653
  REMARK    GeneRIF: CCTeta is a novel soluble guanylyl cyclase-interacting
            protein [CCTeta]
REFERENCE   5  (bases 1 to 2452)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   6  (bases 1 to 2452)
  AUTHORS   Lu,K.P. and Ramos,K.S.
  TITLE     Identification of genes differentially expressed in vascular smooth
            muscle cells following benzo[a]pyrene challenge: implications for
            chemical atherogenesis
  JOURNAL   Biochem Biophys Res Commun 253 (3), 828-833 (1998)
   PUBMED   9918813
REFERENCE   7  (bases 1 to 2452)
  AUTHORS   Kubota,H., Hynes,G. and Willison,K.
  TITLE     The chaperonin containing t-complex polypeptide 1 (TCP-1).
            Multisubunit machinery assisting in protein folding and assembly in
            the eukaryotic cytosol
  JOURNAL   Eur J Biochem 230 (1), 3-16 (1995)
   PUBMED   7601114
  REMARK    Review article
REFERENCE   8  (bases 1 to 2452)
  AUTHORS   Hynes,G., Kubota,H. and Willison,K.R.
  TITLE     Antibody characterisation of two distinct conformations of the
            chaperonin-containing TCP-1 from mouse testis
  JOURNAL   FEBS Lett 358 (2), 129-132 (1995)
   PUBMED   7828721
REFERENCE   9  (bases 1 to 2452)
  AUTHORS   Kubota,H., Hynes,G., Carne,A., Ashworth,A. and Willison,K.
  TITLE     Identification of six Tcp-1-related genes encoding divergent
            subunits of the TCP-1-containing chaperonin
  JOURNAL   Curr Biol 4 (2), 89-99 (1994)
   PUBMED   7953530
REFERENCE   10 (bases 1 to 2452)
  AUTHORS   O'Bryan,J.P., Frye,R.A., Cogswell,P.C., Neubauer,A., Kitch,B.,
            Prokop,C., Espinosa,R. 3rd, Le Beau,M.M., Earp,H.S. and Liu,E.T.
  TITLE     axl, a transforming gene isolated from primary human myeloid
            leukemia cells, encodes a novel receptor tyrosine kinase
  JOURNAL   Mol Cell Biol 11 (10), 5016-5031 (1991)
   PUBMED   1656220
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BQ951185.1, AK150160.1, AK146902.1 and AC155728.13.
            
            On Jun 3, 2009 this sequence version replaced NM_007638.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK146902.1, AK168087.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-514               BQ951185.1         1-514
            515-2061            AK150160.1         2-1548
            2062-2450           AK146902.1         1502-1890
            2451-2452           AC155728.13        162139-162140
FEATURES             Location/Qualifiers
     source          1..2452
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 37.46 cM"
     gene            1..2452
                     /gene="Cct7"
                     /gene_synonym="Ccth; Cctz"
                     /note="chaperonin containing TCP1 subunit 7"
                     /db_xref="GeneID:12468"
                     /db_xref="MGI:MGI:107184"
     exon            1..623
                     /gene="Cct7"
                     /gene_synonym="Ccth; Cctz"
                     /inference="alignment:Splign:2.1.0"
     CDS             618..2252
                     /gene="Cct7"
                     /gene_synonym="Ccth; Cctz"
                     /note="chaperonin containing t-complex subunit eta;
                     CCT-eta; TCP-1-eta; chaperonin subunit 7 (eta); chaperonin
                     containing Tcp1, subunit 7 (eta)"
                     /codon_start=1
                     /product="T-complex protein 1 subunit eta"
                     /protein_id="NP_031664.3"
                     /db_xref="CCDS:CCDS20295.1"
                     /db_xref="GeneID:12468"
                     /db_xref="MGI:MGI:107184"
                     /translation="MMPTPVILLKEGTDSSQGIPQLVSNISACQVIAEAVRTTLGPRG
                     MDKLIVDGRGKATISNDGATILKLLDVVHPAAKTLVDIAKSQDAEVGDGTTSVTLLAA
                     EFLKQVKPYVEEGLHPQIIIRAFRTATQLAVNKIKEIAVTVKKQDKVEQRKMLEKCAM
                     TALSSKLISQQKVFFAKMVVDAVMMLDELLQLKMIGIKKVQGGALEESQLVAGVAFKK
                     TFSYAGFEMQPKKYKNPKIALLNVELELKAEKDNAEIRVHTVEDYQAIVDAEWNILYD
                     KLEKIHQSGAKVILSKLPIGDVATQYFADRDMFCAGRVPEEDLKRTMMACGGSIQTSV
                     NALVPDVLGHCQVFEETQIGGERYNFFTGCPKAKTCTIILRGGAEQFMEETERSLHDA
                     IMIVRRAIKNDSVVAGGGAIEMELSKYLRDYSRTIPGKQQLLIGAYAKALEIIPRQLC
                     DNAGFDATNILNKLRARHAQGGMWYGVDINNENIADNFQAFVWEPAMVRINALTAASE
                     AACLIVSVDETIKNPRSTVDPPAPSAGRGRGQARFH"
     exon            624..777
                     /gene="Cct7"
                     /gene_synonym="Ccth; Cctz"
                     /inference="alignment:Splign:2.1.0"
     exon            778..884
                     /gene="Cct7"
                     /gene_synonym="Ccth; Cctz"
                     /inference="alignment:Splign:2.1.0"
     exon            885..1010
                     /gene="Cct7"
                     /gene_synonym="Ccth; Cctz"
                     /inference="alignment:Splign:2.1.0"
     exon            1011..1063
                     /gene="Cct7"
                     /gene_synonym="Ccth; Cctz"
                     /inference="alignment:Splign:2.1.0"
     exon            1064..1235
                     /gene="Cct7"
                     /gene_synonym="Ccth; Cctz"
                     /inference="alignment:Splign:2.1.0"
     exon            1236..1400
                     /gene="Cct7"
                     /gene_synonym="Ccth; Cctz"
                     /inference="alignment:Splign:2.1.0"
     exon            1401..1589
                     /gene="Cct7"
                     /gene_synonym="Ccth; Cctz"
                     /inference="alignment:Splign:2.1.0"
     exon            1590..1687
                     /gene="Cct7"
                     /gene_synonym="Ccth; Cctz"
                     /inference="alignment:Splign:2.1.0"
     exon            1688..1820
                     /gene="Cct7"
                     /gene_synonym="Ccth; Cctz"
                     /inference="alignment:Splign:2.1.0"
     exon            1821..2027
                     /gene="Cct7"
                     /gene_synonym="Ccth; Cctz"
                     /inference="alignment:Splign:2.1.0"
     exon            2028..2452
                     /gene="Cct7"
                     /gene_synonym="Ccth; Cctz"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2342..2347
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cct7"
                     /gene_synonym="Ccth; Cctz"
                     /note="hexamer: AATAAA"
     polyA_site      2358
                     /gene="Cct7"
                     /gene_synonym="Ccth; Cctz"
                     /note="major polyA site"
     regulatory      2377..2382
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cct7"
                     /gene_synonym="Ccth; Cctz"
                     /note="hexamer: CATAAA"
     polyA_site      2397
                     /gene="Cct7"
                     /gene_synonym="Ccth; Cctz"
     regulatory      2428..2433
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cct7"
                     /gene_synonym="Ccth; Cctz"
                     /note="hexamer: AGTAAA"
     polyA_site      2450
                     /gene="Cct7"
                     /gene_synonym="Ccth; Cctz"
ORIGIN      
        1 gcggggttgc gcgggatcca cggctctcct ccccaggcag agacgggcct cgcgcgaagg
       61 ggcaggcggc acggcgccgc ctcggccgat aaggggcgct acagagctag aagccgaccc
      121 gagcaaattt cctgcgcccg agcgggccgc gcacctgtga cccgggacac tgttcccaac
      181 ttcccaagct acctgtgaaa ctcacggagc tccctcgcca cggagctgag caggtgcagt
      241 gagatcactc acctaaggtg cttctcctag ccggtgttca gtactgatag ctcattgcac
      301 gtctaccatg gcgtctggga gcgcgggctg aggcgggacc ttaccgcacc ttacaaacca
      361 aaagcactgc gagactcgat gacccccgcc aaagctaacg cgagttccta gagcgtccct
      421 ggacctccga ctcctctagc cggctacctc gggagctaac catagagtgg cggaagtggt
      481 ccggcccctt cctctcccgg gctaacgtct cgccagaagc ttctgggcat ttctccggcg
      541 cggagcattg tgggcttggg tgggcggccc cgaggcggac aactgacgag ttgcgggtac
      601 ctgaagccgc ttccaagatg atgcccacac cagttatcct gttgaaagag ggtactgata
      661 gctcccaggg catccctcag ctcgtgagta acatcagtgc ctgccaagtg attgctgagg
      721 ctgtaagaac caccctgggt ccccgtggca tggacaaact tattgtggat ggccgaggca
      781 aagcaacaat atctaatgat ggggccacaa ttctgaaact cctcgatgtt gtccatcctg
      841 cagcaaagac tttagtggac atagccaagt cccaggatgc tgaggttggt gatggcacca
      901 cctcagtgac cctgctggct gcggagtttc tgaagcaggt gaagccctac gtggaagaag
      961 gtttacaccc tcagatcatc atccgagctt tccgcacagc cacccaattg gctgttaaca
     1021 aaatcaaaga gatagctgtg actgtgaaga agcaagataa agtagagcag aggaagatgc
     1081 tggagaagtg tgcgatgaca gccctgagct ccaagctgat ctcccagcag aaggtcttct
     1141 tcgccaagat ggtggttgat gccgtgatga tgcttgacga gctgctgcag cttaaaatga
     1201 ttggcatcaa gaaggtgcag gggggagccc tggaggagtc tcagctagtt gctggtgttg
     1261 cgttcaagaa gactttctct tatgctgggt ttgaaatgca gcccaagaag tataagaacc
     1321 ccaagattgc cctcttaaat gttgagcttg agctgaaagc agagaaagat aatgctgaaa
     1381 tcagagtcca cacagtggag gattaccagg caattgttga tgccgagtgg aatattctct
     1441 atgacaagtt agagaagatc catcagtctg gagccaaagt catcttgtct aaactcccta
     1501 ttggggatgt ggccacccag tactttgctg atagggacat gttctgtgct ggccgagtgc
     1561 ctgaggagga tctgaagagg acgatgatgg cttgtggagg ctcaatccag accagtgtga
     1621 atgctctggt tccagatgtg ctgggccact gccaagtgtt tgaagagacc caaattggag
     1681 gagagaggta caatttcttc actggctgcc ctaaggccaa gacatgtacc atcatcctcc
     1741 gtggtggcgc tgagcagttt atggaagaga cagagaggtc cctacatgat gccatcatga
     1801 ttgtgaggag ggccatcaag aatgactctg tggtggctgg tggtggagcc atcgagatgg
     1861 aactttccaa atacctgcgg gattactcga ggaccattcc tgggaagcag cagctgttga
     1921 ttggggcata tgccaaggcc ctggagatta ttccacgaca gctatgtgac aacgctggct
     1981 ttgatgccac aaacatcctc aacaagctgc gggctcgaca cgcacaggga ggtatgtggt
     2041 atggggtgga catcaacaat gagaacatcg ccgacaactt ccaggcattt gtgtgggagc
     2101 cagccatggt gcgcatcaac gctctgacag cagcttctga ggctgcatgc cttattgtgt
     2161 ccgtggatga gactatcaag aacccccgct ccactgtgga tcctccagct ccatcagctg
     2221 gccgtggcag aggccaagcc cgcttccact gagaggcgag gcggtctgca cctccttgtg
     2281 aggtgagggg gtggatgaga agatggttgc tggtctgctg ggttctcact gaggttattt
     2341 aaataaagct taaggttatt tgcttggtgt gtttttcata aacattttcc tgccttagaa
     2401 ttggagtcat gtatacttgg aaatagaagt aaagaattgt gttagcctgc tg
//
