LOCUS       NM_009839               1817 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus chaperonin containing TCP1 subunit 6B (Cct6b),
            transcript variant 1, mRNA.
ACCESSION   NM_009839
VERSION     NM_009839.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1817)
  AUTHORS   Cazin,C., Neirijnck,Y., Loeuillet,C., Wehrli,L., Kuhne,F.,
            Lordey,I., Mustapha,S.F.B., Bouker,A., Zouari,R., Thierry-Mieg,N.,
            Nef,S., Arnoult,C., Ray,P.F. and Kherraf,Z.E.
  TITLE     Combined Use of Whole Exome Sequencing and CRISPR/Cas9 to Study the
            Etiology of Non-Obstructive Azoospermia: Demonstration of the
            Dispensable Role of the Testis-Specific Genes C1orf185 and CCT6B
  JOURNAL   Cells 11 (1), 118 (2021)
   PUBMED   35011680
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1817)
  AUTHORS   Yang,P., Tang,W., Li,H., Hua,R., Yuan,Y., Zhang,Y., Zhu,Y., Cui,Y.
            and Sha,J.
  TITLE     T-complex protein 1 subunit zeta-2 (CCT6B) deficiency induces
            murine teratospermia
  JOURNAL   PeerJ 9, e11545 (2021)
   PUBMED   34141486
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1817)
  AUTHORS   Lu,Y., Oura,S., Matsumura,T., Oji,A., Sakurai,N., Fujihara,Y.,
            Shimada,K., Miyata,H., Tobita,T., Noda,T., Castaneda,J.M.,
            Kiyozumi,D., Zhang,Q., Larasati,T., Young,S.A.M., Kodani,M.,
            Huddleston,C.A., Robertson,M.J., Coarfa,C., Isotani,A.,
            Aitken,R.J., Okabe,M., Matzuk,M.M., Garcia,T.X. and Ikawa,M.
  TITLE     CRISPR/Cas9-mediated genome editing reveals 30 testis-enriched
            genes dispensable for male fertility in micedagger
  JOURNAL   Biol Reprod 101 (2), 501-511 (2019)
   PUBMED   31201419
REFERENCE   4  (bases 1 to 1817)
  AUTHORS   Slater,L.H., Hett,E.C., Clatworthy,A.E., Mark,K.G. and Hung,D.T.
  TITLE     CCT chaperonin complex is required for efficient delivery of
            anthrax toxin into the cytosol of host cells
  JOURNAL   Proc Natl Acad Sci U S A 110 (24), 9932-9937 (2013)
   PUBMED   23716698
REFERENCE   5  (bases 1 to 1817)
  AUTHORS   Le Bras,S., Cohen-Tannoudji,M., Guyot,V., Vandormael-Pournin,S.,
            Coumailleau,F., Babinet,C. and Baldacci,P.
  TITLE     Transcript map of the Ovum mutant (Om) locus: isolation by exon
            trapping of new candidate genes for the DDK syndrome
  JOURNAL   Gene 296 (1-2), 75-86 (2002)
   PUBMED   12383505
REFERENCE   6  (bases 1 to 1817)
  AUTHORS   Kubota,H., Yokota,S., Yanagi,H. and Yura,T.
  TITLE     Structures and co-regulated expression of the genes encoding mouse
            cytosolic chaperonin CCT subunits
  JOURNAL   Eur J Biochem 262 (2), 492-500 (1999)
   PUBMED   10336634
REFERENCE   7  (bases 1 to 1817)
  AUTHORS   Kubota,H., Hynes,G.M., Kerr,S.M. and Willison,K.R.
  TITLE     Tissue-specific subunit of the mouse cytosolic
            chaperonin-containing TCP-1
  JOURNAL   FEBS Lett 402 (1), 53-56 (1997)
   PUBMED   9013858
REFERENCE   8  (bases 1 to 1817)
  AUTHORS   Hynes,G., Kubota,H. and Willison,K.R.
  TITLE     Antibody characterisation of two distinct conformations of the
            chaperonin-containing TCP-1 from mouse testis
  JOURNAL   FEBS Lett 358 (2), 129-132 (1995)
   PUBMED   7828721
REFERENCE   9  (bases 1 to 1817)
  AUTHORS   Kubota,H., Hynes,G., Carne,A., Ashworth,A. and Willison,K.
  TITLE     Identification of six Tcp-1-related genes encoding divergent
            subunits of the TCP-1-containing chaperonin
  JOURNAL   Curr Biol 4 (2), 89-99 (1994)
   PUBMED   7953530
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK076639.1, BC100457.1 and CF551313.1.
            
            [WARNING] On Jun 6, 2024 this sequence was replaced by NM_009839.4.
            
            On Mar 29, 2014 this sequence version replaced NM_009839.2.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: Z50192.1, BC100457.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-33                AK076639.1         2-34
            34-1792             BC100457.1         1-1759
            1793-1817           CF551313.1         679-703
FEATURES             Location/Qualifiers
     source          1..1817
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 50.18 cM"
     gene            1..1817
                     /gene="Cct6b"
                     /gene_synonym="CCT-zeta-2; Cctz-2; CCTzeta-2;
                     TCP-1-zeta-2"
                     /note="chaperonin containing TCP1 subunit 6B"
                     /db_xref="GeneID:12467"
                     /db_xref="MGI:MGI:1329013"
     exon            1..231
                     /gene="Cct6b"
                     /gene_synonym="CCT-zeta-2; Cctz-2; CCTzeta-2;
                     TCP-1-zeta-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             95..1690
                     /gene="Cct6b"
                     /gene_synonym="CCT-zeta-2; Cctz-2; CCTzeta-2;
                     TCP-1-zeta-2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     T-complex protein 1 subunit zeta-2; chaperonin subunit 6b
                     (zeta); chaperonin containing Tcp1, subunit 6b (zeta)"
                     /codon_start=1
                     /product="T-complex protein 1 subunit zeta-2 isoform 1"
                     /protein_id="NP_033969.2"
                     /db_xref="CCDS:CCDS25145.1"
                     /db_xref="GeneID:12467"
                     /db_xref="MGI:MGI:1329013"
                     /translation="MAAIKIANPGAEVTRSQAALAVNICAARGLQDVLRPTLGPKGAL
                     KMLVSGAGDIKLTKDGNVLLHEMQIQHPTASIIAKVAAAQDHVTGDGTTSNVLIIGEL
                     LKQADLYISEGLHPRIITEGFDVAKTKALEVLDEIKVQKEMKREILLDVARTSLQTKV
                     HAELADILTEAVVDSVLAIRRPGVPIDLFMVEIVEMRHKSETDTQLIRGLVLDHGARH
                     PRMRKQVRDAYILTCNVSLEYEKTEVSSGFFYKTVEEKEKLVKAERKFIEDRVQKIID
                     LKQKVCAESNKGFVVINQKGIDPVSLEMLAKHNIVALRRAKRRNLERLTLACGGLAVN
                     SFEGLSEECLGHAGLVFEYALGEEKFTFIEDCVNPLSVTLLVKGPNKHTLIQIKDALR
                     DGLRAVKNAIEDGCVVPGAGAVEVAIAEALVNYKHRVQGRVRLGIQAFADALLIIPKV
                     LAQNSGYDLQETLIKIQTKHAESKELLGIDLNTGEPMAAAEAGIWDNYCVKKHLLHSC
                     TVIATNILLVDEIMRAGMSSLRD"
     exon            232..295
                     /gene="Cct6b"
                     /gene_synonym="CCT-zeta-2; Cctz-2; CCTzeta-2;
                     TCP-1-zeta-2"
                     /inference="alignment:Splign:2.1.0"
     exon            296..430
                     /gene="Cct6b"
                     /gene_synonym="CCT-zeta-2; Cctz-2; CCTzeta-2;
                     TCP-1-zeta-2"
                     /inference="alignment:Splign:2.1.0"
     exon            431..604
                     /gene="Cct6b"
                     /gene_synonym="CCT-zeta-2; Cctz-2; CCTzeta-2;
                     TCP-1-zeta-2"
                     /inference="alignment:Splign:2.1.0"
     exon            605..708
                     /gene="Cct6b"
                     /gene_synonym="CCT-zeta-2; Cctz-2; CCTzeta-2;
                     TCP-1-zeta-2"
                     /inference="alignment:Splign:2.1.0"
     exon            709..819
                     /gene="Cct6b"
                     /gene_synonym="CCT-zeta-2; Cctz-2; CCTzeta-2;
                     TCP-1-zeta-2"
                     /inference="alignment:Splign:2.1.0"
     exon            820..979
                     /gene="Cct6b"
                     /gene_synonym="CCT-zeta-2; Cctz-2; CCTzeta-2;
                     TCP-1-zeta-2"
                     /inference="alignment:Splign:2.1.0"
     exon            980..1062
                     /gene="Cct6b"
                     /gene_synonym="CCT-zeta-2; Cctz-2; CCTzeta-2;
                     TCP-1-zeta-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1063..1159
                     /gene="Cct6b"
                     /gene_synonym="CCT-zeta-2; Cctz-2; CCTzeta-2;
                     TCP-1-zeta-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1160..1307
                     /gene="Cct6b"
                     /gene_synonym="CCT-zeta-2; Cctz-2; CCTzeta-2;
                     TCP-1-zeta-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1308..1441
                     /gene="Cct6b"
                     /gene_synonym="CCT-zeta-2; Cctz-2; CCTzeta-2;
                     TCP-1-zeta-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1442..1544
                     /gene="Cct6b"
                     /gene_synonym="CCT-zeta-2; Cctz-2; CCTzeta-2;
                     TCP-1-zeta-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1545..1617
                     /gene="Cct6b"
                     /gene_synonym="CCT-zeta-2; Cctz-2; CCTzeta-2;
                     TCP-1-zeta-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1618..1804
                     /gene="Cct6b"
                     /gene_synonym="CCT-zeta-2; Cctz-2; CCTzeta-2;
                     TCP-1-zeta-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1774..1779
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cct6b"
                     /gene_synonym="CCT-zeta-2; Cctz-2; CCTzeta-2;
                     TCP-1-zeta-2"
                     /note="hexamer: AATAAA"
     polyA_site      1792
                     /gene="Cct6b"
                     /gene_synonym="CCT-zeta-2; Cctz-2; CCTzeta-2;
                     TCP-1-zeta-2"
                     /note="major polyA site"
ORIGIN      
        1 acttcctgtt atggcgccga ttggcccaca ctcaggagtg tgggcgtggc gccagggttc
       61 ggagtcggca agtttggggc tggactgttg aaccatggct gcgatcaaaa tcgctaaccc
      121 tggcgctgaa gtgacccgga gccaagcggc cttggctgtg aacatctgcg ccgcccgtgg
      181 gctgcaggat gtgctgcgtc ccaccttggg tcctaagggc gcgctaaaaa tgcttgtttc
      241 tggggcaggt gacatcaaac tcaccaaaga cggcaatgta ctgcttcatg agatgcaaat
      301 tcaacaccca acggcttcca tcattgcaaa agtggcagca gcccaagacc atgtcacagg
      361 ggatggcact acctcaaatg tcctgatcat tggagagttg ctaaagcaag ctgatcttta
      421 catttctgag ggcctgcacc ctagaatcat aactgaagga tttgatgttg caaagacgaa
      481 agcacttgaa gttttggatg aaattaaagt acaaaaggag atgaaaagag aaatcctctt
      541 ggatgtggct agaacatccc tgcagacgaa agttcatgct gaactggccg acatactaac
      601 agaggctgtg gtggattctg tcttggctat cagaagacca ggtgtcccta ttgatctctt
      661 catggtggaa attgtggaga tgaggcacaa gtcagaaacg gacacacagt tgatccgagg
      721 attggttttg gaccatggtg cccgtcatcc aaggatgagg aagcaggtgc gagatgcata
      781 catcctcact tgcaatgtct cactagagta tgaaaaaaca gaagtgagct ctggtttctt
      841 ttataagact gtagaagaga aagagaaatt ggtaaaagct gaaagaaaat ttattgaaga
      901 tagagtgcag aaaataatag acctaaagca gaaagtctgt gctgagtcca ataaaggatt
      961 tgttgtcatt aatcaaaagg gcatcgatcc ggtttcctta gaaatgcttg caaaacataa
     1021 catcgtagct cttcgcaggg caaaaagaag gaatcttgaa aggctcaccc ttgcttgtgg
     1081 aggattggct gtcaactcct ttgaaggcct gagtgaagag tgcctggggc acgctggcct
     1141 tgtcttcgag tacgcattgg gtgaagaaaa gttcactttt attgaggact gtgtaaatcc
     1201 gctctctgtc accttgttgg tcaaagggcc aaataagcat actctcatac agatcaagga
     1261 cgccttaaga gatggactcc gtgcggtcaa aaatgctatt gaagacggct gtgtggttcc
     1321 aggggctggg gcagtggaag ttgcgatagc agaagctctt gttaactaca agcaccgtgt
     1381 gcagggaaga gttcgcctgg ggatccaagc ctttgctgat gccttgctca tcatcccgaa
     1441 ggttcttgct cagaattctg gttatgacct gcaggaaaca ctgataaaaa ttcaaactaa
     1501 acatgccgaa tcaaaagaac tcctgggcat agacctgaac acaggggagc cgatggcagc
     1561 agcagaagca ggaatctggg ataattactg tgtgaaaaaa catcttcttc actcttgcac
     1621 ggtgattgcc accaacatcc tcctggttga tgaaattatg cgagctggga tgtcttctct
     1681 tagagactga ttgaattcca aatcaattca tctggaagac aagattttat acgtgtcata
     1741 cccagcagcg tcacatggcc ttaactgtta gaaaataaag gtagtgcatg tcttttggtc
     1801 tcaaaaaaaa aaaaaaa
//
