LOCUS       NM_009838               2302 bp    mRNA    linear   ROD 10-JUN-2024
DEFINITION  Mus musculus chaperonin containing TCP1 subunit 6A (Cct6a), mRNA.
ACCESSION   NM_009838 XM_001471643
VERSION     NM_009838.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2302)
  AUTHORS   Ying,Z., Tian,H., Li,Y., Lian,R., Li,W., Wu,S., Zhang,H.Z., Wu,J.,
            Liu,L., Song,J., Guan,H., Cai,J., Zhu,X., Li,J. and Li,M.
  TITLE     CCT6A suppresses SMAD2 and promotes prometastatic TGF-beta
            signaling
  JOURNAL   J Clin Invest 127 (5), 1725-1740 (2017)
   PUBMED   28375158
  REMARK    GeneRIF: selective inhibition of SMAD3 or CCT6A efficiently
            suppresses TGF-beta-mediated metastasis. Findings provide a
            mechanism that directs TGF-beta signaling toward its prometastatic
            arm and may contribute to the development of therapeutic strategies
            targeting TGF-beta for non-small-cell lung carcinoma.
REFERENCE   2  (bases 1 to 2302)
  AUTHORS   Guo,X., Sun,X., Hu,D., Wang,Y.J., Fujioka,H., Vyas,R.,
            Chakrapani,S., Joshi,A.U., Luo,Y., Mochly-Rosen,D. and Qi,X.
  TITLE     VCP recruitment to mitochondria causes mitophagy impairment and
            neurodegeneration in models of Huntington's disease
  JOURNAL   Nat Commun 7, 12646 (2016)
   PUBMED   27561680
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2302)
  AUTHORS   Slater,L.H., Hett,E.C., Clatworthy,A.E., Mark,K.G. and Hung,D.T.
  TITLE     CCT chaperonin complex is required for efficient delivery of
            anthrax toxin into the cytosol of host cells
  JOURNAL   Proc Natl Acad Sci U S A 110 (24), 9932-9937 (2013)
   PUBMED   23716698
REFERENCE   4  (bases 1 to 2302)
  AUTHORS   Cotney,J., Leng,J., Oh,S., DeMare,L.E., Reilly,S.K., Gerstein,M.B.
            and Noonan,J.P.
  TITLE     Chromatin state signatures associated with tissue-specific gene
            expression and enhancer activity in the embryonic limb
  JOURNAL   Genome Res 22 (6), 1069-1080 (2012)
   PUBMED   22421546
REFERENCE   5  (bases 1 to 2302)
  AUTHORS   Lo,J.C., Jamsai,D., O'Connor,A.E., Borg,C., Clark,B.J.,
            Whisstock,J.C., Field,M.C., Adams,V., Ishikawa,T., Aitken,R.J.,
            Whittle,B., Goodnow,C.C., Ormandy,C.J. and O'Bryan,M.K.
  TITLE     RAB-like 2 has an essential role in male fertility, sperm
            intra-flagellar transport, and tail assembly
  JOURNAL   PLoS Genet 8 (10), e1002969 (2012)
   PUBMED   23055941
REFERENCE   6  (bases 1 to 2302)
  AUTHORS   Kubota,H., Yokota,S., Yanagi,H. and Yura,T.
  TITLE     Structures and co-regulated expression of the genes encoding mouse
            cytosolic chaperonin CCT subunits
  JOURNAL   Eur J Biochem 262 (2), 492-500 (1999)
   PUBMED   10336634
REFERENCE   7  (bases 1 to 2302)
  AUTHORS   Kubota,H., Hynes,G.M., Kerr,S.M. and Willison,K.R.
  TITLE     Tissue-specific subunit of the mouse cytosolic
            chaperonin-containing TCP-1
  JOURNAL   FEBS Lett 402 (1), 53-56 (1997)
   PUBMED   9013858
REFERENCE   8  (bases 1 to 2302)
  AUTHORS   Kubota,H., Hynes,G. and Willison,K.
  TITLE     The chaperonin containing t-complex polypeptide 1 (TCP-1).
            Multisubunit machinery assisting in protein folding and assembly in
            the eukaryotic cytosol
  JOURNAL   Eur J Biochem 230 (1), 3-16 (1995)
   PUBMED   7601114
  REMARK    Review article
REFERENCE   9  (bases 1 to 2302)
  AUTHORS   Hynes,G., Kubota,H. and Willison,K.R.
  TITLE     Antibody characterisation of two distinct conformations of the
            chaperonin-containing TCP-1 from mouse testis
  JOURNAL   FEBS Lett 358 (2), 129-132 (1995)
   PUBMED   7828721
REFERENCE   10 (bases 1 to 2302)
  AUTHORS   Kubota,H., Hynes,G., Carne,A., Ashworth,A. and Willison,K.
  TITLE     Identification of six Tcp-1-related genes encoding divergent
            subunits of the TCP-1-containing chaperonin
  JOURNAL   Curr Biol 4 (2), 89-99 (1994)
   PUBMED   7953530
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            MG954262.1.
            
            On Jul 30, 2020 this sequence version replaced NM_009838.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK159975.1, AK149757.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-220               MG954262.1         9824-10043
            221-284             MG954262.1         10702-10765
            285-419             MG954262.1         11521-11655
            420-593             MG954262.1         12285-12458
            594-697             MG954262.1         13052-13155
            698-808             MG954262.1         13937-14047
            809-968             MG954262.1         14250-14409
            969-1051            MG954262.1         14487-14569
            1052-1148           MG954262.1         16103-16199
            1149-1296           MG954262.1         16819-16966
            1297-1430           MG954262.1         17586-17719
            1431-1533           MG954262.1         19215-19317
            1534-1606           MG954262.1         19828-19900
            1607-2302           MG954262.1         19993-20688
FEATURES             Location/Qualifiers
     source          1..2302
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 68.26 cM"
     gene            1..2302
                     /gene="Cct6a"
                     /gene_synonym="CCT-zeta; CCT-zeta-1; Cct6; Cctz-1;
                     TCP-1-zeta"
                     /note="chaperonin containing TCP1 subunit 6A"
                     /db_xref="GeneID:12466"
                     /db_xref="MGI:MGI:107943"
     exon            1..220
                     /gene="Cct6a"
                     /gene_synonym="CCT-zeta; CCT-zeta-1; Cct6; Cctz-1;
                     TCP-1-zeta"
                     /inference="alignment:Splign:2.1.0"
     CDS             84..1679
                     /gene="Cct6a"
                     /gene_synonym="CCT-zeta; CCT-zeta-1; Cct6; Cctz-1;
                     TCP-1-zeta"
                     /note="chaperonin subunit 6a (zeta); chaperonin containing
                     TCP-1; chaperonin containing Tcp1, subunit 6a (zeta)"
                     /codon_start=1
                     /product="T-complex protein 1 subunit zeta"
                     /protein_id="NP_033968.2"
                     /db_xref="GeneID:12466"
                     /db_xref="MGI:MGI:107943"
                     /translation="MAAVKTLNPKAEVARAQAALAVNISAARGLQDVLRTNLGPKGTM
                     KMLVSGAGDIKLTKDGNVLLHEMQIQHPTASLIAKVATAQDDITGDGTTSNVLIIGEL
                     LKQADLYISEGLHPRIITEGFEAAKEKALQFLEQVKVSKEMDRETLIDVARTSLRTKV
                     HAELADVLTEAVVDSILAIRKKDEPIDLFMVEIMEMKHKSETDTSLIRGLVLDHGARH
                     PDMKKRVENAYILTCNVSLEYEKTEVNSGFFYKSAEEREKLVKAERKFIEDRVKKIIE
                     LKKKVCGDSDKGFVVINQKGIDPFSLDALAKEGIVALRRAKRRNMERLTLACGGIALN
                     SFDDLNPDCLGHAELVYEYTLGEEKFTFIEKCNNPRSVTLLVKGPNKHTLTQIKDAIR
                     DGLRAVKNAIDDGCVVPGAGAVEVALAEALIKYKPSVKGRAQLGVQAFADALLIIPKV
                     LAQNSGFDLQETLVKVQAEHSESGQLVGVDLSTGEPMVAAEMGVWDNYCVKKQLLHSC
                     TVIATNILLVDEIMRAGMSSLKG"
     exon            221..284
                     /gene="Cct6a"
                     /gene_synonym="CCT-zeta; CCT-zeta-1; Cct6; Cctz-1;
                     TCP-1-zeta"
                     /inference="alignment:Splign:2.1.0"
     exon            285..419
                     /gene="Cct6a"
                     /gene_synonym="CCT-zeta; CCT-zeta-1; Cct6; Cctz-1;
                     TCP-1-zeta"
                     /inference="alignment:Splign:2.1.0"
     exon            420..593
                     /gene="Cct6a"
                     /gene_synonym="CCT-zeta; CCT-zeta-1; Cct6; Cctz-1;
                     TCP-1-zeta"
                     /inference="alignment:Splign:2.1.0"
     exon            594..697
                     /gene="Cct6a"
                     /gene_synonym="CCT-zeta; CCT-zeta-1; Cct6; Cctz-1;
                     TCP-1-zeta"
                     /inference="alignment:Splign:2.1.0"
     exon            698..808
                     /gene="Cct6a"
                     /gene_synonym="CCT-zeta; CCT-zeta-1; Cct6; Cctz-1;
                     TCP-1-zeta"
                     /inference="alignment:Splign:2.1.0"
     exon            809..968
                     /gene="Cct6a"
                     /gene_synonym="CCT-zeta; CCT-zeta-1; Cct6; Cctz-1;
                     TCP-1-zeta"
                     /inference="alignment:Splign:2.1.0"
     exon            969..1051
                     /gene="Cct6a"
                     /gene_synonym="CCT-zeta; CCT-zeta-1; Cct6; Cctz-1;
                     TCP-1-zeta"
                     /inference="alignment:Splign:2.1.0"
     exon            1052..1148
                     /gene="Cct6a"
                     /gene_synonym="CCT-zeta; CCT-zeta-1; Cct6; Cctz-1;
                     TCP-1-zeta"
                     /inference="alignment:Splign:2.1.0"
     exon            1149..1296
                     /gene="Cct6a"
                     /gene_synonym="CCT-zeta; CCT-zeta-1; Cct6; Cctz-1;
                     TCP-1-zeta"
                     /inference="alignment:Splign:2.1.0"
     exon            1297..1430
                     /gene="Cct6a"
                     /gene_synonym="CCT-zeta; CCT-zeta-1; Cct6; Cctz-1;
                     TCP-1-zeta"
                     /inference="alignment:Splign:2.1.0"
     exon            1431..1533
                     /gene="Cct6a"
                     /gene_synonym="CCT-zeta; CCT-zeta-1; Cct6; Cctz-1;
                     TCP-1-zeta"
                     /inference="alignment:Splign:2.1.0"
     exon            1534..1606
                     /gene="Cct6a"
                     /gene_synonym="CCT-zeta; CCT-zeta-1; Cct6; Cctz-1;
                     TCP-1-zeta"
                     /inference="alignment:Splign:2.1.0"
     exon            1607..2302
                     /gene="Cct6a"
                     /gene_synonym="CCT-zeta; CCT-zeta-1; Cct6; Cctz-1;
                     TCP-1-zeta"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1773
                     /gene="Cct6a"
                     /gene_synonym="CCT-zeta; CCT-zeta-1; Cct6; Cctz-1;
                     TCP-1-zeta"
     regulatory      2196..2201
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cct6a"
                     /gene_synonym="CCT-zeta; CCT-zeta-1; Cct6; Cctz-1;
                     TCP-1-zeta"
                     /note="hexamer: AATAAA"
     polyA_site      2216
                     /gene="Cct6a"
                     /gene_synonym="CCT-zeta; CCT-zeta-1; Cct6; Cctz-1;
                     TCP-1-zeta"
                     /note="major polyA site"
     regulatory      2267..2272
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cct6a"
                     /gene_synonym="CCT-zeta; CCT-zeta-1; Cct6; Cctz-1;
                     TCP-1-zeta"
                     /note="hexamer: AATAAA"
     polyA_site      2288
                     /gene="Cct6a"
                     /gene_synonym="CCT-zeta; CCT-zeta-1; Cct6; Cctz-1;
                     TCP-1-zeta"
ORIGIN      
        1 gggcgggccg ggtgcgtaag acttttcgag aagaccccgc agagagcacg ttgttctcgg
       61 cctctcccgg agctaggcca gccatggcgg cggtaaagac cctaaatccg aaggccgagg
      121 tggcccgggc ccaggcagcg ctggcggtga acatcagcgc ggctcggggc ctgcaggatg
      181 ttctgaggac caacttgggg cctaagggca ccatgaagat gcttgtatct ggtgctggag
      241 acatcaaact tactaaagat ggcaatgtgc tgcttcatga aatgcaaatt caacacccaa
      301 cagcctcttt gatagcaaaa gtggctacag cccaggatga cataactggc gatggcacta
      361 catccaatgt cctcatcatc ggggagctgc tcaaacaggc ggacctgtac atttctgaag
      421 gtcttcaccc aagaataata actgaaggtt ttgaagcggc aaaagaaaag gcactccaat
      481 ttctggaaca agtcaaagta agcaaagaga tggacagaga aacactcatc gatgtggcga
      541 ggacatctct gcggactaaa gttcatgctg aacttgcaga tgtcttgaca gaggctgtag
      601 tggactccat cttggccatt aggaaaaagg acgagcccat tgacctcttc atggttgaga
      661 tcatggagat gaagcataaa tctgagacag atacaagctt aatcagaggg cttgttttgg
      721 atcatggagc tcggcatcct gatatgaaga agagagtgga aaatgcctac atcctcactt
      781 gcaacgtgtc cttagagtat gagaaaacag aagtgaattc tgggtttttt tacaagagtg
      841 cagaagagag agaaaaacta gtaaaggctg aaagaaaatt cattgaagat agagttaaaa
      901 aaatcataga gctgaaaaag aaagtctgtg gtgactcaga taaaggattt gtcgttatta
      961 atcaaaaggg gattgacccc ttttccttag atgcccttgc gaaagaaggg atcgtagctc
     1021 tgcgcagagc caagaggaga aacatggaga ggctgacact tgcttgtggt gggatagctc
     1081 tgaattcctt tgatgacctg aatcctgact gtttgggaca tgcagagctt gtctatgagt
     1141 atacactggg tgaggagaag ttcaccttta ttgagaagtg taacaatccc cgttctgtca
     1201 ctttactggt taaaggacca aataagcaca cactgactca aatcaaggat gcaataagag
     1261 atggcttgag ggctgtcaaa aatgctattg atgatggctg tgttgtcccg ggtgcgggtg
     1321 cagtagaagt ggcactggca gaagctctga ttaaatacaa gcccagtgtg aagggcaggg
     1381 cgcagcttgg agtccaggca tttgcagatg ccttgctcat cattcccaag gttcttgcgc
     1441 aaaactctgg ttttgacctt caggaaacat tagttaaagt tcaagctgaa cattcggaat
     1501 ccggccagct cgtaggtgtg gatctgagca caggtgagcc gatggtggct gcagagatgg
     1561 gtgtgtggga taactactgt gtgaagaagc agctgctaca ctcctgtact gtgatcgcca
     1621 ccaacattct cctggtcgac gagatcatgc gagctgggat gtcctctctg aagggttgag
     1681 gcctgcctgt gatactacag gatgttgggg ggaatggtta tttttgtcca agcttcaagt
     1741 gatttggaaa aaaattttct cttcctgatt ggagaaaaga aacgggacat ttgacaccta
     1801 ttcaaattat actgtaaaat tttattttat ttttgccttg agtatctgaa gacactcaaa
     1861 gcagctcttt ttcaacccac tgaacaagat gttttagcta caccgataca aaaattacat
     1921 aagataagca tgttgtctac ccttgttccg taagtgttct ttgaaagttt gtaatggttt
     1981 tctcctaaat aaggcatggt gacacatgcc tgtaagccta gccctttgga aatagtccgg
     2041 aatttctatg ccaactcagg ctacaggaga ccccaggtcg aaagaataat ttgttgtgga
     2101 tgtatttgaa attatccagc caactccctg ttaaacatgt aagatccttg ccagtgtaaa
     2161 acacatctgg gtaatttatg ggtttcataa tgtctaataa atacttaaag agtgaagcta
     2221 ctggatcatt cacacttgaa atgactgaaa atgcttcaga aaagctaata aagccaagtt
     2281 actccgtgga ggctggaagg tc
//
