LOCUS       NM_007637               1912 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus chaperonin containing TCP1 subunit 5 (Cct5),
            transcript variant 1, mRNA.
ACCESSION   NM_007637
VERSION     NM_007637.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1912)
  AUTHORS   Li,L., Huang,J., Zhang,S., Yao,C., Chen,Y., Wang,H. and Guo,B.
  TITLE     The Chaperone Protein Cct5 is Essential for Hematopoietic Stem Cell
            Maintenance
  JOURNAL   Stem Cell Rev Rep 20 (3), 769-778 (2024)
   PUBMED   38153635
  REMARK    GeneRIF: The Chaperone Protein Cct5 is Essential for Hematopoietic
            Stem Cell Maintenance.
REFERENCE   2  (bases 1 to 1912)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 1912)
  AUTHORS   Fink,J.K.
  TITLE     Hereditary spastic paraplegia: clinico-pathologic features and
            emerging molecular mechanisms
  JOURNAL   Acta Neuropathol 126 (3), 307-328 (2013)
   PUBMED   23897027
  REMARK    Review article
REFERENCE   4  (bases 1 to 1912)
  AUTHORS   Tarkar,A., Loges,N.T., Slagle,C.E., Francis,R., Dougherty,G.W.,
            Tamayo,J.V., Shook,B., Cantino,M., Schwartz,D., Jahnke,C.,
            Olbrich,H., Werner,C., Raidt,J., Pennekamp,P., Abouhamed,M.,
            Hjeij,R., Kohler,G., Griese,M., Li,Y., Lemke,K., Klena,N., Liu,X.,
            Gabriel,G., Tobita,K., Jaspers,M., Morgan,L.C., Shapiro,A.J.,
            Letteboer,S.J., Mans,D.A., Carson,J.L., Leigh,M.W., Wolf,W.E.,
            Chen,S., Lucas,J.S., Onoufriadis,A., Plagnol,V., Schmidts,M.,
            Boldt,K., Roepman,R., Zariwala,M.A., Lo,C.W., Mitchison,H.M.,
            Knowles,M.R., Burdine,R.D., Loturco,J.J. and Omran,H.
  CONSRTM   UK10K
  TITLE     DYX1C1 is required for axonemal dynein assembly and ciliary
            motility
  JOURNAL   Nat Genet 45 (9), 995-1003 (2013)
   PUBMED   23872636
REFERENCE   5  (bases 1 to 1912)
  AUTHORS   Tokumoto,M., Horiguchi,R., Nagahama,Y., Ishikawa,K. and Tokumoto,T.
  TITLE     Two proteins, a goldfish 20S proteasome subunit and the protein
            interacting with 26S proteasome, change in the meiotic cell cycle
  JOURNAL   Eur J Biochem 267 (1), 97-103 (2000)
   PUBMED   10601855
REFERENCE   6  (bases 1 to 1912)
  AUTHORS   Kubota,H., Yokota,S., Yanagi,H. and Yura,T.
  TITLE     Structures and co-regulated expression of the genes encoding mouse
            cytosolic chaperonin CCT subunits
  JOURNAL   Eur J Biochem 262 (2), 492-500 (1999)
   PUBMED   10336634
REFERENCE   7  (bases 1 to 1912)
  AUTHORS   Kubota,H., Hynes,G. and Willison,K.
  TITLE     The chaperonin containing t-complex polypeptide 1 (TCP-1).
            Multisubunit machinery assisting in protein folding and assembly in
            the eukaryotic cytosol
  JOURNAL   Eur J Biochem 230 (1), 3-16 (1995)
   PUBMED   7601114
  REMARK    Review article
REFERENCE   8  (bases 1 to 1912)
  AUTHORS   Hynes,G., Kubota,H. and Willison,K.R.
  TITLE     Antibody characterisation of two distinct conformations of the
            chaperonin-containing TCP-1 from mouse testis
  JOURNAL   FEBS Lett 358 (2), 129-132 (1995)
   PUBMED   7828721
REFERENCE   9  (bases 1 to 1912)
  AUTHORS   Kubota,H., Hynes,G., Carne,A., Ashworth,A. and Willison,K.
  TITLE     Identification of six Tcp-1-related genes encoding divergent
            subunits of the TCP-1-containing chaperonin
  JOURNAL   Curr Biol 4 (2), 89-99 (1994)
   PUBMED   7953530
REFERENCE   10 (bases 1 to 1912)
  AUTHORS   O'Bryan,J.P., Frye,R.A., Cogswell,P.C., Neubauer,A., Kitch,B.,
            Prokop,C., Espinosa,R. 3rd, Le Beau,M.M., Earp,H.S. and Liu,E.T.
  TITLE     axl, a transforming gene isolated from primary human myeloid
            leukemia cells, encodes a novel receptor tyrosine kinase
  JOURNAL   Mol Cell Biol 11 (10), 5016-5031 (1991)
   PUBMED   1656220
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ086704.1, BC094427.1 and BY579491.1.
            
            On Jan 11, 2017 this sequence version replaced NM_007637.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849380,
                              SAMN00849381 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-95                CJ086704.1         5-99
            96-1812             BC094427.1         1-1717
            1813-1912           BY579491.1         303-402
FEATURES             Location/Qualifiers
     source          1..1912
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 13.02 cM"
     gene            1..1912
                     /gene="Cct5"
                     /gene_synonym="CCT-epsilon; Ccte; mKIAA0098;
                     TCP-1-epsilon; TCPE"
                     /note="chaperonin containing TCP1 subunit 5"
                     /db_xref="GeneID:12465"
                     /db_xref="MGI:MGI:107185"
     exon            1..246
                     /gene="Cct5"
                     /gene_synonym="CCT-epsilon; Ccte; mKIAA0098;
                     TCP-1-epsilon; TCPE"
                     /inference="alignment:Splign:2.1.0"
     CDS             142..1767
                     /gene="Cct5"
                     /gene_synonym="CCT-epsilon; Ccte; mKIAA0098;
                     TCP-1-epsilon; TCPE"
                     /note="isoform 1 is encoded by transcript variant 1;
                     T-complex protein 1 subunit epsilon; chaperonin containing
                     Tcp1, subunit 5 (epsilon)"
                     /codon_start=1
                     /product="T-complex protein 1 subunit epsilon isoform 1"
                     /protein_id="NP_031663.1"
                     /db_xref="CCDS:CCDS27411.1"
                     /db_xref="GeneID:12465"
                     /db_xref="MGI:MGI:107185"
                     /translation="MASVGTLAFDEYGRPFLIIKDQDRKSRLMGLEALKSHIMAAKAV
                     ANTMRTSLGPNGLDKMMVDKDGDVTITNDGATILSMMDVDHQIAKLMVELSKSQDDEI
                     GDGTTGVVVLAGALLEEAEQLLDRGIHPIRIADGYEQAARIAIQHLDKISDKVLVDIN
                     NPEPLIQTAKTTLGSKVINSCHRQMAEIAVNAVLTVADMERRDVDFELIKVEGKVGGR
                     LEDTKLIKGVIVDKDFSHPQMPKKVVDAKIAILTCPFEPPKPKTKHKLDVMSVEDYKA
                     LQKYEKEKFEEMIKQIKETGANLAICQWGFDDEANHLLLQNGLPAVRWVGGPEIELIA
                     IATGGRIVPRFSELTSEKLGFAGVVQEISFGTTKDKMLVIEKCKNSRAVTIFIRGGNK
                     MIIEEAKRSLHDALCVIRNLIRDNRVVYGGGAAEISCALAVSQEADKCPTLEQYAMRA
                     FADALEVIPMALSENSGMNPIQTMTEVRARQVKESNPALGIDCLHKGSNDMQYQHVIE
                     TLIGKKQQISLATQMVRMILKIDDIRKPGESEE"
     exon            247..307
                     /gene="Cct5"
                     /gene_synonym="CCT-epsilon; Ccte; mKIAA0098;
                     TCP-1-epsilon; TCPE"
                     /inference="alignment:Splign:2.1.0"
     exon            308..472
                     /gene="Cct5"
                     /gene_synonym="CCT-epsilon; Ccte; mKIAA0098;
                     TCP-1-epsilon; TCPE"
                     /inference="alignment:Splign:2.1.0"
     exon            473..671
                     /gene="Cct5"
                     /gene_synonym="CCT-epsilon; Ccte; mKIAA0098;
                     TCP-1-epsilon; TCPE"
                     /inference="alignment:Splign:2.1.0"
     exon            672..864
                     /gene="Cct5"
                     /gene_synonym="CCT-epsilon; Ccte; mKIAA0098;
                     TCP-1-epsilon; TCPE"
                     /inference="alignment:Splign:2.1.0"
     exon            865..1014
                     /gene="Cct5"
                     /gene_synonym="CCT-epsilon; Ccte; mKIAA0098;
                     TCP-1-epsilon; TCPE"
                     /inference="alignment:Splign:2.1.0"
     exon            1015..1134
                     /gene="Cct5"
                     /gene_synonym="CCT-epsilon; Ccte; mKIAA0098;
                     TCP-1-epsilon; TCPE"
                     /inference="alignment:Splign:2.1.0"
     exon            1135..1320
                     /gene="Cct5"
                     /gene_synonym="CCT-epsilon; Ccte; mKIAA0098;
                     TCP-1-epsilon; TCPE"
                     /inference="alignment:Splign:2.1.0"
     exon            1321..1458
                     /gene="Cct5"
                     /gene_synonym="CCT-epsilon; Ccte; mKIAA0098;
                     TCP-1-epsilon; TCPE"
                     /inference="alignment:Splign:2.1.0"
     exon            1459..1639
                     /gene="Cct5"
                     /gene_synonym="CCT-epsilon; Ccte; mKIAA0098;
                     TCP-1-epsilon; TCPE"
                     /inference="alignment:Splign:2.1.0"
     exon            1640..1895
                     /gene="Cct5"
                     /gene_synonym="CCT-epsilon; Ccte; mKIAA0098;
                     TCP-1-epsilon; TCPE"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1763..1768
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cct5"
                     /gene_synonym="CCT-epsilon; Ccte; mKIAA0098;
                     TCP-1-epsilon; TCPE"
                     /note="hexamer: AATAAA"
     polyA_site      1812
                     /gene="Cct5"
                     /gene_synonym="CCT-epsilon; Ccte; mKIAA0098;
                     TCP-1-epsilon; TCPE"
                     /note="major polyA site"
     regulatory      1861..1866
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cct5"
                     /gene_synonym="CCT-epsilon; Ccte; mKIAA0098;
                     TCP-1-epsilon; TCPE"
                     /note="hexamer: AATAAA"
     polyA_site      1882
                     /gene="Cct5"
                     /gene_synonym="CCT-epsilon; Ccte; mKIAA0098;
                     TCP-1-epsilon; TCPE"
                     /note="major polyA site"
ORIGIN      
        1 ctgttgaaaa gtaagtcgcg gggtctgcac tgcgcatgcg cgggattctg cgtcctctcg
       61 cgagagggag gtgcggtgtg tctctcttcc cgagtggtcc ccgctggtta ctggaggagc
      121 gctcgttcta gttcgtccac catggcgtcc gtggggaccc tcgccttcga tgagtatggg
      181 cgcccctttc tcattatcaa ggaccaagat cgcaagtccc gtctcatggg gcttgaggcc
      241 ctcaagtctc acatcatggc tgccaaagct gtagcaaaca caatgcggac gtcactggga
      301 ccaaacgggc tggacaagat gatggttgat aaggatggcg atgtgactat aacaaacgat
      361 ggtgccacca ttctaagcat gatggatgtc gatcatcaga ttgccaagct gatggttgaa
      421 ctgtccaaat cccaggatga tgaaattgga gatgggacca caggagtggt tgtcttggct
      481 ggggccttgt tggaagaagc tgaacagctg ctggaccgag gcatccaccc aatcagaatt
      541 gctgatggct acgagcaggc tgcccgaatt gcaatacaac acctggacaa gatcagcgat
      601 aaagtgcttg tcgacataaa caaccctgaa cctctgattc agactgcaaa aaccacgctg
      661 ggctccaaag tgattaacag ctgtcaccga cagatggctg agatcgccgt gaatgccgtc
      721 ctcacggtgg cagatatgga gcggagagat gttgactttg agctcattaa agtggaaggc
      781 aaagtaggtg ggcggctgga agacaccaag ctcataaagg gtgtgatcgt tgacaaggac
      841 ttcagccacc cacagatgcc gaaaaaagtg gtagatgcta agattgcgat tctcacgtgt
      901 ccatttgagc cacctaaacc taagacaaag cacaagctgg atgtcatgtc tgtggaggac
      961 tacaaagccc tgcagaagta cgaaaaggag aagtttgaag agatgattaa gcagattaaa
     1021 gaaactggtg ctaacctagc tatttgccag tggggctttg acgatgaagc caatcactta
     1081 cttcttcaga acggcctacc tgcagtccgc tgggtagggg gacctgagat tgagctgatc
     1141 gccattgcaa caggaggacg gattgtccca cggttctcag agctcacctc tgagaagctg
     1201 ggctttgctg gtgtggtgca ggagatctcc tttggcacta caaaagacaa aatgctggtt
     1261 atcgagaagt gtaagaactc tagagctgtg accattttca tcagaggagg aaacaagatg
     1321 atcatagaag aagcaaaacg atctctccat gatgccctgt gtgtcatccg gaacctcatc
     1381 cgtgacaacc gtgttgtgta tggaggaggg gcagccgaaa tatcctgcgc cctggcagtc
     1441 agccaagagg cagacaagtg cccaactttg gaacagtatg ccatgagagc ttttgcagat
     1501 gccttggagg tcatccccat ggccctttca gaaaatagtg gcatgaatcc cattcagacc
     1561 atgactgaag ttcgagccag acaggtgaag gagtctaacc ctgccctggg gattgactgt
     1621 ttgcacaagg gcagtaacga tatgcagtat cagcatgtca tagaaacctt gattggcaaa
     1681 aagcagcaga tctctcttgc cacccagatg gttaggatga ttctgaagat tgatgacatc
     1741 cgtaagcctg gagaatctga agaataaact gtaccattta ccactgtgac taaataaagg
     1801 gtgtgtctgt tgtgctgcgt ctgcagttac tgctggtcct ctcacagctg tagatgctgg
     1861 aataaaagca gctgtctggt aactgcttcc acttaaaaaa aaaaaaaaaa aa
//
