LOCUS       NM_009837               1966 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus chaperonin containing TCP1 subunit 4 (Cct4), mRNA.
ACCESSION   NM_009837
VERSION     NM_009837.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1966)
  AUTHORS   Vallin,J. and Grantham,J.
  TITLE     Functional assessment of the V390F mutation in the CCTdelta subunit
            of chaperonin containing tailless complex polypeptide 1
  JOURNAL   Cell Stress Chaperones 26 (6), 955-964 (2021)
   PUBMED   34655026
  REMARK    GeneRIF: Functional assessment of the V390F mutation in the
            CCTdelta subunit of chaperonin containing tailless complex
            polypeptide 1.
REFERENCE   2  (bases 1 to 1966)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   3  (bases 1 to 1966)
  AUTHORS   Tarkar,A., Loges,N.T., Slagle,C.E., Francis,R., Dougherty,G.W.,
            Tamayo,J.V., Shook,B., Cantino,M., Schwartz,D., Jahnke,C.,
            Olbrich,H., Werner,C., Raidt,J., Pennekamp,P., Abouhamed,M.,
            Hjeij,R., Kohler,G., Griese,M., Li,Y., Lemke,K., Klena,N., Liu,X.,
            Gabriel,G., Tobita,K., Jaspers,M., Morgan,L.C., Shapiro,A.J.,
            Letteboer,S.J., Mans,D.A., Carson,J.L., Leigh,M.W., Wolf,W.E.,
            Chen,S., Lucas,J.S., Onoufriadis,A., Plagnol,V., Schmidts,M.,
            Boldt,K., Roepman,R., Zariwala,M.A., Lo,C.W., Mitchison,H.M.,
            Knowles,M.R., Burdine,R.D., Loturco,J.J. and Omran,H.
  CONSRTM   UK10K
  TITLE     DYX1C1 is required for axonemal dynein assembly and ciliary
            motility
  JOURNAL   Nat Genet 45 (9), 995-1003 (2013)
   PUBMED   23872636
REFERENCE   4  (bases 1 to 1966)
  AUTHORS   Slater,L.H., Hett,E.C., Clatworthy,A.E., Mark,K.G. and Hung,D.T.
  TITLE     CCT chaperonin complex is required for efficient delivery of
            anthrax toxin into the cytosol of host cells
  JOURNAL   Proc Natl Acad Sci U S A 110 (24), 9932-9937 (2013)
   PUBMED   23716698
REFERENCE   5  (bases 1 to 1966)
  AUTHORS   Dun,M.D., Smith,N.D., Baker,M.A., Lin,M., Aitken,R.J. and Nixon,B.
  TITLE     The chaperonin containing TCP1 complex (CCT/TRiC) is involved in
            mediating sperm-oocyte interaction
  JOURNAL   J Biol Chem 286 (42), 36875-36887 (2011)
   PUBMED   21880732
REFERENCE   6  (bases 1 to 1966)
  AUTHORS   Kubota,H., Hynes,G. and Willison,K.
  TITLE     The chaperonin containing t-complex polypeptide 1 (TCP-1).
            Multisubunit machinery assisting in protein folding and assembly in
            the eukaryotic cytosol
  JOURNAL   Eur J Biochem 230 (1), 3-16 (1995)
   PUBMED   7601114
  REMARK    Review article
REFERENCE   7  (bases 1 to 1966)
  AUTHORS   Hynes,G., Kubota,H. and Willison,K.R.
  TITLE     Antibody characterisation of two distinct conformations of the
            chaperonin-containing TCP-1 from mouse testis
  JOURNAL   FEBS Lett 358 (2), 129-132 (1995)
   PUBMED   7828721
REFERENCE   8  (bases 1 to 1966)
  AUTHORS   Xie,X. and Palacios,R.
  TITLE     Cloning and expression of a new mammalian chaperonin gene from a
            multipotent hematopoietic progenitor clone
  JOURNAL   Blood 84 (7), 2171-2174 (1994)
   PUBMED   7919332
REFERENCE   9  (bases 1 to 1966)
  AUTHORS   Kubota,H., Hynes,G., Carne,A., Ashworth,A. and Willison,K.
  TITLE     Identification of six Tcp-1-related genes encoding divergent
            subunits of the TCP-1-containing chaperonin
  JOURNAL   Curr Biol 4 (2), 89-99 (1994)
   PUBMED   7953530
REFERENCE   10 (bases 1 to 1966)
  AUTHORS   O'Bryan,J.P., Frye,R.A., Cogswell,P.C., Neubauer,A., Kitch,B.,
            Prokop,C., Espinosa,R. 3rd, Le Beau,M.M., Earp,H.S. and Liu,E.T.
  TITLE     axl, a transforming gene isolated from primary human myeloid
            leukemia cells, encodes a novel receptor tyrosine kinase
  JOURNAL   Mol Cell Biol 11 (10), 5016-5031 (1991)
   PUBMED   1656220
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            Z31554.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: Z31554.1, BC054773.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1966
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="129/Sv"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 14.25 cM"
     gene            1..1966
                     /gene="Cct4"
                     /gene_synonym="2610204B21Rik; A45; Cctd"
                     /note="chaperonin containing TCP1 subunit 4"
                     /db_xref="GeneID:12464"
                     /db_xref="MGI:MGI:104689"
     exon            1..288
                     /gene="Cct4"
                     /gene_synonym="2610204B21Rik; A45; Cctd"
                     /inference="alignment:Splign:2.1.0"
     CDS             162..1781
                     /gene="Cct4"
                     /gene_synonym="2610204B21Rik; A45; Cctd"
                     /function="CCT is a molecular chaperone which assists the
                     folding of proteins in eukaryotic cytosol"
                     /note="CCT-delta; TCP-1-delta; T complex protein 1, delta;
                     chaperonin subunit 4 (delta); chaperonin containing Tcp1,
                     subunit 4 (delta)"
                     /codon_start=1
                     /product="T-complex protein 1 subunit delta"
                     /protein_id="NP_033967.1"
                     /db_xref="CCDS:CCDS24474.1"
                     /db_xref="GeneID:12464"
                     /db_xref="MGI:MGI:104689"
                     /translation="MPENVASRSGAPTAGPGSRGKSAYQDRDKPAQIRFSNISAAKAV
                     ADAIRTSLGPKGMDKMIQDGKGDVTITNDGATILKQMQVLHPAARMLVELSKAQDIEA
                     GDGTTSVVIIAGSLLDSCTKLLQKGIHPTIISESFQKALEKGLEILTDMSRPVQLSDR
                     ETLLNSATTSLNSKVVSQYSSLLSPMSVNAVMKVIDPATATSVDLRDIKIVKKLGGTI
                     DDCELVEGLVLTQKVANSGITRVEKAKIGLIQFCLSAPKTDMDNQIVVSDYAQMDRVL
                     REERAYILNLVKQIKKTGCNVLLIQKSILRDALSDLALHFLNKMKIMVVKDVEREDIE
                     FICKTIGTKPVAHIDQFTADMLGSAELAEEVSLNGSGKLFKITGCTSPGKTVTIVVRG
                     SNKLVIEEAERSIHDALCVIRCLVKKRALIAGGGAPEIELALRLTEYSRTLSGMESYC
                     VRAFADAMEVIPSTLAENAGLNPISTVTELRNRHAQGEKTTGINVRKGGISNILEEMV
                     VQPLLVSVSALTLATETVRSILKIDDVVNTR"
     exon            289..341
                     /gene="Cct4"
                     /gene_synonym="2610204B21Rik; A45; Cctd"
                     /inference="alignment:Splign:2.1.0"
     exon            342..431
                     /gene="Cct4"
                     /gene_synonym="2610204B21Rik; A45; Cctd"
                     /inference="alignment:Splign:2.1.0"
     exon            432..540
                     /gene="Cct4"
                     /gene_synonym="2610204B21Rik; A45; Cctd"
                     /inference="alignment:Splign:2.1.0"
     exon            541..683
                     /gene="Cct4"
                     /gene_synonym="2610204B21Rik; A45; Cctd"
                     /inference="alignment:Splign:2.1.0"
     exon            684..805
                     /gene="Cct4"
                     /gene_synonym="2610204B21Rik; A45; Cctd"
                     /inference="alignment:Splign:2.1.0"
     exon            806..938
                     /gene="Cct4"
                     /gene_synonym="2610204B21Rik; A45; Cctd"
                     /inference="alignment:Splign:2.1.0"
     exon            939..1078
                     /gene="Cct4"
                     /gene_synonym="2610204B21Rik; A45; Cctd"
                     /inference="alignment:Splign:2.1.0"
     exon            1079..1175
                     /gene="Cct4"
                     /gene_synonym="2610204B21Rik; A45; Cctd"
                     /inference="alignment:Splign:2.1.0"
     exon            1176..1286
                     /gene="Cct4"
                     /gene_synonym="2610204B21Rik; A45; Cctd"
                     /inference="alignment:Splign:2.1.0"
     exon            1287..1417
                     /gene="Cct4"
                     /gene_synonym="2610204B21Rik; A45; Cctd"
                     /inference="alignment:Splign:2.1.0"
     exon            1418..1652
                     /gene="Cct4"
                     /gene_synonym="2610204B21Rik; A45; Cctd"
                     /inference="alignment:Splign:2.1.0"
     exon            1653..1766
                     /gene="Cct4"
                     /gene_synonym="2610204B21Rik; A45; Cctd"
                     /inference="alignment:Splign:2.1.0"
     exon            1767..1966
                     /gene="Cct4"
                     /gene_synonym="2610204B21Rik; A45; Cctd"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1966
                     /gene="Cct4"
                     /gene_synonym="2610204B21Rik; A45; Cctd"
ORIGIN      
        1 ggctctccag caggcccctt gctcggcttc cgccttctct cccggcgtcg ctttctggaa
       61 ggttcgtgga ggaggcggtc agggagaccg ttactccaca gcaagccgga atccgtgtcc
      121 atccgtcctc ctgaacccgc gcagacgcca ccaaggtcgc catgccggag aacgtagctt
      181 cccgaagcgg ggcgcccacc gccgggcccg gcagccgcgg gaaaagcgcc taccaggacc
      241 gcgacaagcc agcccagatc cgcttcagca atatttccgc ggccaaagcg gttgctgatg
      301 ctattagaac aagccttgga cctaaaggaa tggacaaaat gattcaagat ggaaaaggcg
      361 atgtgaccat tacaaatgat ggtgccacca ttctgaaaca aatgcaggta ttgcatccag
      421 cagccagaat gctggtggaa ttgtctaaag ctcaagacat agaagcagga gatggcacca
      481 cgtcggttgt catcattgct ggctctcttt tagactcctg taccaaactt ctgcagaaag
      541 gtatacatcc aaccatcatt tccgagtcat tccagaaagc tttggaaaag ggtcttgaaa
      601 tccttactga catgtctcga cctgtgcaac tgagcgacag agaaactttg ttaaatagcg
      661 caactacttc attgaattca aaggttgtct ctcagtattc aagtctactc tctccaatga
      721 gtgtcaatgc ggtgatgaaa gtgattgacc cagccacagc taccagtgta gatcttcgag
      781 atattaaaat agttaagaag cttggtggga caatagatga ctgtgagctg gtggaaggcc
      841 tcgttctcac acagaaagta gcaaattctg gcataacaag agttgaaaag gctaagattg
      901 ggcttattca gttttgctta tctgctccta aaacagatat ggataatcaa atagtagtat
      961 ctgactatgc ccagatggat cgagtgcttc gagaggagag agcctatatt ttaaatttgg
     1021 tgaagcaaat taagaaaaca ggatgtaatg tccttctcat acagaagtct atcctgagag
     1081 atgcccttag tgatcttgca ttacattttc tgaataagat gaagattatg gtggttaagg
     1141 acgttgaaag agaagacatt gaattcatct gtaagacaat tggaaccaaa ccagttgctc
     1201 acattgacca gttcactgct gacatgctgg gttctgctga gttagcagag gaagtcagtt
     1261 taaatggttc tggaaaacta ttcaagatta caggttgtac aagcccaggg aaaacagtta
     1321 caattgtcgt acgtggttct aacaaactgg tgattgaaga agctgagcgc tccattcatg
     1381 atgctctctg tgtcatccga tgcttagtaa agaaaagagc tcttattgca ggaggtggtg
     1441 ctccagaaat agagctggcc ctcagactga cagagtactc ccgaacactg agtggtatgg
     1501 agtcctactg tgttcgtgct ttcgcggatg ctatggaagt cattccatct acactagctg
     1561 aaaatgctgg cctgaatccc atttctacag taacagagct aagaaaccgc catgcccaag
     1621 gagaaaaaac tacaggcatt aatgtccgaa agggtgggat ctccaacatt ttggaggaaa
     1681 tggttgttca gcctctgttg gtgtcagtca gtgctttgac cttagcaact gaaactgtgc
     1741 ggagcattct gaaaatcgat gatgtggtaa atactcgata atctggataa aaggatggtt
     1801 gactgcatca ttatggacag aagtactgtg gctggaatga aggacaacca ccttgttcct
     1861 tgtctggaag cttcagagtt tttggacatt gtcttccagt tggcatttgt ttgaaattgt
     1921 attgaaacaa tttaatgaaa acattaaata cttggtttta aactcc
//
