LOCUS       NM_009836               1957 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus chaperonin containing TCP1 subunit 3 (Cct3), mRNA.
ACCESSION   NM_009836 NM_001243065
VERSION     NM_009836.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1957)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1957)
  AUTHORS   Najas,S., Pijuan,I., Esteve-Codina,A., Usieto,S., Martinez,J.D.,
            Zwijsen,A., Arbones,M.L., Marti,E. and Le Dreau,G.
  TITLE     A SMAD1/5-YAP signalling module drives radial glia
            self-amplification and growth of the developing cerebral cortex
  JOURNAL   Development 147 (13) (2020)
   PUBMED   32541003
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1957)
  AUTHORS   Joachimiak,L.A., Walzthoeni,T., Liu,C.W., Aebersold,R. and
            Frydman,J.
  TITLE     The structural basis of substrate recognition by the eukaryotic
            chaperonin TRiC/CCT
  JOURNAL   Cell 159 (5), 1042-1055 (2014)
   PUBMED   25416944
REFERENCE   4  (bases 1 to 1957)
  AUTHORS   Tarkar,A., Loges,N.T., Slagle,C.E., Francis,R., Dougherty,G.W.,
            Tamayo,J.V., Shook,B., Cantino,M., Schwartz,D., Jahnke,C.,
            Olbrich,H., Werner,C., Raidt,J., Pennekamp,P., Abouhamed,M.,
            Hjeij,R., Kohler,G., Griese,M., Li,Y., Lemke,K., Klena,N., Liu,X.,
            Gabriel,G., Tobita,K., Jaspers,M., Morgan,L.C., Shapiro,A.J.,
            Letteboer,S.J., Mans,D.A., Carson,J.L., Leigh,M.W., Wolf,W.E.,
            Chen,S., Lucas,J.S., Onoufriadis,A., Plagnol,V., Schmidts,M.,
            Boldt,K., Roepman,R., Zariwala,M.A., Lo,C.W., Mitchison,H.M.,
            Knowles,M.R., Burdine,R.D., Loturco,J.J. and Omran,H.
  CONSRTM   UK10K
  TITLE     DYX1C1 is required for axonemal dynein assembly and ciliary
            motility
  JOURNAL   Nat Genet 45 (9), 995-1003 (2013)
   PUBMED   23872636
REFERENCE   5  (bases 1 to 1957)
  AUTHORS   Slater,L.H., Hett,E.C., Clatworthy,A.E., Mark,K.G. and Hung,D.T.
  TITLE     CCT chaperonin complex is required for efficient delivery of
            anthrax toxin into the cytosol of host cells
  JOURNAL   Proc Natl Acad Sci U S A 110 (24), 9932-9937 (2013)
   PUBMED   23716698
REFERENCE   6  (bases 1 to 1957)
  AUTHORS   Sevigny,G., Kothary,R., Tremblay,E., De Repentigny,Y., Joly,E.C.
            and Bibor-Hardy,V.
  TITLE     The cytosolic chaperonin subunit TRiC-P5 begins to be expressed at
            the two-cell stage in mouse embryos
  JOURNAL   Biochem Biophys Res Commun 216 (1), 279-283 (1995)
   PUBMED   7488101
REFERENCE   7  (bases 1 to 1957)
  AUTHORS   Kubota,H., Hynes,G. and Willison,K.
  TITLE     The chaperonin containing t-complex polypeptide 1 (TCP-1).
            Multisubunit machinery assisting in protein folding and assembly in
            the eukaryotic cytosol
  JOURNAL   Eur J Biochem 230 (1), 3-16 (1995)
   PUBMED   7601114
  REMARK    Review article
REFERENCE   8  (bases 1 to 1957)
  AUTHORS   Hynes,G., Kubota,H. and Willison,K.R.
  TITLE     Antibody characterisation of two distinct conformations of the
            chaperonin-containing TCP-1 from mouse testis
  JOURNAL   FEBS Lett 358 (2), 129-132 (1995)
   PUBMED   7828721
REFERENCE   9  (bases 1 to 1957)
  AUTHORS   Creutz,C.E., Liou,A., Snyder,S.L., Brownawell,A. and Willison,K.
  TITLE     Identification of the major chromaffin granule-binding protein,
            chromobindin A, as the cytosolic chaperonin CCT (chaperonin
            containing TCP-1)
  JOURNAL   J Biol Chem 269 (51), 32035-32038 (1994)
   PUBMED   7798195
REFERENCE   10 (bases 1 to 1957)
  AUTHORS   O'Bryan,J.P., Frye,R.A., Cogswell,P.C., Neubauer,A., Kitch,B.,
            Prokop,C., Espinosa,R. 3rd, Le Beau,M.M., Earp,H.S. and Liu,E.T.
  TITLE     axl, a transforming gene isolated from primary human myeloid
            leukemia cells, encodes a novel receptor tyrosine kinase
  JOURNAL   Mol Cell Biol 11 (10), 5016-5031 (1991)
   PUBMED   1656220
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from Z31556.1.
            
            On Jun 13, 2012 this sequence version replaced NM_001243065.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: Z31556.1, AK161630.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1957
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="129/Sv"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 38.79 cM"
     gene            1..1957
                     /gene="Cct3"
                     /gene_synonym="Cctg; Tcp1-rs3; TriC-P5"
                     /note="chaperonin containing TCP1 subunit 3"
                     /db_xref="GeneID:12462"
                     /db_xref="MGI:MGI:104708"
     exon            1..132
                     /gene="Cct3"
                     /gene_synonym="Cctg; Tcp1-rs3; TriC-P5"
                     /inference="alignment:Splign:2.1.0"
     CDS             102..1739
                     /gene="Cct3"
                     /gene_synonym="Cctg; Tcp1-rs3; TriC-P5"
                     /function="CCT is a molecular chaperone which assists the
                     folding of proteins in eukaryotic cytosol"
                     /note="matricin; CCT-gamma; TCP-1-gamma; chaperonin
                     subunit 3 (gamma); chaperonin containing Tcp1, subunit 3
                     (gamma)"
                     /codon_start=1
                     /product="T-complex protein 1 subunit gamma"
                     /protein_id="NP_033966.1"
                     /db_xref="CCDS:CCDS17468.1"
                     /db_xref="GeneID:12462"
                     /db_xref="MGI:MGI:104708"
                     /translation="MMGHRPVLVLSQNTKRESGRKVQSGNINAAKTIADIIRTCLGPK
                     SMMKMLLDPMGGIVMTNDGNAILREIQVQHPAAKSMIEISRTQDEEVGDGTTSVIILA
                     GEMLSVAEHFLEQQMHPTVVISAYRMALDDMISTLKKISTPVDVNNREMMLSIINSSI
                     TTKVISRWSSLACNIALDAVKTVQFEENGRKEIDIKKYARVEKIPGGIIEDSCVLRGV
                     MINKDVTHPRMRRYIKNPRIVLLDSSLEYKKGESQTDIEITREEDFTRILQMEEEYIH
                     QLCEDIIQLKPDVVITEKGISDLAQHYLMRANVTAIRRVRKTDNNRIARACGARIVSR
                     PEELREDDVGTGAGLLEIKKIGDEYFTFITDCKDPKACTILLRGASKEILSEVERNLQ
                     DAMQVCRNVLLDPQLVPGGGASEMAVAHALTEKSKAMTGVEQWPYRAVAQALEVIPRT
                     LIQNCGASTIRLLTSLRAKHTQESCETWGVNGETGTLVDMKELGIWEPLAVKLQTYKT
                     AVETAVLLLRIDDIVSGHKKKGDDQNRQTGAPDAGQE"
     exon            133..194
                     /gene="Cct3"
                     /gene_synonym="Cctg; Tcp1-rs3; TriC-P5"
                     /inference="alignment:Splign:2.1.0"
     exon            195..245
                     /gene="Cct3"
                     /gene_synonym="Cctg; Tcp1-rs3; TriC-P5"
                     /inference="alignment:Splign:2.1.0"
     exon            246..308
                     /gene="Cct3"
                     /gene_synonym="Cctg; Tcp1-rs3; TriC-P5"
                     /inference="alignment:Splign:2.1.0"
     exon            309..405
                     /gene="Cct3"
                     /gene_synonym="Cctg; Tcp1-rs3; TriC-P5"
                     /inference="alignment:Splign:2.1.0"
     exon            406..523
                     /gene="Cct3"
                     /gene_synonym="Cctg; Tcp1-rs3; TriC-P5"
                     /inference="alignment:Splign:2.1.0"
     exon            524..710
                     /gene="Cct3"
                     /gene_synonym="Cctg; Tcp1-rs3; TriC-P5"
                     /inference="alignment:Splign:2.1.0"
     exon            711..860
                     /gene="Cct3"
                     /gene_synonym="Cctg; Tcp1-rs3; TriC-P5"
                     /inference="alignment:Splign:2.1.0"
     exon            861..993
                     /gene="Cct3"
                     /gene_synonym="Cctg; Tcp1-rs3; TriC-P5"
                     /inference="alignment:Splign:2.1.0"
     exon            994..1075
                     /gene="Cct3"
                     /gene_synonym="Cctg; Tcp1-rs3; TriC-P5"
                     /inference="alignment:Splign:2.1.0"
     exon            1076..1256
                     /gene="Cct3"
                     /gene_synonym="Cctg; Tcp1-rs3; TriC-P5"
                     /inference="alignment:Splign:2.1.0"
     exon            1257..1502
                     /gene="Cct3"
                     /gene_synonym="Cctg; Tcp1-rs3; TriC-P5"
                     /inference="alignment:Splign:2.1.0"
     exon            1503..1634
                     /gene="Cct3"
                     /gene_synonym="Cctg; Tcp1-rs3; TriC-P5"
                     /inference="alignment:Splign:2.1.0"
     exon            1635..1957
                     /gene="Cct3"
                     /gene_synonym="Cctg; Tcp1-rs3; TriC-P5"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1957
                     /gene="Cct3"
                     /gene_synonym="Cctg; Tcp1-rs3; TriC-P5"
ORIGIN      
        1 tgtcattcct gaggaggcag cgttttcttc gctgctcttc tctccagaag gttctgccga
       61 ttccccccag ctctggagag tcggctctgc gtcgtgccgc catgatgggc caccgtccag
      121 tgctcgtgct cagtcagaac acaaagcgtg aatctggaag aaaagttcag tctggaaata
      181 tcaatgctgc aaagacaatt gcagacatca tccggacctg cttgggacct aaatctatga
      241 tgaagatgct tttggaccca atgggaggca tcgtgatgac caatgatggc aatgccattc
      301 ttcgagagat tcaagtccag catcccgcag caaagtccat gattgaaatt agcaggaccc
      361 aggatgaaga ggttggagat gggaccacat cagtaattat tcttgcggga gaaatgctct
      421 ctgtggctga acacttccta gagcagcaga tgcacccaac agtggtgatc agtgcttacc
      481 gcatggcact ggatgatatg atcagcactc tgaagaaaat cagtactcct gttgatgtca
      541 ataaccgtga gatgatgttg agcatcatca atagctctat tactacaaaa gtcatcagtc
      601 ggtggtcctc cttggcatgc aacattgcac tggatgctgt taagactgtg cagtttgaag
      661 agaatggcag aaaggaaatt gacatcaaaa aatatgcaag ggtagaaaag atacccgggg
      721 gcatcattga agactcatgt gtcttacgtg gagttatgat taacaaggat gtgacccatc
      781 caaggatgcg ccgctatatt aagaatcctc gaattgtgct attggattct tctttggagt
      841 acaagaaagg agaaagccag accgacatcg agattacccg ggaggaggac ttcacgcgga
      901 tcctgcagat ggaggaggag tacatccatc agctgtgtga ggacatcatc cagctgaagc
      961 ctgacgtggt catcacagag aagggcatct cagatttagc tcagcactac ctcatgcggg
     1021 ccaatgtcac agccattcgt agagtccgga aaacagacaa taatcgcatt gctagagcct
     1081 gtggggcacg gatagtcagc cgacctgagg aactgagaga agatgatgtt ggtacagggg
     1141 caggcttatt ggaaatcaag aagattggag atgagtactt tacattcatc actgactgca
     1201 aagacccaaa ggcctgcacc attcttctta gaggagccag caaagagata ctctcggaag
     1261 tagaacgcaa cctccaggat gccatgcaag tgtgccgcaa tgttctactg gaccctcagc
     1321 tggtgcctgg tggtggagcc tctgagatgg ctgtggctca tgccttgaca gaaaaatcta
     1381 aggccatgac tggtgtggaa caatggccat atagagctgt ggcccaggcg ttagaggtca
     1441 tccctcggac cttgatccag aattgtgggg ccagtaccat tcgtctgctt acctcccttc
     1501 gggccaagca cacacaggag agttgtgaga cctggggtgt gaatggtgag actggtacct
     1561 tggtggacat gaaagagctg ggtatttggg agccattggc tgtgaagcta caaacgtaca
     1621 aaacagcagt agagactgca gttctgcttc tgcggattga tgacattgtc tctggccaca
     1681 agaagaaggg tgatgaccag aaccggcaaa ctggtgctcc agatgctggc caggagtgag
     1741 tgctgagcac ggtgacttcc atgcacagaa ccagcagtct cccctttcct gagccagagt
     1801 tccaggaaca ctgtggacat ctttgtttgc gaaggatcag gttgaggggc agcccccagt
     1861 ctgtcccatc tcagtttgca aaaagcactg acacgtatct cttctattgt aagctttcca
     1921 tttagtttgc ttccaatgat taaatctaag tcatttg
//
