LOCUS       NM_007636               2016 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus chaperonin containing TCP1 subunit 2 (Cct2),
            transcript variant 1, mRNA.
ACCESSION   NM_007636
VERSION     NM_007636.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2016)
  AUTHORS   Suga,A., Minegishi,Y., Yamamoto,M., Ueda,K. and Iwata,T.
  TITLE     Compound heterozygous mutations in a mouse model of Leber
            congenital amaurosis reveal the role of CCT2 in photoreceptor
            maintenance
  JOURNAL   Commun Biol 7 (1), 676 (2024)
   PUBMED   38830954
  REMARK    GeneRIF: Compound heterozygous mutations in a mouse model of Leber
            congenital amaurosis reveal the role of CCT2 in photoreceptor
            maintenance.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2016)
  AUTHORS   Elenbaas,J.S., Pudupakkam,U., Ashworth,K.J., Kang,C.J., Patel,V.,
            Santana,K., Jung,I.H., Lee,P.C., Burks,K.H., Amrute,J.M.,
            Mecham,R.P., Halabi,C.M., Alisio,A., Di Paola,J. and Stitziel,N.O.
  TITLE     SVEP1 is an endogenous ligand for the orphan receptor PEAR1
  JOURNAL   Nat Commun 14 (1), 850 (2023)
   PUBMED   36792666
  REMARK    Erratum:[Nat Commun. 2023 Mar 17;14(1):1511. doi:
            10.1038/s41467-023-37005-x.. PMID: 36932061]
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2016)
  AUTHORS   Ma,X., Lu,C., Chen,Y., Li,S., Ma,N., Tao,X., Li,Y., Wang,J.,
            Zhou,M., Yan,Y.B., Li,P., Heydari,K., Deng,H., Zhang,M., Yi,C. and
            Ge,L.
  TITLE     CCT2 is an aggrephagy receptor for clearance of solid protein
            aggregates
  JOURNAL   Cell 185 (8), 1325-1345 (2022)
   PUBMED   35366418
  REMARK    GeneRIF: CCT2 is an aggrephagy receptor for clearance of solid
            protein aggregates.
REFERENCE   4  (bases 1 to 2016)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2016)
  AUTHORS   Fantauzzo,K.A. and Soriano,P.
  TITLE     PI3K-mediated PDGFRalpha signaling regulates survival and
            proliferation in skeletal development through p53-dependent
            intracellular pathways
  JOURNAL   Genes Dev 28 (9), 1005-1017 (2014)
   PUBMED   24788519
REFERENCE   6  (bases 1 to 2016)
  AUTHORS   Furumura,M., Sakai,C., Potterf,S.B., Vieira,W.D., Barsh,G.S. and
            Hearing,V.J.
  TITLE     Characterization of genes modulated during pheomelanogenesis using
            differential display
  JOURNAL   Proc Natl Acad Sci U S A 95 (13), 7374-7378 (1998)
   PUBMED   9636156
REFERENCE   7  (bases 1 to 2016)
  AUTHORS   Kubota,H., Hynes,G. and Willison,K.
  TITLE     The chaperonin containing t-complex polypeptide 1 (TCP-1).
            Multisubunit machinery assisting in protein folding and assembly in
            the eukaryotic cytosol
  JOURNAL   Eur J Biochem 230 (1), 3-16 (1995)
   PUBMED   7601114
  REMARK    Review article
REFERENCE   8  (bases 1 to 2016)
  AUTHORS   Hynes,G., Kubota,H. and Willison,K.R.
  TITLE     Antibody characterisation of two distinct conformations of the
            chaperonin-containing TCP-1 from mouse testis
  JOURNAL   FEBS Lett 358 (2), 129-132 (1995)
   PUBMED   7828721
REFERENCE   9  (bases 1 to 2016)
  AUTHORS   Kubota,H., Hynes,G., Carne,A., Ashworth,A. and Willison,K.
  TITLE     Identification of six Tcp-1-related genes encoding divergent
            subunits of the TCP-1-containing chaperonin
  JOURNAL   Curr Biol 4 (2), 89-99 (1994)
   PUBMED   7953530
REFERENCE   10 (bases 1 to 2016)
  AUTHORS   O'Bryan,J.P., Frye,R.A., Cogswell,P.C., Neubauer,A., Kitch,B.,
            Prokop,C., Espinosa,R. 3rd, Le Beau,M.M., Earp,H.S. and Liu,E.T.
  TITLE     axl, a transforming gene isolated from primary human myeloid
            leukemia cells, encodes a novel receptor tyrosine kinase
  JOURNAL   Mol Cell Biol 11 (10), 5016-5031 (1991)
   PUBMED   1656220
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL589661.21, AK145406.1 and BU755483.1.
            
            On Dec 9, 2017 this sequence version replaced NM_007636.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK145406.1, BC007470.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-38                AL589661.21        110146-110183
            39-1997             AK145406.1         2-1960
            1998-2016           BU755483.1         1-19                c
FEATURES             Location/Qualifiers
     source          1..2016
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 65.07 cM"
     gene            1..2016
                     /gene="Cct2"
                     /gene_synonym="Cctb"
                     /note="chaperonin containing TCP1 subunit 2"
                     /db_xref="GeneID:12461"
                     /db_xref="MGI:MGI:107186"
     exon            1..147
                     /gene="Cct2"
                     /gene_synonym="Cctb"
                     /inference="alignment:Splign:2.1.0"
     CDS             145..1752
                     /gene="Cct2"
                     /gene_synonym="Cctb"
                     /note="CCT-beta; TCP-1-beta; chaperonin subunit 2 (beta);
                     chaperonin containing Tcp1, subunit 2 (beta)"
                     /codon_start=1
                     /product="T-complex protein 1 subunit beta"
                     /protein_id="NP_031662.2"
                     /db_xref="CCDS:CCDS36067.1"
                     /db_xref="GeneID:12461"
                     /db_xref="MGI:MGI:107186"
                     /translation="MASLSLAPVNIFKAGADEERAETARLSSFIGAIAIGDLVKSTLG
                     PKGMDKILLSSGRDAALMVTNDGATILKNIGVDNPAAKVLVDMSRVQDDEVGDGTTSV
                     TVLAAELLREAESLIAKKIHPQTIISGWREATKAAREALLSSAVDHGSDEARFWQDLM
                     NIAGTTLSSKLLTHHKDHFTKLAVEAVLRLKGSGNLEAIHVIKKLGGSLADSYLDEGF
                     LLDKKIGVNQPKRIENAKILIANTGMDTDKIKIFGSRVRVDSTAKVAEIEHAEKEKMK
                     EKVERILKHGINCFINRQLIYNYPEQLFGAAGVMAIEHADFAGVERLALVTGGEIAST
                     FDHPELVKLGSCKLIEEVMIGEDKLIHFSGVALGEACTIVLRGATQQILDEAERSLHD
                     ALCVLAQTVKDPRTVYGGGCSEMLMAHAVTQLANRTPGKEAVAMESFAKALRMLPTII
                     ADNAGYDSADLVAQLRAAHSEGHITAGLDMKEGTIGDMAVLGITESFQVKRQVLLSAA
                     EAAEVILRVDNIIKAAPRKRVPDHHPC"
     exon            148..222
                     /gene="Cct2"
                     /gene_synonym="Cctb"
                     /inference="alignment:Splign:2.1.0"
     exon            223..288
                     /gene="Cct2"
                     /gene_synonym="Cctb"
                     /inference="alignment:Splign:2.1.0"
     exon            289..400
                     /gene="Cct2"
                     /gene_synonym="Cctb"
                     /inference="alignment:Splign:2.1.0"
     exon            401..477
                     /gene="Cct2"
                     /gene_synonym="Cctb"
                     /inference="alignment:Splign:2.1.0"
     exon            478..590
                     /gene="Cct2"
                     /gene_synonym="Cctb"
                     /inference="alignment:Splign:2.1.0"
     exon            591..793
                     /gene="Cct2"
                     /gene_synonym="Cctb"
                     /inference="alignment:Splign:2.1.0"
     exon            794..894
                     /gene="Cct2"
                     /gene_synonym="Cctb"
                     /inference="alignment:Splign:2.1.0"
     exon            895..1022
                     /gene="Cct2"
                     /gene_synonym="Cctb"
                     /inference="alignment:Splign:2.1.0"
     exon            1023..1126
                     /gene="Cct2"
                     /gene_synonym="Cctb"
                     /inference="alignment:Splign:2.1.0"
     exon            1127..1246
                     /gene="Cct2"
                     /gene_synonym="Cctb"
                     /inference="alignment:Splign:2.1.0"
     exon            1247..1375
                     /gene="Cct2"
                     /gene_synonym="Cctb"
                     /inference="alignment:Splign:2.1.0"
     exon            1376..1479
                     /gene="Cct2"
                     /gene_synonym="Cctb"
                     /inference="alignment:Splign:2.1.0"
     exon            1480..1579
                     /gene="Cct2"
                     /gene_synonym="Cctb"
                     /inference="alignment:Splign:2.1.0"
     exon            1580..1721
                     /gene="Cct2"
                     /gene_synonym="Cctb"
                     /inference="alignment:Splign:2.1.0"
     exon            1722..2001
                     /gene="Cct2"
                     /gene_synonym="Cctb"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1974..1979
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cct2"
                     /gene_synonym="Cctb"
                     /note="hexamer: AATAAA"
     polyA_site      2001
                     /gene="Cct2"
                     /gene_synonym="Cctb"
                     /note="major polyA site"
ORIGIN      
        1 acgcaggagg cggaaacccg tgcgtccggc tccgcccccc gcggcggagc gtgtcgtcac
       61 ttccgccttt ctctctttcc ccggcctggc ttcccggcgc ggattgtgag gggttctctc
      121 ctctacgcgg aatccgtcgg aaccatggct tccctttccc tcgcacctgt taatatcttc
      181 aaggctggag ctgatgaaga gagggccgag acagctcgcc tgtcgtcgtt tatcggtgcc
      241 atcgccattg gagacttggt gaagagcact ttgggaccga agggcatgga caaaattctc
      301 ctaagcagtg gacgagacgc cgctctgatg gtgaccaacg acggtgctac cattctcaag
      361 aacattggtg tggacaaccc cgcagcaaag gttctagttg atatgtcaag ggttcaagat
      421 gatgaagttg gtgatggcac tacctctgtt actgtcttag ccgcagagct gctccgggaa
      481 gcagaatctt taattgcaaa aaagatacat ccacagacca tcatctcagg ttggagagaa
      541 gccacaaagg cagcaagaga ggccctgctg agctccgctg tggatcatgg ttctgatgaa
      601 gccagattct ggcaggactt aatgaacatt gcaggaacga cattgtcctc aaagctcctt
      661 actcaccaca aggaccactt tactaaactg gccgtggaag cggttctcag actgaaaggc
      721 tctggcaacc tggaggcgat tcatgtcatc aagaaactag gtgggagtct ggcagactcc
      781 tatctagatg aaggttttct tttggataaa aaaattggag taaatcaacc aaagagaatt
      841 gaaaatgcta aaattcttat tgcaaatact gggatggata cagacaaaat aaagatattt
      901 ggctctcggg taagagttga ttccacagca aaggttgcag agatagaaca tgcagaaaag
      961 gagaagatga aggagaaagt tgaacgtatt cttaagcatg gaataaattg ctttattaac
     1021 agacagttaa tttataatta ccctgaacaa ctcttcggcg ctgctggcgt catggctatt
     1081 gagcatgcgg atttcgcagg tgtggagcgc ctcgctcttg tcacaggtgg tgagattgcc
     1141 tctacctttg atcacccaga acttgtgaag cttggaagtt gcaaacttat tgaagaagtt
     1201 atgatcgggg aagataaact cattcacttt tctggggttg cccttggtga ggcatgcacc
     1261 attgtgcttc gtggtgccac tcagcaaatt ctggatgaag ctgaacgatc tctgcatgat
     1321 gctctttgtg ttcttgctca gactgtaaaa gatcctagaa cagtttacgg gggaggctgc
     1381 tctgagatgc tgatggccca tgctgtgaca cagcttgcca acagaacccc aggaaaagaa
     1441 gctgtagcaa tggagtcgtt tgcaaaagcc ctgagaatgt tgccgaccat catagccgac
     1501 aatgcgggct atgacagtgc agatctggtg gcacagctcc gagctgctca cagtgaaggc
     1561 catataactg ctggactgga tatgaaggaa ggtaccatcg gcgatatggc agtactgggt
     1621 ataacagaga gttttcaagt gaagcgacag gttcttctga gtgcggctga agcagcagag
     1681 gtgatcctgc gagtggacaa cattatcaaa gcagcaccaa ggaaacgtgt ccccgatcac
     1741 cacccctgtt aagcattccc atttgctgat gaactctggg ccagttcata gcaaagttgt
     1801 acttggaaga cttcaacctt taaagaagac tggtggaatt gacctgtcca tgatagcctt
     1861 aagtttgaac attagctgac cttctgtgtt aaacatgggt ctaatttatt tactgtttca
     1921 ttttccatac aattcagttg atttacaagt tcatttctca tactgtgtat taaaataaaa
     1981 atccagttac ttagccctta aaaaaaaaaa aaaaaa
//
