LOCUS       NM_016892               1033 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus copper chaperone for superoxide dismutase (Ccs),
            transcript variant 1, mRNA.
ACCESSION   NM_016892
VERSION     NM_016892.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1033)
  AUTHORS   Baker,Z.N., Jett,K., Boulet,A., Hossain,A., Cobine,P.A., Kim,B.E.,
            El Zawily,A.M., Lee,L., Tibbits,G.F., Petris,M.J. and Leary,S.C.
  TITLE     The mitochondrial metallochaperone SCO1 maintains CTR1 at the
            plasma membrane to preserve copper homeostasis in the murine heart
  JOURNAL   Hum Mol Genet 26 (23), 4617-4628 (2017)
   PUBMED   28973536
REFERENCE   2  (bases 1 to 1033)
  AUTHORS   Wu,Y., Wei,F.Y., Kawarada,L., Suzuki,T., Araki,K., Komohara,Y.,
            Fujimura,A., Kaitsuka,T., Takeya,M., Oike,Y., Suzuki,T. and
            Tomizawa,K.
  TITLE     Mtu1-Mediated Thiouridine Formation of Mitochondrial tRNAs Is
            Required for Mitochondrial Translation and Is Involved in
            Reversible Infantile Liver Injury
  JOURNAL   PLoS Genet 12 (9), e1006355 (2016)
   PUBMED   27689697
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1033)
  AUTHORS   Lassi,K.C. and Prohaska,J.R.
  TITLE     Erythrocyte copper chaperone for superoxide dismutase is increased
            following marginal copper deficiency in adult and postweanling mice
  JOURNAL   J Nutr 142 (2), 292-297 (2012)
   PUBMED   22190021
REFERENCE   4  (bases 1 to 1033)
  AUTHORS   Yoo,D.Y., Shin,B.N., Kim,I.H., Kim,W., Kim,D.W., Yoo,K.Y.,
            Choi,J.H., Lee,C.H., Yoon,Y.S., Choi,S.Y., Won,M.H. and Hwang,I.K.
  TITLE     Effects of Cu,Zn-superoxide dismutase on cell proliferation and
            neuroblast differentiation in the mouse dentate gyrus
  JOURNAL   Neurochem Res 37 (2), 261-267 (2012)
   PUBMED   21927927
  REMARK    GeneRIF: results suggest that a SOD1 supplement to healthy mice may
            not be necessary to modulate cell proliferation and neuroblast
            differentiation in the dentate gyrus
REFERENCE   5  (bases 1 to 1033)
  AUTHORS   Miyayama,T., Ishizuka,Y., Iijima,T., Hiraoka,D. and Ogra,Y.
  TITLE     Roles of copper chaperone for superoxide dismutase 1 and
            metallothionein in copper homeostasis
  JOURNAL   Metallomics 3 (7), 693-701 (2011)
   PUBMED   21409224
  REMARK    GeneRIF: Small interfering RNA (siRNA) targeting CCS was introduced
            into metallothionein-knockout mouse fibroblasts (MT-KO cells) and
            their wild type cells (MT-WT cells) to reveal the interactive role
            of CCS with other Cu-regulating proteins.
REFERENCE   6  (bases 1 to 1033)
  AUTHORS   Bartnikas,T.B., Waggoner,D.J., Casareno,R.L., Gaedigk,R.,
            White,R.A. and Gitlin,J.D.
  TITLE     Chromosomal localization of CCS, the copper chaperone for Cu/Zn
            superoxide dismutase
  JOURNAL   Mamm Genome 11 (5), 409-411 (2000)
   PUBMED   10790544
REFERENCE   7  (bases 1 to 1033)
  AUTHORS   Wong,P.C., Waggoner,D., Subramaniam,J.R., Tessarollo,L.,
            Bartnikas,T.B., Culotta,V.C., Price,D.L., Rothstein,J. and
            Gitlin,J.D.
  TITLE     Copper chaperone for superoxide dismutase is essential to activate
            mammalian Cu/Zn superoxide dismutase
  JOURNAL   Proc Natl Acad Sci U S A 97 (6), 2886-2891 (2000)
   PUBMED   10694572
REFERENCE   8  (bases 1 to 1033)
  AUTHORS   Moore,S.D., Chen,M.M. and Cox,D.W.
  TITLE     Cloning and mapping of murine superoxide dismutase copper chaperone
            (Ccsd) and mapping of the human ortholog
  JOURNAL   Cytogenet Cell Genet 88 (1-2), 35-37 (2000)
   PUBMED   10773661
REFERENCE   9  (bases 1 to 1033)
  AUTHORS   Rothstein,J.D., Dykes-Hoberg,M., Corson,L.B., Becker,M.,
            Cleveland,D.W., Price,D.L., Culotta,V.C. and Wong,P.C.
  TITLE     The copper chaperone CCS is abundant in neurons and astrocytes in
            human and rodent brain
  JOURNAL   J Neurochem 72 (1), 422-429 (1999)
   PUBMED   9886096
REFERENCE   10 (bases 1 to 1033)
  AUTHORS   Nishihara,E., Furuyama,T., Yamashita,S. and Mori,N.
  TITLE     Expression of copper trafficking genes in the mouse brain
  JOURNAL   Neuroreport 9 (14), 3259-3263 (1998)
   PUBMED   9831461
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC141437.4.
            
            On Jul 25, 2022 this sequence version replaced NM_016892.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF173379.1, BC026938.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849385
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-102               AC141437.4         71432-71533
            103-175             AC141437.4         71827-71899
            176-313             AC141437.4         76420-76557
            314-491             AC141437.4         77212-77389
            492-552             AC141437.4         77837-77897
            553-630             AC141437.4         84709-84786
            631-734             AC141437.4         84857-84960
            735-1033            AC141437.4         85066-85364
FEATURES             Location/Qualifiers
     source          1..1033
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 4.11 cM"
     gene            1..1033
                     /gene="Ccs"
                     /gene_synonym="Ccsd"
                     /note="copper chaperone for superoxide dismutase"
                     /db_xref="GeneID:12460"
                     /db_xref="MGI:MGI:1333783"
     exon            1..102
                     /gene="Ccs"
                     /gene_synonym="Ccsd"
                     /inference="alignment:Splign:2.1.0"
     CDS             64..888
                     /gene="Ccs"
                     /gene_synonym="Ccsd"
                     /note="superoxide dismutase copper chaperone"
                     /codon_start=1
                     /product="copper chaperone for superoxide dismutase"
                     /protein_id="NP_058588.1"
                     /db_xref="CCDS:CCDS29438.1"
                     /db_xref="GeneID:12460"
                     /db_xref="MGI:MGI:1333783"
                     /translation="MASKSGDGGTVCALEFAVQMSCQSCVDAVHKTLKGVAGVQNVDV
                     QLENQMVLVQTTLPSQEVQALLESTGRQAVLKGMGSSQLQNLGAAVAILEGCGSIQGV
                     VRFLQLSSELCLIEGTIDGLEPGLHGLHVHQYGDLTRDCNSCGDHFNPDGASHGGPQD
                     TDRHRGDLGNVRAEAGGRATFRIEDKQLKVWDVIGRSLVIDEGEDDLGRGGHPLSKIT
                     GNSGKRLACGIIARSAGLFQNPKQICSCDGLTIWEERGRPIAGQGRKDSAQPPAHL"
     exon            103..175
                     /gene="Ccs"
                     /gene_synonym="Ccsd"
                     /inference="alignment:Splign:2.1.0"
     exon            176..313
                     /gene="Ccs"
                     /gene_synonym="Ccsd"
                     /inference="alignment:Splign:2.1.0"
     exon            314..491
                     /gene="Ccs"
                     /gene_synonym="Ccsd"
                     /inference="alignment:Splign:2.1.0"
     exon            492..552
                     /gene="Ccs"
                     /gene_synonym="Ccsd"
                     /inference="alignment:Splign:2.1.0"
     exon            553..630
                     /gene="Ccs"
                     /gene_synonym="Ccsd"
                     /inference="alignment:Splign:2.1.0"
     exon            631..734
                     /gene="Ccs"
                     /gene_synonym="Ccsd"
                     /inference="alignment:Splign:2.1.0"
     exon            735..1033
                     /gene="Ccs"
                     /gene_synonym="Ccsd"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1009..1014
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ccs"
                     /gene_synonym="Ccsd"
                     /note="hexamer: ATTAAA"
     polyA_site      1033
                     /gene="Ccs"
                     /gene_synonym="Ccsd"
                     /note="major polyA site"
ORIGIN      
        1 agagttgtgt tggtctctgg accctaccgg ttcggtgcgg cctaggcagt gacaacagct
       61 aggatggctt cgaagtcggg ggacggtggg actgtgtgtg cgttggagtt tgcagtgcag
      121 atgagttgtc agagctgtgt ggatgctgtg cacaagaccc tgaaaggggt ggcaggtgtc
      181 cagaatgtgg acgttcagtt ggagaaccag atggtgttgg tgcagacgac tctgcccagc
      241 caggaggtac aagcactcct ggaaagcaca gggaggcagg ctgtactcaa gggtatgggc
      301 agtagccaat tacagaatct gggagcagca gtggccattc tggagggctg tggctccata
      361 cagggggtgg tccgcttcct acagctatcc tctgaactct gcttgattga gggaaccatc
      421 gacggcctag agcctgggct gcatggactc catgtgcatc agtatgggga ccttacgagg
      481 gactgcaata gctgtgggga ccattttaac cctgatggag catctcatgg gggtcctcag
      541 gacactgatc ggcaccgggg agatctgggc aatgtccggg ctgaagctgg tggccgagct
      601 accttccgga tagaggataa acagctgaag gtgtgggatg tgattggccg cagcctggtt
      661 atcgatgagg gggaagatga cctgggccgg ggaggccatc ccttatccaa gatcacaggg
      721 aattctggga agaggttggc ctgtggcatc attgcacgct ctgccggcct tttccagaac
      781 cccaagcaga tctgctcctg tgatggcctc actatctggg aggagcgagg ccggcccatt
      841 gccggtcaag gccgaaagga ctcagcccaa cccccagctc acctctaaac agagcctcat
      901 gtcaggttat ttggtcctcg tagctgaaca tcttcttgca gagggagctg cgggcccttg
      961 cttgtacagg cctaagtaca gggcagataa gtgctgtagc ctgaacaaat taaattgtta
     1021 ctttcatatg gca
//
