LOCUS       NM_001302376            1871 bp    mRNA    linear   ROD 24-SEP-2024
DEFINITION  Mus musculus C-C motif chemokine receptor-like 2 (Ccrl2),
            transcript variant 2, mRNA.
ACCESSION   NM_001302376 XM_006512185
VERSION     NM_001302376.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1871)
  AUTHORS   Srivastava,N., Hu,H., Peterson,O.J., Vomund,A.N., Stremska,M.,
            Zaman,M., Giri,S., Li,T., Lichti,C.F., Zakharov,P.N., Zhang,B.,
            Abumrad,N.A., Chen,Y.G., Ravichandran,K.S., Unanue,E.R. and Wan,X.
  TITLE     CXCL16-dependent scavenging of oxidized lipids by islet macrophages
            promotes differentiation of pathogenic CD8+ T cells in diabetic
            autoimmunity
  JOURNAL   Immunity 57 (7), 1629-1647 (2024)
   PUBMED   38754432
REFERENCE   2  (bases 1 to 1871)
  AUTHORS   Chen,L., Meng,J., Zheng,J., Zhao,T., Li,Q. and Lu,C.
  TITLE     Role of CCRL2 in the Pathogenesis of Experimental Autoimmune
            Myocarditis via P21-Activated Kinase 1/NOD-Like Receptor Protein 3
            Pathway
  JOURNAL   Int Heart J 65 (2), 339-348 (2024)
   PUBMED   38556341
  REMARK    GeneRIF: Role of CCRL2 in the Pathogenesis of Experimental
            Autoimmune Myocarditis via P21-Activated Kinase 1/NOD-Like Receptor
            Protein 3 Pathway.
REFERENCE   3  (bases 1 to 1871)
  AUTHORS   Tang,C., Chen,G., Wu,F., Cao,Y., Yang,F., You,T., Liu,C., Li,M.,
            Hu,S., Ren,L., Lu,Q., Deng,W., Xu,Y., Wang,G., Jo,H., Zhang,Y.,
            Wu,Y., Zabel,B.A. and Zhu,L.
  TITLE     Endothelial CCRL2 induced by disturbed flow promotes
            atherosclerosis via chemerin-dependent beta2 integrin activation in
            monocytes
  JOURNAL   Cardiovasc Res 119 (9), 1811-1824 (2023)
   PUBMED   37279540
  REMARK    GeneRIF: Endothelial CCRL2 induced by disturbed flow promotes
            atherosclerosis via chemerin-dependent beta2 integrin activation in
            monocytes.
REFERENCE   4  (bases 1 to 1871)
  AUTHORS   Zhi,J.J., Wu,S.L., Wu,H.Q., Ran,Q., Gao,X., Chen,J.F., Gu,X.M.,
            Li,T., Wang,F., Xiao,L., Ye,J. and Mei,F.
  TITLE     Insufficient Oligodendrocyte Turnover in Optic Nerve Contributes to
            Age-Related Axon Loss and Visual Deficits
  JOURNAL   J Neurosci 43 (11), 1859-1870 (2023)
   PUBMED   36725322
REFERENCE   5  (bases 1 to 1871)
  AUTHORS   Su,Z., Brooks,J., Pelker,J., Andreyeva,T., Sobon,H., Gifford,R.,
            Powers,M., Wang,J., Dower,C., Hegen,M., Messing,D., Sheehan,A.D.
            and Brennan,J.J.
  TITLE     Studies with neutralizing antibodies suggest CXCL8-mediated
            neutrophil activation is independent of C-C motif chemokine
            receptor-like 2 (CCRL2) ligand binding function
  JOURNAL   PLoS One 18 (1), e0280590 (2023)
   PUBMED   36662882
  REMARK    GeneRIF: Studies with neutralizing antibodies suggest
            CXCL8-mediated neutrophil activation is independent of C-C motif
            chemokine receptor-like 2 (CCRL2) ligand binding function.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1871)
  CONSRTM   IUIS/WHO Subcommittee on Chemokine Nomenclature
  TITLE     Chemokine/chemokine receptor nomenclature
  JOURNAL   J Immunol Methods 262 (1-2), 1-3 (2002)
   PUBMED   12080938
REFERENCE   7  (bases 1 to 1871)
  AUTHORS   Shimada,T., Matsumoto,M., Tatsumi,Y., Kanamaru,A. and Akira,S.
  TITLE     A novel lipopolysaccharide inducible C-C chemokine receptor related
            gene in murine macrophages
  JOURNAL   FEBS Lett 425 (3), 490-494 (1998)
   PUBMED   9563519
REFERENCE   8  (bases 1 to 1871)
  AUTHORS   Quackenbush,E.J., Aguirre,V., Wershil,B.K. and Gutierrez-Ramos,J.C.
  TITLE     Eotaxin influences the development of embryonic hematopoietic
            progenitors in the mouse
  JOURNAL   J Leukoc Biol 62 (5), 661-666 (1997)
   PUBMED   9365121
REFERENCE   9  (bases 1 to 1871)
  AUTHORS   Post,T.W., Bozic,C.R., Rothenberg,M.E., Luster,A.D., Gerard,N. and
            Gerard,C.
  TITLE     Molecular characterization of two murine eosinophil beta chemokine
            receptors
  JOURNAL   J Immunol 155 (11), 5299-5305 (1995)
   PUBMED   7594543
REFERENCE   10 (bases 1 to 1871)
  AUTHORS   Gao,J.L. and Murphy,P.M.
  TITLE     Cloning and differential tissue-specific expression of three mouse
            beta chemokine receptor-like genes, including the gene for a
            functional macrophage inflammatory protein-1 alpha receptor
  JOURNAL   J Biol Chem 270 (29), 17494-17501 (1995)
   PUBMED   7542241
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY162594.1, AK007808.1, AK145946.1 and BC038631.1.
            
            On Oct 22, 2014 this sequence version replaced XM_006512185.1.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1, 2 and 3 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC038631.1, AB009384.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-359               BY162594.1         1-359
            360-1678            AK007808.1         611-1929
            1679-1679           AK145946.1         1905-1905
            1680-1860           AK007808.1         1931-2111
            1861-1871           BC038631.1         1769-1779
FEATURES             Location/Qualifiers
     source          1..1871
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 60.92 cM"
     gene            1..1871
                     /gene="Ccrl2"
                     /gene_synonym="1810047I05Rik; Ackr5; CCR11; Cmkbr1l2; E01;
                     L-CCR"
                     /note="C-C motif chemokine receptor-like 2"
                     /db_xref="GeneID:54199"
                     /db_xref="MGI:MGI:1920904"
     exon            1..138
                     /gene="Ccrl2"
                     /gene_synonym="1810047I05Rik; Ackr5; CCR11; Cmkbr1l2; E01;
                     L-CCR"
                     /inference="alignment:Splign:2.1.0"
     exon            139..255
                     /gene="Ccrl2"
                     /gene_synonym="1810047I05Rik; Ackr5; CCR11; Cmkbr1l2; E01;
                     L-CCR"
                     /inference="alignment:Splign:2.1.0"
     exon            256..1861
                     /gene="Ccrl2"
                     /gene_synonym="1810047I05Rik; Ackr5; CCR11; Cmkbr1l2; E01;
                     L-CCR"
                     /inference="alignment:Splign:2.1.0"
     CDS             267..1349
                     /gene="Ccrl2"
                     /gene_synonym="1810047I05Rik; Ackr5; CCR11; Cmkbr1l2; E01;
                     L-CCR"
                     /note="chemokine (C-C) receptor 1-like 2;
                     lipopolysaccharide inducible C-C chemokine receptor
                     related; chemokine (C-C motif) receptor-like 2; chemokine
                     receptor CCR11; G-protein coupled beta chemokine receptor;
                     lipopolysacharide-inducible C-C chemokine receptor;
                     lipopolysaccharide-inducible C-C chemokine receptor"
                     /codon_start=1
                     /product="C-C chemokine receptor-like 2"
                     /protein_id="NP_001289305.1"
                     /db_xref="CCDS:CCDS23582.1"
                     /db_xref="GeneID:54199"
                     /db_xref="MGI:MGI:1920904"
                     /translation="MDNYTVAPDDEYDVLILDDYLDNSGPDQVPAPEFLSPQQVLQFC
                     CAVFAVGLLDNVLAVFILVKYKGLKNLGNIYFLNLALSNLCFLLPLPFWAHTAAHGES
                     PGNGTCKVLVGLHSSGLYSEVFSNILLLVQGYRVFSQGRLASIFTTVSCGIVACILAW
                     AMATALSLPESVFYEPRMERQKHKCAFGKPHFLPIEAPLWKYVLTSKMIILVLAFPLL
                     VFIICCRQLRRRQSFRERQYDLHKPALVITGVFLLMWAPYNTVLFLSAFQEHLSLQDE
                     KSSYHLDASVQVTQLVATTHCCVNPLLYLLLDRKAFMRYLRSLFPRCNDIPYQSSGGY
                     QQAPPREGHGRPIELYSNLHQRQDII"
     regulatory      1343..1348
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ccrl2"
                     /gene_synonym="1810047I05Rik; Ackr5; CCR11; Cmkbr1l2; E01;
                     L-CCR"
                     /note="hexamer: AATATA"
     regulatory      1350..1355
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ccrl2"
                     /gene_synonym="1810047I05Rik; Ackr5; CCR11; Cmkbr1l2; E01;
                     L-CCR"
                     /note="hexamer: TATAAA"
     polyA_site      1362
                     /gene="Ccrl2"
                     /gene_synonym="1810047I05Rik; Ackr5; CCR11; Cmkbr1l2; E01;
                     L-CCR"
                     /note="major polyA site"
     polyA_site      1375
                     /gene="Ccrl2"
                     /gene_synonym="1810047I05Rik; Ackr5; CCR11; Cmkbr1l2; E01;
                     L-CCR"
     regulatory      1496..1501
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ccrl2"
                     /gene_synonym="1810047I05Rik; Ackr5; CCR11; Cmkbr1l2; E01;
                     L-CCR"
                     /note="hexamer: TATAAA"
     polyA_site      1517
                     /gene="Ccrl2"
                     /gene_synonym="1810047I05Rik; Ackr5; CCR11; Cmkbr1l2; E01;
                     L-CCR"
ORIGIN      
        1 ttccagctgc ttgcaacact ctttgctttc tgacgtagga atgctcacac cagacttgca
       61 tttagcagcg ctccttttct gtccagctct gtccccaacc tccttcccga ctgataccac
      121 ttgcttccat gttctctgct tgtcctcgtg cttgaccagc gcagtttcac ttttgcaaac
      181 atctgtttat atcccttgag agaaaaaata tcaagcaacc tgcctcaaac gacgctgttt
      241 tgtccggtga gcaaggacag cctccgatgg ataactacac agtggccccg gacgatgaat
      301 atgatgtcct aatcttagac gactacctgg acaacagtgg gccggaccaa gttccggccc
      361 ccgagttcct ctccccccag caggtgctgc agttctgctg cgcggtgttt gcggtgggtc
      421 tcttggacaa cgtgctggcg gtgtttatct tggtgaaata caaaggactc aagaatctgg
      481 ggaacatcta cttcctaaac ctggcacttt caaacctgtg tttcctgctt cccctgccgt
      541 tctgggccca tactgcagca cacggggaaa gccctggcaa tgggacctgt aaagttcttg
      601 tcggactcca ctcctcgggc ttatacagcg aggtgttttc caacatcctc ctccttgtgc
      661 aaggatacag ggtgttttcc caagggcgac tggcctccat cttcacgaca gtgtcttgtg
      721 gtattgttgc gtgcatcctg gcatgggcca tggctactgc gctctctttg cccgagtctg
      781 tgttttatga gcctcggatg gaaagacaga aacacaagtg tgcctttggc aaacctcact
      841 tcttgccaat cgaagcgccg ctctggaagt acgttctgac gtcaaaaatg atcatcttgg
      901 tacttgcttt tcctctgctg gtttttataa tctgctgcag gcaactgagg agaaggcaga
      961 gcttcaggga gagacagtac gacctccaca agccggctct tgtcataacg ggcgtgttcc
     1021 ttttgatgtg ggcgccttac aacactgtgc ttttcctgtc tgctttccag gaacacttgt
     1081 ccctgcagga tgagaagagc agctaccacc tggacgcaag tgttcaggtc acacagctgg
     1141 tagcgaccac ccactgctgc gtcaacccgc tgctctattt gcttcttgac cggaaggcct
     1201 ttatgagata ccttcgcagc ctgttcccac ggtgcaatga tatcccctat caaagtagtg
     1261 gaggctatca gcaagcgcct ccaagggaag gtcatggcag gcccattgaa ctgtacagca
     1321 atttgcatca aaggcaggat ataatataat ataaacactc aaccttgtct cttcacattg
     1381 ttttatgcca tttttatatg tttgtataaa aatagaatat aagaggaaag ggggctggtt
     1441 aatgaacatt tactactaag cgttgaattt gtctctggca cacggttaag ttatttataa
     1501 aggtgaattc cactcttcct ctttagcgtt tgtccgcagt gtgggcgtgg gcggtgtgca
     1561 ttccataaac tgaagctcgg tagttgtcca aagttacata actataaagt ggcaaaactg
     1621 atgtgtaaac tcagagatca ctggccccag agtctgtgag ttatccaagc gtgccagcct
     1681 ttcagtaact gtcagctagc agtggtggca tgtctgtcat cccagcactc taggaggcgg
     1741 aggcaggagg catctcacaa atgcaagtat aacctgactt cccccaacct caattctttt
     1801 ttttttgttg ttgttgttgt tcatcaaaat acatgcaata aatatatata tttttaaagc
     1861 aaaaaaaaaa a
//
