LOCUS       NM_007720               1156 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus C-C motif chemokine receptor 8 (Ccr8), mRNA.
ACCESSION   NM_007720 XM_913831
VERSION     NM_007720.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1156)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1156)
  AUTHORS   Sun,Z., Sen,H., Zhu,X. and Islam,S.A.
  TITLE     Cutting Edge: CCR8 Signaling Regulates IL-25- and IL-33-Responsive
            Skin Group 2 Innate Lymphoid Cell Migration and Function
  JOURNAL   J Immunol 211 (12), 1751-1755 (2023)
   PUBMED   37921466
  REMARK    GeneRIF: Cutting Edge: CCR8 Signaling Regulates IL-25- and
            IL-33-Responsive Skin Group 2 Innate Lymphoid Cell Migration and
            Function.
REFERENCE   3  (bases 1 to 1156)
  AUTHORS   Liu,S., Zhang,Z., Wang,Y., Zhang,Y., Min,J., Li,X. and Liu,S.
  TITLE     The chemokine CCL1 facilitates pulmonary fibrosis by promoting
            macrophage migration and M2 polarization
  JOURNAL   Int Immunopharmacol 120, 110343 (2023)
   PUBMED   37220693
REFERENCE   4  (bases 1 to 1156)
  AUTHORS   Kidani,Y., Nogami,W., Yasumizu,Y., Kawashima,A., Tanaka,A.,
            Sonoda,Y., Tona,Y., Nashiki,K., Matsumoto,R., Hagiwara,M.,
            Osaki,M., Dohi,K., Kanazawa,T., Ueyama,A., Yoshikawa,M.,
            Yoshida,T., Matsumoto,M., Hojo,K., Shinonome,S., Yoshida,H.,
            Hirata,M., Haruna,M., Nakamura,Y., Motooka,D., Okuzaki,D.,
            Sugiyama,Y., Kinoshita,M., Okuno,T., Kato,T., Hatano,K., Uemura,M.,
            Imamura,R., Yokoi,K., Tanemura,A., Shintani,Y., Kimura,T.,
            Nonomura,N., Wada,H., Mori,M., Doki,Y., Ohkura,N. and Sakaguchi,S.
  TITLE     CCR8-targeted specific depletion of clonally expanded Treg cells in
            tumor tissues evokes potent tumor immunity with long-lasting memory
  JOURNAL   Proc Natl Acad Sci U S A 119 (7) (2022)
   PUBMED   35140181
  REMARK    GeneRIF: CCR8-targeted specific depletion of clonally expanded Treg
            cells in tumor tissues evokes potent tumor immunity with
            long-lasting memory.
REFERENCE   5  (bases 1 to 1156)
  AUTHORS   Liu,S.S., Liu,C., Lv,X.X., Cui,B., Yan,J., Li,Y.X., Li,K., Hua,F.,
            Zhang,X.W., Yu,J.J., Yu,J.M., Wang,F., Shang,S., Li,P.P.,
            Zhou,Z.G., Xiao,Y. and Hu,Z.W.
  TITLE     The chemokine CCL1 triggers an AMFR-SPRY1 pathway that promotes
            differentiation of lung fibroblasts into myofibroblasts and drives
            pulmonary fibrosis
  JOURNAL   Immunity 54 (9), 2042-2056 (2021)
   PUBMED   34407391
  REMARK    Erratum:[Immunity. 2021 Oct 12;54(10):2433-2435. doi:
            10.1016/j.immuni.2021.09.009.. PMID: 34644559]
REFERENCE   6  (bases 1 to 1156)
  AUTHORS   Murphy,C.A., Hoek,R.M., Wiekowski,M.T., Lira,S.A. and Sedgwick,J.D.
  TITLE     Interactions between hemopoietically derived TNF and central
            nervous system-resident glial chemokines underlie initiation of
            autoimmune inflammation in the brain
  JOURNAL   J Immunol 169 (12), 7054-7062 (2002)
   PUBMED   12471141
REFERENCE   7  (bases 1 to 1156)
  AUTHORS   Oliveira,S.H., Lira,S., Martinez-A,C., Wiekowski,M., Sullivan,L.
            and Lukacs,N.W.
  TITLE     Increased responsiveness of murine eosinophils to MIP-1beta (CCL4)
            and TCA-3 (CCL1) is mediated by their specific receptors, CCR5 and
            CCR8
  JOURNAL   J Leukoc Biol 71 (6), 1019-1025 (2002)
   PUBMED   12050188
  REMARK    GeneRIF: mediates increased responsiveness of murine eosinophils to
            TCA-3
REFERENCE   8  (bases 1 to 1156)
  AUTHORS   Chensue,S.W., Lukacs,N.W., Yang,T.Y., Shang,X., Frait,K.A.,
            Kunkel,S.L., Kung,T., Wiekowski,M.T., Hedrick,J.A., Cook,D.N.,
            Zingoni,A., Narula,S.K., Zlotnik,A., Barrat,F.J., O'Garra,A.,
            Napolitano,M. and Lira,S.A.
  TITLE     Aberrant in vivo T helper type 2 cell response and impaired
            eosinophil recruitment in CC chemokine receptor 8 knockout mice
  JOURNAL   J Exp Med 193 (5), 573-584 (2001)
   PUBMED   11238588
REFERENCE   9  (bases 1 to 1156)
  AUTHORS   Zingoni,A., Soto,H., Hedrick,J.A., Stoppacciaro,A., Storlazzi,C.T.,
            Sinigaglia,F., D'Ambrosio,D., O'Garra,A., Robinson,D., Rocchi,M.,
            Santoni,A., Zlotnik,A. and Napolitano,M.
  TITLE     The chemokine receptor CCR8 is preferentially expressed in Th2 but
            not Th1 cells
  JOURNAL   J Immunol 161 (2), 547-551 (1998)
   PUBMED   9670926
REFERENCE   10 (bases 1 to 1156)
  AUTHORS   Goya,I., Gutierrez,J., Varona,R., Kremer,L., Zaballos,A. and
            Marquez,G.
  TITLE     Identification of CCR8 as the specific receptor for the human
            beta-chemokine I-309: cloning and molecular characterization of
            murine CCR8 as the receptor for TCA-3
  JOURNAL   J Immunol 160 (4), 1975-1981 (1998)
   PUBMED   9469461
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            Z98205.1 and AC117245.3.
            
            On or before Dec 7, 2005 this sequence version replaced
            XM_913831.1, NM_007720.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: Z98205.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-190               Z98205.1           1-190
            191-1156            AC117245.3         2465-3430           c
FEATURES             Location/Qualifiers
     source          1..1156
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 71.39 cM"
     gene            1..1156
                     /gene="Ccr8"
                     /gene_synonym="C-C; C-C CKR-8; CC-CKR-8; CCR-8; CKR-8;
                     Cmkbr8; mCCR8"
                     /note="C-C motif chemokine receptor 8"
                     /db_xref="GeneID:12776"
                     /db_xref="MGI:MGI:1201402"
     exon            1..56
                     /gene="Ccr8"
                     /gene_synonym="C-C; C-C CKR-8; CC-CKR-8; CCR-8; CKR-8;
                     Cmkbr8; mCCR8"
                     /inference="alignment:Splign:2.1.0"
     exon            57..1156
                     /gene="Ccr8"
                     /gene_synonym="C-C; C-C CKR-8; CC-CKR-8; CCR-8; CKR-8;
                     Cmkbr8; mCCR8"
                     /inference="alignment:Splign:2.1.0"
     CDS             71..1132
                     /gene="Ccr8"
                     /gene_synonym="C-C; C-C CKR-8; CC-CKR-8; CCR-8; CKR-8;
                     Cmkbr8; mCCR8"
                     /note="chemokine (C-C motif) receptor 8"
                     /codon_start=1
                     /product="C-C chemokine receptor type 8"
                     /protein_id="NP_031746.1"
                     /db_xref="CCDS:CCDS23621.1"
                     /db_xref="GeneID:12776"
                     /db_xref="MGI:MGI:1201402"
                     /translation="MDYTMEPNVTMTDYYPDFFTAPCDAEFLLRGSMLYLAILYCVLF
                     VLGLLGNSLVILVLVGCKKLRSITDIYLLNLAASDLLFVLSIPFQTHNLLDQWVFGTA
                     MCKVVSGLYYIGFFSSMFFITLMSVDRYLAIVHAVYAIKVRTASVGTALSLTVWLAAV
                     TATIPLMVFYQVASEDGMLQCFQFYEEQSLRWKLFTHFEINALGLLLPFAILLFCYVR
                     ILQQLRGCLNHNRTRAIKLVLTVVIVSLLFWVPFNVALFLTSLHDLHILDGCATRQRL
                     ALAIHVTEVISFTHCCVNPVIYAFIGEKFKKHLMDVFQKSCSHIFLYLGRQMPVGALE
                     RQLSSNQRSSHSSTLDDIL"
ORIGIN      
        1 tggcagagga gtgggcagct ctgaaacctc agaagaaagg ctcgctcaga taattggtct
       61 tcctgcctcg atggattaca cgatggagcc caacgtcacg atgaccgact actaccctga
      121 tttcttcacc gccccctgtg acgcagagtt cctcctcagg ggcagcatgc tgtatctggc
      181 catcttgtac tgcgtcttgt ttgtgctggg ccttctgggg aacagcctgg tcatcttagt
      241 cctcgtgggc tgcaagaaac tgaggagcat cacagatatc tacctcctga acctggccgc
      301 atccgacctg ctctttgtcc tctctattcc ttttcagacc cacaacctgc tggaccagtg
      361 ggtgtttggg actgcgatgt gtaaggtggt ctctggcctt tattacattg gttttttcag
      421 cagtatgttc ttcatcaccc taatgagtgt ggacaggtat ctggctattg tccacgctgt
      481 ctatgccatc aaggtgagga cggccagcgt gggcacagcc ctgagtctga cagtgtggct
      541 ggctgctgtc acagccacca tccccttgat ggttttttac caagtggcct ctgaagacgg
      601 catgctacaa tgtttccagt tttatgaaga gcagtctttg aggtggaagc tctttaccca
      661 ctttgaaatc aacgccttgg gtctgctgct cccctttgcc atcctcctgt tctgctatgt
      721 caggatcctg cagcagctgc ggggctgcct gaaccacaac aggaccagag ccatcaagct
      781 ggtgctcacc gtagtcattg tgtctttact cttctgggtc ccattcaacg tggccctttt
      841 cctcacgtcc ctgcacgacc tgcacatctt ggatggatgt gccacgaggc agaggctggc
      901 tctggccatc catgtcacag aggtcatctc ttttacccac tgctgcgtga accccgtcat
      961 ctacgcgttc ataggagaga agtttaagaa acacctcatg gatgtgtttc aaaagagctg
     1021 cagccacatc ttcctctact tagggagaca aatgcccgtg ggggcgttgg aaaggcagct
     1081 gtcctcgaac cagcgatctt cccattcttc caccctggat gacatcttgt aaggggagtg
     1141 tgcagggcag gcagac
//
