LOCUS       NM_007719               1975 bp    mRNA    linear   ROD 11-FEB-2025
DEFINITION  Mus musculus C-C motif chemokine receptor 7 (Ccr7), transcript
            variant 1, mRNA.
ACCESSION   NM_007719
VERSION     NM_007719.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1975)
  AUTHORS   Chen,K.Y., De Giovanni,M., Xu,Y., An,J., Kirthivasan,N., Lu,E.,
            Jiang,K., Brooks,S., Ranucci,S., Yang,J., Kanameishi,S.,
            Kabashima,K., Brulois,K., Bscheider,M., Butcher,E.C. and
            Cyster,J.G.
  TITLE     Inflammation switches the chemoattractant requirements for naive
            lymphocyte entry into lymph nodes
  JOURNAL   Cell (2024) In press
   PUBMED   39708807
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   2  (bases 1 to 1975)
  AUTHORS   Raquer-McKay,H.M., Maqueda-Alfaro,R.A., Saravanan,S., Arroyo
            Hornero,R., Clausen,B.E., Gottfried-Blackmore,A. and Idoyaga,J.
  TITLE     Monocytes give rise to Langerhans cells that preferentially migrate
            to lymph nodes at steady state
  JOURNAL   Proc Natl Acad Sci U S A 121 (47), e2404927121 (2024)
   PUBMED   39541348
REFERENCE   3  (bases 1 to 1975)
  AUTHORS   Kim,W., Sakai,Y., Matsuoka,M., Hosokawa,Y., Fukuda,R., Homan,K.,
            Onodera,T. and Iwasaki,N.
  TITLE     CCR7 depletion alleviates bony growth imbalance following physeal
            injury in mice
  JOURNAL   Sci Rep 14 (1), 24891 (2024)
   PUBMED   39438569
  REMARK    GeneRIF: CCR7 depletion alleviates bony growth imbalance following
            physeal injury in mice.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1975)
  AUTHORS   Gao,J., Wang,Z., Lin,S., Tian,Y., Wu,H., Li,Z. and Liu,F.
  TITLE     CCR7/DUSP1 signaling Axis mediates iCAF to regulates head and neck
            squamous cell carcinoma growth
  JOURNAL   Cell Signal 122, 111305 (2024)
   PUBMED   39067836
  REMARK    GeneRIF: CCR7/DUSP1 signaling Axis mediates iCAF to regulates head
            and neck squamous cell carcinoma growth.
REFERENCE   5  (bases 1 to 1975)
  AUTHORS   Zhivaki,D., Kennedy,S.N., Park,J., Boriello,F., Devant,P., Cao,A.,
            Bahleda,K.M., Murphy,S., McCabe,C., Evavold,C.L., Chapman,K.L.,
            Zanoni,I., Ashenberg,O., Xavier,R.J. and Kagan,J.C.
  TITLE     Correction of age-associated defects in dendritic cells enables
            CD4+ T cells to eradicate tumors
  JOURNAL   Cell 187 (15), 3888-3903 (2024)
   PUBMED   38870946
REFERENCE   6  (bases 1 to 1975)
  AUTHORS   Cyster,J.G.
  TITLE     Chemokines and cell migration in secondary lymphoid organs
  JOURNAL   Science 286 (5447), 2098-2102 (1999)
   PUBMED   10617422
  REMARK    Review article
REFERENCE   7  (bases 1 to 1975)
  AUTHORS   Forster,R., Schubel,A., Breitfeld,D., Kremmer,E., Renner-Muller,I.,
            Wolf,E. and Lipp,M.
  TITLE     CCR7 coordinates the primary immune response by establishing
            functional microenvironments in secondary lymphoid organs
  JOURNAL   Cell 99 (1), 23-33 (1999)
   PUBMED   10520991
REFERENCE   8  (bases 1 to 1975)
  AUTHORS   Steel,M., Moss,J., Clark,K.A., Kearns,I.R., Davies,C.H.,
            Morris,R.G., Skarnes,W.C. and Lathe,R.
  TITLE     Gene-trapping to identify and analyze genes expressed in the mouse
            hippocampus
  JOURNAL   Hippocampus 8 (5), 444-457 (1998)
   PUBMED   9825957
REFERENCE   9  (bases 1 to 1975)
  AUTHORS   Mosialos,G., Birkenbach,M., Yalamanchili,R., VanArsdale,T., Ware,C.
            and Kieff,E.
  TITLE     The Epstein-Barr virus transforming protein LMP1 engages signaling
            proteins for the tumor necrosis factor receptor family
  JOURNAL   Cell 80 (3), 389-399 (1995)
   PUBMED   7859281
REFERENCE   10 (bases 1 to 1975)
  AUTHORS   Schweickart,V.L., Raport,C.J., Godiska,R., Byers,M.G., Eddy,R.L.
            Jr., Shows,T.B. and Gray,P.W.
  TITLE     Cloning of human and mouse EBI1, a lymphoid-specific
            G-protein-coupled receptor encoded on human chromosome 17q12-q21.2
  JOURNAL   Genomics 23 (3), 643-650 (1994)
   PUBMED   7851893
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK037965.1 and BF020112.1.
            
            On Oct 19, 2006 this sequence version replaced NM_007719.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK037965.1, AK154736.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849376
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1522              AK037965.1         2-1523
            1523-1975           BF020112.1         1-453               c
FEATURES             Location/Qualifiers
     source          1..1975
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 62.92 cM"
     gene            1..1975
                     /gene="Ccr7"
                     /gene_synonym="CC-CKR-7; CCR-7; CD197; Cdw197; Cmkbr7;
                     EBI1; Ebi1h"
                     /note="C-C motif chemokine receptor 7"
                     /db_xref="GeneID:12775"
                     /db_xref="MGI:MGI:103011"
     exon            1..89
                     /gene="Ccr7"
                     /gene_synonym="CC-CKR-7; CCR-7; CD197; Cdw197; Cmkbr7;
                     EBI1; Ebi1h"
                     /inference="alignment:Splign:2.1.0"
     CDS             80..1216
                     /gene="Ccr7"
                     /gene_synonym="CC-CKR-7; CCR-7; CD197; Cdw197; Cmkbr7;
                     EBI1; Ebi1h"
                     /note="isoform a precursor is encoded by transcript
                     variant 1; C-C chemokine receptor type 7; MIP-3 beta
                     receptor; EBV-induced G-protein coupled receptor 1;
                     epstein-Barr virus-induced G-protein coupled receptor 1;
                     chemokine (C-C) receptor 7; chemokine (C-C motif) receptor
                     7"
                     /codon_start=1
                     /product="C-C chemokine receptor type 7 isoform a
                     precursor"
                     /protein_id="NP_031745.2"
                     /db_xref="CCDS:CCDS25373.1"
                     /db_xref="GeneID:12775"
                     /db_xref="MGI:MGI:103011"
                     /translation="MDPGKPRKNVLVVALLVIFQVCFCQDEVTDDYIGENTTVDYTLY
                     ESVCFKKDVRNFKAWFLPLMYSVICFVGLLGNGLVILTYIYFKRLKTMTDTYLLNLAV
                     ADILFLLILPFWAYSEAKSWIFGVYLCKGIFGIYKLSFFSGMLLLLCISIDRYVAIVQ
                     AVSAHRHRARVLLISKLSCVGIWMLALFLSIPELLYSGLQKNSGEDTLRCSLVSAQVE
                     ALITIQVAQMVFGFLVPMLAMSFCYLIIIRTLLQARNFERNKAIKVIIAVVVVFIVFQ
                     LPYNGVVLAQTVANFNITNSSCETSKQLNIAYDVTYSLASVRCCVNPFLYAFIGVKFR
                     SDLFKLFKDLGCLSQERLRHWSSCRHVRNASVSMEAETTTTFSP"
     exon            90..139
                     /gene="Ccr7"
                     /gene_synonym="CC-CKR-7; CCR-7; CD197; Cdw197; Cmkbr7;
                     EBI1; Ebi1h"
                     /inference="alignment:Splign:2.1.0"
     exon            140..1975
                     /gene="Ccr7"
                     /gene_synonym="CC-CKR-7; CCR-7; CD197; Cdw197; Cmkbr7;
                     EBI1; Ebi1h"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccagagagg gctagctgga gagagacaag aaccaaaagc acagccttcc tgtgtgattt
       61 ctacagcccc cagagcacca tggacccagg gaaacccagg aaaaacgtgc tggtggtggc
      121 tctccttgtc attttccagg tgtgcttctg ccaagatgag gtcaccgatg actacatcgg
      181 cgagaatacc acggtggact acaccctgta cgagtcggtg tgcttcaaga aggatgtgcg
      241 gaactttaag gcctggttcc tgcctctcat gtattctgtc atctgcttcg tgggcctgct
      301 cggcaacggg ctggtgatac tgacgtacat ctatttcaag aggctcaaga ccatgacgga
      361 tacctacctg ctcaacctgg ccgtggcaga catccttttc ctcctaattc ttcccttctg
      421 ggcctacagc gaagccaagt cctggatctt tggcgtctac ctgtgtaagg gcatctttgg
      481 catctataag ttaagcttct tcagcgggat gctgctgctc ctatgcatca gcattgaccg
      541 ctacgtagcc atcgtccagg ccgtgtcggc tcatcgccac cgcgcccgcg tgcttctcat
      601 cagcaagctg tcctgtgtgg gcatctggat gctggccctc ttcctctcca tcccggagct
      661 gctctacagc ggcctccaga agaacagcgg cgaggacacg ctgagatgct cactggtcag
      721 tgcccaagtg gaggccttga tcaccatcca agtggcccag atggtttttg ggttcctagt
      781 gcctatgctg gctatgagtt tctgctacct cattatcatc cgtaccttgc tccaggcacg
      841 caactttgag cggaacaagg ccatcaaggt gatcattgcc gtggtggtag tcttcatagt
      901 cttccagctg ccctacaatg gggtggtcct ggctcagacg gtggccaact tcaacatcac
      961 caatagcagc tgcgaaacca gcaagcagct caacattgcc tatgacgtca cctacagcct
     1021 ggcctccgtc cgctgctgcg tcaacccttt cttgtatgcc ttcatcggcg tcaagttccg
     1081 cagcgacctc ttcaagctct tcaaggactt gggctgcctc agccaggaac ggctccggca
     1141 ctggtcttcc tgccggcatg tacggaacgc gtcggtgagc atggaggcgg agaccaccac
     1201 aaccttctcc ccgtaggggg ctcccctgcc cggactacaa ggacctctcc caggagcctt
     1261 aatgtggtgc acacatgcac agactctcca tccaccgaat tgctgctgag ggaagagcaa
     1321 ttctggccag tcaggttgac atgaggacct aagaaactgc ttaaccccat cccacttata
     1381 actacctcaa ccaaagctgt aaaagatatg gctgagaagt taacactcaa gccaagacag
     1441 ctatccccaa aacgacagcc aaaagtgaaa gtgagaggct gccacacttt ccggagtgag
     1501 ggatgtgggg ccagtgaaca ccctggttga gtagtcttcg gaggcctctg aatgaacctg
     1561 cttctagctt agagagatgt cccggagatt caaggacaga gcttatctcc acacttagca
     1621 agcaagcaag agatgacagt ctctctaaat gctcccacag agcacccctg cccctccctt
     1681 ctgcctctcc accgcctttc ctgaggtcca ggccacacca tcagcctgaa ggcagtccca
     1741 gctggggctc tggatggcaa tgacaagtag ttgggtctct atgatgggaa taaaaaggta
     1801 ggggaaaggt gacagaaagg agagaaggtg accctgctgg ctgacagagg ccagcaagct
     1861 acttctttgt tctctgtcag ccactgatac ctttcctcat gttctgcttt tgattcatat
     1921 atcttttatg aagaaacaaa taaaaaaaaa attttccctc gaggaaacaa cttgg
//
