LOCUS       NM_009835               1769 bp    mRNA    linear   ROD 26-NOV-2024
DEFINITION  Mus musculus C-C motif chemokine receptor 6 (Ccr6), transcript
            variant 1, mRNA.
ACCESSION   NM_009835
VERSION     NM_009835.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1769)
  AUTHORS   Singh,A., Kraaijeveld,A.O., Curaj,A., Wichapong,K., Hammerich,L.,
            de Jager,S.C.A., Bot,I., Atamas,S.P., van Berkel,T.J.C.,
            Jukema,J.W., Comerford,I., McColl,S.R., Mees,B., Heemskerk,J.W.M.,
            Nicolaes,G.A.F., Hackeng,T., Liehn,E.A., Tacke,F. and
            Biessen,E.A.L.
  TITLE     CCL18 aggravates atherosclerosis by inducing CCR6-dependent T-cell
            influx and polarization
  JOURNAL   Front Immunol 15, 1327051 (2024)
   PUBMED   38807599
  REMARK    GeneRIF: CCL18 aggravates atherosclerosis by inducing
            CCR6-dependent T-cell influx and polarization.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1769)
  AUTHORS   Zhu,Y., Tan,J., Wang,Y., Gong,Y., Zhang,X., Yuan,Z., Lu,X.,
            Tang,H., Zhang,Z., Jiang,X., Zhu,W. and Gong,L.
  TITLE     Atg5 deficiency in macrophages protects against kidney fibrosis via
            the CCR6-CCL20 axis
  JOURNAL   Cell Commun Signal 22 (1), 223 (2024)
   PUBMED   38594728
  REMARK    GeneRIF: Atg5 deficiency in macrophages protects against kidney
            fibrosis via the CCR6-CCL20 axis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1769)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 1769)
  AUTHORS   Cha,J., Kim,T.G., Bhae,E., Gwak,H.J., Ju,Y., Choe,Y.H., Jang,I.H.,
            Jung,Y., Moon,S., Kim,T., Lee,W., Park,J.S., Chung,Y.W., Yang,S.,
            Kang,Y.K., Hyun,Y.M., Hwang,G.S., Lee,W.J., Rho,M. and Ryu,J.H.
  TITLE     Skin microbe-dependent TSLP-ILC2 priming axis in early life is
            co-opted in allergic inflammation
  JOURNAL   Cell Host Microbe 32 (2), 244-260 (2024)
   PUBMED   38198924
REFERENCE   5  (bases 1 to 1769)
  AUTHORS   Lorchner,H., Canes Esteve,L., Goes,M.E., Harzenetter,R.,
            Brachmann,N., Gajawada,P., Gunther,S., Doll,N., Poling,J. and
            Braun,T.
  TITLE     Neutrophils for Revascularization Require Activation of CCR6 and
            CCL20 by TNFalpha
  JOURNAL   Circ Res 133 (7), 592-610 (2023)
   PUBMED   37641931
  REMARK    GeneRIF: Neutrophils for Revascularization Require Activation of
            CCR6 and CCL20 by TNFalpha.
REFERENCE   6  (bases 1 to 1769)
  AUTHORS   Lukacs,N.W., Prosser,D.M., Wiekowski,M., Lira,S.A. and Cook,D.N.
  TITLE     Requirement for the chemokine receptor CCR6 in allergic pulmonary
            inflammation
  JOURNAL   J Exp Med 194 (4), 551-555 (2001)
   PUBMED   11514610
REFERENCE   7  (bases 1 to 1769)
  AUTHORS   Varona,R., Villares,R., Carramolino,L., Goya,I., Zaballos,A.,
            Gutierrez,J., Torres,M., Martinez-A,C. and Marquez,G.
  TITLE     CCR6-deficient mice have impaired leukocyte homeostasis and altered
            contact hypersensitivity and delayed-type hypersensitivity
            responses
  JOURNAL   J Clin Invest 107 (6), R37-R45 (2001)
   PUBMED   11254677
REFERENCE   8  (bases 1 to 1769)
  AUTHORS   Cook,D.N., Prosser,D.M., Forster,R., Zhang,J., Kuklin,N.A.,
            Abbondanzo,S.J., Niu,X.D., Chen,S.C., Manfra,D.J., Wiekowski,M.T.,
            Sullivan,L.M., Smith,S.R., Greenberg,H.B., Narula,S.K., Lipp,M. and
            Lira,S.A.
  TITLE     CCR6 mediates dendritic cell localization, lymphocyte homeostasis,
            and immune responses in mucosal tissue
  JOURNAL   Immunity 12 (5), 495-503 (2000)
   PUBMED   10843382
REFERENCE   9  (bases 1 to 1769)
  AUTHORS   Varona,R., Zaballos,A., Gutierrez,J., Martin,P., Roncal,F.,
            Albar,J.P., Ardavin,C. and Marquez,G.
  TITLE     Molecular cloning, functional characterization and mRNA expression
            analysis of the murine chemokine receptor CCR6 and its specific
            ligand MIP-3alpha
  JOURNAL   FEBS Lett 440 (1-2), 188-194 (1998)
   PUBMED   9862452
  REMARK    GeneRIF: This gene is a mouse CC chemokine receptor CCR6 but not
            carbon catabolite repression 6. The definition line of the GenBank
            file (AB009639) has been corrected as G protein-coupled receptor.
REFERENCE   10 (bases 1 to 1769)
  AUTHORS   Nibbs,R.J., Wylie,S.M., Pragnell,I.B. and Graham,G.J.
  TITLE     Cloning and characterization of a novel murine beta chemokine
            receptor, D6. Comparison to three other related macrophage
            inflammatory protein-1alpha receptors, CCR-1, CCR-3, and CCR-5
  JOURNAL   J Biol Chem 272 (19), 12495-12504 (1997)
   PUBMED   9139699
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC164431.2.
            
            On Jun 17, 2010 this sequence version replaced NM_009835.3.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the shorter isoform (A).
            
            Sequence Note: This RefSeq record was created from genomic sequence
            data to make the sequence consistent with the reference genome
            assembly. The genomic coordinates used for the transcript record
            were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK089712.1, BY750769.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-128               AC164431.2         44489-44616
            129-182             AC164431.2         45770-45823
            183-273             AC164431.2         47071-47161
            274-475             AC164431.2         53882-54083
            476-590             AC164431.2         57715-57829
            591-1769            AC164431.2         57926-59104
FEATURES             Location/Qualifiers
     source          1..1769
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 4.9 cM"
     gene            1..1769
                     /gene="Ccr6"
                     /gene_synonym="CC-CKR-6; CCR-6; Cmkbr6; KY411"
                     /note="C-C motif chemokine receptor 6"
                     /db_xref="GeneID:12458"
                     /db_xref="MGI:MGI:1333797"
     exon            1..128
                     /gene="Ccr6"
                     /gene_synonym="CC-CKR-6; CCR-6; Cmkbr6; KY411"
                     /inference="alignment:Splign:2.1.0"
     exon            129..182
                     /gene="Ccr6"
                     /gene_synonym="CC-CKR-6; CCR-6; Cmkbr6; KY411"
                     /inference="alignment:Splign:2.1.0"
     exon            183..273
                     /gene="Ccr6"
                     /gene_synonym="CC-CKR-6; CCR-6; Cmkbr6; KY411"
                     /inference="alignment:Splign:2.1.0"
     exon            274..475
                     /gene="Ccr6"
                     /gene_synonym="CC-CKR-6; CCR-6; Cmkbr6; KY411"
                     /inference="alignment:Splign:2.1.0"
     exon            476..590
                     /gene="Ccr6"
                     /gene_synonym="CC-CKR-6; CCR-6; Cmkbr6; KY411"
                     /inference="alignment:Splign:2.1.0"
     exon            591..1769
                     /gene="Ccr6"
                     /gene_synonym="CC-CKR-6; CCR-6; Cmkbr6; KY411"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctagagaat acacaaggca ccgcttgaga gaccacggct ccgtaccatc tacagaggcc
       61 agggaacagt ggccatttga acggaagcca tctggtgtgg actgagagcc ctggaaagct
      121 gggtaaagca tttcctggga cttgcttcct ggccaccgag gtgtgaacaa cttcacagtt
      181 ctaatagtcc tcacattctt aggactggag cctggataac cactgaggca ggagtacctg
      241 gccagtctac tttggagctc agcattttct ggggtactgt gagtgtctgc cattcaagta
      301 agcatgacag tgaccttctc tccgagagct ctgattgcca atctcaccgt gctgagatca
      361 gcgttctgca gagttccagg gtgctggccc agcacatcat agcattgtgc agagacaggg
      421 gcaacttaca aatcctgggt ctttcggact tggttcgcca ctctaatcag taagacttca
      481 cctctgctct cccgacatct gcactagtga gagtgtggtt gaactgccca cttccctttc
      541 tacaccagat ctggctctcc catccacata gagaaccacg cctgcctggg gaatgaattc
      601 cacagagtcc tactttggaa cggatgatta tgacaacaca gagtattatt ctattcctcc
      661 agaccatggg ccatgctccc tagaagaggt cagaaacttc accaaggtat ttgtgccaat
      721 tgcctactcc ttaatatgtg tctttggcct cctgggcaac attatggtgg tgatgacctt
      781 tgccttctac aagaaagcca gatccatgac tgacgtctac ctgttgaaca tggccatcac
      841 agacatactc tttgtcctca ccctaccgtt ctgggcagtt actcatgcca ccaacacttg
      901 ggttttcagc gatgcactgt gtaaactgat gaaaggcaca tatgcggtca actttaactg
      961 tgggatgctg ctcctggcct gtatcagcat ggaccggtac attgccatcg tccaggcaac
     1021 caaatctttc cgggtacgct ccagaacact gacgcacagt aaggtcatct gtgtggcagt
     1081 gtggttcatc tccatcatca tctcaagccc tacatttatc ttcaacaaga aatacgagct
     1141 gcaggatcgt gatgtctgtg agccacggta caggtctgtc tcagagccca tcacgtggaa
     1201 gctgctgggt atgggactgg agctgttctt tgggttcttc acccctttgc tgtttatggt
     1261 gttctgctat ctgttcatta tcaagacctt ggtgcaggcc cagaactcca agaggcacag
     1321 agcaatccga gtcgtgatcg ctgtggttct cgtgttcctg gcttgtcaga tccctcacaa
     1381 catggtcctc ctcgtgactg cggtcaacac gggcaaagtg ggccggagct gcagcaccga
     1441 gaaagtcctc gcctacacca ggaacgtggc cgaggtcctg gctttcctgc attgctgcct
     1501 caaccccgtg ttgtatgcgt ttattggaca gaaattcaga aactacttca tgaagatcat
     1561 gaaggatgtg tggtgtatga gaaggaagaa taagatgcct ggcttcctct gtgcccgggt
     1621 ttactcggaa agctacatct ccaggcagac cagtgagacc gtcgaaaatg ataatgcatc
     1681 gtcctttacc atgtaacacg agagcacaaa gcaacattgc cccaaaagcc ttggtgaaac
     1741 ttgctattac atatgaaaaa aaaaaaaaa
//
