LOCUS       NM_009917               2926 bp    mRNA    linear   ROD 17-DEC-2024
DEFINITION  Mus musculus C-C motif chemokine receptor 5 (Ccr5), mRNA.
ACCESSION   NM_009917
VERSION     NM_009917.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2926)
  AUTHORS   Ren,X.S., He,J., Li,S., Hu,H., Kyle,M., Kohsaka,S. and Zhao,L.R.
  TITLE     Hematopoietic Growth Factors Regulate the Entry of Monocytes into
            the Adult Brain via Chemokine Receptor CCR5
  JOURNAL   Int J Mol Sci 25 (16), 8898 (2024)
   PUBMED   39201584
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2926)
  AUTHORS   Amorim Sacramento,L., Farias Amorim,C., G Lombana,C., Beiting,D.,
            Novais,F., P Carvalho,L., M Carvalho,E. and Scott,P.
  TITLE     CCR5 promotes the migration of pathological CD8+ T cells to the
            leishmanial lesions
  JOURNAL   PLoS Pathog 20 (5), e1012211 (2024)
   PUBMED   38709823
  REMARK    GeneRIF: CCR5 promotes the migration of pathological CD8+ T cells
            to the leishmanial lesions.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2926)
  AUTHORS   Costa,R.M., Cerqueira,D.M., Bruder-Nascimento,A., Alves,J.V.,
            Awata,W.M.C., Singh,S., Kufner,A., Prado,D.S., Johny,E.,
            Cifuentes-Pagano,E., Hawse,W.F., Dutta,P., Pagano,P.J., Ho,J. and
            Bruder-Nascimento,T.
  TITLE     Role of the CCL5 and Its Receptor, CCR5, in the Genesis of
            Aldosterone-Induced Hypertension, Vascular Dysfunction, and
            End-Organ Damage
  JOURNAL   Hypertension 81 (4), 776-786 (2024)
   PUBMED   38240165
  REMARK    GeneRIF: Role of the CCL5 and Its Receptor, CCR5, in the Genesis of
            Aldosterone-Induced Hypertension, Vascular Dysfunction, and
            End-Organ Damage.
REFERENCE   4  (bases 1 to 2926)
  AUTHORS   Huang,H.Y., Salinas,S., Cornell,J., Udoh,I.B., Shen,Y. and Zhou,M.
  TITLE     CCR5 regulates Abeta1-42-induced learning and memory deficits in
            mice
  JOURNAL   Neurobiol Learn Mem 208, 107890 (2024)
   PUBMED   38215963
  REMARK    GeneRIF: CCR5 regulates Abeta1-42-induced learning and memory
            deficits in mice.
REFERENCE   5  (bases 1 to 2926)
  AUTHORS   Heine,A., Lemmermann,N.A.W., Flores,C., Becker-Gotot,J., Garbi,N.,
            Brossart,P. and Kurts,C.
  TITLE     Rapid protection against viral infections by chemokine-accelerated
            post-exposure vaccination
  JOURNAL   Front Immunol 15, 1338499 (2024)
   PUBMED   38348028
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2926)
  AUTHORS   Doranz,B.J., Lu,Z.H., Rucker,J., Zhang,T.Y., Sharron,M., Cen,Y.H.,
            Wang,Z.X., Guo,H.H., Du,J.G., Accavitti,M.A., Doms,R.W. and
            Peiper,S.C.
  TITLE     Two distinct CCR5 domains can mediate coreceptor usage by human
            immunodeficiency virus type 1
  JOURNAL   J Virol 71 (9), 6305-6314 (1997)
   PUBMED   9261347
REFERENCE   7  (bases 1 to 2926)
  AUTHORS   Bieniasz,P.D., Fridell,R.A., Aramori,I., Ferguson,S.S., Caron,M.G.
            and Cullen,B.R.
  TITLE     HIV-1-induced cell fusion is mediated by multiple regions within
            both the viral envelope and the CCR-5 co-receptor
  JOURNAL   EMBO J 16 (10), 2599-2609 (1997)
   PUBMED   9184207
REFERENCE   8  (bases 1 to 2926)
  AUTHORS   Nibbs,R.J., Wylie,S.M., Pragnell,I.B. and Graham,G.J.
  TITLE     Cloning and characterization of a novel murine beta chemokine
            receptor, D6. Comparison to three other related macrophage
            inflammatory protein-1alpha receptors, CCR-1, CCR-3, and CCR-5
  JOURNAL   J Biol Chem 272 (19), 12495-12504 (1997)
   PUBMED   9139699
REFERENCE   9  (bases 1 to 2926)
  AUTHORS   Meyer,A., Coyle,A.J., Proudfoot,A.E., Wells,T.N. and Power,C.A.
  TITLE     Cloning and characterization of a novel murine macrophage
            inflammatory protein-1 alpha receptor
  JOURNAL   J Biol Chem 271 (24), 14445-14451 (1996)
   PUBMED   8662890
  REMARK    Erratum:[J Biol Chem 1996 Sep 20;271(38):23601]
REFERENCE   10 (bases 1 to 2926)
  AUTHORS   Boring,L., Gosling,J., Monteclaro,F.S., Lusis,A.J., Tsou,C.L. and
            Charo,I.F.
  TITLE     Molecular cloning and functional expression of murine JE (monocyte
            chemoattractant protein 1) and murine macrophage inflammatory
            protein 1alpha receptors: evidence for two closely linked C-C
            chemokine receptors on chromosome 9
  JOURNAL   J Biol Chem 271 (13), 7551-7558 (1996)
   PUBMED   8631787
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY198155.1, BC103574.1, AK155628.1 and BG091923.1.
            
            On Dec 11, 2007 this sequence version replaced NM_009917.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK154595.1, AK155628.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-61                BY198155.1         2-62
            62-1388             BC103574.1         1-1327
            1389-2549           AK155628.1         1363-2523
            2550-2924           AK155628.1         2525-2899
            2925-2926           BG091923.1         3-4                 c
FEATURES             Location/Qualifiers
     source          1..2926
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 75.05 cM"
     gene            1..2926
                     /gene="Ccr5"
                     /gene_synonym="AM4-7; CD195; Cmkbr5"
                     /note="C-C motif chemokine receptor 5"
                     /db_xref="GeneID:12774"
                     /db_xref="MGI:MGI:107182"
     exon            1..93
                     /gene="Ccr5"
                     /gene_synonym="AM4-7; CD195; Cmkbr5"
                     /inference="alignment:Splign:2.1.0"
     exon            94..2926
                     /gene="Ccr5"
                     /gene_synonym="AM4-7; CD195; Cmkbr5"
                     /inference="alignment:Splign:2.1.0"
     CDS             105..1169
                     /gene="Ccr5"
                     /gene_synonym="AM4-7; CD195; Cmkbr5"
                     /note="CCR-5; CC-CKR-5; C-C CKR-5; MIP-1 alpha receptor;
                     chemokine (C-C) receptor 5; chemokine (C-C motif) receptor
                     5"
                     /codon_start=1
                     /product="C-C chemokine receptor type 5"
                     /protein_id="NP_034047.2"
                     /db_xref="CCDS:CCDS40821.1"
                     /db_xref="GeneID:12774"
                     /db_xref="MGI:MGI:107182"
                     /translation="MDFQGSVPTYSYDIDYGMSAPCQKINVKQIAAQLLPPLYSLVFI
                     FGFVGNMMVFLILISCKKLKSVTDIYLLNLAISDLLFLLTLPFWAHYAANEWVFGNIM
                     CKVFTGLYHIGYFGGIFFIILLTIDRYLAIVHAVFALKVRTVNFGVITSVVTWAVAVF
                     ASLPEIIFTRSQKEGFHYTCSPHFPHTQYHFWKSFQTLKMVILSLILPLLVMVICYSG
                     ILHTLFRCRNEKKRHRAVRLIFAIMIVYFLFWTPYNIVLLLTTFQEFFGLNNCSSSNR
                     LDQAMQATETLGMTHCCLNPVIYAFVGEKFRSYLSVFFRKHMVKRFCKRCSIFQQDNP
                     DRASSVYTRSTGEHEVSTGL"
     regulatory      2907..2912
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ccr5"
                     /gene_synonym="AM4-7; CD195; Cmkbr5"
                     /note="hexamer: AATAAA"
     polyA_site      2926
                     /gene="Ccr5"
                     /gene_synonym="AM4-7; CD195; Cmkbr5"
                     /note="major polyA site"
ORIGIN      
        1 gtgtttctta ctttatactg tcttcatgtt agatttgtac agctctccta gccagaggag
       61 gtgagacatc cgttccccct acaagagact ctggctcttg caggatggat tttcaagggt
      121 cagttccgac ctatagctat gacatcgatt atggtatgtc agcaccctgc caaaaaatca
      181 atgtgaaaca aattgcggct cagctcctgc ccccactcta ctccctggta ttcatctttg
      241 gttttgtggg taacatgatg gtcttcctca tcttgataag ctgcaaaaag ctgaagagcg
      301 tgactgatat ctacctgctc aacctggcca tctctgacct gctcttcctg ctcacactac
      361 cattctgggc tcactatgct gcaaatgagt gggtctttgg gaacataatg tgtaaagtat
      421 tcacagggct ctatcacatt ggttattttg gtggaatctt cttcattatc ctcctgacaa
      481 ttgataggta cttggctatt gtccatgctg tgtttgcttt aaaagtcaga acggtcaact
      541 ttggggtgat aacaagtgta gtcacttggg cggtggctgt gtttgcctct ctcccagaaa
      601 taatctttac cagatctcag aaagaaggtt ttcattatac atgcagtcct cattttccac
      661 acactcagta tcatttctgg aagagtttcc aaacattaaa gatggtcatc ttgagcctga
      721 tcctgcctct acttgtcatg gtcatctgct actcaggaat tctccacacc ctgtttcgct
      781 gtaggaatga gaagaagagg cacagggctg tgaggctcat ctttgccatc atgattgtct
      841 actttctctt ctggactccc tacaacattg tcctcctcct gaccaccttc caggaattct
      901 ttggactgaa taactgcagt agttctaata gactagacca ggccatgcag gcaacagaga
      961 ctcttggaat gacacactgc tgcctaaacc ctgtcatcta tgcctttgtt ggagagaagt
     1021 tccggagtta tctctcagtg ttcttccgaa aacacatggt caaacgcttt tgcaaacggt
     1081 gttcaatttt ccagcaagac aatcctgatc gtgcaagctc agtctatacc cgatccacag
     1141 gagaacatga agtttctact ggtttatgac ctggttgact tttgtgtatc acgtagtttt
     1201 tctatgcagc ttgggagtag gaatggttct tttaaaaaaa gaaattagta tcatagaggg
     1261 cccaagatac atgcatcttt ttgatattta tttttagata gattgggtct tttaaaactg
     1321 aatggggagg ttggggtgga ggagcaggga gaacgagtct tttatcaggg ccgggaaata
     1381 tgcacaaaga gacttgaggc aggtgccatg acccatatgc aaagggacgg acacagggcc
     1441 gatgctgtgg cctagagatg acgtgtctca ccgctgggtt cctgaaaggc ggctgtaaat
     1501 atgcctgatt gccataaagt cgcttcttgc tgtctatgga tgtgcctgac tgccaacagg
     1561 gaagaaccac ttctgcctat aaaacgtaga gtcagcagaa cttggggtaa atcggagtta
     1621 gaggtgcata agaaccccta ggcttagtta ggttgaaata cccattgagg aaacagcaaa
     1681 tacaaaggaa gaataaagag tttagccggg aaggtagtct cattttacag ccggaatata
     1741 atgttatctc aggctagcat tttgttcctg ccttcagacc taaatcctac cacaccggga
     1801 ctgtgaaaca cctggattat gaatcatgag cctgaggtct aggaataata ataacgtttg
     1861 tgattttaga tgagggctgt ttccatagtt tgaagccaga actttatcat cttgagcaga
     1921 agctccaaga gatgaggaaa gagcaccaat ttttctctaa tttacttagc agtcatcatc
     1981 tctggaagat tcattttaga aacaagttgt tgtgcccctc agaagccatg agagtataac
     2041 gactgctctc tgtgttccag gctgagtatg aggacttcag tcacactttc cagatggctt
     2101 ctccacacaa acaatgctaa gtttggccat ttcagaggtt taggattttt tgttgttttt
     2161 gcagttgata ttttgaattt tagagcagtt gagatcttcc tagtgaaggc tagaggagga
     2221 aagaaagggg ttagaatctc tcaggagatt aaagtttctg cctaacaaga ggtgttactg
     2281 gtttttctca agctccgatt gtgaaaccag aggcctggga ctgtcagcag gaagtgagca
     2341 tttgcttttt tcttccttgt gatccacatt cctcccccac tctgttgctc agactggcgt
     2401 caagctcacg atcctcctgc ttacatctca agttctgaga ttacaagtat atgtgaacat
     2461 atccagcggt tattttattc attagcatat agaaagttat acgttctttg aagataatga
     2521 gtcttataaa aagtgctttg taaaaaaaat tgcattttat actttcaatc aagtgtacat
     2581 ttagtgagta gtacgtaaaa ttatgagagt attttgtaag tagttgtttt ggagaacgcc
     2641 cccaataata cttgtttaaa tatagcgttc ttggattaag tgggtggtgg tgatgataat
     2701 atttccttga aagtattttt agccgttaac tttcttcctt aaacaatttt tcataataat
     2761 ttgttcttaa agatgttatg tccaagcatg cagtttcgga gcagtgttgc tttgaaagag
     2821 tgtaaatttt aaattgtgct tactctcaat caaaagagtt ttaacatatt tacgaattta
     2881 tttcagaagt caagaatctg gttgaaaata aagatatgca acttta
//
