LOCUS       NM_009916               2787 bp    mRNA    linear   ROD 11-OCT-2024
DEFINITION  Mus musculus C-C motif chemokine receptor 4 (Ccr4), mRNA.
ACCESSION   NM_009916
VERSION     NM_009916.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2787)
  AUTHORS   Yuan,Y., Hu,R., Park,J., Xiong,S., Wang,Z., Qian,Y., Shi,Z., Wu,R.,
            Han,Z., Ong,S.G., Lin,S., Varady,K.A., Xu,P., Berry,D.C., Shu,G.
            and Jiang,Y.
  TITLE     Macrophage-derived chemokine CCL22 establishes local LN-mediated
            adaptive thermogenesis and energy expenditure
  JOURNAL   Sci Adv 10 (26), eadn5229 (2024)
   PUBMED   38924414
REFERENCE   2  (bases 1 to 2787)
  AUTHORS   Lee,S., Kim,J., You,J.S., Hyun,Y.M., Kim,J.Y. and Lee,J.E.
  TITLE     Ischemic stroke outcome after promoting CD4+CD25+ Treg cell
            migration through CCR4 overexpression in a tMCAO animal model
  JOURNAL   Sci Rep 14 (1), 10201 (2024)
   PUBMED   38702399
  REMARK    GeneRIF: Ischemic stroke outcome after promoting CD4+CD25+ Treg
            cell migration through CCR4 overexpression in a tMCAO animal model.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2787)
  AUTHORS   Heine,A., Lemmermann,N.A.W., Flores,C., Becker-Gotot,J., Garbi,N.,
            Brossart,P. and Kurts,C.
  TITLE     Rapid protection against viral infections by chemokine-accelerated
            post-exposure vaccination
  JOURNAL   Front Immunol 15, 1338499 (2024)
   PUBMED   38348028
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2787)
  AUTHORS   Sato,M., Matsuo,K., Susami,Y., Yamashita,A., Hayasaka,H., Hara,Y.,
            Nishiwaki,K., Oiso,N., Kawada,A., Otsuka,A. and Nakayama,T.
  TITLE     A CCR4 antagonist attenuates atopic dermatitis-like skin
            inflammation by inhibiting the recruitment and expansion of Th2
            cells and Th17 cells
  JOURNAL   Int Immunol 35 (9), 437-446 (2023)
   PUBMED   37279584
REFERENCE   5  (bases 1 to 2787)
  AUTHORS   Li,Y., Guaman Tipan,P., Selden,H.J., Srinivasan,J., Hale,L.P. and
            Ehrlich,L.I.R.
  TITLE     CCR4 and CCR7 differentially regulate thymocyte localization with
            distinct outcomes for central tolerance
  JOURNAL   Elife 12, e80443 (2023)
   PUBMED   37266571
  REMARK    GeneRIF: CCR4 and CCR7 differentially regulate thymocyte
            localization with distinct outcomes for central tolerance.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2787)
  AUTHORS   Youn,B.S., Kim,S.H., Lyu,M.S., Kozak,C.A., Taub,D.D. and Kwon,B.S.
  TITLE     Molecular cloning and characterization of a cDNA, CHEMR1, encoding
            a chemokine receptor with a homology to the human C-C chemokine
            receptor, CCR-4
  JOURNAL   Blood 89 (12), 4448-4460 (1997)
   PUBMED   9192769
REFERENCE   7  (bases 1 to 2787)
  AUTHORS   Heesen,M., Berman,M.A., Hopken,U.E., Gerard,N.P. and Dorf,M.E.
  TITLE     Alternate splicing of mouse fusin/CXC chemokine receptor-4: stromal
            cell-derived factor-1alpha is a ligand for both CXC chemokine
            receptor-4 isoforms
  JOURNAL   J Immunol 158 (8), 3561-3564 (1997)
   PUBMED   9103415
REFERENCE   8  (bases 1 to 2787)
  AUTHORS   Heesen,M., Berman,M.A., Benson,J.D., Gerard,C. and Dorf,M.E.
  TITLE     Cloning of the mouse fusin gene, homologue to a human HIV-1
            co-factor
  JOURNAL   J Immunol 157 (12), 5455-5460 (1996)
   PUBMED   8955194
REFERENCE   9  (bases 1 to 2787)
  AUTHORS   Nagasawa,T., Nakajima,T., Tachibana,K., Iizasa,H., Bleul,C.C.,
            Yoshie,O., Matsushima,K., Yoshida,N., Springer,T.A. and
            Kishimoto,T.
  TITLE     Molecular cloning and characterization of a murine pre-B-cell
            growth-stimulating factor/stromal cell-derived factor 1 receptor, a
            murine homolog of the human immunodeficiency virus 1 entry
            coreceptor fusin
  JOURNAL   Proc Natl Acad Sci U S A 93 (25), 14726-14729 (1996)
   PUBMED   8962122
REFERENCE   10 (bases 1 to 2787)
  AUTHORS   Hoogewerf,A., Black,D., Proudfoot,A.E., Wells,T.N. and Power,C.A.
  TITLE     Molecular cloning of murine CC CKR-4 and high affinity binding of
            chemokines to murine and human CC CKR-4
  JOURNAL   Biochem Biophys Res Commun 218 (1), 337-343 (1996)
   PUBMED   8573157
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC119171.1 and AC164109.2.
            
            On Dec 11, 2007 this sequence version replaced NM_009916.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript that matched the
            reference genome assembly perfectly was available for the full
            length of the gene. The extent of this transcript is supported by
            transcript alignments and published experimental data.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK042013.1, X90862.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1382              BC119171.1         6-1387
            1383-2787           AC164109.2         105405-106809
FEATURES             Location/Qualifiers
     source          1..2787
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 64.49 cM"
     gene            1..2787
                     /gene="Ccr4"
                     /gene_synonym="C-C CKR-4; CHEMR1; Cmkbr4; LESTR; Sdf1r"
                     /note="C-C motif chemokine receptor 4"
                     /db_xref="GeneID:12773"
                     /db_xref="MGI:MGI:107824"
     exon            1..47
                     /gene="Ccr4"
                     /gene_synonym="C-C CKR-4; CHEMR1; Cmkbr4; LESTR; Sdf1r"
                     /inference="alignment:Splign:2.1.0"
     exon            48..2787
                     /gene="Ccr4"
                     /gene_synonym="C-C CKR-4; CHEMR1; Cmkbr4; LESTR; Sdf1r"
                     /inference="alignment:Splign:2.1.0"
     CDS             108..1190
                     /gene="Ccr4"
                     /gene_synonym="C-C CKR-4; CHEMR1; Cmkbr4; LESTR; Sdf1r"
                     /EC_number="3.1.13.4"
                     /note="fusin; leukocyte-expressed
                     seven-transmembrane-domain receptor; chemokine (C-C)
                     receptor 4; chemokine (C-C motif) receptor 4"
                     /codon_start=1
                     /product="C-C chemokine receptor type 4"
                     /protein_id="NP_034046.2"
                     /db_xref="CCDS:CCDS23594.1"
                     /db_xref="GeneID:12773"
                     /db_xref="MGI:MGI:107824"
                     /translation="MNATEVTDTTQDETVYNSYYFYESMPKPCTKEGIKAFGEVFLPP
                     LYSLVFLLGLFGNSVVVLVLFKYKRLKSMTDVYLLNLAISDLLFVLSLPFWGYYAADQ
                     WVFGLGLCKIVSWMYLVGFYSGIFFIMLMSIDRYLAIVHAVFSLKARTLTYGVITSLI
                     TWSVAVFASLPGLLFSTCYTEHNHTYCKTQYSVNSTTWKVLSSLEINVLGLLIPLGIM
                     LFCYSMIIRTLQHCKNEKKNRAVRMIFAVVVLFLGFWTPYNVVLFLETLVELEVLQDC
                     TLERYLDYAIQATETLAFIHCCLNPVIYFFLGEKFRKYITQLFRTCRGPLVLCKHCDF
                     LQVYSADMSSSSYTQSTVDHDFRDAL"
     regulatory      1458..1463
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ccr4"
                     /gene_synonym="C-C CKR-4; CHEMR1; Cmkbr4; LESTR; Sdf1r"
                     /note="hexamer: CATAAA"
     polyA_site      1481
                     /gene="Ccr4"
                     /gene_synonym="C-C CKR-4; CHEMR1; Cmkbr4; LESTR; Sdf1r"
                     /note="major polyA site"
ORIGIN      
        1 ggcattgctt catagactgt cctcaggatc actttcagaa gagcaaggca gctcaactgt
       61 tctcattggc ttctcctgct ggtacccgga gcgcgacgat tccaaagatg aatgccacag
      121 aggtcacaga caccacccag gatgaaactg tgtacaatag ttattacttc tacgaaagca
      181 tgccaaagcc ttgcaccaag gaaggtatca aggcatttgg ggaggtcttc ctgcctcctc
      241 tctactcctt ggtcttcttg ttgggtctgt ttggaaattc tgttgtggtt ctggtcctgt
      301 tcaaatacaa gaggctcaag tccatgacgg acgtgtacct gctgaacctg gccatctcgg
      361 atttgctgtt cgtcctgtcc ctcccattct ggggctacta cgccgccgac cagtgggttt
      421 ttggactagg tctgtgcaag atcgtttcat ggatgtacct ggtgggcttc tacagcggca
      481 tcttcttcat catgctcatg agcatagaca gatacctggc catcgtgcac gcggtattct
      541 ccttgaaggc aaggaccctg acctatggcg tcatcaccag cctgatcacg tggtcagtgg
      601 ctgtgtttgc ctccctccca ggcctcttgt tcagcacttg ctacacagag cacaaccaca
      661 cgtactgcaa aacccagtac tcggtcaact cgacgacgtg gaaagtcctc agctccctgg
      721 agatcaacgt cctggggctg cttatccccc tgggcatcat gctgttttgt tattccatga
      781 tcattaggac tctgcaacac tgcaagaatg agaagaagaa cagagcagtg cgcatgatct
      841 tcgccgtggt ggtcctcttc ctcggcttct ggacgccgta caacgtggtg cttttcctgg
      901 agacgctggt ggagcttgaa gtccttcagg actgcacctt ggagaggtac ctagactacg
      961 ccatccaggc tacagaaacc ctggccttca ttcactgctg ccttaacccc gtcatttact
     1021 tctttctcgg ggagaaattc cgcaagtaca tcacccaact cttcagaaca tgccggggtc
     1081 ccctcgtgct ctgcaaacac tgtgacttcc tccaggtcta ctcggctgac atgtccagct
     1141 cctcttacac gcagtccact gtggatcatg acttccgtga cgctttgtaa ggtgtgagtg
     1201 ggggtaacat ggcgttaaca agctccacac acccagcacc tgctcgcctt gtttcagtca
     1261 gggtgccctg aacagggctc tgaggaagaa aacaagtaaa accaagacca tggcaagatg
     1321 gcttctcacc ctgcaggtgg ctcccaagag gttcagagcc ctgctgggtg gaggaaatca
     1381 ccccttcatg acaatgagcc cttgagtgga tctctagttt tgttgaacta cctagaattc
     1441 ttggacatgc tgtattccat aaagccagat gtctggagaa atgaggatct gacatcttga
     1501 ttctcttatt atagaggatg cttcattgaa gcctggttac aagcgtagag ataagggtgt
     1561 tgggacaatc ccttctccac ttaacacaag gtgtgtagaa cacacatcgg ttgaaatgtc
     1621 cgtgcagttt ggctttctgg tatgttttaa ttgtgatagg tgtttgttca gcttgtagaa
     1681 gaagctcgtc ggtgcagaga agggtgaaat gcccttgtaa ttctagctac tccggggata
     1741 aggccaagag atcttagatt caaggatggc ctggacaata cagtgaaagc ctgtccccaa
     1801 accaaaccaa accaaaccca aacccaaatc aaaaccaaat gaaaggcaag caatacccca
     1861 aaagttagct ctgaaatgct cttgtgagca ccctaagttc atctttcttt tcattttctt
     1921 ttatttacgc cttctctttc cttctccttc ttctttctcc ttcttcttgt cctccttctt
     1981 tcttctcctc cttctttctt cttttcttct tcttcttctt cttcttcttc ttcttcttct
     2041 tcttcttctt cttcttcttc ttcttcttct tcttcttctt cttctaactg ttattgggta
     2101 ttgggcatgg tggaggcaga ggcaggagta tctctgagtt cgaggccagc ctggtctaca
     2161 aatctagttc caggacagat agggctacac agagaaaccc tgtcttgcag aaacaaacaa
     2221 acaaacaagc aagcaaacaa acaaatgtaa actggatgag cctgtggtgg gcacaccttt
     2281 aatcccagcg ctcgacaggc caggcaggtg gatttctgta agtcgaggcc agcctggtct
     2341 acagagctag ttccagacca gccaaggcta tttagtgaga ctttgtcttg aaaagaaagg
     2401 aggaaagaaa gaaaatagta aatgtattaa taaagtatga caatattcct ttaatcactt
     2461 taaagggtca tgtcaactac tgagacacaa ataatcactt aaaaatcatt ataggtaggg
     2521 tgttaaaata actatcaaat tatgaagttg taaaaaacat cctttgtaaa atattggctc
     2581 cagtttctga atattagttg tattaaaagt tagaacagtt agggcatgac ggtactcacc
     2641 tttaatttca gcactccaga ggccagggga ggagttcaag tctcgcctgg tctacagcat
     2701 gagctccagg acagataaca ttagaacagt tattcttacg ttatcttaat tgtttaatgt
     2761 gttagatcat taaagttatt tgctaag
//
