LOCUS       NM_009914               3273 bp    mRNA    linear   ROD 06-DEC-2024
DEFINITION  Mus musculus C-C motif chemokine receptor 3 (Ccr3), mRNA.
ACCESSION   NM_009914
VERSION     NM_009914.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3273)
  AUTHORS   Immler,R., Nussbaumer,K., Doerner,A., El Bounkari,O., Huber,S.,
            Abisch,J., Napoli,M., Schmidt,S., Margraf,A., Pruenster,M.,
            Rohwedder,I., Lange-Sperandio,B., Mall,M.A., de Jong,R.,
            Ohnmacht,C., Bernhagen,J., Voehringer,D., Marth,J.D., Frommhold,D.
            and Sperandio,M.
  TITLE     CCR3-dependent eosinophil recruitment is regulated by
            sialyltransferase ST3Gal-IV
  JOURNAL   Proc Natl Acad Sci U S A 121 (19), e2319057121 (2024)
   PUBMED   38687790
  REMARK    GeneRIF: CCR3-dependent eosinophil recruitment is regulated by
            sialyltransferase ST3Gal-IV.
REFERENCE   2  (bases 1 to 3273)
  AUTHORS   Kim,H.J., Jang,J., Na,K., Lee,E.H., Gu,H.J., Lim,Y.H., Joo,S.A.,
            Baek,S.E., Roh,J.Y., Maeng,H.J., Kim,Y.H., Lee,Y.J., Oh,B.C. and
            Jung,Y.
  TITLE     TLR7-dependent eosinophil degranulation links psoriatic skin
            inflammation to small intestinal inflammatory changes in mice
  JOURNAL   Exp Mol Med 56 (5), 1164-1177 (2024)
   PUBMED   38689088
REFERENCE   3  (bases 1 to 3273)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 3273)
  AUTHORS   Zhang,Y., Wang,M., Liu,Z., Zhu,X., Huang,Q., Wang,J. and Liu,Y.
  TITLE     CCR3 gene knockout inhibits proliferation, differentiation, and
            migration of eosinophils in allergic rhinitis model mice
  JOURNAL   Mol Immunol 162, 1-10 (2023)
   PUBMED   37611377
  REMARK    GeneRIF: CCR3 gene knockout inhibits proliferation,
            differentiation, and migration of eosinophils in allergic rhinitis
            model mice.
REFERENCE   5  (bases 1 to 3273)
  AUTHORS   Rege,S.V., Teichert,A., Masumi,J., Dhande,O.S., Harish,R.,
            Higgins,B.W., Lopez,Y., Akrapongpisak,L., Hackbart,H.,
            Caryotakis,S., Leone,D.P., Szoke,B., Hannestad,J., Nikolich,K.,
            Braithwaite,S.P. and Minami,S.S.
  TITLE     CCR3 plays a role in murine age-related cognitive changes and
            T-cell infiltration into the brain
  JOURNAL   Commun Biol 6 (1), 292 (2023)
   PUBMED   36934154
  REMARK    GeneRIF: CCR3 plays a role in murine age-related cognitive changes
            and T-cell infiltration into the brain.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3273)
  AUTHORS   Quackenbush,E.J., Aguirre,V., Wershil,B.K. and Gutierrez-Ramos,J.C.
  TITLE     Eotaxin influences the development of embryonic hematopoietic
            progenitors in the mouse
  JOURNAL   J Leukoc Biol 62 (5), 661-666 (1997)
   PUBMED   9365121
REFERENCE   7  (bases 1 to 3273)
  AUTHORS   Nibbs,R.J., Wylie,S.M., Pragnell,I.B. and Graham,G.J.
  TITLE     Cloning and characterization of a novel murine beta chemokine
            receptor, D6. Comparison to three other related macrophage
            inflammatory protein-1alpha receptors, CCR-1, CCR-3, and CCR-5
  JOURNAL   J Biol Chem 272 (19), 12495-12504 (1997)
   PUBMED   9139699
REFERENCE   8  (bases 1 to 3273)
  AUTHORS   Post,T.W., Bozic,C.R., Rothenberg,M.E., Luster,A.D., Gerard,N. and
            Gerard,C.
  TITLE     Molecular characterization of two murine eosinophil beta chemokine
            receptors
  JOURNAL   J Immunol 155 (11), 5299-5305 (1995)
   PUBMED   7594543
REFERENCE   9  (bases 1 to 3273)
  AUTHORS   Kozak,C.A., Gao,J.L. and Murphy,P.M.
  TITLE     Mapping of the mouse macrophage inflammatory protein-1 alpha
            receptor gene Scya3r and two related mouse beta chemokine
            receptor-like genes to chromosome 9
  JOURNAL   Genomics 29 (1), 294-296 (1995)
   PUBMED   8530091
REFERENCE   10 (bases 1 to 3273)
  AUTHORS   Gao,J.L. and Murphy,P.M.
  TITLE     Cloning and differential tissue-specific expression of three mouse
            beta chemokine receptor-like genes, including the gene for a
            functional macrophage inflammatory protein-1 alpha receptor
  JOURNAL   J Biol Chem 270 (29), 17494-17501 (1995)
   PUBMED   7542241
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK041106.1, AK153518.1 and AC192862.1.
            
            On Sep 6, 2007 this sequence version replaced NM_009914.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK153518.1, AK089895.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1759              AK041106.1         2-1760
            1760-2524           AK153518.1         1762-2526
            2525-3273           AC192862.1         78038-78786
FEATURES             Location/Qualifiers
     source          1..3273
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 75.05 cM"
     gene            1..3273
                     /gene="Ccr3"
                     /gene_synonym="CC-CKR3; CKR3; Cmkbr1l2; Cmkbr3"
                     /note="C-C motif chemokine receptor 3"
                     /db_xref="GeneID:12771"
                     /db_xref="MGI:MGI:104616"
     exon            1..202
                     /gene="Ccr3"
                     /gene_synonym="CC-CKR3; CKR3; Cmkbr1l2; Cmkbr3"
                     /inference="alignment:Splign:2.1.0"
     exon            203..3273
                     /gene="Ccr3"
                     /gene_synonym="CC-CKR3; CKR3; Cmkbr1l2; Cmkbr3"
                     /inference="alignment:Splign:2.1.0"
     CDS             214..1293
                     /gene="Ccr3"
                     /gene_synonym="CC-CKR3; CKR3; Cmkbr1l2; Cmkbr3"
                     /note="chemokine (C-C) receptor 3; CC chemokine receptor
                     3; CCR-3; CC-CKR-3; C-C CKR-3; MIP-1 alpha RL2; macrophage
                     inflammatory protein 1-alpha receptor-like 2; chemokine
                     (C-C) receptor 1,-like 2; MIP-1 alphaRL2; chemokine (C-C
                     motif) receptor 3"
                     /codon_start=1
                     /product="probable C-C chemokine receptor type 3"
                     /protein_id="NP_034044.3"
                     /db_xref="CCDS:CCDS23668.1"
                     /db_xref="GeneID:12771"
                     /db_xref="MGI:MGI:104616"
                     /translation="MAFNTDEIKTVVESFETTPYEYEWAPPCEKVRIKELGSWLLPPL
                     YSLVFIIGLLGNMMVVLILIKYRKLQIMTNIYLFNLAISDLLFLFTVPFWIHYVLWNE
                     WGFGHYMCKMLSGFYYLALYSEIFFIILLTIDRYLAIVHAVFALRARTVTFATITSII
                     TWGLAGLAALPEFIFHESQDSFGEFSCSPRYPEGEEDSWKRFHALRMNIFGLALPLLI
                     MVICYSGIIKTLLRCPNKKKHKAIRLIFVVMIVFFIFWTPYNLVLLFSAFHSTFLETS
                     CQQSKHLDLAMQVTEVIAYTHCCINPVIYAFVGERFRKHLRLFFHRNVAVYLGKYIPF
                     LPGEKMERTSSVSPSTGEQEISVVF"
     regulatory      2263..2268
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ccr3"
                     /gene_synonym="CC-CKR3; CKR3; Cmkbr1l2; Cmkbr3"
                     /note="hexamer: AATAAA"
     polyA_site      2289
                     /gene="Ccr3"
                     /gene_synonym="CC-CKR3; CKR3; Cmkbr1l2; Cmkbr3"
                     /note="major polyA site"
ORIGIN      
        1 agtaaataac aaaacggaag aactgtaaca agttggtatc tctctgaaaa cttgcaaaac
       61 ctgagaagct agccttttta aaacaggaag ctatgatgtt tactacctga ctggtgtata
      121 tgatcaagtg ttatctctgt ttcattagca gtgaaactta agttactact ggactcataa
      181 aggacttagc aaaattcacc agagacaagt agaatggcat tcaacacaga tgaaatcaag
      241 actgtggttg aaagctttga gaccacaccc tatgaatatg agtgggcacc accctgtgaa
      301 aaagtcagaa tcaaagagct ggggtcatgg ctcctgcctc cactgtactc cctggtgttc
      361 atcatcggcc tcctgggcaa catgatggtt gtgttgatcc tcataaagta caggaagcta
      421 caaattatga ctaatatcta cctgttcaac ttggcaattt ctgacctgct ctttctcttc
      481 actgtcccat tctggattca ctatgttctg tggaatgagt ggggttttgg ccactacatg
      541 tgcaaaatgc tgtctgggtt ttattacctg gccttgtaca gcgagatctt tttcatcatc
      601 ctgctgacaa ttgacagata cctggctatc gtccatgctg tgtttgccct tcgagcccga
      661 actgtgactt ttgctactat caccagtatc attacctggg gccttgcagg actggcagca
      721 ttgcctgaat ttatcttcca tgagtctcaa gacagctttg gagagttttc ctgcagtcct
      781 cgctatccag agggtgaaga agacagctgg aaacgtttcc atgctctaag aatgaatatc
      841 tttggtctag ctcttcctct cctcattatg gttatctgct actcaggaat cattaaaact
      901 ctgctgagat gtcccaataa aaaaaaacac aaggccatcc gtcttatttt tgttgttatg
      961 atagtctttt ttattttttg gaccccgtac aacctggttc tccttttttc tgcttttcac
     1021 agcacatttt tagagaccag ctgtcagcag agtaaacatc tggacctggc catgcaggtg
     1081 actgaggtga ttgcctacac ccactgctgt attaatccag taatctacgc ctttgttggt
     1141 gagaggttcc ggaaacacct tcggctcttt ttccacagaa atgtggcagt ttacctggga
     1201 aaatatattc cgtttcttcc tggtgagaaa atggaaagaa caagctctgt ctccccatca
     1261 actggggagc aagaaatctc tgtggtgttt tagttgggca gagaaaattg tcacttattc
     1321 catggactga aagatgaagc aaacacatta agtcagtcac aatgacctct agctcagtca
     1381 tttgtactct ccatgcaatg ctgatgctct caaagacctg taaacacaca taataactgc
     1441 agaatatctt catctacccc aagatcatta gtagaggaca tgtgctggcc agttgacaat
     1501 tcatcaaaca tgacatgaaa aagacagctt ttttttttta ttctccaaag agttatacat
     1561 gttctgattc acttaaatgt taaataatcc attcacaagt aggaaggttt aaaaaatatt
     1621 taaactactt ttgccacttt ttgacatcag tgaaatgttt cacaaaatgc atttatttta
     1681 tttcctaacg taagtagttc tttttcttct tgatgaatgg ctttcttttt cctcttttta
     1741 aaaaaattat tatttgaata tagactggat gttatatctt gtttaatttt ttcttaaaag
     1801 tcaaatgaaa tcatatttcc tattagtgat tgaaagcatc ttggaaggaa cacactctcc
     1861 tcataatgcc agttttatgt tgaaaaacag gctggggcca tctgtattga gaagtccagg
     1921 tgtggtgctg tcgttaattc ttcctagact tgacatcata agtacctgga gggtatagtg
     1981 acacatgcac aggtaactcc tattacagga gaagagtaga aatttggaaa cagacatcaa
     2041 gattaacaga tgaagtaaga ctggaaaccc ctttctaccg gccctcacat accaaataga
     2101 ggatgtacaa gaaaagtata tgatatcaca cagaaagaag ttggcactat gcaaataacc
     2161 catgaatgat aagaattcat atgatgcagt gcttttgggt gtttgtcttt tcacagatca
     2221 ttagcctact tctatcctca agaatatctt tttatctttc ttaataaact gcctgtgttt
     2281 ctatcattat ctatatgttc attattctgg cacacagacc ctagaaatct caggaggtgc
     2341 tctctggatt gaagtgtgca cttatagcac cacctcagtg cttatgactc atgtttgaag
     2401 tgaggtctga gcatcaacaa cacgttccca ggtggtggac gtgatacttg tcccaagatc
     2461 acactttcag aattatgttg taactgtgat gcgttcagag actcaacaat tgaaaatgag
     2521 gatgtcacaa gtgttgtagg aggaatatat gggctcttta gatgtttgat aaggttatat
     2581 gctatcatgg tcagctgata agatatgcta gtctatctga aatattacta tagggggaac
     2641 ttacagttct atcagtctat cagttttata cagttgagct tttcttgagt atatgtgttt
     2701 agtactatga actagaagct gtgagagaca caaagatgaa ggaggaaaat ggagtggcta
     2761 tggctcaggc acctttctct cattccttta cttctgatta tagcttcttg gggatgtaac
     2821 ttctaagcct ttacttaact tggcactttt cttttgggta tagcatagtc atctcatgat
     2881 tattttgaag tagagattac cttggtctag taaccatgac aactatttga gcagaacaat
     2941 gaagaggtaa gttagtcagt agtgatgcta ttggagttac tgatactcca tagtagaagg
     3001 aaatataggg tcatagtccc ctcatcttgt attacaacca ttactctctc cttctccaaa
     3061 ttgctcatga tcttgggaga tgataaagat atataagatt ggaagagtta cttgagagtg
     3121 tgactccatg atttcatttt catgaggtca ttatccataa tgggatgaga ttttttgtga
     3181 tgagacagct gtttgagggt aactcactct tttaagtatc ccttcaataa tgctctgtaa
     3241 gtaggctcaa taaactcatt ggtttgctaa gtt
//
