LOCUS       NM_009915               3589 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Mus musculus C-C motif chemokine receptor 2 (Ccr2), mRNA.
ACCESSION   NM_009915
VERSION     NM_009915.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3589)
  AUTHORS   Lehtonen,H., Jokela,H., Hofmann,J., Tola,L., Mehmood,A.,
            Ginhoux,F., Becher,B., Greter,M., Yegutkin,G.G., Salmi,M., Gerke,H.
            and Rantakari,P.
  TITLE     Early precursor-derived pituitary gland tissue-resident macrophages
            play a pivotal role in modulating hormonal balance
  JOURNAL   Cell Rep 44 (2), 115227 (2025)
   PUBMED   39841599
REFERENCE   2  (bases 1 to 3589)
  AUTHORS   De Ponti,F.F., Bujko,A., Liu,Z., Collins,P.J., Schuermans,S.,
            Maueroder,C., Amstelveen,S., Thone,T., Martens,L., McKendrick,J.G.,
            Louwe,P.A., Sanchez Cruz,A., Saelens,W., Matchett,K.P.,
            Waller,K.J., Zwicker,C., Buglar-Lamb,A., Vanneste,B.,
            Parmentier,F., Binte Abdul Latib,M., Remmerie,A., Kertesz,L.,
            Kremer,A., Verbeke,J., Ipsen,D.H., Pfister,D.R., Liu,Z.,
            Guilliams,M., Henderson,N.C., Ravichandran,K., Marques,P.E. and
            Scott,C.L.
  TITLE     Spatially restricted and ontogenically distinct hepatic macrophages
            are required for tissue repair
  JOURNAL   Immunity 58 (2), 362-380 (2025)
   PUBMED   39862865
REFERENCE   3  (bases 1 to 3589)
  AUTHORS   Pryce,B.R., Oles,A., Talbert,E.E., Romeo,M.J., Vaena,S., Sharma,S.,
            Spadafora,V., Tolliver,L., Mahvi,D.A., Morgan,K.A., Lancaster,W.P.,
            Beal,E., Koren,N., Watts,B., Overstreet,M., Berto,S.,
            Subramanian,S., Calisir,K., Crawford,A., Neelon,B., Ostrowski,M.C.,
            Zimmers,T.A., Tidball,J.G., Wang,D.J. and Guttridge,D.C.
  TITLE     Muscle inflammation is regulated by NF-kappaB from multiple cells
            to control distinct states of wasting in cancer cachexia
  JOURNAL   Cell Rep 43 (11), 114925 (2024)
   PUBMED   39475511
REFERENCE   4  (bases 1 to 3589)
  AUTHORS   Ryu,S., Zhang,J., Simoes,R., Liu,X., Guo,Z., Feng,L., Unsinger,J.,
            Hotchkiss,R.S. and Cao,Y.Q.
  TITLE     Regulatory T cells require peripheral CCL2-CCR2 signaling to
            facilitate the resolution of medication overuse headache-related
            behavioral sensitization
  JOURNAL   J Headache Pain 25 (1), 197 (2024)
   PUBMED   39528947
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3589)
  AUTHORS   Fattori,V., Zaninelli,T.H., Rasquel-Oliveira,F.S., Heintz,O.K.,
            Jain,A., Sun,L., Seshan,M.L., Peterse,D., Lindholm,A.E.,
            Anchan,R.M., Verri,W.A. Jr. and Rogers,M.S.
  TITLE     Nociceptor-to-macrophage communication through CGRP/RAMP1 signaling
            drives endometriosis-associated pain and lesion growth in mice
  JOURNAL   Sci Transl Med 16 (772), eadk8230 (2024)
   PUBMED   39504351
REFERENCE   6  (bases 1 to 3589)
  AUTHORS   Sarafi,M.N., Garcia-Zepeda,E.A., MacLean,J.A., Charo,I.F. and
            Luster,A.D.
  TITLE     Murine monocyte chemoattractant protein (MCP)-5: a novel CC
            chemokine that is a structural and functional homologue of human
            MCP-1
  JOURNAL   J Exp Med 185 (1), 99-109 (1997)
   PUBMED   8996246
REFERENCE   7  (bases 1 to 3589)
  AUTHORS   Heesen,M., Tanabe,S., Berman,M.A., Yoshizawa,I., Luo,Y., Kim,R.J.,
            Post,T.W., Gerard,C. and Dorf,M.E.
  TITLE     Mouse astrocytes respond to the chemokines MCP-1 and KC, but
            reverse transcriptase-polymerase chain reaction does not detect
            mRNA for the KC or new MCP-1 receptor
  JOURNAL   J Neurosci Res 45 (4), 382-391 (1996)
   PUBMED   8872898
REFERENCE   8  (bases 1 to 3589)
  AUTHORS   Kurihara,T. and Bravo,R.
  TITLE     Cloning and functional expression of mCCR2, a murine receptor for
            the C-C chemokines JE and FIC
  JOURNAL   J Biol Chem 271 (20), 11603-11607 (1996)
   PUBMED   8662823
REFERENCE   9  (bases 1 to 3589)
  AUTHORS   Boring,L., Gosling,J., Monteclaro,F.S., Lusis,A.J., Tsou,C.L. and
            Charo,I.F.
  TITLE     Molecular cloning and functional expression of murine JE (monocyte
            chemoattractant protein 1) and murine macrophage inflammatory
            protein 1alpha receptors: evidence for two closely linked C-C
            chemokine receptors on chromosome 9
  JOURNAL   J Biol Chem 271 (13), 7551-7558 (1996)
   PUBMED   8631787
REFERENCE   10 (bases 1 to 3589)
  AUTHORS   Kozak,C.A., Gao,J.L. and Murphy,P.M.
  TITLE     Mapping of the mouse macrophage inflammatory protein-1 alpha
            receptor gene Scya3r and two related mouse beta chemokine
            receptor-like genes to chromosome 9
  JOURNAL   Genomics 29 (1), 294-296 (1995)
   PUBMED   8530091
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            U56819.1, AK138599.1 and AK162705.1.
            
            On Nov 15, 2007 this sequence version replaced NM_009915.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U56819.1, BB645326.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-567               U56819.1           1-567
            568-2616            AK138599.1         881-2929
            2617-3589           AK162705.1         1624-2596
FEATURES             Location/Qualifiers
     source          1..3589
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 75.05 cM"
     gene            1..3589
                     /gene="Ccr2"
                     /gene_synonym="Cc-ckr-2; Ccr2a; Ccr2b; Ckr2; Ckr2a; Ckr2b;
                     Cmkbr2; mJe-r"
                     /note="C-C motif chemokine receptor 2"
                     /db_xref="GeneID:12772"
                     /db_xref="MGI:MGI:106185"
     exon            1..25
                     /gene="Ccr2"
                     /gene_synonym="Cc-ckr-2; Ccr2a; Ccr2b; Ckr2; Ckr2a; Ckr2b;
                     Cmkbr2; mJe-r"
                     /inference="alignment:Splign:2.1.0"
     exon            26..122
                     /gene="Ccr2"
                     /gene_synonym="Cc-ckr-2; Ccr2a; Ccr2b; Ckr2; Ckr2a; Ckr2b;
                     Cmkbr2; mJe-r"
                     /inference="alignment:Splign:2.1.0"
     exon            123..3589
                     /gene="Ccr2"
                     /gene_synonym="Cc-ckr-2; Ccr2a; Ccr2b; Ckr2; Ckr2a; Ckr2b;
                     Cmkbr2; mJe-r"
                     /inference="alignment:Splign:2.1.0"
     CDS             134..1255
                     /gene="Ccr2"
                     /gene_synonym="Cc-ckr-2; Ccr2a; Ccr2b; Ckr2; Ckr2a; Ckr2b;
                     Cmkbr2; mJe-r"
                     /note="chemokine (C-C) receptor 2; CCR-2; C-C CKR-2; MCP-1
                     receptor; JE/FIC receptor; MIP-1 alphaR; chemoattractant
                     protein-1 receptor; C-C CHEMOKINE RECEPTOR TYPE 2 (C-C
                     CKR-2) (CC-CKR-2) (CCR-2) (CCR2) (JE/FIC RECEPTOR) (MCP-1
                     RECEPTOR); chemokine (C-C motif) receptor 2"
                     /codon_start=1
                     /product="C-C chemokine receptor type 2"
                     /protein_id="NP_034045.1"
                     /db_xref="CCDS:CCDS23669.1"
                     /db_xref="GeneID:12772"
                     /db_xref="MGI:MGI:106185"
                     /translation="MEDNNMLPQFIHGILSTSHSLFTRSIQELDEGATTPYDYDDGEP
                     CHKTSVKQIGAWILPPLYSLVFIFGFVGNMLVIIILIGCKKLKSMTDIYLLNLAISDL
                     LFLLTLPFWAHYAANEWVFGNIMCKVFTGLYHIGYFGGIFFIILLTIDRYLAIVHAVF
                     ALKARTVTFGVITSVVTWVVAVFASLPGIIFTKSKQDDHHYTCGPYFTQLWKNFQTIM
                     RNILSLILPLLVMVICYSGILHTLFRCRNEKKRHRAVRLIFAIMIVYFLFWTPYNIVL
                     FLTTFQESLGMSNCVIDKHLDQAMQVTETLGMTHCCINPVIYAFVGEKFRRYLSIFFR
                     KHIAKRLCKQCPVFYRETADRVSSTFTPSTGEQEVSVGL"
     regulatory      3570..3575
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ccr2"
                     /gene_synonym="Cc-ckr-2; Ccr2a; Ccr2b; Ckr2; Ckr2a; Ckr2b;
                     Cmkbr2; mJe-r"
                     /note="hexamer: AACAAG"
     polyA_site      3589
                     /gene="Ccr2"
                     /gene_synonym="Cc-ckr-2; Ccr2a; Ccr2b; Ckr2; Ckr2a; Ckr2b;
                     Cmkbr2; mJe-r"
                     /note="major polyA site"
ORIGIN      
        1 tgccatcata aaggagccat acctgtaaat gccatgcaag ttcagctgcc tgcaaagacc
       61 agaagagggc attggattca ccacatgtgc taagaattga acttgaatca tctgcaaaaa
      121 caaatcaaag gaaatggaag acaataatat gttacctcag ttcatccacg gcatactatc
      181 aacatctcat tctctattta cacgaagtat ccaagagctt gatgaagggg ccaccacacc
      241 gtatgactac gatgatggtg agccttgtca taaaaccagt gtgaagcaaa ttggagcttg
      301 gatcctgcct ccactctact ccctggtatt catctttggt tttgtgggca acatgttggt
      361 cattataatt ctgataggct gtaaaaagct gaagagcatg actgatatct atctgctcaa
      421 cttggccatc tctgacctgc tcttcctgct cacattacca ttctgggctc actatgctgc
      481 aaatgagtgg gtctttggga atataatgtg taaagtattc acagggctct atcacattgg
      541 ttattttggt ggaatctttt tcattatcct cctgacaatt gataggtact tggctattgt
      601 tcatgctgtg tttgctttaa aagccaggac agttaccttt ggggtgataa caagtgtagt
      661 cacttgggtg gtggctgtgt ttgcctctct accaggaatc atatttacta aatccaaaca
      721 agatgatcac cattacacct gtggccctta ttttacacaa ctatggaaga atttccaaac
      781 aataatgaga aatatcttga gcctgatcct gcctctactt gtcatggtca tctgctactc
      841 aggaattctc cacaccctgt ttcgctgtag gaatgagaag aagaggcaca gggctgtgag
      901 gctcatcttt gccatcatga ttgtctactt tctcttctgg actccataca atattgttct
      961 cttcttgacc accttccagg aatccttggg aatgagtaac tgtgtgattg acaagcactt
     1021 agaccaggcc atgcaggtga cagagactct tggaatgaca cactgctgca ttaatcctgt
     1081 catttatgcc tttgttggag agaagttccg aaggtatctc tccatatttt tcagaaagca
     1141 cattgctaaa cgtctctgca aacagtgccc agttttctat agggagacag cagatcgagt
     1201 gagctctaca ttcactcctt ccactgggga gcaagaggtc tcggttgggt tgtaaagtaa
     1261 gtgacagttt gccttttttt aagcagggaa ggagggagca gtttgtacat agcaacaagc
     1321 ctcaaagaca gtggttctta ctttgggtca tgatccctat gtgggggtca aatgaccctt
     1381 tcacagaggt cactaaaacc attagaaaac ataggtattt acattataat tcataacagt
     1441 agcaaaatta cagctatgaa gtagcagcaa aaataatttt attgttgtag atcaccacaa
     1501 catgaggaac tgtattaaag ggtcacagga ttaggaaggt ttcaaaccac tgctcatgga
     1561 tatattgaac aatagagacc tttaaatcag gtgcccagaa cgttataatt atgccgtgac
     1621 tgaaccatat ctcttcttgt atatataata catgtttgag aaatatttta gaataataat
     1681 tggtaaattc ttcagctttc cagggaactc tatccctatg aggagcctct ttgccttgtg
     1741 gcaatattat tttaccaatc ttcaccatgt ttttccttac ttataacatg aaagacatgg
     1801 aatttaagaa aggagggcat gaggctgcca ggactgagtg agaaggagga gatatgcact
     1861 gttgctcctg agtgaaaatg gaaatgaaag tgagcagggc tctcaaattt ctttctcatt
     1921 tgggaagaaa tgtcttgctc tttggttcct tctcctatct gtgtttaatt ttggaggctt
     1981 tatcaggttg tggaaaatct agaaactgta ataggttgtt ggaaacctca tttgagtacc
     2041 atagtccttt tatacataat tgcacaacac atttttgctt tgttattttt ttttatcttt
     2101 gacaacatgg acaatttttt tcaatatcac actccactgt tgatatgttt ctcaagccac
     2161 agttccttac atgatattta taaaattatt gtttataaaa tatgcattat tagtgattag
     2221 actaaaaata ataagggctc ttgtttgatc tttccttctg ctttccaggg agagcagaag
     2281 gctaaaagta gtgaatgacc aagaataagg agaaaagcca actccttcat caggcacaga
     2341 gagctgcagc aaaaaggcag agatctgtgg gacagaggaa gtggtgtgct tagaactaca
     2401 tagaatcaga agcaaaatgg atgccttagc actgaggaaa ggtttctgtc aggttataaa
     2461 ctggttttat attattgctg ctattttctg cctcctcagt acctttgcaa ctgcctcttt
     2521 cctcatagca tttatctctc aacctcttcc tgggaaaggt gtatatggaa tagccaaaca
     2581 tgaaaacctg gatagttcta tgagaaaaaa aaaaaacact gttatattat gtttttgtgg
     2641 gtaaaacaaa actggatgaa gcagggacag aagtcttgct ttgaaaataa tacttgggaa
     2701 catatcttaa ttacaggcaa aataaacctg gataaaaatg attataaatg gagtgggaag
     2761 aagtatgtca cagattatct tccaatgcct tatttttgga tataaacata attcaaatat
     2821 ttaaaaattg aaaatagaaa aaaaaataaa atcaagactg gaaacttcaa cttctaaatg
     2881 tgatgaaata cctttgtaag agctcttatc ttgccaaggt tgaaaatagt tcattagtta
     2941 taaaagaaat tctgactttg agcttatgaa ctaacataga cagctcagga ttaacaggga
     3001 cttgtggttt gtggtctgtg ggcttatcca agcatggtga tttagactct aaggtccgtc
     3061 tggatcctag catatgctac atagatgtca tgtgtgcatg caagtggtgt acttgctctt
     3121 tcaccaaact cctttggatc ttttgtccta aatgtgatct tggtgaaaga ttgtcctttg
     3181 agtgagtggg aactcctaag tcaaatcaac ttcttatcaa ggatttaaaa gtaaatatgc
     3241 aaaggagaga agttagagaa actcctctca taagaaaaat gtcttccctg aattgagcca
     3301 aaaatgttct tccctgtcca ctaatgcgtt tcttatctaa cagaagcaag aaacaaagga
     3361 acagacaact tgagagttaa aagtcattgt ggtctggctt tgctaccaca tgatgagaag
     3421 aaatttctga aagaagtagg ggatgagagt atcaccttca gatagcctaa cagtttcatt
     3481 ttaatgataa tgagatgcaa atacctgtaa aactatgatt tagaaaataa accaatgctc
     3541 tatctatatt gctagaaata ttaaaaagaa acaagcatat gctttgtta
//
