LOCUS       NM_009912               2831 bp    mRNA    linear   ROD 05-AUG-2024
DEFINITION  Mus musculus C-C motif chemokine receptor 1 (Ccr1), mRNA.
ACCESSION   NM_009912
VERSION     NM_009912.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2831)
  AUTHORS   Masui,H., Kawada,K., Itatani,Y., Hirai,H., Nakanishi,Y., Kiyasu,Y.,
            Hanada,K., Okamoto,M., Hirata,W., Nishikawa,Y., Sugimoto,N.,
            Tamura,T., Sakai,Y. and Obama,K.
  TITLE     Synergistic antitumor activity by dual blockade of CCR1 and CXCR2
            expressed on myeloid cells within the tumor microenvironment
  JOURNAL   Br J Cancer 131 (1), 63-76 (2024)
   PUBMED   38750114
  REMARK    GeneRIF: Synergistic antitumor activity by dual blockade of CCR1
            and CXCR2 expressed on myeloid cells within the tumor
            microenvironment.
REFERENCE   2  (bases 1 to 2831)
  AUTHORS   Li,H., Pan,T., Gao,L., Ding,R., Yu,Y., Ma,M., Wang,Y., Jin,S.,
            Chen,Y., Ding,C. and Xu,L.
  TITLE     Chemokine receptor CCR1 regulates macrophage activation through
            mTORC1 signaling in nonalcoholic steatohepatitis
  JOURNAL   Metabolism 151, 155758 (2024)
   PUBMED   38070823
  REMARK    GeneRIF: Chemokine receptor CCR1 regulates macrophage activation
            through mTORC1 signaling in nonalcoholic steatohepatitis.
REFERENCE   3  (bases 1 to 2831)
  AUTHORS   Tian,Q., Li,Y., Feng,S., Liu,C., Guo,Y., Wang,G., Wei,H., Chen,Z.,
            Gu,L. and Li,M.
  TITLE     Inhibition of CCR1 attenuates neuroinflammation via the JAK2/STAT3
            signaling pathway after subarachnoid hemorrhage
  JOURNAL   Int Immunopharmacol 125 (Pt A), 111106 (2023)
   PUBMED   37925951
  REMARK    GeneRIF: Inhibition of CCR1 attenuates neuroinflammation via the
            JAK2/STAT3 signaling pathway after subarachnoid hemorrhage.
REFERENCE   4  (bases 1 to 2831)
  AUTHORS   Zeren,N., Afzal,Z., Morgan,S., Marshall,G., Uppiliappan,M.,
            Merritt,J. and Coniglio,S.J.
  TITLE     The Chemokine Receptor CCR1 Mediates Microglia Stimulated Glioma
            Invasion
  JOURNAL   Int J Mol Sci 24 (6), 5136 (2023)
   PUBMED   36982211
  REMARK    GeneRIF: The Chemokine Receptor CCR1 Mediates Microglia Stimulated
            Glioma Invasion.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2831)
  AUTHORS   Lopez-Tello,J. and Sferruzzi-Perri,A.N.
  TITLE     Characterization of placental endocrine function and fetal brain
            development in a mouse model of small for gestational age
  JOURNAL   Front Endocrinol (Lausanne) 14, 1116770 (2023)
   PUBMED   36843585
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2831)
  AUTHORS   Boring,L., Gosling,J., Monteclaro,F.S., Lusis,A.J., Tsou,C.L. and
            Charo,I.F.
  TITLE     Molecular cloning and functional expression of murine JE (monocyte
            chemoattractant protein 1) and murine macrophage inflammatory
            protein 1alpha receptors: evidence for two closely linked C-C
            chemokine receptors on chromosome 9
  JOURNAL   J Biol Chem 271 (13), 7551-7558 (1996)
   PUBMED   8631787
REFERENCE   7  (bases 1 to 2831)
  AUTHORS   Hoogewerf,A., Black,D., Proudfoot,A.E., Wells,T.N. and Power,C.A.
  TITLE     Molecular cloning of murine CC CKR-4 and high affinity binding of
            chemokines to murine and human CC CKR-4
  JOURNAL   Biochem Biophys Res Commun 218 (1), 337-343 (1996)
   PUBMED   8573157
REFERENCE   8  (bases 1 to 2831)
  AUTHORS   Post,T.W., Bozic,C.R., Rothenberg,M.E., Luster,A.D., Gerard,N. and
            Gerard,C.
  TITLE     Molecular characterization of two murine eosinophil beta chemokine
            receptors
  JOURNAL   J Immunol 155 (11), 5299-5305 (1995)
   PUBMED   7594543
REFERENCE   9  (bases 1 to 2831)
  AUTHORS   Kozak,C.A., Gao,J.L. and Murphy,P.M.
  TITLE     Mapping of the mouse macrophage inflammatory protein-1 alpha
            receptor gene Scya3r and two related mouse beta chemokine
            receptor-like genes to chromosome 9
  JOURNAL   Genomics 29 (1), 294-296 (1995)
   PUBMED   8530091
REFERENCE   10 (bases 1 to 2831)
  AUTHORS   Gao,J.L. and Murphy,P.M.
  TITLE     Cloning and differential tissue-specific expression of three mouse
            beta chemokine receptor-like genes, including the gene for a
            functional macrophage inflammatory protein-1 alpha receptor
  JOURNAL   J Biol Chem 270 (29), 17494-17501 (1995)
   PUBMED   7542241
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK031109.1, AK076275.1 and AK036597.1.
            
            On Sep 6, 2007 this sequence version replaced NM_009912.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK076275.1, AK036690.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-126               AK031109.1         2-127
            127-599             AK076275.1         2-474
            600-2590            AK036597.1         302-2292
            2591-2831           AK076275.1         2466-2706
FEATURES             Location/Qualifiers
     source          1..2831
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 75.05 cM"
     gene            1..2831
                     /gene="Ccr1"
                     /gene_synonym="Cmkbr1; Mip-1a-R"
                     /note="C-C motif chemokine receptor 1"
                     /db_xref="GeneID:12768"
                     /db_xref="MGI:MGI:104618"
     exon            1..398
                     /gene="Ccr1"
                     /gene_synonym="Cmkbr1; Mip-1a-R"
                     /inference="alignment:Splign:2.1.0"
     exon            399..2831
                     /gene="Ccr1"
                     /gene_synonym="Cmkbr1; Mip-1a-R"
                     /inference="alignment:Splign:2.1.0"
     CDS             466..1533
                     /gene="Ccr1"
                     /gene_synonym="Cmkbr1; Mip-1a-R"
                     /note="MIP-1 alpha R; CCR-1; CC-CKR-1; RANTES-R; C-C
                     CKR-1; MIP-1alpha-R; macrophage inflammatory protein
                     1-alpha receptor; chemokine (C-C) receptor 1; MIP-1
                     alphaR; chemokine (C-C motif) receptor 1"
                     /codon_start=1
                     /product="C-C chemokine receptor type 1"
                     /protein_id="NP_034042.3"
                     /db_xref="CCDS:CCDS23666.1"
                     /db_xref="GeneID:12768"
                     /db_xref="MGI:MGI:104618"
                     /translation="MEISDFTEAYPTTTEFDYGDSTPCQKTAVRAFGAGLLPPLYSLV
                     FIIGVVGNVLVILVLMQHRRLQSMTSIYLFNLAVSDLVFLFTLPFWIDYKLKDDWIFG
                     DAMCKLLSGFYYLGLYSEIFFIILLTIDRYLAIVHAVFALRARTVTFGIITSIITWAL
                     AILASMPALYFFKAQWEFTHRTCSPHFPYKSLKQWKRFQALKLNLLGLILPLLVMIIC
                     YAGIIRILLRRPSEKKVKAVRLIFAITLLFFLLWTPYNLSVFVSAFQDVLFTNQCEQS
                     KQLDLAMQVTEVIAYTHCCVNPIIYVFVGERFWKYLRQLFQRHVAIPLAKWLPFLSVD
                     QLERTSSISPSTGEHELSAGF"
     regulatory      1964..1969
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ccr1"
                     /gene_synonym="Cmkbr1; Mip-1a-R"
                     /note="hexamer: ATTAAA"
     polyA_site      1985
                     /gene="Ccr1"
                     /gene_synonym="Cmkbr1; Mip-1a-R"
                     /note="major polyA site"
     regulatory      2096..2101
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ccr1"
                     /gene_synonym="Cmkbr1; Mip-1a-R"
                     /note="hexamer: TATAAA"
     polyA_site      2121
                     /gene="Ccr1"
                     /gene_synonym="Cmkbr1; Mip-1a-R"
     regulatory      2409..2414
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ccr1"
                     /gene_synonym="Cmkbr1; Mip-1a-R"
                     /note="hexamer: ATTAAA"
     polyA_site      2432
                     /gene="Ccr1"
                     /gene_synonym="Cmkbr1; Mip-1a-R"
     regulatory      2578..2583
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ccr1"
                     /gene_synonym="Cmkbr1; Mip-1a-R"
                     /note="hexamer: AATAAA"
     polyA_site      2598
                     /gene="Ccr1"
                     /gene_synonym="Cmkbr1; Mip-1a-R"
     regulatory      2708..2713
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ccr1"
                     /gene_synonym="Cmkbr1; Mip-1a-R"
                     /note="hexamer: AATAAA"
     polyA_site      2731
                     /gene="Ccr1"
                     /gene_synonym="Cmkbr1; Mip-1a-R"
ORIGIN      
        1 atgagtccta ggaacagctc attgtcacac acagagttca actcaactcc atccaacccc
       61 tccctacaca attcttgtag ggcagagcta cctctgagaa gactggaact ttactggaac
      121 tggagcagag aggaaagaca gaacacttta gtgaacttgg accccaggaa ttggccactg
      181 gtgagcactg tagtgcttca taggcagcca accataaaaa agaagaactt tacaccattc
      241 ttgtcattct gaaagactat aaaaccagag tctaatctcc atcatcatac aggaagccaa
      301 gaacttccta ctaggttggg accttgaacc ttgaattcat aaagatcctc aaaggcccag
      361 aaacaaagtc tgtgtggaca aaatactctg gaaacacaga ctcactgtct ttaacagaaa
      421 agtaaattca gaagctatta ttcctgacca gttcctcagc aaaggatgga gatttcagat
      481 ttcacagaag cctaccccac aactacagaa tttgactatg gggactccac tccatgccaa
      541 aagactgctg taagagcctt tggggctgga ctcctgcccc ccctgtattc tctagtgttc
      601 atcattggag tggtgggcaa tgtcctagtg attctggtgc tcatgcagca taggaggctt
      661 caaagcatga ccagcatcta cctgttcaac ctggctgtct ctgatctggt cttccttttc
      721 actttacctt tctggattga ctacaagttg aaagacgact ggatttttgg tgatgccatg
      781 tgcaagcttc tctctgggtt ttattacctg ggtttataca gtgagatctt ctttatcatc
      841 ctgttgacga ttgacagata cctggccatt gtccatgctg tgtttgccct gagggcccga
      901 actgttactt ttggcatcat caccagtatt atcacctggg ccctagccat cttagcttcc
      961 atgcctgcct tatacttttt taaggcccag tgggagttca ctcaccgtac ctgtagccct
     1021 catttcccct acaagagcct gaagcagtgg aagaggtttc aagctctaaa gctaaacctt
     1081 cttggactaa ttttgcctct gttagtcatg ataatctgct atgcagggat catcagaatt
     1141 ctgctcagaa gacccagtga gaagaaggtc aaagccgtgc gtctgatatt tgctattact
     1201 cttctattct tcctcctctg gaccccctac aatctgagtg tatttgtttc tgctttccaa
     1261 gatgttctat tcaccaatca gtgtgagcag agtaagcaac tggacctggc catgcaggtg
     1321 actgaggtga ttgcctacac ccactgttgt gtcaacccaa tcatttatgt ttttgtgggt
     1381 gaacggttct ggaagtacct tcggcagctg tttcaaaggc atgtggctat accactggca
     1441 aaatggctgc ccttcctctc tgtggaccaa ctagaaagga ccagttctat atctccatcc
     1501 acaggagaac atgagctctc tgctggcttc tgattcagac cataggtgtc aaccaaggaa
     1561 ggtctaagaa gagaatgagg agacagtata tagctctcca agactgatac tgacagttct
     1621 tacagtcagg attcccaatc ttttagggtc aaaggaaact tagaggtagc ttaggtataa
     1681 gtcacctctt taattgtttc cttgaacttc tctctgttag aaaggagatg aataaacaaa
     1741 atggggcatt ccagaaactg gaataaaggt gacaatgagt ggcatgggcc caataagaga
     1801 taggatctgt ggttattaat ttaaaaacaa agccactact tttactgaat tcaattccta
     1861 atgatgttat attctgaaaa aaattaaagc attgtaatag agaagaattt tgcatatttg
     1921 catattgaca tatattataa agtataagat gttatgtcaa aaaattaaat ctgtaacaaa
     1981 ctaaagtttt tctatccaat tattttaaat aattagcaaa gatgcaaata gatcagagga
     2041 taaatgcaat agcattgata tgaaaatact gatcaaaagg aaatgacaat taaaatataa
     2101 aagttctttt ggatgctgaa agtagtgaat aaatattatt tcattttact aacaaaaatg
     2161 cacattacag gtccagatat ggcaaaaaca gtcactgact tgcagtttga tacaaatgta
     2221 aattagtgca gtatttctga aaaggaattt gaaaagttca agaatactca aacaatttta
     2281 gggtgatatt aacaaatgct attaaaatgt catatagttt aataatttca gaaatattaa
     2341 atgtcagtca atatggtata ttttaaagaa tttttattga tctgggaata tgttcataat
     2401 attactaaat taaaatggaa aattaaaaac tggcaaatgg ctcactggaa aaggcactta
     2461 ccaccaacct taacaacctg agttcaattt taggaactca catgatgaaa ggaaagaact
     2521 gattctaaca aatagtcctt tgatctctaa atgtgcacat atggagacat acacccaaat
     2581 aaattaatgc aaaaaatata gaattctttt ggcccatatt ttatatatga aaagaacaaa
     2641 ctaaaagaat acatcaatcc attttcctct gctataataa aatccccaaa gctgatactt
     2701 tataaagaat aaaggtttgt ttagcttgaa actttggaga ctcagcatga cattctgctc
     2761 agctctcata agagctccat cagtgcatca ctgcacggaa taggcttcat gatctgagca
     2821 caggcaagaa g
//
