LOCUS       NM_001097644            2940 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus cyclin Y-like 1 (Ccnyl1), mRNA.
ACCESSION   NM_001097644 XM_001001771 XM_001475701
VERSION     NM_001097644.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2940)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2940)
  AUTHORS   Zhang,K., Da Silva,F., Seidl,C., Wilsch-Brauninger,M., Herbst,J.,
            Huttner,W.B. and Niehrs,C.
  TITLE     Primary cilia are WNT-transducing organelles whose biogenesis is
            controlled by a WNT-PP1 axis
  JOURNAL   Dev Cell 58 (2), 139-154 (2023)
   PUBMED   36693320
REFERENCE   3  (bases 1 to 2940)
  AUTHORS   Da Silva,F., Zhang,K., Pinson,A., Fatti,E., Wilsch-Brauninger,M.,
            Herbst,J., Vidal,V., Schedl,A., Huttner,W.B. and Niehrs,C.
  TITLE     Mitotic WNT signalling orchestrates neurogenesis in the developing
            neocortex
  JOURNAL   EMBO J 40 (19), e108041 (2021)
   PUBMED   34431536
REFERENCE   4  (bases 1 to 2940)
  AUTHORS   Zeng,L., Cai,C., Li,S., Wang,W., Li,Y., Chen,J., Zhu,X. and
            Zeng,Y.A.
  TITLE     Essential Roles of Cyclin Y-Like 1 and Cyclin Y in Dividing
            Wnt-Responsive Mammary Stem/Progenitor Cells
  JOURNAL   PLoS Genet 12 (5), e1006055 (2016)
   PUBMED   27203244
  REMARK    GeneRIF: Here we show that Cyclin Y-like 1 (Ccnyl1) and Cyclin Y
            (Ccny) have overlapping function and are crucial for mouse
            embryonic development and mammary stem/progenitor cell functions.
            Double knockout of Ccnys results in embryonic lethality at E16.5
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2940)
  AUTHORS   Koch,S., Acebron,S.P., Herbst,J., Hatiboglu,G. and Niehrs,C.
  TITLE     Post-transcriptional Wnt Signaling Governs Epididymal Sperm
            Maturation
  JOURNAL   Cell 163 (5), 1225-1236 (2015)
   PUBMED   26590424
REFERENCE   6  (bases 1 to 2940)
  AUTHORS   Zi,Z., Zhang,Z., Li,Q., An,W., Zeng,L., Gao,D., Yang,Y., Zhu,X.,
            Zeng,R., Shum,W.W. and Wu,J.
  TITLE     CCNYL1, but Not CCNY, Cooperates with CDK16 to Regulate
            Spermatogenesis in Mouse
  JOURNAL   PLoS Genet 11 (8), e1005485 (2015)
   PUBMED   26305884
  REMARK    GeneRIF: CCNYL1 regulates spermatogenesis through the interaction
            and modulation of CDK16.
            Erratum:[PLoS Genet. 2019 Mar 4;15(3):e1008021. doi:
            10.1371/journal.pgen.1008021.. PMID: 30830908]
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 2940)
  AUTHORS   Evsikov,A.V., Graber,J.H., Brockman,J.M., Hampl,A., Holbrook,A.E.,
            Singh,P., Eppig,J.J., Solter,D. and Knowles,B.B.
  TITLE     Cracking the egg: molecular dynamics and evolutionary aspects of
            the transition from the fully grown oocyte to embryo
  JOURNAL   Genes Dev 20 (19), 2713-2727 (2006)
   PUBMED   17015433
REFERENCE   8  (bases 1 to 2940)
  AUTHORS   Sharov,A.A., Piao,Y., Matoba,R., Dudekula,D.B., Qian,Y.,
            VanBuren,V., Falco,G., Martin,P.R., Stagg,C.A., Bassey,U.C.,
            Wang,Y., Carter,M.G., Hamatani,T., Aiba,K., Akutsu,H., Sharova,L.,
            Tanaka,T.S., Kimber,W.L., Yoshikawa,T., Jaradat,S.A., Pantano,S.,
            Nagaraja,R., Boheler,K.R., Taub,D., Hodes,R.J., Longo,D.L.,
            Schlessinger,D., Keller,J., Klotz,E., Kelsoe,G., Umezawa,A.,
            Vescovi,A.L., Rossant,J., Kunath,T., Hogan,B.L., Curci,A.,
            D'Urso,M., Kelso,J., Hide,W. and Ko,M.S.
  TITLE     Transcriptome analysis of mouse stem cells and early embryos
  JOURNAL   PLoS Biol 1 (3), E74 (2003)
   PUBMED   14691545
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK132782.1, CN668580.1, DV657169.1, AK079350.1 and BE944301.1.
            
            On or before Jul 25, 2007 this sequence version replaced
            XM_001475701.1, XM_001001771.2.
            
            ##Evidence-Data-START##
            CDS exon combination :: AK132782.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMN00849374, SAMN00849375 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-298               AK132782.1         356-653
            299-859             CN668580.1         17-577
            860-1645            DV657169.1         2-787
            1646-2919           AK079350.1         344-1617
            2920-2940           BE944301.1         1-21                c
FEATURES             Location/Qualifiers
     source          1..2940
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 32.74 cM"
     gene            1..2940
                     /gene="Ccnyl1"
                     /gene_synonym="9630037P07Rik"
                     /note="cyclin Y-like 1"
                     /db_xref="GeneID:227210"
                     /db_xref="MGI:MGI:2138614"
     exon            1..56
                     /gene="Ccnyl1"
                     /gene_synonym="9630037P07Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             47..922
                     /gene="Ccnyl1"
                     /gene_synonym="9630037P07Rik"
                     /codon_start=1
                     /product="cyclin-Y-like protein 1"
                     /protein_id="NP_001091113.1"
                     /db_xref="CCDS:CCDS48281.1"
                     /db_xref="GeneID:227210"
                     /db_xref="MGI:MGI:2138614"
                     /translation="MPEDLALESNPSDHPRASTIFLSKSQTDVREKRKSNHLNHVSPG
                     QLTKKYSSCSTIFLDDSTVSQPNLRTTIKCVTLAIYYHIKNRDANRSLDIFDERSHPL
                     TREKVPEEYFKHDPEHKFIYRFVRTLFSAAQLTAECAIVTLVYLERLLTYAEIDICPT
                     NWKRIVLGAILLASKVWDDQAVWNVDYCQILKDITVEDMNEMERHFLELLQFNINVPA
                     SVYAKYYFDLRSLADDNNLNFLFAPLSKERAQNLEAISRLCEDKYKDLCRAAMRRSLS
                     ADNFIGIQRSNAILS"
     exon            57..131
                     /gene="Ccnyl1"
                     /gene_synonym="9630037P07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            132..166
                     /gene="Ccnyl1"
                     /gene_synonym="9630037P07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            167..267
                     /gene="Ccnyl1"
                     /gene_synonym="9630037P07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            268..303
                     /gene="Ccnyl1"
                     /gene_synonym="9630037P07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            304..355
                     /gene="Ccnyl1"
                     /gene_synonym="9630037P07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            356..475
                     /gene="Ccnyl1"
                     /gene_synonym="9630037P07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            476..642
                     /gene="Ccnyl1"
                     /gene_synonym="9630037P07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            643..805
                     /gene="Ccnyl1"
                     /gene_synonym="9630037P07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            806..2927
                     /gene="Ccnyl1"
                     /gene_synonym="9630037P07Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2905..2910
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ccnyl1"
                     /gene_synonym="9630037P07Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2927
                     /gene="Ccnyl1"
                     /gene_synonym="9630037P07Rik"
                     /note="major polyA site"
ORIGIN      
        1 cggagccggc gagggccacc acctgcagca catcagtgac cgagagatgc ccgaagatct
       61 agctttggaa tcaaaccctt ccgaccaccc gagggcaagc acaattttcc tgagcaaatc
      121 tcaaacggat gtgcgtgaaa agaggaagag caaccattta aaccatgtat ctccagggca
      181 gcttactaaa aagtatagct catgctcaac aatatttcta gatgacagca cagtcagcca
      241 gcctaacctt agaaccacaa taaaatgtgt gaccttagca atatattacc acataaagaa
      301 cagagatgca aatagatccc tggacatttt tgatgagcgg tcacatcctc tcacaagaga
      361 gaaagttcca gaggagtact ttaagcatga ccctgaacac aaatttattt acagatttgt
      421 tcgtacactt tttagtgctg cacagctgac agcggaatgt gcaatagtga cgttggttta
      481 cttagagagg ctcctaactt atgctgagat cgacatttgt cccaccaact ggaaaagaat
      541 tgttctggga gccattcttc ttgcctccaa ggtttgggat gaccaggctg tatggaatgt
      601 agactactgc cagatcctca aggacattac ggttgaggac atgaatgaga tggaaaggca
      661 tttcttggag ctactccagt ttaatattaa tgttcctgcc agtgtttatg ccaaatacta
      721 ctttgacctt cgctccttag cagatgacaa caacctgaat tttctgtttg ctcctctcag
      781 caaagaaaga gcacagaacc tagaggccat ttcaagattg tgtgaagaca aatacaaaga
      841 cttgtgtaga gctgctatga gaagatcttt aagcgctgat aatttcattg gtattcagcg
      901 ctctaatgcc atcctctctt aagagagaga ctcgaggagt aagaacacca gggactcctc
      961 atagacaggc tggagcaaca gcacctctcc tgatcagaga gcagcagagg tgggactcca
     1021 cgggatggga agacctcgga ttcaagagac tctggacagt gactgctgac tccataggaa
     1081 agaatgggac cttgtcaaag caacagctct ctgtcctttg taatgtaaac ggttacagaa
     1141 accactccac agcaacagcg ctgaccacag atcgtgctta ccatgtaggc caatggctgt
     1201 gaaatatgcg aggtttttac attgtttcaa tgtttagact tttgtttgag acagggtctt
     1261 acatagcctg ggctggcctc aaactaagta tacgattgag gctgtccttg aactcctatc
     1321 ttcctgcctc tacctcccaa atgctgggat taccatgcct ggctcagatt tttagacttt
     1381 aaagacacta accatataac tttggttttt cttgcccctg ccccacccaa ctgctgcata
     1441 tgcttttaga attgatgcat ttcagtatta ccattaaaac atgagaatcc ttctccattt
     1501 ttgtggtgct gggaatcaaa ttgaagacct agcaagtgct tggtaagcat ttgaccactg
     1561 agcaacactc ctcagcccca aacaggattc ttaacactca tgaaaccacc taggagcaga
     1621 ttgtagcctc attaggtatt aaaggttctc tcactgtatc atcagagctg ctagtcatta
     1681 ctggcaatca gtttaaatta ccagaaagct gctggaaaca ctcgccattc acgttgttcg
     1741 taagcgctgc ttgctggcat tttggtgtgt ttggagccat agagagagag tgtcctgtgc
     1801 tgaccacttc tgttgcgtcc acgctgcgtt catttcctgt tcactactaa tggtgcttct
     1861 catcctctga tctcttctct ctcgtgtgtt aaacaagtgt attaaagatg cttcataatg
     1921 ccaacaacat agcaggtcag tgaacatgat cccatagtaa aatacaaggg gtccccaaaa
     1981 ttagtgattg cttcacactt actgccctgt gggctctctg gggacactgc aacagaagcc
     2041 acaaacttgc acaaaacatc atttgaaagt tttaatttta ccaatttgaa gctaatttaa
     2101 ttttattgtt tctcagttat aaccgtaaac caaaaatatt ccaaatgtgg gaaattaagt
     2161 tgaagggaaa ggtgacttaa aactttcaaa taatgtttca ttagttttgt agcgtttgtg
     2221 attgtaaggc atcagagctg acaactacgt ggagctgtgg gagctgccgt gcctttccat
     2281 ggaagcactc tgttctcaag tgttctttgc caggctgggc tctagccgct ttgatcacct
     2341 aagtgtcttt acgctcagtc aagggaggct attaaagtgg tggtaactca catggaacaa
     2401 atcaaaagaa atcagatcct caaacagcag gtgaaatgag caattaaaac cctgcgcgct
     2461 ctcctgggtg caggtctctc tcaagccgca tccttgcagg cctatgcacc ggctttcaac
     2521 ggcagggagc gaagactggg aaagggatgg cagtagcagc taaagctgaa ataataaaag
     2581 atttgcatcc tacaactatg tgcattctat ttcttctcac atctaacctt gggagtctta
     2641 cctaaaaagc cttttgtggg ccacgaatac ttcctcttga ggctgcaatg cttcccatgc
     2701 tcgtcagtgc tgccaggctc atcactttca agggacagac ataagtgtta cggaaggatg
     2761 tatgaaatat tacaatctac cacctcaaaa aacattgttt atggagttca gagcttagag
     2821 attcaagtat tgattgcagt tttattttga aaagaatgct acaacttaac gtggtttttc
     2881 tttctcatgt ttatattaaa agctaataaa ttctatttta attaaaaaaa aaaaaaaaaa
//
