LOCUS       NM_028399               3514 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus cyclin T2 (Ccnt2), mRNA.
ACCESSION   NM_028399 XM_129395
VERSION     NM_028399.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3514)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3514)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   3  (bases 1 to 3514)
  AUTHORS   Marchesi,I., Nieddu,V., Caracciolo,V., Maioli,M., Gaspa,L.,
            Giordano,A. and Bagella,L.
  TITLE     Activation and function of murine Cyclin T2A and Cyclin T2B during
            skeletal muscle differentiation
  JOURNAL   J Cell Biochem 114 (3), 728-734 (2013)
   PUBMED   23060074
  REMARK    GeneRIF: both isoforms of Cyclin T2 are able to activate the
            myogenic program but Cyclin T2b has a predominant role, in
            particular during the latest stages.
REFERENCE   4  (bases 1 to 3514)
  AUTHORS   Teng,Y., Wang,Y., Fu,J., Cheng,X., Miao,S. and Wang,L.
  TITLE     Cyclin T2: a novel miR-15a target gene involved in early
            spermatogenesis
  JOURNAL   FEBS Lett 585 (15), 2493-2500 (2011)
   PUBMED   21740905
  REMARK    GeneRIF: miR-15a inhibited muscle differentiation at least in part
            by targeting Ccnt2; roles in spermatogenesis.
REFERENCE   5  (bases 1 to 3514)
  AUTHORS   Yokoyama,S., Ito,Y., Ueno-Kudoh,H., Shimizu,H., Uchibe,K.,
            Albini,S., Mitsuoka,K., Miyaki,S., Kiso,M., Nagai,A., Hikata,T.,
            Osada,T., Fukuda,N., Yamashita,S., Harada,D., Mezzano,V., Kasai,M.,
            Puri,P.L., Hayashizaki,Y., Okado,H., Hashimoto,M. and Asahara,H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
REFERENCE   6  (bases 1 to 3514)
  AUTHORS   Oven,I., Brdickova,N., Kohoutek,J., Vaupotic,T., Narat,M. and
            Peterlin,B.M.
  TITLE     AIRE recruits P-TEFb for transcriptional elongation of target genes
            in medullary thymic epithelial cells
  JOURNAL   Mol Cell Biol 27 (24), 8815-8823 (2007)
   PUBMED   17938200
REFERENCE   7  (bases 1 to 3514)
  AUTHORS   Xiao,W., Liu,W., Li,Z., Liang,D., Li,L., White,L.D., Fox,D.A.,
            Overbeek,P.A. and Chen,Q.
  TITLE     Gene expression profiling in embryonic mouse lenses
  JOURNAL   Mol Vis 12, 1692-1698 (2006)
   PUBMED   17213798
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 3514)
  AUTHORS   Giacinti,C., Bagella,L., Puri,P.L., Giordano,A. and Simone,C.
  TITLE     MyoD recruits the cdk9/cyclin T2 complex on myogenic-genes
            regulatory regions
  JOURNAL   J Cell Physiol 206 (3), 807-813 (2006)
   PUBMED   16245309
REFERENCE   9  (bases 1 to 3514)
  AUTHORS   Jang,M.K., Mochizuki,K., Zhou,M., Jeong,H.S., Brady,J.N. and
            Ozato,K.
  TITLE     The bromodomain protein Brd4 is a positive regulatory component of
            P-TEFb and stimulates RNA polymerase II-dependent transcription
  JOURNAL   Mol Cell 19 (4), 523-534 (2005)
   PUBMED   16109376
REFERENCE   10 (bases 1 to 3514)
  AUTHORS   Simone,C., Stiegler,P., Bagella,L., Pucci,B., Bellan,C., De
            Falco,G., De Luca,A., Guanti,G., Puri,P.L. and Giordano,A.
  TITLE     Activation of MyoD-dependent transcription by cdk9/cyclin T2
  JOURNAL   Oncogene 21 (26), 4137-4148 (2002)
   PUBMED   12037670
  REMARK    GeneRIF: activation of MyoD-dependent transcription by cdk9/cyclin
            T2
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC054122.1, BB511168.1 and BG277049.1.
            
            On Dec 16, 2004 this sequence version replaced XM_129395.5.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC054122.1, AK152399.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3164              BC054122.1         1-3164
            3165-3166           BB511168.1         42-43
            3167-3421           BC054122.1         3167-3421
            3422-3514           BG277049.1         58-150
FEATURES             Location/Qualifiers
     source          1..3514
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 55.8 cM"
     gene            1..3514
                     /gene="Ccnt2"
                     /gene_synonym="2900041I18Rik; CycT2; CycT2a; CycT2b"
                     /note="cyclin T2"
                     /db_xref="GeneID:72949"
                     /db_xref="MGI:MGI:1920199"
     exon            1..222
                     /gene="Ccnt2"
                     /gene_synonym="2900041I18Rik; CycT2; CycT2a; CycT2b"
                     /inference="alignment:Splign:2.1.0"
     CDS             65..2236
                     /gene="Ccnt2"
                     /gene_synonym="2900041I18Rik; CycT2; CycT2a; CycT2b"
                     /note="cyclin T2b; cyclin T2a"
                     /codon_start=1
                     /product="cyclin-T2"
                     /protein_id="NP_082675.1"
                     /db_xref="CCDS:CCDS15248.1"
                     /db_xref="GeneID:72949"
                     /db_xref="MGI:MGI:1920199"
                     /translation="MASGRGASSRWFFTREQLENTPSRRCGVEADEELSHRQQAANLI
                     QDMGQRLNVSQLTINTAIVYMHRFYMHHSFTKFNRNIISPTALFLAAKVEEQARKLEH
                     VIKVAHACLHPLEPLLDTKCDAYLQQTQELVLLETIMLQTLGFEITIEHPHTDVVKCT
                     QLVRASKDLAQTSYFMATNSLHLTTFCLQYKPTVIACVCIHLACKWSNWEIPVSTDGK
                     HWWEYVDPTVTLELLDELTHEFLQILEKTPSRLKRIRNWRAMAKKPKVDGQVSETPLL
                     GSSLVQNSILVDSVTGVPANPSFQKPSTSTFPAPIPLNSGSTSVQDSRASDNLSVLAA
                     GMPSTSYSLSSHQEWPQHPDSARTDPVYTQKQEATLSGSQYISFQQGPSMALHSGLHH
                     RPDKVADHSSAKQEYTHKAGSSKHHGPIPATPGMLPQKMSLDKYREKRKLETLDVDTR
                     DHYLAAHAEQQHKHGPAQAVTGTSVTSPIKMKLPLTNSDRPEKHVAEKKERSGSLKLR
                     IPIPPPDKGPSKEELKMKIKVASSERHSSSDEGSGKSKHSSPHISRDHKEKHKEHPAN
                     RHHSSHKYLHMHSGGSKHTADGMPPTVLRSPVGLGPEGVSSASSARKKLHSSEASHNH
                     HSKMSKSSKSAGSSSSSSSVKQYLSSHSSVFNHPLPPPPPVTYQVGYGHLSTLVKLDK
                     KPVEPHGPEANHEYSTSSQHMDYKDTFDMLDSLLSAQGMNM"
     exon            223..304
                     /gene="Ccnt2"
                     /gene_synonym="2900041I18Rik; CycT2; CycT2a; CycT2b"
                     /inference="alignment:Splign:2.1.0"
     exon            305..433
                     /gene="Ccnt2"
                     /gene_synonym="2900041I18Rik; CycT2; CycT2a; CycT2b"
                     /inference="alignment:Splign:2.1.0"
     exon            434..494
                     /gene="Ccnt2"
                     /gene_synonym="2900041I18Rik; CycT2; CycT2a; CycT2b"
                     /inference="alignment:Splign:2.1.0"
     exon            495..557
                     /gene="Ccnt2"
                     /gene_synonym="2900041I18Rik; CycT2; CycT2a; CycT2b"
                     /inference="alignment:Splign:2.1.0"
     exon            558..603
                     /gene="Ccnt2"
                     /gene_synonym="2900041I18Rik; CycT2; CycT2a; CycT2b"
                     /inference="alignment:Splign:2.1.0"
     exon            604..767
                     /gene="Ccnt2"
                     /gene_synonym="2900041I18Rik; CycT2; CycT2a; CycT2b"
                     /inference="alignment:Splign:2.1.0"
     exon            768..838
                     /gene="Ccnt2"
                     /gene_synonym="2900041I18Rik; CycT2; CycT2a; CycT2b"
                     /inference="alignment:Splign:2.1.0"
     exon            839..3514
                     /gene="Ccnt2"
                     /gene_synonym="2900041I18Rik; CycT2; CycT2a; CycT2b"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3340..3345
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ccnt2"
                     /gene_synonym="2900041I18Rik; CycT2; CycT2a; CycT2b"
                     /note="hexamer: TATAAA"
     regulatory      3352..3357
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ccnt2"
                     /gene_synonym="2900041I18Rik; CycT2; CycT2a; CycT2b"
                     /note="hexamer: ATTAAA"
     polyA_site      3361
                     /gene="Ccnt2"
                     /gene_synonym="2900041I18Rik; CycT2; CycT2a; CycT2b"
     polyA_site      3388
                     /gene="Ccnt2"
                     /gene_synonym="2900041I18Rik; CycT2; CycT2a; CycT2b"
     regulatory      3394..3399
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ccnt2"
                     /gene_synonym="2900041I18Rik; CycT2; CycT2a; CycT2b"
                     /note="hexamer: AATAAA"
     regulatory      3401..3406
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ccnt2"
                     /gene_synonym="2900041I18Rik; CycT2; CycT2a; CycT2b"
                     /note="hexamer: AAGAAA"
     polyA_site      3417
                     /gene="Ccnt2"
                     /gene_synonym="2900041I18Rik; CycT2; CycT2a; CycT2b"
                     /note="major polyA site"
     polyA_site      3434
                     /gene="Ccnt2"
                     /gene_synonym="2900041I18Rik; CycT2; CycT2a; CycT2b"
ORIGIN      
        1 cgcggagtcc cggaggcagg cggggagggg gcgggctcag ggcgcgggcg gaggaggaag
       61 tgtcatggcg tcgggccgtg gagcttcttc tcgctggttc tttactcggg aacagctgga
      121 gaacacgccg agccgccgct gcggagtgga agcggatgaa gagctgtcgc atcgccagca
      181 ggcggccaac ctcatccagg acatggggca acgtctcaat gtctctcagc ttacaataaa
      241 cactgcgatt gtttatatgc acaggtttta tatgcaccat tccttcacca aattcaacag
      301 aaatataata tcacctactg cattgttttt ggctgcaaaa gtggaagagc aggctcgaaa
      361 gcttgaacat gttatcaaag tagcacacgc ttgtcttcat cccctagagc cactcctgga
      421 cacaaaatgt gatgcttatc ttcagcagac tcaagaactg gttttacttg aaaccataat
      481 gctacaaaca ctgggttttg agatcaccat tgaacaccca cacacagatg tggtgaaatg
      541 cacccagtta gtaagagcaa gcaaggattt ggcacagaca tcctatttca tggctaccaa
      601 cagtttgcat cttacgacct tctgtcttca gtacaaaccc acagtgatag catgtgtatg
      661 cattcatttg gcttgcaaat ggtccaattg ggagattcct gtgtcaacag atggaaagca
      721 ctggtgggag tatgtggacc ccacggttac cctagagctg ctagatgaac taacacatga
      781 gtttctacaa atattggaga aaacgcctag taggttgaag aggattcgaa actggagggc
      841 tatggctaag aaaccaaaag tagatggaca agtatcagag acaccactgc ttggttcatc
      901 tttggtccag aattctattt tagtagatag tgtcactggt gtacctgcca acccaagctt
      961 tcagaaacca tcaacatcaa cgttccctgc tccaatacct ctaaattcag gaagtacttc
     1021 tgttcaagat agccgtgcat ctgataattt atcagtgcta gcagcaggaa tgcccagtac
     1081 ctcatacagt ttgtcatcac accaagagtg gccccagcat ccagattcag ccaggacaga
     1141 cccagtgtac acacagaaac aggaggccac tctctctggg agccagtaca taagcttcca
     1201 gcagggacct tcaatggcac tgcattctgg attacatcac aggccggaca aagttgctga
     1261 tcattcatca gctaagcaag aatatactca caaagctggg agcagtaaac accatggtcc
     1321 catacctgct actcctggaa tgcttcctca gaaaatgtct ttagataagt acagagagaa
     1381 gcggaagctg gaaacccttg acgtggacac aagggatcac tatctagctg cccatgcaga
     1441 acagcagcac aagcatgggc cggctcaggc agtcacgggc acttctgtca cttctcccat
     1501 caagatgaag ctccccctca ccaactcgga caggcctgag aaacacgtgg cagagaaaaa
     1561 ggagaggagt ggatcactga agctccgcat tcccatcccc ccgcctgaca aaggtcccag
     1621 caaagaggag ctgaagatga aaatcaaagt ggcatcctcg gaaagacaca gctcttctga
     1681 tgaaggcagt gggaagagca agcactcaag cccacacatc agcagagacc acaaggagaa
     1741 gcacaaggag caccctgcca accgccacca cagcagccac aagtatttgc acatgcacag
     1801 tggaggcagt aagcacacag cggatggaat gcctcccacg gtgctcagga gtcctgtggg
     1861 cctgggccct gaaggcgtct cctccgcctc cagtgcaagg aagaagctgc atagcagcga
     1921 agcctcccac aaccaccact ccaaaatgag caaaagttcc aaaagtgcag gtagttcatc
     1981 tagttcttcc tctgttaagc agtatctatc ctctcacagc tctgttttta accatccctt
     2041 accccctcct ccccctgtca cataccaggt gggctacgga catctcagca ccctcgtgaa
     2101 actggacaag aaaccagtgg agccccacgg tcctgaggcc aatcacgagt acagtacaag
     2161 cagccagcat atggactaca aagacacatt cgacatgctg gactcgctgc taagtgccca
     2221 aggaatgaat atgtaacctt tgtttaggtc aacttttcct tgccttttta atttaaaaat
     2281 ggttggaatg gaaaacgccc tcctggtccg gcggtggtgc cactgcttcc atatttgtaa
     2341 gtgctgcttt gttcttcatt ctgaaagaag agatgatagt aaacaagcct atctccacat
     2401 acgatagtgt taccaggact gtaaccgcat ggaagatgca gctgagaaca ttaggatgaa
     2461 tggctggctg ctgctaggag cctaagctgc ttcaagcttc tcttatttat gatttgaata
     2521 ttgtagctgt tttttgttgt tgcttggctt tgaatgagtg tcagttgttt tcttttgtgt
     2581 atttatactt gtatgtatgg tttgcatgtc tcagtgataa agggataaaa cagtatactg
     2641 acagctgttt acaagaaagt ggagaaaaat gtacatacat ttttgtatgt ttagatatta
     2701 ccataaatac tcaggattgg agctgcttgt aagaataaca atatacagaa taactttatt
     2761 ttctctcgtc agagtccatc actaatctaa aacacaagtg gcactttttt tatgttaacc
     2821 ttaattaaac tctaggcctt actggaagcc gctgagggga cacttcacta ctagacggga
     2881 atgtggtgcc atgggtggtc cttaacactg ggaagcactc agtttgcctt cagaggtcct
     2941 gaccagattg gctgcagaat cagccgttga tttctgaagg cttgaagagg aaaacacaat
     3001 aaagtttaca tactcttgat gtgaagtgca tttaaatgtt tgttggcttg ttgcagtgct
     3061 gtagaaagca gctaataatt ggtgtgagga tgactgtgac tttgctcaca gcagctccca
     3121 gtgaagatga gtccatttct tcaggaacgc tgacactaca gattctaaga gtgaacaggg
     3181 gtcacttttc ctttagcatt gcagtgacac catagtcttg aatatactct tcccatggag
     3241 agagagagtg agtgtgtatg tgagagagag tgtgagtgtg tgggtatggg tgtgagggag
     3301 agataccata tttctttttc aggtaaatgc agtcttcctt ataaaaatga aattaaacct
     3361 atgctctctt gattctttta tattctaaca ataaataaaa aagaaaagat tgctgactgt
     3421 gcattgtacc tgtatttata gcttatggtc attatcagga aaatgtaagg aaaaaggcca
     3481 gcctcaggca agccactgct ggggttttac atgc
//
