LOCUS       NM_001368702             754 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus cyclin T1 (Ccnt1), transcript variant 2, mRNA.
ACCESSION   NM_001368702
VERSION     NM_001368702.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 754)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 754)
  AUTHORS   Novakova,M., Hampl,M., Vrabel,D., Prochazka,J., Petrezselyova,S.,
            Prochazkova,M., Sedlacek,R., Kavkova,M., Zikmund,T., Kaiser,J.,
            Juan,H.C., Fann,M.J., Buchtova,M. and Kohoutek,J.
  TITLE     Mouse Model of Congenital Heart Defects, Dysmorphic Facial Features
            and Intellectual Developmental Disorders as a Result of
            Non-functional CDK13
  JOURNAL   Front Cell Dev Biol 7, 155 (2019)
   PUBMED   31440507
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 754)
  AUTHORS   Shiozaki,Y., Okamura,K., Kohno,S., Keenan,A.L., Williams,K.,
            Zhao,X., Chick,W.S., Miyazaki-Anzai,S. and Miyazaki,M.
  TITLE     The CDK9-cyclin T1 complex mediates saturated fatty acid-induced
            vascular calcification by inducing expression of the transcription
            factor CHOP
  JOURNAL   J Biol Chem 293 (44), 17008-17020 (2018)
   PUBMED   30209133
  REMARK    GeneRIF: CDK9-cyclin T1 and CDK9-cyclin T2/K complexes have
            opposing roles in CHOP expression and chronic kidney disease
            -induced vascular calcification.
REFERENCE   4  (bases 1 to 754)
  AUTHORS   Oqani,R.K., Lin,T., Lee,J.E., Kim,S.Y., Sa,S.J., Woo,J.S. and
            Jin,D.I.
  TITLE     Inhibition of P-TEFb disrupts global transcription, oocyte
            maturation, and embryo development in the mouse
  JOURNAL   Genesis 54 (9), 470-482 (2016)
   PUBMED   27488304
REFERENCE   5  (bases 1 to 754)
  AUTHORS   Gaucher,J., Boussouar,F., Montellier,E., Curtet,S., Buchou,T.,
            Bertrand,S., Hery,P., Jounier,S., Depaux,A., Vitte,A.L.,
            Guardiola,P., Pernet,K., Debernardi,A., Lopez,F., Holota,H.,
            Imbert,J., Wolgemuth,D.J., Gerard,M., Rousseaux,S. and Khochbin,S.
  TITLE     Bromodomain-dependent stage-specific male genome programming by
            Brdt
  JOURNAL   EMBO J 31 (19), 3809-3820 (2012)
   PUBMED   22922464
REFERENCE   6  (bases 1 to 754)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
REFERENCE   7  (bases 1 to 754)
  AUTHORS   Kwak,Y.T., Ivanov,D., Guo,J., Nee,E. and Gaynor,R.B.
  TITLE     Role of the human and murine cyclin T proteins in regulating HIV-1
            tat-activation
  JOURNAL   J Mol Biol 288 (1), 57-69 (1999)
   PUBMED   10329126
REFERENCE   8  (bases 1 to 754)
  AUTHORS   Fujinaga,K., Taube,R., Wimmer,J., Cujec,T.P. and Peterlin,B.M.
  TITLE     Interactions between human cyclin T, Tat, and the transactivation
            response element (TAR) are disrupted by a cysteine to tyrosine
            substitution found in mouse cyclin T
  JOURNAL   Proc Natl Acad Sci U S A 96 (4), 1285-1290 (1999)
   PUBMED   9990016
REFERENCE   9  (bases 1 to 754)
  AUTHORS   Bieniasz,P.D., Grdina,T.A., Bogerd,H.P. and Cullen,B.R.
  TITLE     Recruitment of a protein complex containing Tat and cyclin T1 to
            TAR governs the species specificity of HIV-1 Tat
  JOURNAL   EMBO J 17 (23), 7056-7065 (1998)
   PUBMED   9843510
REFERENCE   10 (bases 1 to 754)
  AUTHORS   Garber,M.E., Wei,P., KewalRamani,V.N., Mayall,T.P., Herrmann,C.H.,
            Rice,A.P., Littman,D.R. and Jones,K.A.
  TITLE     The interaction between HIV-1 Tat and human cyclin T1 requires zinc
            and a critical cysteine residue that is not conserved in the murine
            CycT1 protein
  JOURNAL   Genes Dev 12 (22), 3512-3527 (1998)
   PUBMED   9832504
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC138221.23.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.574297.1,
                                           SRR11927937.4217299.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849380,
                                           SAMN00849382 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-261               AC138221.23        187311-187571       c
            262-343             AC138221.23        184882-184963       c
            344-472             AC138221.23        180032-180160       c
            473-754             AC138221.23        179646-179927       c
FEATURES             Location/Qualifiers
     source          1..754
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 54.54 cM"
     gene            1..754
                     /gene="Ccnt1"
                     /gene_synonym="2810478G24Rik; CycT1"
                     /note="cyclin T1"
                     /db_xref="GeneID:12455"
                     /db_xref="MGI:MGI:1328363"
     exon            1..261
                     /gene="Ccnt1"
                     /gene_synonym="2810478G24Rik; CycT1"
                     /inference="alignment:Splign:2.1.0"
     CDS             101..589
                     /gene="Ccnt1"
                     /gene_synonym="2810478G24Rik; CycT1"
                     /note="isoform 2 is encoded by transcript variant 2;
                     cyclin-T"
                     /codon_start=1
                     /product="cyclin-T1 isoform 2"
                     /protein_id="NP_001355631.1"
                     /db_xref="GeneID:12455"
                     /db_xref="MGI:MGI:1328363"
                     /translation="MEGERKNNNKRWYFTREQLENSPSRRFGVDSDKELSYRQQAANL
                     LQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFHRYSMAPAALFLAAKVEEQPKKLE
                     HVIKVAHTCLHPQESLPDTRSEPEMGFLCVAMTIDQVRLEPTEILQLCTYTSLPVFNF
                     EN"
     exon            262..343
                     /gene="Ccnt1"
                     /gene_synonym="2810478G24Rik; CycT1"
                     /inference="alignment:Splign:2.1.0"
     exon            344..472
                     /gene="Ccnt1"
                     /gene_synonym="2810478G24Rik; CycT1"
                     /inference="alignment:Splign:2.1.0"
     exon            473..754
                     /gene="Ccnt1"
                     /gene_synonym="2810478G24Rik; CycT1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      585..590
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ccnt1"
                     /gene_synonym="2810478G24Rik; CycT1"
                     /note="hexamer: ATTAAA"
     polyA_site      616
                     /gene="Ccnt1"
                     /gene_synonym="2810478G24Rik; CycT1"
ORIGIN      
        1 gtcacgtcgc agtagtctcg gcacggcgga tgtgtgtcgc cgctccggtg acgctgggaa
       61 gtgctcgcag cccccgccgc tgcctcttgg ttgaagcact atggagggag agaggaagaa
      121 caacaacaag cggtggtatt ttactcgcga gcagctggag aacagcccgt cgcgtcgctt
      181 tggcgtggac tccgataaag aactctctta ccgccagcag gcggccaatc tcctccagga
      241 catgggacaa cgtctgaacg tctcacaact gacgatcaat actgctatag tatacatgca
      301 ccgattctac atgattcagt cttttacaca gtttcatcga tattccatgg ctccagcagc
      361 cttgtttcta gcagcaaaag tagaagaaca accaaagaaa ttggagcatg tcatcaaggt
      421 ggcacacact tgcctgcacc cacaggagtc acttcctgac acgaggagtg agcctgagat
      481 gggattcctc tgtgtagcca tgactataga ccaggttaga cttgaaccca cagaaatcct
      541 tcaactgtgt acctacacct ccctgccagt gtttaatttt gaaaattaaa aacatacata
      601 tcaatttcat ctaaaagttt gtcttaaaat tgaaagctgc ataagagcaa aagagagtta
      661 tatcacctgg ataaatttct ttccaccctc tagatccaaa atattttctt tttctctact
      721 gtttaaaaat gattaaaaag tgtgcagcac cacc
//
