LOCUS       NM_001081062            1850 bp    mRNA    linear   ROD 31-DEC-2024
DEFINITION  Mus musculus cyclin O (Ccno), mRNA.
ACCESSION   NM_001081062 XM_127523
VERSION     NM_001081062.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1850)
  AUTHORS   Wang,L., Gao,L., Chen,Y. and Xu,B.
  TITLE     Transcriptional regulation of CCNO during the formation of multiple
            motile cilia
  JOURNAL   Biochem Biophys Res Commun 735, 150428 (2024)
   PUBMED   39094231
REFERENCE   2  (bases 1 to 1850)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 1850)
  AUTHORS   Moreau,M.X., Saillour,Y., Elorriaga,V., Bouloudi,B., Delberghe,E.,
            Deutsch Guerrero,T., Ochandorena-Saa,A., Maeso-Alonso,L.,
            Marques,M.M., Marin,M.C., Spassky,N., Pierani,A. and Causeret,F.
  TITLE     Repurposing of the multiciliation gene regulatory network in fate
            specification of Cajal-Retzius neurons
  JOURNAL   Dev Cell 58 (15), 1365-1382 (2023)
   PUBMED   37321213
REFERENCE   4  (bases 1 to 1850)
  AUTHORS   Li,Q., Han,Z., Singh,N., Terre,B., Fame,R.M., Arif,U., Page,T.D.,
            Zahran,T., Abdeltawab,A., Huang,Y., Cao,P., Wang,J., Lu,H.,
            Lidov,H.G.W., Surendran,K., Wu,L., Virga,J.Q., Zhao,Y.T.,
            Schuller,U., Wechsler-Reya,R.J., Lehtinen,M.K., Roy,S., Liu,Z.,
            Stracker,T.H. and Zhao,H.
  TITLE     Disruption of GMNC-MCIDAS multiciliogenesis program is critical in
            choroid plexus carcinoma development
  JOURNAL   Cell Death Differ 29 (8), 1596-1610 (2022)
   PUBMED   35322202
REFERENCE   5  (bases 1 to 1850)
  AUTHORS   Terre,B., Lewis,M., Gil-Gomez,G., Han,Z., Lu,H., Aguilera,M.,
            Prats,N., Roy,S., Zhao,H. and Stracker,T.H.
  TITLE     Defects in efferent duct multiciliogenesis underlie male
            infertility in GEMC1-, MCIDAS- or CCNO-deficient mice
  JOURNAL   Development 146 (8) (2019)
   PUBMED   30936178
  REMARK    GeneRIF: Data show defects in efferent duct multiciliogenesis
            underlie male infertility in GEMC1-, MCIDAS- or CCNO-deficient mice
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1850)
  AUTHORS   Sharbeen,G., Yee,C.W., Smith,A.L. and Jolly,C.J.
  TITLE     Ectopic restriction of DNA repair reveals that UNG2 excises
            AID-induced uracils predominantly or exclusively during G1 phase
  JOURNAL   J Exp Med 209 (5), 965-974 (2012)
   PUBMED   22529268
REFERENCE   7  (bases 1 to 1850)
  AUTHORS   Krijger,P.H., Langerak,P., van den Berk,P.C. and Jacobs,H.
  TITLE     Dependence of nucleotide substitutions on Ung2, Msh2, and PCNA-Ub
            during somatic hypermutation
  JOURNAL   J Exp Med 206 (12), 2603-2611 (2009)
   PUBMED   19901081
REFERENCE   8  (bases 1 to 1850)
  AUTHORS   Roig,M.B., Roset,R., Ortet,L., Balsiger,N.A., Anfosso,A.,
            Cabellos,L., Garrido,M., Alameda,F., Brady,H.J. and Gil-Gomez,G.
  TITLE     Identification of a novel cyclin required for the intrinsic
            apoptosis pathway in lymphoid cells
  JOURNAL   Cell Death Differ 16 (2), 230-243 (2009)
   PUBMED   18927588
  REMARK    GeneRIF: Cyclin O activation correlates with apoptosis induction in
            vivo.
REFERENCE   9  (bases 1 to 1850)
  AUTHORS   Hirst,R., Gosden,R. and Miller,D.
  TITLE     The cyclin-like uracil DNA glycosylase (UDG) of murine oocytes and
            its relationship to human and chimpanzee homologues
  JOURNAL   Gene 375, 95-102 (2006)
   PUBMED   16697536
REFERENCE   10 (bases 1 to 1850)
  AUTHORS   Forrest,A.R., Taylor,D. and Grimmond,S.
  CONSRTM   RIKEN GER Group; GSL Members
  TITLE     Exploration of the cell-cycle genes found within the RIKEN FANTOM2
            data set
  JOURNAL   Genome Res 13 (6B), 1366-1375 (2003)
   PUBMED   12819135
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC165265.2.
            
            On Jan 14, 2022 this sequence version replaced NM_001081062.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK086507.1, BC147759.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-456               AC165265.2         180436-180891
            457-642             AC165265.2         181498-181683
            643-1850            AC165265.2         182179-183386
FEATURES             Location/Qualifiers
     source          1..1850
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 63.93 cM"
     gene            1..1850
                     /gene="Ccno"
                     /gene_synonym="Ccnu; E130318K11; UDG2; Ung2"
                     /note="cyclin O"
                     /db_xref="GeneID:218630"
                     /db_xref="MGI:MGI:2145534"
     exon            1..456
                     /gene="Ccno"
                     /gene_synonym="Ccnu; E130318K11; UDG2; Ung2"
                     /inference="alignment:Splign:2.1.0"
     CDS             70..1128
                     /gene="Ccno"
                     /gene_synonym="Ccnu; E130318K11; UDG2; Ung2"
                     /note="uracil DNA glycosylase 2; cyclin-like uracil-DNA
                     glycosylase; cyclin U"
                     /codon_start=1
                     /product="cyclin-O"
                     /protein_id="NP_001074531.1"
                     /db_xref="CCDS:CCDS36782.1"
                     /db_xref="GeneID:218630"
                     /db_xref="MGI:MGI:2145534"
                     /translation="MVTPCPASPGSPAAGAGRRDSHQNLRAPVKKSRRPCLRRKKPLR
                     PLNACSLPGDSGVCDLFESPSSSSDGADSPAVSAARDCSSLLNPAQPLTALDLQTFRE
                     YGQSCYDFRKAQENLFHPRESLARQPQVTAESRCKLLSWLLQVHRQFGLSFESLCLTV
                     NTLDRFLLTTPVAADCFQLLGVTCLLIACKQVEVHPPRLKQLLALCGGAFSRQQLCNL
                     ECIVLHKLHFSLGAPTINFFLEHFTQWRMEAGQAEVTEALEAQTLARGVAELSLTDYA
                     FTTYTPSLMAICCLALADGLLQHQHEMDLRLGEHPEATLQDCLGKLQTLVSINSSSLP
                     RILPPQIWERCSLPQSWQ"
     exon            457..642
                     /gene="Ccno"
                     /gene_synonym="Ccnu; E130318K11; UDG2; Ung2"
                     /inference="alignment:Splign:2.1.0"
     exon            643..1850
                     /gene="Ccno"
                     /gene_synonym="Ccnu; E130318K11; UDG2; Ung2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1824..1829
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ccno"
                     /gene_synonym="Ccnu; E130318K11; UDG2; Ung2"
                     /note="hexamer: AATAAA"
     polyA_site      1850
                     /gene="Ccno"
                     /gene_synonym="Ccnu; E130318K11; UDG2; Ung2"
                     /note="major polyA site"
ORIGIN      
        1 atcttcctcg cagctctcgc gccgacgctc cgggcgtcgt agacgctagg agcgctaccc
       61 gattgtaaca tggttacccc ttgccctgcc agcccgggca gccccgccgc gggagccggg
      121 aggcgagaca gccaccagaa cctccgcgcc ccagtgaaga agagcagacg cccgtgcctc
      181 cggagaaaga agccgctgcg gccgctgaac gcgtgttcgc tcccgggaga ctcgggcgtc
      241 tgtgaccttt tcgagtcccc cagctccagc tcggacggcg ccgacagccc cgcagtgtct
      301 gcggcgcggg actgcagctc cctactcaac cctgcccagc ccttgacagc gctggatctc
      361 cagaccttcc gagaatacgg ccagagctgc tacgacttcc gaaaggcgca ggagaatctt
      421 ttccacccgc gggagtcgct ggcgcgccag ccacaagtga ctgccgaatc gcgctgtaaa
      481 ctgctcagct ggctcctgca agtccaccgc cagttcggcc tctctttcga gtcgctgtgt
      541 ctgaccgtga atactctgga ccgttttctc ctcacgaccc ctgttgctgc agactgcttc
      601 cagctgctcg gggtcacctg tctgctcatc gcttgcaagc aggtagaggt gcacccacct
      661 cgcttgaaac agctcctggc cctgtgcggc ggtgcgttct cccggcagca gctgtgcaac
      721 ctggagtgca tcgtgctgca taagctccac ttcagcctgg gcgcgcccac catcaacttc
      781 ttcctggagc acttcactca gtggcgcatg gaagccggcc aggctgaggt caccgaagct
      841 ctagaggctc aaaccctggc ccggggagtg gcggagctga gcctaacgga ttacgcgttc
      901 actacctaca cgccgtccct gatggctatc tgctgcctgg cgctggctga cggattgctg
      961 cagcaccagc acgagatgga cctgcgcctg ggagagcacc cagaggccac actgcaagac
     1021 tgtctgggca agctgcagac gctagtgtcc atcaatagca gctccctgcc tcgcattctg
     1081 cctccccaga tctgggagag gtgcagcctg ccccagagtt ggcaataaaa agcaccccct
     1141 tgagctcctt tttaaaattc cctggtccct gctccgtgcc ttaaggagaa tatgcagtac
     1201 agatccaaag agaagttgag gtctcctacc tgtaaatact gtacaataac ggattcttta
     1261 tttattttgt agtacacaag ggcaggggtg acagttctgg cttgtctaaa tgctgctgtt
     1321 ggcatgcctg actgtctgct tttcccaggc gaagtccatc acgaggtagc caattccgga
     1381 ggctcttccc tgctcccaca gttttacttt gtagttagct ctgtgaaaac aacctggcaa
     1441 gattttatat gccactgttc cagaaagcag acaagtcaag gtggcttgtc cgtatcttaa
     1501 ccccctccag tcaggaggct gagttccctc ccccatgcca gtggcccaag gagaatgaga
     1561 cagggttaga agtcagagtg gtctgtgctg tccggaaagg cagtggctgc actaactgat
     1621 gtggagctgg gaagctttgg ggaccgggca gccatactag cagtgggtga agcaagagac
     1681 agtccctggt gcaacacagg aaatgctgga atgccttttg cgtattgtta tagctgttgc
     1741 aacctgggtc atttcctctg cagctacact catggttcag tttatactgc agcatgagcc
     1801 cagggtaatt ctggtacggc agtaataaat attatactat ttgcaacata
//
