LOCUS       NM_207678               2435 bp    mRNA    linear   ROD 14-JUN-2024
DEFINITION  Mus musculus cyclin L2 (Ccnl2), transcript variant 1, mRNA.
ACCESSION   NM_207678 XM_194178
VERSION     NM_207678.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2435)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2435)
  AUTHORS   Simonson,L., Vold,S., Mowers,C., Massey,R.J., Ong,I.M.,
            Longley,B.J. and Chang,H.
  TITLE     Keratin 13 deficiency causes white sponge nevus in mice
  JOURNAL   Dev Biol 468 (1-2), 146-153 (2020)
   PUBMED   32758484
REFERENCE   3  (bases 1 to 2435)
  AUTHORS   Rakkaa,T., Escude,C., Giet,R., Magnaghi-Jaulin,L. and Jaulin,C.
  TITLE     CDK11(p58) kinase activity is required to protect sister chromatid
            cohesion at centromeres in mitosis
  JOURNAL   Chromosome Res 22 (3), 267-276 (2014)
   PUBMED   24436071
REFERENCE   4  (bases 1 to 2435)
  AUTHORS   Zhuo,L., Gong,J., Yang,R., Sheng,Y., Zhou,L., Kong,X. and Cao,K.
  TITLE     Inhibition of proliferation and differentiation and promotion of
            apoptosis by cyclin L2 in mouse embryonic carcinoma P19 cells
  JOURNAL   Biochem Biophys Res Commun 390 (3), 451-457 (2009)
   PUBMED   19785986
  REMARK    GeneRIF: These data suggest that overexpression of CCNL2 inhibited
            proliferation and differentiation of mouse embryonic carcinoma P19
            cells and induced them to undergo apoptosis, possibly through the
            Wnt signal transduction pathway.
REFERENCE   5  (bases 1 to 2435)
  AUTHORS   Yun,X., Wu,Y., Yao,L., Zong,H., Hong,Y., Jiang,J., Yang,J.,
            Zhang,Z. and Gu,J.
  TITLE     CDK11(p58) protein kinase activity is associated with Bcl-2
            down-regulation in pro-apoptosis pathway
  JOURNAL   Mol Cell Biochem 304 (1-2), 213-218 (2007)
   PUBMED   17516030
REFERENCE   6  (bases 1 to 2435)
  AUTHORS   Berke,J.D., Sgambato,V., Zhu,P.P., Lavoie,B., Vincent,M., Krause,M.
            and Hyman,S.E.
  TITLE     Dopamine and glutamate induce distinct striatal splice forms of
            Ania-6, an RNA polymerase II-associated cyclin
  JOURNAL   Neuron 32 (2), 277-287 (2001)
   PUBMED   11683997
REFERENCE   7  (bases 1 to 2435)
  AUTHORS   Bachmanov,A.A., Li,X., Reed,D.R., Ohmen,J.D., Li,S., Chen,Z.,
            Tordoff,M.G., de Jong,P.J., Wu,C., West,D.B., Chatterjee,A.,
            Ross,D.A. and Beauchamp,G.K.
  TITLE     Positional cloning of the mouse saccharin preference (Sac) locus
  JOURNAL   Chem Senses 26 (7), 925-933 (2001)
   PUBMED   11555487
REFERENCE   8  (bases 1 to 2435)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
REFERENCE   9  (bases 1 to 2435)
  AUTHORS   Cheng,H. and Bjerknes,M.
  TITLE     Patterns of gene expression along the crypt-villus axis in mouse
            jejunal epithelium
  JOURNAL   Anat Rec 244 (1), 78-94 (1996)
   PUBMED   8838426
REFERENCE   10 (bases 1 to 2435)
  AUTHORS   Bunnell,B.A., Heath,L.S., Adams,D.E., Lahti,J.M. and Kidd,V.J.
  TITLE     Increased expression of a 58-kDa protein kinase leads to changes in
            the CHO cell cycle
  JOURNAL   Proc Natl Acad Sci U S A 87 (19), 7467-7471 (1990)
   PUBMED   2217177
  REMARK    Erratum:[Proc Natl Acad Sci U S A 1991 Mar 15;88(6):2612]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL670236.9.
            
            On Jan 3, 2023 this sequence version replaced NM_207678.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB041605.1, BC132295.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-309               AL670236.9         119091-119399
            310-384             AL670236.9         119758-119832
            385-494             AL670236.9         120049-120158
            495-615             AL670236.9         121833-121953
            616-680             AL670236.9         124513-124577
            681-780             AL670236.9         126919-127018
            781-885             AL670236.9         127374-127478
            886-1027            AL670236.9         127563-127704
            1028-1136           AL670236.9         128402-128510
            1137-1229           AL670236.9         128595-128687
            1230-2435           AL670236.9         129933-131138
FEATURES             Location/Qualifiers
     source          1..2435
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 87.47 cM"
     gene            1..2435
                     /gene="Ccnl2"
                     /gene_synonym="1700010A01Rik; 1810019L15Rik;
                     2010319M22Rik; Ania-6b; HCLA-150; Pcee; SB138"
                     /note="cyclin L2"
                     /db_xref="GeneID:56036"
                     /db_xref="MGI:MGI:1927119"
     exon            1..309
                     /gene="Ccnl2"
                     /gene_synonym="1700010A01Rik; 1810019L15Rik;
                     2010319M22Rik; Ania-6b; HCLA-150; Pcee; SB138"
                     /inference="alignment:Splign:2.1.0"
     CDS             28..1584
                     /gene="Ccnl2"
                     /gene_synonym="1700010A01Rik; 1810019L15Rik;
                     2010319M22Rik; Ania-6b; HCLA-150; Pcee; SB138"
                     /note="isoform 1 is encoded by transcript variant 1;
                     paneth cell enhanced expression; cyclin Ania-6b; paneth
                     cell-enhanced expression protein"
                     /codon_start=1
                     /product="cyclin-L2 isoform 1"
                     /protein_id="NP_997561.1"
                     /db_xref="CCDS:CCDS19042.1"
                     /db_xref="GeneID:56036"
                     /db_xref="MGI:MGI:1927119"
                     /translation="MAAAAAGAAGLMAPASAACSSGSAGAAPGSQGVLIGDRLYSGVL
                     ITLENCLLPDDKLRFTPSMSSGLDVDTETGLRVVGCELIQAAGILLRLPQVAMATGQV
                     LFQRFFYTKSFVKHSMEHVSMACVHLASKIEEAPRRIRDVINVFHRLRHLREKKKPVP
                     LVLDQEYVNLKNQIIKAERRVLKELGFCVHVKHPHKIIVMYLQVLECERNQHLVQTAW
                     NYMNDSLRTDVFVRFQPESIACACIYLAARTLEIPLPNRPHWFLLFGATEEEIQEICF
                     KILQLYTRKKVDLTHLESEVEKRKHAIEEAKARAKGLLPGTAPGLDSAAGFSPAPKLE
                     SPKEGKGGKPSPPSGKSAKRKMEGPKKAQGHSPVNGLLKGQESRSQSRSREQSYSRSP
                     SRSASPKRRKSDSGSTSGGSKSQSRSRSRSDSPPRQVHRGAPYKGSEVRGSRKSKDCK
                     YLTQKPHKSRSRSSSRSRSRSRERTDNSGKYKKKSHYYRDQRRERSRSYERTGHRYER
                     DHPGHSRHRR"
     exon            310..384
                     /gene="Ccnl2"
                     /gene_synonym="1700010A01Rik; 1810019L15Rik;
                     2010319M22Rik; Ania-6b; HCLA-150; Pcee; SB138"
                     /inference="alignment:Splign:2.1.0"
     exon            385..494
                     /gene="Ccnl2"
                     /gene_synonym="1700010A01Rik; 1810019L15Rik;
                     2010319M22Rik; Ania-6b; HCLA-150; Pcee; SB138"
                     /inference="alignment:Splign:2.1.0"
     exon            495..615
                     /gene="Ccnl2"
                     /gene_synonym="1700010A01Rik; 1810019L15Rik;
                     2010319M22Rik; Ania-6b; HCLA-150; Pcee; SB138"
                     /inference="alignment:Splign:2.1.0"
     exon            616..680
                     /gene="Ccnl2"
                     /gene_synonym="1700010A01Rik; 1810019L15Rik;
                     2010319M22Rik; Ania-6b; HCLA-150; Pcee; SB138"
                     /inference="alignment:Splign:2.1.0"
     exon            681..780
                     /gene="Ccnl2"
                     /gene_synonym="1700010A01Rik; 1810019L15Rik;
                     2010319M22Rik; Ania-6b; HCLA-150; Pcee; SB138"
                     /inference="alignment:Splign:2.1.0"
     exon            781..885
                     /gene="Ccnl2"
                     /gene_synonym="1700010A01Rik; 1810019L15Rik;
                     2010319M22Rik; Ania-6b; HCLA-150; Pcee; SB138"
                     /inference="alignment:Splign:2.1.0"
     exon            886..1027
                     /gene="Ccnl2"
                     /gene_synonym="1700010A01Rik; 1810019L15Rik;
                     2010319M22Rik; Ania-6b; HCLA-150; Pcee; SB138"
                     /inference="alignment:Splign:2.1.0"
     exon            1028..1136
                     /gene="Ccnl2"
                     /gene_synonym="1700010A01Rik; 1810019L15Rik;
                     2010319M22Rik; Ania-6b; HCLA-150; Pcee; SB138"
                     /inference="alignment:Splign:2.1.0"
     exon            1137..1229
                     /gene="Ccnl2"
                     /gene_synonym="1700010A01Rik; 1810019L15Rik;
                     2010319M22Rik; Ania-6b; HCLA-150; Pcee; SB138"
                     /inference="alignment:Splign:2.1.0"
     exon            1230..2435
                     /gene="Ccnl2"
                     /gene_synonym="1700010A01Rik; 1810019L15Rik;
                     2010319M22Rik; Ania-6b; HCLA-150; Pcee; SB138"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2213..2218
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ccnl2"
                     /gene_synonym="1700010A01Rik; 1810019L15Rik;
                     2010319M22Rik; Ania-6b; HCLA-150; Pcee; SB138"
                     /note="hexamer: AATAAA"
     polyA_site      2244
                     /gene="Ccnl2"
                     /gene_synonym="1700010A01Rik; 1810019L15Rik;
                     2010319M22Rik; Ania-6b; HCLA-150; Pcee; SB138"
                     /note="major polyA site"
     regulatory      2411..2416
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ccnl2"
                     /gene_synonym="1700010A01Rik; 1810019L15Rik;
                     2010319M22Rik; Ania-6b; HCLA-150; Pcee; SB138"
                     /note="hexamer: ATTAAA"
     polyA_site      2435
                     /gene="Ccnl2"
                     /gene_synonym="1700010A01Rik; 1810019L15Rik;
                     2010319M22Rik; Ania-6b; HCLA-150; Pcee; SB138"
ORIGIN      
        1 gggcccgaga agagtcggcg gcacaaaatg gcggcggcgg cggccggggc tgcggggttg
       61 atggctccgg cgtcggcggc ctgctcttcc ggctcggcgg gagcggcccc ggggtctcag
      121 ggggtgctga tcggcgacag gctctactcg ggcgtgctca tcaccttgga aaactgcctg
      181 ctgcccgacg acaagctccg cttcacgccg tccatgtcga gcggcctcga cgtcgatacg
      241 gagacgggac tccgcgtcgt gggctgcgag ctcatccagg cagccggcat cctgctccgc
      301 ctgccgcagg tggccatggc tacagggcag gtgctgttcc agcggttctt ttacactaag
      361 tccttcgtga aacattccat ggagcatgtg tccatggctt gtgttcacct ggcttccaaa
      421 atagaagagg ctccgagacg aatcagggat gtcatcaatg tattccatcg ccttcggcat
      481 ctgagagaga aaaagaagcc cgtgcctctg gtgcttgatc aagagtatgt taacctaaag
      541 aaccagatta taaaggcaga gagacgggtt ctcaaggagt tgggcttttg tgtccatgtg
      601 aagcaccctc acaagataat cgttatgtac cttcaggtgt tagaatgtga gcgtaatcaa
      661 cacctggtcc agactgcatg gaactacatg aatgacagcc ttcgcacaga tgtctttgtc
      721 cggttccagc ctgaaagcat tgcttgtgcc tgtatctacc ttgctgcccg gacactggag
      781 atccctttac ccaatcgtcc acattggttt cttttgtttg gagcaactga agaagaaatt
      841 caagaaattt gctttaaaat cttgcagctt tatacacgga aaaaggttga tttgacgcat
      901 ctggagagtg aagtggagaa gagaaagcac gccattgaag aagcaaaggc ccgagcaaag
      961 ggcctgctcc cagggactgc gccaggcctg gacagtgctg cggggttctc gcctgctccc
     1021 aagctggaat ccccaaaaga aggtaaagga ggcaagcctt ccccgccctc tggaaagagc
     1081 gccaaacgga aaatggaagg cccaaagaaa gcccagggcc acagccctgt aaatggcttg
     1141 ctgaaagggc aggagagtcg aagtcaaagc aggagtcgtg agcagagcta ctcaaggtcc
     1201 ccatcacggt ccgcttctcc aaagagaagg aaaagtgata gtggctctac ctcaggtggg
     1261 tccaagtcac agagtcgttc tcggagccga agtgactctc ctccaaggca ggtacaccga
     1321 ggtgctccct acaaaggctc agaagtgagg ggctcccgga aatcaaagga ctgcaagtac
     1381 ctcacccaga agccacacaa gtctcgtagc cggagctcct ctcgttcccg aagccggtca
     1441 cgagagcgga cggacaattc tggaaaatac aagaagaaaa gtcattacta tagagatcaa
     1501 agacgtgagc gctcaaggtc atatgagcgc acaggccatc gctatgagag ggaccaccct
     1561 ggacacagca ggcatcggag gtgagatagg atccctggtg gctgcccttg gtccctccct
     1621 gttgggcaca ccttggcgtc agtggccttg tagcatgatg tttttcgaaa gtgtttttaa
     1681 ttggaccttg aggtgaattt gattgatgag acagtgggca aggtgccctt caggctggcc
     1741 tggggagtgc tgtgcatctg tcccggttaa tggtccacct caactgcaga ccttcaggta
     1801 gctggatgga acagcaaagg cacacgtccc cattggcgtg gcttggtgct attgacaagc
     1861 tgtctcttca ctcctaaact gatactcaat tacgttaagc caagaaagat gatttttgaa
     1921 atctttgcct atattaggtt gtacttgtgt acatattttg cagtggttca caatgagaaa
     1981 atggccttaa tagccccctt gttctctatt cacgttgtaa ataaacatgt ttaatacaag
     2041 taaaagctat atacgagaac tcagaatttt gattctgtta gcttaacact tgtatagaaa
     2101 attgagattt ttaaaatgtg aaggtattta ggtctgtgtt caaagtccgt atatttttat
     2161 ctgtgcaatg ctgagtgcag gccaccagct ggagagaaat tttacgtggt tgaataaaca
     2221 attctcagga cacttgttat gtaagacttt gtgggctgtc attctggttg tttctttgag
     2281 tgtatgcctg ggatttggct gtgggaccca ggcctggtgg gatatttgtg tgcaactgtg
     2341 cactgccagt ttagctatat gccaggggct gtaggagctg tatatgccct ggtccttgct
     2401 ccctgttctc attaaagtgt tagattttgt actga
//
