LOCUS       NM_019937               2185 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus cyclin L1 (Ccnl1), transcript variant 1, mRNA.
ACCESSION   NM_019937
VERSION     NM_019937.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2185)
  AUTHORS   Simonson,L., Vold,S., Mowers,C., Massey,R.J., Ong,I.M.,
            Longley,B.J. and Chang,H.
  TITLE     Keratin 13 deficiency causes white sponge nevus in mice
  JOURNAL   Dev Biol 468 (1-2), 146-153 (2020)
   PUBMED   32758484
REFERENCE   2  (bases 1 to 2185)
  AUTHORS   Rakkaa,T., Escude,C., Giet,R., Magnaghi-Jaulin,L. and Jaulin,C.
  TITLE     CDK11(p58) kinase activity is required to protect sister chromatid
            cohesion at centromeres in mitosis
  JOURNAL   Chromosome Res 22 (3), 267-276 (2014)
   PUBMED   24436071
REFERENCE   3  (bases 1 to 2185)
  AUTHORS   Yun,X., Wu,Y., Yao,L., Zong,H., Hong,Y., Jiang,J., Yang,J.,
            Zhang,Z. and Gu,J.
  TITLE     CDK11(p58) protein kinase activity is associated with Bcl-2
            down-regulation in pro-apoptosis pathway
  JOURNAL   Mol Cell Biochem 304 (1-2), 213-218 (2007)
   PUBMED   17516030
REFERENCE   4  (bases 1 to 2185)
  AUTHORS   Herrmann,A., Fleischer,K., Czajkowska,H., Muller-Newen,G. and
            Becker,W.
  TITLE     Characterization of cyclin L1 as an immobile component of the
            splicing factor compartment
  JOURNAL   FASEB J 21 (12), 3142-3152 (2007)
   PUBMED   17494991
REFERENCE   5  (bases 1 to 2185)
  AUTHORS   Chen,H.H., Wong,Y.H., Geneviere,A.M. and Fann,M.J.
  TITLE     CDK13/CDC2L5 interacts with L-type cyclins and regulates
            alternative splicing
  JOURNAL   Biochem Biophys Res Commun 354 (3), 735-740 (2007)
   PUBMED   17261272
REFERENCE   6  (bases 1 to 2185)
  AUTHORS   Okada,A., Kushima,K., Aoki,Y., Bialer,M. and Fujiwara,M.
  TITLE     Identification of early-responsive genes correlated to valproic
            acid-induced neural tube defects in mice
  JOURNAL   Birth Defects Res A Clin Mol Teratol 73 (4), 229-238 (2005)
   PUBMED   15799026
REFERENCE   7  (bases 1 to 2185)
  AUTHORS   Sgambato,V., Minassian,R., Nairn,A.C. and Hyman,S.E.
  TITLE     Regulation of ania-6 splice variants by distinct signaling pathways
            in striatal neurons
  JOURNAL   J Neurochem 86 (1), 153-164 (2003)
   PUBMED   12807435
REFERENCE   8  (bases 1 to 2185)
  AUTHORS   Berke,J.D., Sgambato,V., Zhu,P.P., Lavoie,B., Vincent,M., Krause,M.
            and Hyman,S.E.
  TITLE     Dopamine and glutamate induce distinct striatal splice forms of
            Ania-6, an RNA polymerase II-associated cyclin
  JOURNAL   Neuron 32 (2), 277-287 (2001)
   PUBMED   11683997
REFERENCE   9  (bases 1 to 2185)
  AUTHORS   Nairn,A.C. and Greengard,P.
  TITLE     A novel cyclin provides a link between dopamine and RNA processing
  JOURNAL   Neuron 32 (2), 174-176 (2001)
   PUBMED   11683987
REFERENCE   10 (bases 1 to 2185)
  AUTHORS   Bunnell,B.A., Heath,L.S., Adams,D.E., Lahti,J.M. and Kidd,V.J.
  TITLE     Increased expression of a 58-kDa protein kinase leads to changes in
            the CHO cell cycle
  JOURNAL   Proc Natl Acad Sci U S A 87 (19), 7467-7471 (1990)
   PUBMED   2217177
  REMARK    Erratum:[Proc Natl Acad Sci U S A 1991 Mar 15;88(6):2612]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC165307.6, CJ150556.1 and BC094383.1.
            
            On Sep 16, 2017 this sequence version replaced NM_019937.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC094383.1, AF159159.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164137
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-24                AC165307.6         85108-85131         c
            25-88               CJ150556.1         5-68
            89-2185             BC094383.1         1-2097
FEATURES             Location/Qualifiers
     source          1..2185
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 30.25 cM"
     gene            1..2185
                     /gene="Ccnl1"
                     /gene_synonym="2610030E23Rik; ania-6a; Ccnl"
                     /note="cyclin L1"
                     /db_xref="GeneID:56706"
                     /db_xref="MGI:MGI:1922664"
     exon            1..442
                     /gene="Ccnl1"
                     /gene_synonym="2610030E23Rik; ania-6a; Ccnl"
                     /inference="alignment:Splign:2.1.0"
     CDS             122..1720
                     /gene="Ccnl1"
                     /gene_synonym="2610030E23Rik; ania-6a; Ccnl"
                     /note="isoform 1 is encoded by transcript variant 1;
                     cyclin ania-6a; cyclin-L"
                     /codon_start=1
                     /product="cyclin-L1 isoform 1"
                     /protein_id="NP_064321.2"
                     /db_xref="CCDS:CCDS17390.1"
                     /db_xref="GeneID:56706"
                     /db_xref="MGI:MGI:1922664"
                     /translation="MASGPHPTSTAAAAAAAAASASSAAPSAGGSSSGTTTTTTTTTG
                     GILIGDRLYSEVSLTIDHSLIPEERLSPTPSMQDGLDLPSETDLRILGCELIQAAGIL
                     LRLPQVAMATGQVLFHRFFYSKSFVKHSFEIVAMACINLASKIEEAPRRIRDVINVFH
                     HLRQLRGKRTPSPLILDQNYINTKNQVIKAERRVLKELGFCVHVKHPHKIIVMYLQVL
                     ECERNQTLVQTAWNYMNDSLRTNVFVRFQPETIACACIYLAARALQIPLPTRPHWFLL
                     FGTTEEEIQEICIETLRLYTRKKPNYELLEKEVEKRKVALQEAKLKAKGLNLDGTPAL
                     STLGGFSPASKPSSPREVKAEEKSPVSINVKTVKKEPEDRQQASKSPYNGVRKDSKRS
                     RTSRSASRSRSRTRSRSRSHSPRRHYNNRRSRSGTYSSRSRSRSRSHSESPRRHHNHG
                     SPHLKAKHTREDLKSSNRHGHKRKKSRSRSQSKTRDHSDVTKKHRHERGHHRDRRERS
                     RSFERSHKGKHHGGSRSGHGRHRR"
     exon            443..517
                     /gene="Ccnl1"
                     /gene_synonym="2610030E23Rik; ania-6a; Ccnl"
                     /inference="alignment:Splign:2.1.0"
     exon            518..627
                     /gene="Ccnl1"
                     /gene_synonym="2610030E23Rik; ania-6a; Ccnl"
                     /inference="alignment:Splign:2.1.0"
     exon            628..748
                     /gene="Ccnl1"
                     /gene_synonym="2610030E23Rik; ania-6a; Ccnl"
                     /inference="alignment:Splign:2.1.0"
     exon            749..813
                     /gene="Ccnl1"
                     /gene_synonym="2610030E23Rik; ania-6a; Ccnl"
                     /inference="alignment:Splign:2.1.0"
     exon            814..913
                     /gene="Ccnl1"
                     /gene_synonym="2610030E23Rik; ania-6a; Ccnl"
                     /inference="alignment:Splign:2.1.0"
     exon            914..1018
                     /gene="Ccnl1"
                     /gene_synonym="2610030E23Rik; ania-6a; Ccnl"
                     /inference="alignment:Splign:2.1.0"
     exon            1019..1160
                     /gene="Ccnl1"
                     /gene_synonym="2610030E23Rik; ania-6a; Ccnl"
                     /inference="alignment:Splign:2.1.0"
     exon            1161..1272
                     /gene="Ccnl1"
                     /gene_synonym="2610030E23Rik; ania-6a; Ccnl"
                     /inference="alignment:Splign:2.1.0"
     exon            1273..1371
                     /gene="Ccnl1"
                     /gene_synonym="2610030E23Rik; ania-6a; Ccnl"
                     /inference="alignment:Splign:2.1.0"
     exon            1372..2169
                     /gene="Ccnl1"
                     /gene_synonym="2610030E23Rik; ania-6a; Ccnl"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2142..2147
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ccnl1"
                     /gene_synonym="2610030E23Rik; ania-6a; Ccnl"
                     /note="hexamer: AATAAA"
     regulatory      2147..2152
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ccnl1"
                     /gene_synonym="2610030E23Rik; ania-6a; Ccnl"
                     /note="hexamer: AATACA"
     polyA_site      2165
                     /gene="Ccnl1"
                     /gene_synonym="2610030E23Rik; ania-6a; Ccnl"
                     /note="major polyA site"
     polyA_site      2169
                     /gene="Ccnl1"
                     /gene_synonym="2610030E23Rik; ania-6a; Ccnl"
                     /note="major polyA site"
ORIGIN      
        1 gcacgctgcg tgcggcggcc tggaagccgg cggtcacggg aagatccgtc gcgccgagga
       61 cgctggttag tctcgctttg ggttccggct gcgtcgggcg tgcgtggagc tcgctggaac
      121 tatggcgtcc gggcctcacc cgacctcgac cgctgccgcc gccgccgccg ctgccgcctc
      181 cgcctcgtcc gccgccccga gcgcgggcgg ctccagctcc ggcacgacca ccacgacgac
      241 gaccacgacc ggagggatcc tgatcggcga ccgcctgtat tcggaggtgt cgctcaccat
      301 cgaccactcg ctgatcccgg aggagcggct ctcgcctacc ccgtccatgc aggacggcct
      361 ggacctgccc agcgagacgg atctgcgcat cttgggctgc gagctcatcc aggccgccgg
      421 catcctcctc cggctgccgc aggtggcgat ggctacaggg caggtgctgt tccatcggtt
      481 cttctactcc aagtcgttcg tcaaacacag tttcgagatt gttgctatgg cctgtattaa
      541 tcttgcgtca aaaatcgaag aagcgccaag aagaataaga gatgtgatta atgtattcca
      601 ccacctccgc cagttaagag gaaaaaggac tccaagcccc ctgatccttg atcagaacta
      661 cattaacacc aaaaatcaag ttatcaaggc agagaggagg gtgctaaagg agttgggatt
      721 ttgtgttcat gtcaagcatc cccataagat cattgtaatg tatttacaag tcttagaatg
      781 tgaacgtaac caaaccctgg ttcaaactgc ctggaattac atgaatgaca gtcttcgaac
      841 caatgtcttt gttcgctttc aaccagagac tatagcatgt gcttgtatct accttgcagc
      901 tagagcactt caaattccct tgccaactcg gccccattgg tttcttctgt ttggtaccac
      961 agaagaggag attcaggaaa tctgcataga gacgcttaga ctttatacca ggaaaaagcc
     1021 taactatgaa ttgctggaaa aggaagtaga aaaaagaaaa gtagccttac aggaagccaa
     1081 gttaaaagca aagggattga atcttgatgg aactccagcc ctttcaactc ttggtggatt
     1141 ttctccagcc tctaaaccat catcaccaag agaagtgaaa gctgaagaga aatcaccagt
     1201 ctccattaat gtgaagacag tcaaaaaaga acctgaggat agacagcagg cgtcaaaaag
     1261 cccttacaat ggtgtaagaa aagacagcaa gagaagcaga accagcagaa gtgctagtag
     1321 atcaaggtca agaaccaggt cccgttccag atcacacagc ccaagaagac attataataa
     1381 taggcgaagt cgatctggaa catacagctc aagatcaaga agcaggtctc gcagtcacag
     1441 tgaaagccct cgaagacatc ataatcatgg ttctcctcac cttaaggcca aacataccag
     1501 agaagattta aaaagctcaa atagacacgg tcataagagg aaaaagtctc ggtctcgatc
     1561 tcagagcaag actcgggatc actcagatgt taccaagaaa cacaggcacg aaaggggaca
     1621 tcacagagac aggcgtgaac gatctcgctc ctttgagagg tcccataaag gcaagcacca
     1681 tggtggcagt cgctcaggac atggcaggca taggcgctga ctttcatcct ctgacactgc
     1741 agcggttcct ggtgttgccc atatgcagtg taatgatgtg tggactcaat cgaaacataa
     1801 aaaaaaaaaa actgattagg aaatgattta ttaaaattgt ctaggtttct agaaacactg
     1861 aggacatttt ctttggaaaa gaactatgtt aaggtttttt gcacattaaa atgccctagc
     1921 agtatctaat tgaaaaccat ggtcaggttc aattgtactt tattatagtt gtgtattgtt
     1981 tattgctata agaactggag cataaattct gtaaaaatgt atcttatttt tatacagatg
     2041 aaacttgcag acttgttgta tttaagtggt tatttgttta aatgatggtg aatactttcc
     2101 taacactggt ttgtctgcat gggcaaagat ttttacaagg aaataaaata caaatcttgt
     2161 ttttataaaa aaaaaaaaaa aaaaa
//
