LOCUS       NM_009832               2632 bp    mRNA    linear   ROD 18-DEC-2022
DEFINITION  Mus musculus cyclin K (Ccnk), mRNA.
ACCESSION   NM_009832 XM_194862
VERSION     NM_009832.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2632)
  AUTHORS   Chen HR, Juan HC, Wong YH, Tsai JW and Fann MJ.
  TITLE     Cdk12 Regulates Neurogenesis and Late-Arising Neuronal Migration in
            the Developing Cerebral Cortex
  JOURNAL   Cereb Cortex 27 (3), 2289-2302 (2017)
   PUBMED   27073218
REFERENCE   2  (bases 1 to 2632)
  AUTHORS   Juan HC, Lin Y, Chen HR and Fann MJ.
  TITLE     Cdk12 is essential for embryonic development and the maintenance of
            genomic stability
  JOURNAL   Cell Death Differ 23 (6), 1038-1048 (2016)
   PUBMED   26658019
REFERENCE   3  (bases 1 to 2632)
  AUTHORS   Xiang X, Deng L, Zhang J, Zhang X, Lei T, Luan G, Yang C, Xiao ZX,
            Li Q and Li Q.
  TITLE     A distinct expression pattern of cyclin K in mammalian testes
            suggests a functional role in spermatogenesis
  JOURNAL   PLoS One 9 (7), e101539 (2014)
   PUBMED   25004108
  REMARK    GeneRIF: that cyclin K may be a novel molecular link between germ
            cell development, cancer development and embryonic stem cell
            maintenance.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2632)
  AUTHORS   Dai Q, Lei T, Zhao C, Zhong J, Tang YZ, Chen B, Yang J, Li C, Wang
            S, Song X, Li L and Li Q.
  TITLE     Cyclin K-containing kinase complexes maintain self-renewal in
            murine embryonic stem cells
  JOURNAL   J Biol Chem 287 (30), 25344-25352 (2012)
   PUBMED   22547058
  REMARK    GeneRIF: Cyclin K-containing kinase complexes maintain self-renewal
            in murine embryonic stem cells.
REFERENCE   5  (bases 1 to 2632)
  AUTHORS   Sugaya M, Kuwano Y, Suga H, Miyagaki T, Ohmatsu H, Kadono T, Okochi
            H, Blauvelt A, Tamaki K and Sato S.
  TITLE     Lymphatic dysfunction impairs antigen-specific immunization, but
            augments tissue swelling following contact with allergens
  JOURNAL   J Invest Dermatol 132 (3 Pt 1), 667-676 (2012)
   PUBMED   22071476
REFERENCE   6  (bases 1 to 2632)
  AUTHORS   Bennett B, Downing C, Carosone-Link P, Ponicsan H, Ruf C and
            Johnson TE.
  TITLE     Quantitative trait locus mapping for acute functional tolerance to
            ethanol in the L x S recombinant inbred panel
  JOURNAL   Alcohol Clin Exp Res 31 (2), 200-208 (2007)
   PUBMED   17250610
REFERENCE   7  (bases 1 to 2632)
  AUTHORS   Blackshaw S, Harpavat S, Trimarchi J, Cai L, Huang H, Kuo WP, Weber
            G, Lee K, Fraioli RE, Cho SH, Yung R, Asch E, Ohno-Machado L, Wong
            WH and Cepko CL.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   8  (bases 1 to 2632)
  AUTHORS   Togashi T, Obata M, Aoyagi Y, Kominami R and Mishima Y.
  TITLE     Two distinct methods analyzing chromatin structure using
            centrifugation and antibodies to modified histone H3: both provide
            similar chromatin states of the Rit1/Bcl11b gene
  JOURNAL   Biochem Biophys Res Commun 313 (3), 489-495 (2004)
   PUBMED   14697215
REFERENCE   9  (bases 1 to 2632)
  AUTHORS   Barroco RM, De Veylder L, Magyar Z, Engler G, Inze D and Mironov V.
  TITLE     Novel complexes of cyclin-dependent kinases and a cyclin-like
            protein from Arabidopsis thaliana with a function unrelated to cell
            division
  JOURNAL   Cell Mol Life Sci 60 (2), 401-412 (2003)
   PUBMED   12678503
REFERENCE   10 (bases 1 to 2632)
  AUTHORS   Edwards MC, Wong C and Elledge SJ.
  TITLE     Human cyclin K, a novel RNA polymerase II-associated cyclin
            possessing both carboxy-terminal domain kinase and Cdk-activating
            kinase activity
  JOURNAL   Mol Cell Biol 18 (7), 4291-4300 (1998)
   PUBMED   9632813
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CA984404.1 and AK146711.1.
            
            [WARNING] On May 24, 2023 this sequence was replaced by
            NM_009832.3.
            
            On Oct 4, 2007 this sequence version replaced NM_009832.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK146711.1, AK154679.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-64                CA984404.1         159-222
            65-2632             AK146711.1         2-2569
FEATURES             Location/Qualifiers
     source          1..2632
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 59.23 cM"
     gene            1..2632
                     /gene="Ccnk"
                     /gene_synonym="CPR4; CycK"
                     /note="cyclin K"
                     /db_xref="GeneID:12454"
                     /db_xref="MGI:MGI:1276106"
     exon            1..143
                     /gene="Ccnk"
                     /gene_synonym="CPR4; CycK"
                     /inference="alignment:Splign:2.1.0"
     exon            144..175
                     /gene="Ccnk"
                     /gene_synonym="CPR4; CycK"
                     /inference="alignment:Splign:2.1.0"
     exon            176..422
                     /gene="Ccnk"
                     /gene_synonym="CPR4; CycK"
                     /inference="alignment:Splign:2.1.0"
     CDS             226..1974
                     /gene="Ccnk"
                     /gene_synonym="CPR4; CycK"
                     /codon_start=1
                     /product="cyclin-K"
                     /protein_id="NP_033962.2"
                     /db_xref="CCDS:CCDS49165.1"
                     /db_xref="GeneID:12454"
                     /db_xref="MGI:MGI:1276106"
                     /translation="MKENKENSSPSVTSANLDHTKPCWYWDKKDLAHTPSQLEGLDPA
                     TEARYRREGARFIFDVGTRLGLHYDTLATGIIYFHRFYMFHSFKQFPRYVTGACCLFL
                     AGKVEETPKKCKDIIKTARSLLNDVQFGQFGDDPKEEVMVLERILLQTIKFDLQVEHP
                     YQFLLKYAKQLKGDKNKIQKLVQMAWTFVNDSLCTTLSLQWEPEIIAVAVMYLAGRLC
                     KFEIQEWTSKPMYRRWWEQFVQDVPVDVLEDICHQILDLYSQGKQQMPHHTPHQLQQP
                     PSLQPTPQVPQGPQSQPSQGSEAAQPPQKDSQQSAQQQQQQAQQPKKPSPQPSPPRQA
                     KRAVVVSPKEENKATEPPPPPKIPKLEATHPPLPPAHPPPDRKPPLAPALGEAEATGP
                     VETSDLPKVQIPPPAHPAPVHQPPPLPHRPPPPPPSSYMTGMSTTSSYMSGEGYQSLQ
                     SMMKTEGPSYGALPPAYGPPAHLTYHPHVYPPNPPPPPVPPPPASFPPPTIPPPTPGY
                     PPPPPTYNPNFPPPPPRLPPTHAVPPHPPPGLGLPPASYPPPAVPPGGQPPVPPPIPP
                     PGMPPVGGLGRAAWMR"
     exon            423..504
                     /gene="Ccnk"
                     /gene_synonym="CPR4; CycK"
                     /inference="alignment:Splign:2.1.0"
     exon            505..636
                     /gene="Ccnk"
                     /gene_synonym="CPR4; CycK"
                     /inference="alignment:Splign:2.1.0"
     exon            637..742
                     /gene="Ccnk"
                     /gene_synonym="CPR4; CycK"
                     /inference="alignment:Splign:2.1.0"
     exon            743..800
                     /gene="Ccnk"
                     /gene_synonym="CPR4; CycK"
                     /inference="alignment:Splign:2.1.0"
     exon            801..970
                     /gene="Ccnk"
                     /gene_synonym="CPR4; CycK"
                     /inference="alignment:Splign:2.1.0"
     exon            971..1239
                     /gene="Ccnk"
                     /gene_synonym="CPR4; CycK"
                     /inference="alignment:Splign:2.1.0"
     exon            1240..1273
                     /gene="Ccnk"
                     /gene_synonym="CPR4; CycK"
                     /inference="alignment:Splign:2.1.0"
     exon            1274..1348
                     /gene="Ccnk"
                     /gene_synonym="CPR4; CycK"
                     /inference="alignment:Splign:2.1.0"
     exon            1349..2632
                     /gene="Ccnk"
                     /gene_synonym="CPR4; CycK"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2609..2614
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ccnk"
                     /gene_synonym="CPR4; CycK"
                     /note="putative"
     polyA_site      2632
                     /gene="Ccnk"
                     /gene_synonym="CPR4; CycK"
                     /note="putative"
ORIGIN      
        1 gcacctgact ttcgccgccc cctccggccg cttcttaacg tcccgagacg cagggaaatg
       61 acgtagttcc ccgacattcc acctccaaga tggctgctgt caggaaggag agacgtcgct
      121 gagggttttg cctgaggcga ggggttgatg ttggcctgaa gaaagatctt cagaggatta
      181 caacattcca gagtcccact ggggaagaac aagatacttc aataaatgaa ggagaacaaa
      241 gaaaactcaa gcccttcagt cacgtcagca aacctggacc acacaaaacc atgttggtac
      301 tgggataaga aggacctagc gcacacaccc tcacaacttg aaggactcga tccagccact
      361 gaggcccggt accgccgaga gggggctcgc ttcatctttg atgtgggcac acgtttgggg
      421 ttacactatg acaccctggc aactggaatc atttattttc accgatttta tatgttccat
      481 tccttcaaac aattcccaag atacgtgaca ggagcttgtt gtctttttct ggctgggaaa
      541 gtagaggaaa cgccaaaaaa gtgtaaagat atcatcaaaa cggctcgtag tttattaaat
      601 gatgtccagt tcggccagtt tggagatgac ccaaaggaag aagtcatggt gttggagagg
      661 atcttactgc agaccataaa gtttgactta caagtagagc atccgtacca gttcctgctc
      721 aaatatgcaa agcagctcaa aggtgataaa aacaaaattc agaagttggt tcaaatggca
      781 tggacatttg taaatgacag tctctgcacc accctgtcac tgcagtggga accagagatc
      841 atagctgtcg cagtaatgta tcttgcggga cgtttgtgca aatttgaaat acaagagtgg
      901 acctccaaac ccatgtatag gagatggtgg gagcagttcg ttcaagatgt ccctgttgac
      961 gttctggaag acatctgcca ccaaatcctg gacctttact cacaagggaa acaacagatg
     1021 cctcatcaca cccctcatca gctgcagcag cccccatctc ttcagcctac accacaagtg
     1081 ccccaggggc cacagtccca accatctcaa ggctcagaag cagcccagcc tccacagaag
     1141 gactcgcagc agtcagccca gcagcaacag cagcaagcac aacagcccaa gaaaccatcc
     1201 cctcagccca gtcctccccg acaggccaag cgcgccgtgg tggtttctcc caaggaagag
     1261 aacaaagcta cagaaccacc accaccacct aaaattccca aacttgaggc tactcaccca
     1321 ccattgcctc cagcacaccc acctccagac cggaagcctc ccctcgcccc tgccttaggt
     1381 gaggctgaag caactggtcc tgtggaaaca agtgatctcc ccaaagtcca gattccccct
     1441 ccagcccacc cggcccctgt gcaccagccc ccaccattgc cacatcggcc accacccccg
     1501 ccaccctcca gctacatgac ggggatgtcc accaccagct cctacatgtc aggagagggc
     1561 tatcagagcc tgcagtccat gatgaagacg gagggcccct cctatggtgc cctgccccca
     1621 gcctacggcc cacctgctca cctaacctac cacccccatg tctatccccc caacccacct
     1681 ccacctcctg ttcctccacc cccagcctcc tttcccccac ccaccattcc tccccctacc
     1741 ccaggctacc ctccccctcc ccctacctac aaccccaatt tcccaccccc acccccacgc
     1801 ctgcccccaa ctcatgcagt ccctcctcac cctcctccag gcttgggttt gccaccagcc
     1861 agctacccac ctccagctgt cccccctggg ggacagcccc ctgttccccc acccatcccc
     1921 ccacctggta tgccacctgt tggggggcta gggcgggcgg cctggatgag ataacggggc
     1981 gcccccccct ttgttttaag aattgttttc caaccaactt gaagaataga ctgagggggc
     2041 ggcagcaggg cgccttgtat atgctagaca gttgcagtgt gggagggctg ggccctggca
     2101 tgaactgtgt gccctgggca gtgcctgctg tggtgtgatc acatccagtc cccgctgccg
     2161 tctgtgtcct gcacggggct actttaatac tagtgaagat gttaagtagc cacattggct
     2221 cagttaatag cttcagtaag gagtgactaa ccctctagaa atcagtgcct aattttcctg
     2281 agaactaact tttggtatcc atgtcctcct gtctgcagtc tggctgttgt tcttccattc
     2341 tgtggcttct ctctgtggcc cctagtaggt gaggtgactc cccacttagc ttgtaactct
     2401 gtcctctatt gtcatctggg gggctgcctt gacgggtggc tgtctccttc cctccatgga
     2461 gaaaggaggt gtgtacttgg aaaacaatgt atgtttacat ctctttgcaa agtcttgtac
     2521 atagagagat attttttaag cgtgaatgta acaacatact gtgaattcca tcttggttac
     2581 aaatgagaat ccttcagtca gttgcccgaa taaaatcagt tctgaaacta cc
//
