LOCUS       NM_017367               2830 bp    mRNA    linear   ROD 21-DEC-2022
DEFINITION  Mus musculus cyclin I (Ccni), mRNA.
ACCESSION   NM_017367
VERSION     NM_017367.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2830)
  AUTHORS   Hagmann H, Taniguchi Y, Pippin JW, Kauerz HM, Benzing T, Shankland
            SJ and Brinkkoetter PT.
  TITLE     Cyclin I and p35 determine the subcellular distribution of Cdk5
  JOURNAL   Am J Physiol Cell Physiol 308 (4), C339-C347 (2015)
   PUBMED   25500740
  REMARK    GeneRIF: Subcellular localization of Cdk5 is determined by its
            specific activators, cyclin I and p35.
REFERENCE   2  (bases 1 to 2830)
  AUTHORS   Taniguchi Y, Pippin JW, Hagmann H, Krofft RD, Chang AM, Zhang J,
            Terada Y, Brinkkoetter P and Shankland SJ.
  TITLE     Both cyclin I and p35 are required for maximal survival benefit of
            cyclin-dependent kinase 5 in kidney podocytes
  JOURNAL   Am J Physiol Renal Physiol 302 (9), F1161-F1171 (2012)
   PUBMED   22262481
  REMARK    GeneRIF: Both cyclin I and p35 are required for maximal survival
            benefit of cyclin-dependent kinase 5 in kidney podocytes.
REFERENCE   3  (bases 1 to 2830)
  AUTHORS   Sato A, Sekine Y, Saruta C, Nishibe H, Morita N, Sato Y, Sadakata
            T, Shinoda Y, Kojima T and Furuichi T.
  TITLE     Cerebellar development transcriptome database (CDT-DB): profiling
            of spatio-temporal gene expression during the postnatal development
            of mouse cerebellum
  JOURNAL   Neural Netw 21 (8), 1056-1069 (2008)
   PUBMED   18603407
REFERENCE   4  (bases 1 to 2830)
  AUTHORS   Griffin SV, Olivier JP, Pippin JW, Roberts JM and Shankland SJ.
  TITLE     Cyclin I protects podocytes from apoptosis
  JOURNAL   J Biol Chem 281 (38), 28048-28057 (2006)
   PUBMED   16847066
  REMARK    GeneRIF: Cyclin I protects podocytes from apoptosis, and we provide
            preliminary data to suggest that this is mediated by stabilization
            of p21(Cip1/Waf1).
REFERENCE   5  (bases 1 to 2830)
  AUTHORS   Blackshaw S, Harpavat S, Trimarchi J, Cai L, Huang H, Kuo WP, Weber
            G, Lee K, Fraioli RE, Cho SH, Yung R, Asch E, Ohno-Machado L, Wong
            WH and Cepko CL.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   6  (bases 1 to 2830)
  AUTHORS   Jensen MR, Audolfsson T, Factor VM and Thorgeirsson SS.
  TITLE     In vivo expression and genomic organization of the mouse cyclin I
            gene (Ccni)
  JOURNAL   Gene 256 (1-2), 59-67 (2000)
   PUBMED   11054536
REFERENCE   7  (bases 1 to 2830)
  AUTHORS   Jensen MR, Audolfsson T, Keck CL, Zimonjic DB and Thorgeirsson SS.
  TITLE     Assignment of the cyclin I gene (Ccni) to mouse chromosome
            5E3.3-F1. 3 by in situ hybridization
  JOURNAL   Cytogenet Cell Genet 83 (3-4), 242-243 (1998)
   PUBMED   10072591
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK050465.1, AF005886.2, AK079476.1, AK152614.1 and CA451138.1.
            
            [WARNING] On May 5, 2023 this sequence was replaced by NM_017367.4.
            
            On Apr 21, 2009 this sequence version replaced NM_017367.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK152614.1, AK079476.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-468               AK050465.1         2-469
            469-1106            AF005886.2         121-758
            1107-2063           AK079476.1         1048-2004
            2064-2151           AK152614.1         2020-2107
            2152-2798           AK079476.1         2093-2739
            2799-2830           CA451138.1         319-350
FEATURES             Location/Qualifiers
     source          1..2830
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5"
     gene            1..2830
                     /gene="Ccni"
                     /note="cyclin I"
                     /db_xref="GeneID:12453"
                     /db_xref="MGI:MGI:1341077"
     exon            1..582
                     /gene="Ccni"
                     /inference="alignment:Splign:2.1.0"
     exon            583..740
                     /gene="Ccni"
                     /inference="alignment:Splign:2.1.0"
     CDS             627..1760
                     /gene="Ccni"
                     /codon_start=1
                     /product="cyclin-I"
                     /protein_id="NP_059063.2"
                     /db_xref="CCDS:CCDS19436.1"
                     /db_xref="GeneID:12453"
                     /db_xref="MGI:MGI:1341077"
                     /translation="MKFPGPLENQRLSSLLERAISREAQMWKVNVPKIPTNQNVSPSQ
                     RDEVIQWLAKLKYQFNLYPETFALASSLLDRFLATVKAHPKYLNCIAISCFFLAAKTV
                     EEDEKIPVLKVLARDSFCGCSSSEILRMERIILDKLNWDLHTATPLDFLHIFHAIAVS
                     ARPQLLFSLPKLSPSQHLAVLTKQLLHCMACNQLLQFKGSMLALAMVSLEMEKLIPDW
                     LPLTIELLQKAQMDSSQLIHCRELVAYHLSALQSALPLNSVYVYRPLKHTLVTCDKGA
                     FKLHPSSVSGPDFSKDNSKPEVPVRGPAAFHLHLPAASGCKQTSAKRKVEEMEVDDFY
                     DGIKRLYNEDNGPENVGSVCGTDLSRQEGHASPCPPLQPVSVM"
     exon            741..869
                     /gene="Ccni"
                     /inference="alignment:Splign:2.1.0"
     exon            870..944
                     /gene="Ccni"
                     /inference="alignment:Splign:2.1.0"
     exon            945..1085
                     /gene="Ccni"
                     /inference="alignment:Splign:2.1.0"
     exon            1086..1316
                     /gene="Ccni"
                     /inference="alignment:Splign:2.1.0"
     exon            1317..2804
                     /gene="Ccni"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtccgcgag ggcggggcta ggcggccggc gctttttcgt acgctcctcc ctccccagcc
       61 ttcccccgcg agcggacgcg ccagcgcctc tgtctcgctt tttcttattt tctccccctt
      121 tccccttcct tttcttttct tttttcccct tccccccttc caccatttcc cctcggaggc
      181 gtttccctcg ggcaggggca gagccggcct caccccgcgc ctctccccgg cccccgccgc
      241 cctatggcga gagggcgccc cctcctcacc cgggcaccag cggcggcggt cggaggagcg
      301 ggaccggcgg cggcggcctc gggcccaggg tcatcatgga actagttcgc tgagtgaccc
      361 ctcggccgca gccgtgcgtc ccgcccgagt acccgcgccc gccggcccgg tttgccctct
      421 tctccctcct cagacggccc ggccctggtc ccgcgcgccc cgctgccgcg cgccgaggat
      481 catgaggtgg taacgggccc ccggatgacc ccgcgtcacc actgtgaggc ctacagctct
      541 gccggggagg aggaggagga ggaagaggag gagaagaaga aggtagctac atcaagctgg
      601 gtggcaggca gatccaaagg gataccatga agtttccagg acctttggaa aaccagagat
      661 tgtcttctct gttggaaagg gcaatctcca gggaagccca gatgtggaag gtgaatgtgc
      721 cgaaaatacc tacaaatcag aatgtttctc catcccagag agatgaagta attcaatggt
      781 tggccaaact caaataccag ttcaacctct atccagaaac atttgctctg gcaagcagtc
      841 ttttggatag gtttttagct acagtaaaag cccatccaaa atatttgaat tgtattgcaa
      901 tcagctgttt ttttctggct gctaagactg ttgaggaaga tgagaaaatt ccagtgctaa
      961 aggtattggc aagagacagt ttctgtggat gttcctcatc tgagattttg agaatggaga
     1021 gaattattct ggataaattg aattgggatc ttcacacggc tacaccattg gattttcttc
     1081 acattttcca tgccattgcg gtgtcagcta ggcctcagtt acttttcagt ttgcccaaat
     1141 tgagcccatc tcaacatttg gcagtcctga ccaagcagct gcttcactgt atggcctgca
     1201 accaacttct gcagttcaaa gggtccatgc ttgctctggc catggttagt ctggaaatgg
     1261 agaaactcat tcctgattgg cttcctctta cgattgaact gcttcagaaa gcacagatgg
     1321 acagctccca gttgatccac tgtcgggagc tggtggcata tcacctttct gctctgcagt
     1381 ctgccctgcc tctaaattcc gtttatgtct accgtcccct caagcacacc ctggtaacct
     1441 gtgacaaagg agcattcaaa ttacatccct cctctgtctc aggcccagat ttctccaagg
     1501 acaacagcaa gccagaagtg ccagtccgag gtccagcagc cttccacctg catctccccg
     1561 ctgccagtgg gtgcaagcaa acctctgcta aacggaaagt ggaggagatg gaggtggatg
     1621 acttctacga tgggatcaag cggctctata atgaggacaa tggtcctgag aatgtgggtt
     1681 ctgtatgtgg cactgattta tcaaggcaag agggccatgc ttccccctgt ccacctttgc
     1741 agcctgtttc tgtcatgtag tttcaggtgt cagcttccag tgcacacgaa ggctgactac
     1801 tcggggtgag actagaaacc cagggaaggc tgtggagaag gcatgtgctt tatcagactg
     1861 actgaagtga gccaggaaaa aaagaaaacc actcttaatc tttcgtgcgg ttacttacaa
     1921 tccaacgtaa tttaatataa aggctatatt tgtagactca agatccaaaa tatatttaaa
     1981 agtaaagcaa aagttctttg tactatgtca gttccaccat tgttaaataa gtttgcccca
     2041 tgtcaaaaaa aaatgtttag cggaaagttg caaactctca gctaggaacc ttgttccagt
     2101 gtccttattt tcctcttgcc ttttcttgcc tcggttgaat acttaactaa gctgtgtgct
     2161 tgttgatcta tgtattctga cttcacttga gtaccaccca ccttttcttt taaagtaatt
     2221 cagtaagtaa attatttttg tgtggcagcc atgtttaatc cacagttcaa gtatgttagt
     2281 ttgaaaaggg cactttgaag ctatccccat gaatcagtgg cagtaggaaa agttctcttt
     2341 ttttgtgtct catttcagtt tttagtttaa aattattatt gtcctttttt tgtttatctt
     2401 gaagctcaat aaaatggcac gtaattagga cattttaagc atttttgaca tttatataaa
     2461 agaatttctg ataaggttaa tatatccagg tgctcaccaa agaaacatgt atgtaatata
     2521 cacgtagatt tttgtaactg atctgttctt gctcatttat aatccgtaga agcaactgtc
     2581 tagatactgg ggcagccctg atttgagtct gtaacttata atttaattca ttaccctagt
     2641 ttcatattat gccattagga ttttcttgat aaggaattat tcccttgttt ctctctgagc
     2701 aatgtctgga ccctgagctc cctttgcagt ctgaaggcac tgcagtcaga accatgtact
     2761 gctgataaag cctctggtag caataaaatg ttgtccttaa cgttaaaaaa aaaaaaaaaa
     2821 aaaaaaaaaa
//
