LOCUS       NM_023243               2094 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus cyclin H (Ccnh), transcript variant 1, mRNA.
ACCESSION   NM_023243
VERSION     NM_023243.6
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2094)
  AUTHORS   Akagawa,R., Nabeshima,Y.I. and Kawauchi,T.
  TITLE     Alternative Functions of Cell Cycle-Related and DNA Repair Proteins
            in Post-mitotic Neurons
  JOURNAL   Front Cell Dev Biol 9, 753175 (2021)
   PUBMED   34746147
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2094)
  AUTHORS   Talchai,S.C. and Accili,D.
  TITLE     Legacy Effect of Foxo1 in Pancreatic Endocrine Progenitors on Adult
            beta-Cell Mass and Function
  JOURNAL   Diabetes 64 (8), 2868-2879 (2015)
   PUBMED   25784544
REFERENCE   3  (bases 1 to 2094)
  AUTHORS   Patel,S.A. and Simon,M.C.
  TITLE     Functional analysis of the Cdk7.cyclin H.Mat1 complex in mouse
            embryonic stem cells and embryos
  JOURNAL   J Biol Chem 285 (20), 15587-15598 (2010)
   PUBMED   20231280
  REMARK    GeneRIF: investigated the function of the Cdk7.cyclin H.Mat1
            complex in murine embryonic stem (ES) cells and preimplantation
            embryos to determine whether it regulates the unique cell cycle
            structure and transcriptional network of pluripotent cells
REFERENCE   4  (bases 1 to 2094)
  AUTHORS   Yokoyama,S., Ito,Y., Ueno-Kudoh,H., Shimizu,H., Uchibe,K.,
            Albini,S., Mitsuoka,K., Miyaki,S., Kiso,M., Nagai,A., Hikata,T.,
            Osada,T., Fukuda,N., Yamashita,S., Harada,D., Mezzano,V., Kasai,M.,
            Puri,P.L., Hayashizaki,Y., Okado,H., Hashimoto,M. and Asahara,H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
REFERENCE   5  (bases 1 to 2094)
  AUTHORS   Sato,A., Sekine,Y., Saruta,C., Nishibe,H., Morita,N., Sato,Y.,
            Sadakata,T., Shinoda,Y., Kojima,T. and Furuichi,T.
  TITLE     Cerebellar development transcriptome database (CDT-DB): profiling
            of spatio-temporal gene expression during the postnatal development
            of mouse cerebellum
  JOURNAL   Neural Netw 21 (8), 1056-1069 (2008)
   PUBMED   18603407
REFERENCE   6  (bases 1 to 2094)
  AUTHORS   Kozar,K., Ciemerych,M.A., Rebel,V.I., Shigematsu,H., Zagozdzon,A.,
            Sicinska,E., Geng,Y., Yu,Q., Bhattacharya,S., Bronson,R.T.,
            Akashi,K. and Sicinski,P.
  TITLE     Mouse development and cell proliferation in the absence of
            D-cyclins
  JOURNAL   Cell 118 (4), 477-491 (2004)
   PUBMED   15315760
REFERENCE   7  (bases 1 to 2094)
  AUTHORS   Carninci,P., Waki,K., Shiraki,T., Konno,H., Shibata,K., Itoh,M.,
            Aizawa,K., Arakawa,T., Ishii,Y., Sasaki,D., Bono,H., Kondo,S.,
            Sugahara,Y., Saito,R., Osato,N., Fukuda,S., Sato,K., Watahiki,A.,
            Hirozane-Kishikawa,T., Nakamura,M., Shibata,Y., Yasunishi,A.,
            Kikuchi,N., Yoshiki,A., Kusakabe,M., Gustincich,S., Beisel,K.,
            Pavan,W., Aidinis,V., Nakagawara,A., Held,W.A., Iwata,H., Kono,T.,
            Nakauchi,H., Lyons,P., Wells,C., Hume,D.A., Fagiolini,M.,
            Hensch,T.K., Brinkmeier,M., Camper,S., Hirota,J., Mombaerts,P.,
            Muramatsu,M., Okazaki,Y., Kawai,J. and Hayashizaki,Y.
  TITLE     Targeting a complex transcriptome: the construction of the mouse
            full-length cDNA encyclopedia
  JOURNAL   Genome Res 13 (6B), 1273-1289 (2003)
   PUBMED   12819125
REFERENCE   8  (bases 1 to 2094)
  AUTHORS   Guo,Z., Yikang,S., Yoshida,H., Mak,T.W. and Zacksenhaus,E.
  TITLE     Inactivation of the retinoblastoma tumor suppressor induces
            apoptosis protease-activating factor-1 dependent and independent
            apoptotic pathways during embryogenesis
  JOURNAL   Cancer Res 61 (23), 8395-8400 (2001)
   PUBMED   11731416
  REMARK    GeneRIF: Inactivation of the retinoblastoma tumor suppressor
            induces apoptosis protease-activating factor-1 dependent and
            independent apoptotic pathways during embryogenesis.
REFERENCE   9  (bases 1 to 2094)
  AUTHORS   Kim,J.M., McGaughy,J.T., Bogle,R.K. and Ravnik,S.E.
  TITLE     Meiotic expression of the cyclin H/Cdk7 complex in male germ cells
            of the mouse
  JOURNAL   Biol Reprod 64 (5), 1400-1408 (2001)
   PUBMED   11319144
REFERENCE   10 (bases 1 to 2094)
  AUTHORS   De Graeve,F., Bahr,A., Chatton,B. and Kedinger,C.
  TITLE     A murine ATFa-associated factor with transcriptional repressing
            activity
  JOURNAL   Oncogene 19 (14), 1807-1819 (2000)
   PUBMED   10777215
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY767531.1, AK078059.1 and BM899601.1.
            
            On Dec 1, 2016 this sequence version replaced NM_023243.5.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660811.29420.1,
                                           SRR1660817.134117.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-145               BY767531.1         2-146
            146-1693            AK078059.1         55-1602
            1694-2094           BM899601.1         1-401               c
FEATURES             Location/Qualifiers
     source          1..2094
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 45.05 cM"
     gene            1..2094
                     /gene="Ccnh"
                     /gene_synonym="6330408H09Rik"
                     /note="cyclin H"
                     /db_xref="GeneID:66671"
                     /db_xref="MGI:MGI:1913921"
     exon            1..268
                     /gene="Ccnh"
                     /gene_synonym="6330408H09Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             152..1123
                     /gene="Ccnh"
                     /gene_synonym="6330408H09Rik"
                     /note="isoform a is encoded by transcript variant 1"
                     /codon_start=1
                     /product="cyclin-H isoform a"
                     /protein_id="NP_075732.1"
                     /db_xref="CCDS:CCDS26666.1"
                     /db_xref="GeneID:66671"
                     /db_xref="MGI:MGI:1913921"
                     /translation="MYHSSSQKRHWTFASEEQLARLRADANRKFKCKAVANGKVLPND
                     PVFLEPHEELTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPR
                     IIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQERALEQILEYELLLIQQLNFHLIV
                     HNPYRPFEGFLIDIKTRYPMLENPEILRKTADDFLSRIALTDAYLLYTPSQIALTAIL
                     SSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSDEVAVLKQK
                     LERCHSSDLALNAVTKKRKGYEDDDYVSKKPKQEEEEWTDDDLVDSL"
     exon            269..391
                     /gene="Ccnh"
                     /gene_synonym="6330408H09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            392..465
                     /gene="Ccnh"
                     /gene_synonym="6330408H09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            466..676
                     /gene="Ccnh"
                     /gene_synonym="6330408H09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            677..840
                     /gene="Ccnh"
                     /gene_synonym="6330408H09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            841..911
                     /gene="Ccnh"
                     /gene_synonym="6330408H09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            912..1023
                     /gene="Ccnh"
                     /gene_synonym="6330408H09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1024..1084
                     /gene="Ccnh"
                     /gene_synonym="6330408H09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1085..2076
                     /gene="Ccnh"
                     /gene_synonym="6330408H09Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1229..1234
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ccnh"
                     /gene_synonym="6330408H09Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      1253
                     /gene="Ccnh"
                     /gene_synonym="6330408H09Rik"
                     /note="major polyA site"
     regulatory      2045..2050
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ccnh"
                     /gene_synonym="6330408H09Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2069
                     /gene="Ccnh"
                     /gene_synonym="6330408H09Rik"
ORIGIN      
        1 agagcagacg ctggcacgtg accgggacgt cacgcacgcg tccgcggtct gggcgggggc
       61 gggggttcgc gcgttggccg tcgctcgtgg tcgctgtctc tcggagtgtc gctgtttttg
      121 tcgcggccct gcggcccgtg agggctacag catgtatcac agcagcagcc agaaacggca
      181 ctggaccttc gctagcgagg agcagctggc gcgcctgcgg gcggacgcca accgcaaatt
      241 caagtgcaaa gctgtggcta acgggaaggt tcttccaaat gatccagtgt ttctggagcc
      301 tcatgaagaa ttgacacttt gcaagtacta tgaaaaaaga ttattggaat tctgttcagt
      361 gtttaaacca gctatgccac ggtctgttgt gggtacagct tgtatgtatt tcaagcgttt
      421 ttatcttaat aactcagtaa tggaatatca ccctcggata ataatgctta cttgtgcatt
      481 tttggcctgc aaagtagatg aattcaatgt gtctagtccc cagtttgttg gaaatcttcg
      541 agagagtcct cttggacagg agagggcact ggaacagatt ttggaatatg aactactact
      601 tatacaacaa cttaattttc accttattgt ccacaatcca tacagaccat ttgaaggctt
      661 cctcatcgat ataaagactc ggtaccccat gttggagaat ccggagattc tgaggaaaac
      721 agctgatgat tttcttagta gaattgcatt gacagatgct tatcttttat acacaccttc
      781 acagattgcc ctgaccgcca ttttatcaag tgcctctaga gctggaatta ctatggaaag
      841 ctacttatca gagagtctaa tgctaaaaga aaacagaact tgcctgtcac agttactgga
      901 tataatgaaa agcatgagaa atctagtaaa aaagtacgag ccgcccaggt ctgacgaggt
      961 tgctgtcctg aaacagaagc tggagcggtg tcattcttct gaccttgcac ttaatgcggt
     1021 tacgaagaag aggaaaggct atgaagatga tgactatgtg tcaaagaaac ccaaacagga
     1081 agaggaggaa tggactgatg acgacctggt agattctctc taaccataat aaatgaccgc
     1141 agcagtactt attaaccaac ggaagtagga agcatgtctg acattttact ttttaaaaaa
     1201 atagtacaat gtgaaaacat caaaatatat taaacttttc tagttgttct atatattttc
     1261 tttgtgattg ttttatataa catatagctt caaaaggggt gaatgccacc tagtttgaat
     1321 attcataatc cactaggatt agttgcaaac catgtcctcc tgtggtagac aaagtcagac
     1381 tgtgctacac ttccttgtat tgttttagac aaactataat aaacaaacct ttccatttag
     1441 aagcattata ctagaaaaaa aaaaaacctg aacaataggt aaacatctga aaagttaaga
     1501 aaataggttt tatcctccag aagcccttac aaatgcttct cagatgtctc tccagtagac
     1561 tgaactattg atgattcatt actaagctgg agaatgtact gggcacttac gtagtactta
     1621 ggtgctaaat tttattacat gcagttacag atatcttcta ggtttaaata aaaatagaat
     1681 ttttgagtat agataaaaaa aaatcttaaa tttctacaga taagtcatag taaatgatat
     1741 agtcaatttt atcattaaat gattacctct cagtaaatcc ttataaagtt ggcattatag
     1801 tgactagaaa tctgtagaaa aattatatgc aaaaatttaa agttaaataa cttaatataa
     1861 aaacccaaaa catatgcctc tacttttcta tgactttagt taattatata cctcaatgtg
     1921 ctattttccc aaatacagat tggggaaaat aatgcctgct cctgatggga ttagtcacag
     1981 cagtgcttga catactagta tgtatttgct gtatattaat aatatgtgtt acagttaaga
     2041 ccaaaataaa gatagatatg catatattag accagtaaaa aaaaaaaaaa aaaa
//
