LOCUS       NM_007635               2510 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus cyclin G2 (Ccng2), mRNA.
ACCESSION   NM_007635
VERSION     NM_007635.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2510)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2510)
  AUTHORS   Nakano,T., Aochi,H., Hirasaki,M., Takenaka,Y., Fujita,K.,
            Tamura,M., Soma,H., Kamezawa,H., Koizumi,T., Shibuya,H.,
            Inomata,R., Okuda,A., Murakoshi,T., Shimada,A. and Inoue,I.
  TITLE     Effects of Ppargamma1 deletion on late-stage murine embryogenesis
            and cells that undergo endocycle
  JOURNAL   Dev Biol 478, 222-235 (2021)
   PUBMED   34246625
REFERENCE   3  (bases 1 to 2510)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2510)
  AUTHORS   Sun,M., Gao,J., Meng,T., Liu,S., Chen,H., Liu,Q., Xing,X., Zhao,C.
            and Luo,Y.
  TITLE     Cyclin G2 upregulation impairs migration, invasion, and network
            formation through RNF123/Dvl2/JNK signaling in the trophoblast cell
            line HTR8/SVneo, a possible role in preeclampsia
  JOURNAL   FASEB J 35 (2), e21169 (2021)
   PUBMED   33205477
  REMARK    GeneRIF: Cyclin G2 upregulation impairs migration, invasion, and
            network formation through RNF123/Dvl2/JNK signaling in the
            trophoblast cell line HTR8/SVneo, a possible role in preeclampsia.
REFERENCE   5  (bases 1 to 2510)
  AUTHORS   Zhao,C., Gao,J., Li,S., Liu,Q., Hou,X., Xing,X., Wang,D., Sun,M.,
            Wang,S. and Luo,Y.
  TITLE     Cyclin G2 regulates canonical Wnt signalling via interaction with
            Dapper1 to attenuate tubulointerstitial fibrosis in diabetic
            nephropathy
  JOURNAL   J Cell Mol Med 24 (5), 2749-2760 (2020)
   PUBMED   31978940
  REMARK    GeneRIF: Cyclin G2 regulates canonical Wnt signalling via
            interaction with Dapper1 to attenuate tubulointerstitial fibrosis
            in diabetic nephropathy.
REFERENCE   6  (bases 1 to 2510)
  AUTHORS   Mason,J.L., Xuan,S., Dragatsis,I., Efstratiadis,A. and Goldman,J.E.
  TITLE     Insulin-like growth factor (IGF) signaling through type 1 IGF
            receptor plays an important role in remyelination
  JOURNAL   J Neurosci 23 (20), 7710-7718 (2003)
   PUBMED   12930811
REFERENCE   7  (bases 1 to 2510)
  AUTHORS   Kannan,K., Kaminski,N., Rechavi,G., Jakob-Hirsch,J., Amariglio,N.
            and Givol,D.
  TITLE     DNA microarray analysis of genes involved in p53 mediated
            apoptosis: activation of Apaf-1
  JOURNAL   Oncogene 20 (26), 3449-3455 (2001)
   PUBMED   11423996
REFERENCE   8  (bases 1 to 2510)
  AUTHORS   Jensen,M.R., Audolfsson,T., Keck,C.L., Zimonjic,D.B. and
            Thorgeirsson,S.S.
  TITLE     Gene structure and chromosomal localization of mouse cyclin G2
            (Ccng2)
  JOURNAL   Gene 230 (2), 171-180 (1999)
   PUBMED   10216255
REFERENCE   9  (bases 1 to 2510)
  AUTHORS   Horne,M.C., Donaldson,K.L., Goolsby,G.L., Tran,D., Mulheisen,M.,
            Hell,J.W. and Wahl,A.F.
  TITLE     Cyclin G2 is up-regulated during growth inhibition and B cell
            antigen receptor-mediated cell cycle arrest
  JOURNAL   J Biol Chem 272 (19), 12650-12661 (1997)
   PUBMED   9139721
REFERENCE   10 (bases 1 to 2510)
  AUTHORS   Horne,M.C., Goolsby,G.L., Donaldson,K.L., Tran,D., Neubauer,M. and
            Wahl,A.F.
  TITLE     Cyclin G1 and cyclin G2 comprise a new family of cyclins with
            contrasting tissue-specific and cell cycle-regulated expression
  JOURNAL   J Biol Chem 271 (11), 6050-6061 (1996)
   PUBMED   8626390
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY065574.1, BC088980.1, AK168891.1 and BE957050.1.
            
            On Dec 4, 2007 this sequence version replaced NM_007635.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK041941.1, AK170651.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-194               BY065574.1         1-194
            195-2299            BC088980.1         1-2105
            2300-2487           AK168891.1         2143-2330
            2488-2510           BE957050.1         1-23                c
FEATURES             Location/Qualifiers
     source          1..2510
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 47.29 cM"
     gene            1..2510
                     /gene="Ccng2"
                     /note="cyclin G2"
                     /db_xref="GeneID:12452"
                     /db_xref="MGI:MGI:1095734"
     exon            1..225
                     /gene="Ccng2"
                     /inference="alignment:Splign:2.1.0"
     CDS             226..1260
                     /gene="Ccng2"
                     /codon_start=1
                     /product="cyclin-G2"
                     /protein_id="NP_031661.3"
                     /db_xref="CCDS:CCDS19437.1"
                     /db_xref="GeneID:12452"
                     /db_xref="MGI:MGI:1095734"
                     /translation="MKDLGAKHLAGGEGVQLFGLLNFYLEQEQRYQPREKGLILMEAT
                     PENDNTLCSRLRNAKVEDLRSLTNFFGSGTETFVLAVNILDRFLALMKVKPKHLSCIG
                     VCCFLLAARLAEEEGDVPPTHDVIRISQCKCTASDIKRMEKIISEKLHYELEATTALN
                     FLHLYHAIVFCHTSERKEILSLDKLEAQLKACNCRVVFSKARPSVLALCLLNLEIETI
                     KSVELLEILLLVKKHLKLSDTEFFYWRELVSKCLAEYSSPRCCKPDLKKLVWIVSRRT
                     AQNLHSSYYSVPELPTIPEGGCFDGSESEDSGEDMSCGEESLSSSPPSDQECTFFFDF
                     QVAQTLCFPP"
     exon            226..363
                     /gene="Ccng2"
                     /inference="alignment:Splign:2.1.0"
     exon            364..501
                     /gene="Ccng2"
                     /inference="alignment:Splign:2.1.0"
     exon            502..752
                     /gene="Ccng2"
                     /inference="alignment:Splign:2.1.0"
     exon            753..831
                     /gene="Ccng2"
                     /inference="alignment:Splign:2.1.0"
     exon            832..930
                     /gene="Ccng2"
                     /inference="alignment:Splign:2.1.0"
     exon            931..1136
                     /gene="Ccng2"
                     /inference="alignment:Splign:2.1.0"
     exon            1137..2494
                     /gene="Ccng2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2462..2467
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ccng2"
                     /note="hexamer: AATAAA"
     polyA_site      2488
                     /gene="Ccng2"
                     /note="major polyA site"
ORIGIN      
        1 ggtttgctca gctccggagg ctgcggcgga gccgggagga ggtggcggtg cagggcgggc
       61 gctgagcccc gctgaggagc aagatgcagc cggggctgtg aggccgggcg gcggcgggga
      121 ggtcggatgc gggtctcggg gtgccgctga ggaggctggt ccctgagctc ggagacgggt
      181 ccggacgccc ccgccgcgcc ggtccgtgac gccggggccg acacgatgaa ggatttgggg
      241 gccaagcact tggcaggtgg cgaaggggtt cagcttttcg gattgttgaa cttctacctg
      301 gaacaagaac agagatacca acctcgggaa aaagggctga tcttgatgga ggctaccccg
      361 gagaatgata acactttgtg ttcaagactg agaaatgcca aagtggaaga tttaagaagt
      421 ttaactaact tctttggatc tggcactgaa actttcgttc tggctgtcaa tattttggat
      481 agattcttgg cccttatgaa ggtgaaaccg aaacacctgt cctgcattgg cgtctgctgc
      541 tttttgctgg ccgccaggct ggcggaagaa gaaggtgacg ttccccccac gcacgatgtg
      601 atccgcatca gtcagtgtaa atgcacagcg tctgacatta aacgcatgga gaaaatcatc
      661 tcagagaaac tgcactatga gctggaagct accactgcct taaacttttt gcacttgtac
      721 cacgcgattg tattttgtca cacttcagaa aggaaggaga ttctcagcct cgataaactc
      781 gaagcgcagc tgaaagcttg caactgccga gttgtcttct ccaaagcaag accatctgta
      841 ttagctctgt gccttctcaa tttggaaata gaaacgataa aatccgtgga actgctggaa
      901 attctcttgc ttgttaaaaa acatttgaag ctcagcgaca ctgaattctt ttactggagg
      961 gaactggttt ctaaatgtct agcagagtat tcttcgcctc gctgctgcaa gcctgatctg
     1021 aagaagctgg tatggattgt ttcgcgacgc actgcgcaga acctccacag cagctactac
     1081 agtgttcctg agctgcccac tatcccagag gggggttgct ttgacggaag tgaaagtgag
     1141 gactctggtg aagacatgag ttgtggagag gagagtctca gcagctcccc acccagcgat
     1201 caggagtgca ccttcttctt tgacttccaa gtggctcaga cactgtgctt tccaccatag
     1261 aggtcacatg tctgtgtcag ggtttaaagt gtgtgtacct atttcaaagc aatacttggg
     1321 ggtgtgggta gttttctagt ccagcccccg tctagacagg aatttcacag actggaatac
     1381 ctaccttcta tttattattc agatcagatc tggcctattt tcatatttaa tcctaagcca
     1441 tcaaatgggt tagtgcctct taacagtact taaaacgttg gcactttatt ttttgttgac
     1501 atttatcttg gggaggaggg aaggtgctga ttccttcatt cctttcaggc ctttgaaaga
     1561 tgaacagtgt agcctgtctg aaactgtaga gccttcaggt gtctttattt aataggttgg
     1621 gagtgtgcaa gggcttcctt agcagggaca gaaggcaatc ctttcatggt ttatcttgga
     1681 tttccttctc ccttgttctc agaacagaga ctgcagtact cttgagtgtc aaacaccaat
     1741 tctgtttttc taatggtggt gtattgtccg atacagatcc tacatgttaa gaattgacat
     1801 gtctgtgaat tttagttcat aaatgtcttg agctttctgc tgaagcagaa gttgccatca
     1861 agctaggact gttagttgca ttcttaatac ctaagtattg tcagactgta gtattatttt
     1921 agtgttacct aaaaaagttc ataatctgct agctttgcat gcacctgtgt gaaagcagaa
     1981 cagggaatgg agttgataag tgctgattta gctcatctca ctttcttgta ttaaaatatc
     2041 tgcatgatta ctttctaatt gttttataat tcacatttca taatgtattg tatatgggtg
     2101 ccaagatgtg aatatgaagt gaaagacctc cagtgtttgt agtgttagtt taaagcaatt
     2161 ctgtgtggtg atggagccat aaggatgaag atgtgtacac tctgtacact gaagcttttg
     2221 tacagagaat ttttaacttt ataaacctat gtgaaaatgt aaatctttaa aaatgtacat
     2281 aaaatactgt atttttttac ctttgtgtgt gataattggt cagtgcatgt aaatataatt
     2341 tattgtgtgt tctatattat actcagacat tgatgactta ctttttatta gtaagtcaac
     2401 acccagtgag gtgttttcca aagtagattt tttttgaatt ccgaataggt cataattcaa
     2461 aaataaaaat attaatgaat tctccttaca tgtaaaaaaa aaaaaaaaaa
//
