LOCUS       NM_001409832            3851 bp    mRNA    linear   ROD 24-SEP-2024
DEFINITION  Mus musculus cyclin F (Ccnf), transcript variant 11, mRNA.
ACCESSION   NM_001409832 XM_006523554
VERSION     NM_001409832.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3851)
  AUTHORS   Noonan,M.L., Muto,Y., Yoshimura,Y., Leckie-Harre,A., Wu,H.,
            Kalinichenko,V.V., Humphreys,B.D. and Chang-Panesso,M.
  TITLE     Injury-induced Foxm1 expression in the mouse kidney drives
            epithelial proliferation by a cyclin F-dependent mechanism
  JOURNAL   JCI Insight 9 (15), e175416 (2024)
   PUBMED   38916959
  REMARK    GeneRIF: Injury-induced Foxm1 expression in the mouse kidney drives
            epithelial proliferation by a cyclin F-dependent mechanism.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3851)
  AUTHORS   Akagawa,R., Nabeshima,Y.I. and Kawauchi,T.
  TITLE     Alternative Functions of Cell Cycle-Related and DNA Repair Proteins
            in Post-mitotic Neurons
  JOURNAL   Front Cell Dev Biol 9, 753175 (2021)
   PUBMED   34746147
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3851)
  AUTHORS   Nakano,T., Aochi,H., Hirasaki,M., Takenaka,Y., Fujita,K.,
            Tamura,M., Soma,H., Kamezawa,H., Koizumi,T., Shibuya,H.,
            Inomata,R., Okuda,A., Murakoshi,T., Shimada,A. and Inoue,I.
  TITLE     Effects of Ppargamma1 deletion on late-stage murine embryogenesis
            and cells that undergo endocycle
  JOURNAL   Dev Biol 478, 222-235 (2021)
   PUBMED   34246625
REFERENCE   4  (bases 1 to 3851)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3851)
  AUTHORS   Yu,Y., Nakagawa,T., Morohoshi,A., Nakagawa,M., Ishida,N.,
            Suzuki,N., Aoki,M. and Nakayama,K.
  TITLE     Pathogenic mutations in the ALS gene CCNF cause cytoplasmic
            mislocalization of Cyclin F and elevated VCP ATPase activity
  JOURNAL   Hum Mol Genet 28 (20), 3486-3497 (2019)
   PUBMED   31577344
  REMARK    GeneRIF: Pathogenic mutations in the ALS gene CCNF cause
            cytoplasmic mislocalization of Cyclin F and elevated VCP ATPase
            activity
REFERENCE   6  (bases 1 to 3851)
  AUTHORS   Kozar,K., Ciemerych,M.A., Rebel,V.I., Shigematsu,H., Zagozdzon,A.,
            Sicinska,E., Geng,Y., Yu,Q., Bhattacharya,S., Bronson,R.T.,
            Akashi,K. and Sicinski,P.
  TITLE     Mouse development and cell proliferation in the absence of
            D-cyclins
  JOURNAL   Cell 118 (4), 477-491 (2004)
   PUBMED   15315760
REFERENCE   7  (bases 1 to 3851)
  AUTHORS   Tetzlaff,M.T., Bai,C., Finegold,M., Wilson,J., Harper,J.W.,
            Mahon,K.A. and Elledge,S.J.
  TITLE     Cyclin F disruption compromises placental development and affects
            normal cell cycle execution
  JOURNAL   Mol Cell Biol 24 (6), 2487-2498 (2004)
   PUBMED   14993286
  REMARK    GeneRIF: CycF(-/-) animals, with a myriad of developmental
            anomalies due in large part to failures in yolk sac and
            chorioallantoic placentation, die around embryonic day 10.5.
REFERENCE   8  (bases 1 to 3851)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   9  (bases 1 to 3851)
  AUTHORS   Brinkmeier,M.L. and Camper,S.A.
  TITLE     Localization of somatostatin receptor genes on mouse chromosomes 2,
            11, 12, 15, and 17: correlation with growth QTLs
  JOURNAL   Genomics 43 (1), 9-14 (1997)
   PUBMED   9226367
REFERENCE   10 (bases 1 to 3851)
  AUTHORS   Obermayr,F., Sutherland,H.F., Kraus,B. and Frischauf,A.M.
  TITLE     Mouse cyclin F maps to a conserved linkage group on mouse
            chromosome 17
  JOURNAL   Mamm Genome 6 (2), 149-150 (1995)
   PUBMED   7767003
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC117577.16.
            
            On Jul 26, 2022 this sequence version replaced XM_006523554.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17253012.2363746.1,
                                           SRR7345562.149551.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-179               AC117577.16        101287-101465
            180-334             AC117577.16        103241-103395
            335-441             AC117577.16        108060-108166
            442-509             AC117577.16        109300-109367
            510-703             AC117577.16        110313-110506
            704-757             AC117577.16        111205-111258
            758-862             AC117577.16        111763-111867
            863-940             AC117577.16        112722-112799
            941-1092            AC117577.16        115414-115565
            1093-1257           AC117577.16        118112-118276
            1258-1381           AC117577.16        120738-120861
            1382-1562           AC117577.16        121155-121335
            1563-1650           AC117577.16        122243-122330
            1651-1750           AC117577.16        125863-125962
            1751-1878           AC117577.16        126044-126171
            1879-2048           AC117577.16        127569-127738
            2049-3851           AC117577.16        128300-130102
FEATURES             Location/Qualifiers
     source          1..3851
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 12.32 cM"
     gene            1..3851
                     /gene="Ccnf"
                     /gene_synonym="CycF; Fbxo1"
                     /note="cyclin F"
                     /db_xref="GeneID:12449"
                     /db_xref="MGI:MGI:102551"
     exon            1..179
                     /gene="Ccnf"
                     /gene_synonym="CycF; Fbxo1"
                     /inference="alignment:Splign:2.1.0"
     CDS             125..2497
                     /gene="Ccnf"
                     /gene_synonym="CycF; Fbxo1"
                     /note="isoform 10 is encoded by transcript variant 11;
                     G2/mitotic-specific cyclin-F"
                     /codon_start=1
                     /product="cyclin-F isoform 10"
                     /protein_id="NP_001396761.1"
                     /db_xref="GeneID:12449"
                     /db_xref="MGI:MGI:102551"
                     /translation="MDSGPCDPGVRVASPKARVIHCRCAKCFCYPTKRRIKRRPRNLT
                     ILSLPEDVLFHILKWLSVGDILAVRAVHSHLKYLVDNHASVWASASFQELWPSPQNLK
                     LFERAAEKGNFEAAVKLGIAYLYNEGLSVSDEACAEVNGLKASRFFSMAERLNTGSEP
                     FIWLFIRPPWSVSGSCCKAVVHDSLRAECQLQRSHKASILHCLGRVLNLFEDEEKRKQ
                     ARSLLEESSRQGCLISSYLLWESDRKVDMSDPGRCLHSFRKLRDYAAKGCWEAQLALA
                     KACAGGSQLGLEGKACSESVCQLFQASQAVNKQQIFSVQKGLSDTMRYILIDWLVEVA
                     TMKDFTSLCLHLTVECVDRYLRRRLVPRYKLQLLGIACMVICTRFISKEILTIREAVW
                     LTDNTYKYEDLVRVMGEIISALEGKIRIPTVVDYKEVLLTLVPVAPRTQHLCSFLCEL
                     TLLHTSLSIYAPARLASAALLLARLMHGQTQPWTTHLWDLTGFSYSDLVPCVLSLHKK
                     CFHDDAPKDYRQVSLTAVKQRFEDKCYEEISREEVLSYADLCSTIGVKQESPEPPSFP
                     SSGEIHTFLSSPSGRRSKRKRENSLQEDRGSFVTTPTAELSNQEETLLGSLLDWSLEC
                     CSGYEGDQESEGEKEGDVTAPSRLLDVTVVYLNPEEHCCQESSDEEAWPEDKIHPAPG
                     TQAPPASAPRPLLCNRGDRAKDITTSGYSSVSSSSPISSLDGGMGGSPQSTSVLSVGS
                     HSSTKPCHHQAKKSCLQCRPPNSPESGVHQQPVKRQNLSVHSDKDMHLAS"
     exon            180..334
                     /gene="Ccnf"
                     /gene_synonym="CycF; Fbxo1"
                     /inference="alignment:Splign:2.1.0"
     exon            335..441
                     /gene="Ccnf"
                     /gene_synonym="CycF; Fbxo1"
                     /inference="alignment:Splign:2.1.0"
     exon            442..509
                     /gene="Ccnf"
                     /gene_synonym="CycF; Fbxo1"
                     /inference="alignment:Splign:2.1.0"
     exon            510..703
                     /gene="Ccnf"
                     /gene_synonym="CycF; Fbxo1"
                     /inference="alignment:Splign:2.1.0"
     exon            704..757
                     /gene="Ccnf"
                     /gene_synonym="CycF; Fbxo1"
                     /inference="alignment:Splign:2.1.0"
     exon            758..862
                     /gene="Ccnf"
                     /gene_synonym="CycF; Fbxo1"
                     /inference="alignment:Splign:2.1.0"
     exon            863..940
                     /gene="Ccnf"
                     /gene_synonym="CycF; Fbxo1"
                     /inference="alignment:Splign:2.1.0"
     exon            941..1092
                     /gene="Ccnf"
                     /gene_synonym="CycF; Fbxo1"
                     /inference="alignment:Splign:2.1.0"
     exon            1093..1257
                     /gene="Ccnf"
                     /gene_synonym="CycF; Fbxo1"
                     /inference="alignment:Splign:2.1.0"
     exon            1258..1381
                     /gene="Ccnf"
                     /gene_synonym="CycF; Fbxo1"
                     /inference="alignment:Splign:2.1.0"
     exon            1382..1562
                     /gene="Ccnf"
                     /gene_synonym="CycF; Fbxo1"
                     /inference="alignment:Splign:2.1.0"
     exon            1563..1650
                     /gene="Ccnf"
                     /gene_synonym="CycF; Fbxo1"
                     /inference="alignment:Splign:2.1.0"
     exon            1651..1750
                     /gene="Ccnf"
                     /gene_synonym="CycF; Fbxo1"
                     /inference="alignment:Splign:2.1.0"
     exon            1751..1878
                     /gene="Ccnf"
                     /gene_synonym="CycF; Fbxo1"
                     /inference="alignment:Splign:2.1.0"
     exon            1879..2048
                     /gene="Ccnf"
                     /gene_synonym="CycF; Fbxo1"
                     /inference="alignment:Splign:2.1.0"
     exon            2049..3851
                     /gene="Ccnf"
                     /gene_synonym="CycF; Fbxo1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3142..3147
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ccnf"
                     /gene_synonym="CycF; Fbxo1"
                     /note="hexamer: AATAAA"
     polyA_site      3165
                     /gene="Ccnf"
                     /gene_synonym="CycF; Fbxo1"
                     /note="major polyA site"
     regulatory      3829..3834
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ccnf"
                     /gene_synonym="CycF; Fbxo1"
                     /note="hexamer: ATTAAA"
     polyA_site      3851
                     /gene="Ccnf"
                     /gene_synonym="CycF; Fbxo1"
ORIGIN      
        1 gcgggcgcgc ttgagagcgg tctaaagcgg cagtggaggg agctcggcga tggggagcgg
       61 cggtggtgag tgctggcggg agccgggtag gcgataggtc atacggaacg gaggccggag
      121 gagcatggac tcgggcccct gtgacccggg agtgcgcgtc gcatccccca aagcacgggt
      181 gatccattgt aggtgtgcca agtgtttctg ttatcctact aaacgaagaa tcaaaagaag
      241 acccagaaac ttaaccatct tgagtctccc agaagatgta ctctttcata tcctgaaatg
      301 gctttctgtt ggggacatcc ttgctgtccg agctgtccac tcccacctca agtacctggt
      361 ggacaaccat gccagtgtgt gggcatctgc cagcttccag gagctgtggc cttctccaca
      421 gaacctgaag ctctttgaaa gggctgctga aaagggaaat tttgaagctg ctgtgaagtt
      481 ggggattgcc tacctctaca atgaaggcct gtctgtgtca gatgaggcct gcgcagaagt
      541 gaacggcttg aaggcctctc gcttcttcag catggctgag agactgaata cgggttctga
      601 gcccttcatc tggctcttca tccgcccacc gtggtcagtg tccggaagct gctgcaaggc
      661 tgtggttcat gacagcctcc gagcggagtg tcagttacag agaagtcata aagcttccat
      721 actacactgc ttgggaaggg tgctaaatct ttttgaggac gaagagaaaa ggaagcaggc
      781 gcgtagcctt ttggaagagt cttctcgtca gggatgctta atcagctcat acctcctttg
      841 ggaaagcgac agaaaggtgg atatgtccga ccccggacga tgcctccaca gcttccggaa
      901 actcagggac tacgctgcga aaggctgctg ggaagcacag ctggctttgg ccaaagcctg
      961 tgcaggtgga agccaacttg gactggaagg gaaggcctgc agtgagtcgg tctgccagct
     1021 cttccaggcc tcccaggctg tcaacaagca gcagatattc tctgtgcaga aggggctcag
     1081 cgacaccatg aggtacattc taatcgactg gttggtggaa gttgccacaa tgaaggactt
     1141 tacaagcctg tgtcttcacc tgactgtgga gtgtgtagac cggtacctgc gaaggaggct
     1201 ggtccccaga tacaagctgc agctcctggg tattgcctgc atggtcatct gtacccggtt
     1261 catcagcaaa gagattctga cgattagaga ggctgtgtgg ctcacagaca acacgtataa
     1321 atacgaggac ttggtgcgcg tgatggggga gatcatttcc gccctggaag ggaagattcg
     1381 gatccctacc gtggttgact ataaagaggt cctgctgaca ctggtccccg tcgcacccag
     1441 aacccagcac ctgtgcagct tcctctgtga gctcaccctg ctgcacacca gcctgtccat
     1501 ctatgcccca gcccgcctgg cctctgcggc ccttctcctg gccagactca tgcatgggca
     1561 gacacagccc tggaccactc atctgtggga cctcactggc ttctcctaca gtgacctcgt
     1621 accctgtgtc ctgagccttc ataagaagtg tttccacgat gatgcaccca aagactacag
     1681 acaagtctct ctgacggccg tgaagcagag gttcgaggat aagtgctatg aggaaatcag
     1741 ccgggaagag gtgctgagct atgctgactt gtgcagtaca ataggagtaa aacaggaaag
     1801 cccagagccc ccatctttcc ctagctcagg ggagatccac accttcctca gctcgccctc
     1861 cgggaggagg agcaaacgga agcgagaaaa cagccttcag gaggacagag gcagctttgt
     1921 caccacaccc accgcagagc tatcgaatca ggaggagaca ctgctaggca gccttctgga
     1981 ctggagcctg gagtgctgct ctggctatga gggagaccag gagagcgaag gcgagaagga
     2041 gggtgatgtc acagctccca gcagactcct tgatgtcact gtggtctacc tgaacccaga
     2101 agaacattgc tgccaggagt ccagtgatga ggaggcctgg ccagaggaca agatccaccc
     2161 agcaccaggc acccaggcac ctccagcctc agctcccagg ccccttctct gcaatcgggg
     2221 agatcgggcc aaggacatta cgacctcagg atactcctct gttagcagct cgagtcccat
     2281 aagctccctg gatggtggca tggggggctc tccgcaatct acctcagtgc tctctgtggg
     2341 cagccactca agcacaaagc cttgccacca tcaggccaag aagtcatgtt tacagtgtcg
     2401 tcccccaaac tccccagaga gcggtgttca ccagcagcct gtaaagcgcc aaaacctgtc
     2461 tgtacacagt gacaaggaca tgcacctggc ttcctgaagc tcggagtgtg ttagccttca
     2521 ctatggtgaa tgtttactga gggagggctg ctgtttctct aggacactgc ctatgggtac
     2581 tgtgtagatc cttaggggag ttcagtgcaa gctgtcagga cactgagctc agtgaccagc
     2641 tcagcctcta cgtgttggac agcagccacc cagctgtcat gcgcacctgt gaaacccatc
     2701 cctgtctacc cttctgtgtc ctgttgtctc cgggagcatg agcctctgtg ttggcattca
     2761 ctttctgagg ccaggagctg acagcctcct tggaatacta gcggcccagg tggcctaaca
     2821 cagttcaaac ccttgctggc aagtcttgtt ttagaccagt ggggagctct caagtgaaga
     2881 cagcactctc ctcccacacc ccttcagcct agggagcctg tgtccctgca tatcagtgtt
     2941 gactgtagcc taatggtgtg tgaggccctt aaagctggag ttgcaggcat ccctgtccct
     3001 cccaaagtgg tttgtctgtg tcccattgta tccatgtgac cgtatctctg cactgaattt
     3061 caaggccatt ctttgcctgt ctttatttct acatttcttc taatggggaa caaaaggaag
     3121 catttgaaat agagggtatt gaataaaaag ataacagatc cccaatatta ctgtgcttca
     3181 actgaaaaaa gaaaaaatct agtcctgcac agtgcctctc ccgactgtcc cggcaggcag
     3241 aaggactgca agaggacccg aagctccaag tcaacggggc ctgggtcatc tgacctcaga
     3301 accggaaact cctactccca ccccttggtt ctagccatat gttctttcct tgtgaaaaac
     3361 gaatctttct agaggatcac cataaacaat cacttgtaat ccccaaggcc acaaagatgc
     3421 aggagagcga gaagtcagaa gagttgctgg gtttgtggct ggattccgtg gggagaaacc
     3481 agcagggtct ggtccctttg agcatgtcag cgaatgcttt gccttgtgat ttatgaggca
     3541 gctgtcctca acacctgggg tgtctgctga agcctgcgca gatatgctga cccctgaaga
     3601 aagtaccagg agtgccccag atacccttga acaagtacaa acccattagc tctctgtttt
     3661 ctgttccatc cctatggcag ctctttttta ctactgttag cagcattctg accaccctgc
     3721 cgaggcattt tggttgttgt cctacacctc tgagtgttaa cctgggatgc gtcagcctcc
     3781 tcccatgaga ggggacagta atgcctacct cacaggaatg ccgtgaggat taaatgcatg
     3841 agtggtaatt a
//
