LOCUS       NM_001037134            3113 bp    mRNA    linear   ROD 22-DEC-2022
DEFINITION  Mus musculus cyclin E2 (Ccne2), transcript variant 1, mRNA.
ACCESSION   NM_001037134
VERSION     NM_001037134.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3113)
  AUTHORS   Nishio M, Matsuura T, Hibi S, Ohta S, Oka C, Sasai N, Ishida Y and
            Matsuda E.
  TITLE     Heterozygous loss of Zbtb38 leads to early embryonic lethality via
            the suppression of Nanog and Sox2 expression
  JOURNAL   Cell Prolif 55 (4), e13215 (2022)
   PUBMED   35297517
REFERENCE   2  (bases 1 to 3113)
  AUTHORS   Prokopuk L, Jarred EG, Blucher RO, McLaughlin EA, Stringer JM and
            Western PS.
  TITLE     An essential role for Polycomb Repressive Complex 2 in the mouse
            ovary
  JOURNAL   Reproduction 163 (3), 167-182 (2022)
   PUBMED   35084365
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3113)
  AUTHORS   Yadav VK, Berger JM, Singh P, Nagarajan P and Karsenty G.
  TITLE     Embryonic osteocalcin signaling determines lifelong adrenal
            steroidogenesis and homeostasis in the mouse
  JOURNAL   J Clin Invest 132 (4) (2022)
   PUBMED   34905510
REFERENCE   4  (bases 1 to 3113)
  AUTHORS   Tampakakis E, Gangrade H, Glavaris S, Htet M, Murphy S, Lin BL, Liu
            T, Saberi A, Miyamoto M, Kowalski W, Mukouyama YS, Lee G,
            Minichiello L and Kwon C.
  TITLE     Heart neurons use clock genes to control myocyte proliferation
  JOURNAL   Sci Adv 7 (49), eabh4181 (2021)
   PUBMED   34851661
REFERENCE   5  (bases 1 to 3113)
  AUTHORS   Akagawa R, Nabeshima YI and Kawauchi T.
  TITLE     Alternative Functions of Cell Cycle-Related and DNA Repair Proteins
            in Post-mitotic Neurons
  JOURNAL   Front Cell Dev Biol 9, 753175 (2021)
   PUBMED   34746147
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3113)
  AUTHORS   Geng Y, Yu Q, Whoriskey W, Dick F, Tsai KY, Ford HL, Biswas DK,
            Pardee AB, Amati B, Jacks T, Richardson A, Dyson N and Sicinski P.
  TITLE     Expression of cyclins E1 and E2 during mouse development and in
            neoplasia
  JOURNAL   Proc Natl Acad Sci U S A 98 (23), 13138-13143 (2001)
   PUBMED   11687642
REFERENCE   7  (bases 1 to 3113)
  AUTHORS   Spruck C, Strohmaier H, Watson M, Smith AP, Ryan A, Krek TW and
            Reed SI.
  TITLE     A CDK-independent function of mammalian Cks1: targeting of
            SCF(Skp2) to the CDK inhibitor p27Kip1
  JOURNAL   Mol Cell 7 (3), 639-650 (2001)
   PUBMED   11463388
REFERENCE   8  (bases 1 to 3113)
  AUTHORS   Gudas JM, Payton M, Thukral S, Chen E, Bass M, Robinson MO and
            Coats S.
  TITLE     Cyclin E2, a novel G1 cyclin that binds Cdk2 and is aberrantly
            expressed in human cancers
  JOURNAL   Mol Cell Biol 19 (1), 612-622 (1999)
   PUBMED   9858585
REFERENCE   9  (bases 1 to 3113)
  AUTHORS   Lauper N, Beck AR, Cariou S, Richman L, Hofmann K, Reith W,
            Slingerland JM and Amati B.
  TITLE     Cyclin E2: a novel CDK2 partner in the late G1 and S phases of the
            mammalian cell cycle
  JOURNAL   Oncogene 17 (20), 2637-2643 (1998)
   PUBMED   9840927
REFERENCE   10 (bases 1 to 3113)
  AUTHORS   Hirai H, Roussel MF, Kato JY, Ashmun RA and Sherr CJ.
  TITLE     Novel INK4 proteins, p19 and p18, are specific inhibitors of the
            cyclin D-dependent kinases CDK4 and CDK6
  JOURNAL   Mol Cell Biol 15 (5), 2672-2681 (1995)
   PUBMED   7739547
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK158720.1, AK010929.1 and AK031116.1.
            
            [WARNING] On Apr 24, 2023 this sequence was replaced by
            NM_001037134.3.
            
            On Sep 24, 2013 this sequence version replaced NM_001037134.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript. Variants 1 and 3 encode the same isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849384,
                              SAMN01164131 [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2137              AK158720.1         427-2563
            2138-2827           AK010929.1         1978-2667
            2828-3113           AK031116.1         2666-2951
FEATURES             Location/Qualifiers
     source          1..3113
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4"
     gene            1..3113
                     /gene="Ccne2"
                     /note="cyclin E2"
                     /db_xref="GeneID:12448"
                     /db_xref="MGI:MGI:1329034"
     exon            1..194
                     /gene="Ccne2"
                     /inference="alignment:Splign:2.1.0"
     exon            195..231
                     /gene="Ccne2"
                     /inference="alignment:Splign:2.1.0"
     CDS             218..1432
                     /gene="Ccne2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     G1/S-specific cyclin-E2"
                     /codon_start=1
                     /product="G1/S-specific cyclin-E2 isoform 1"
                     /protein_id="NP_001032211.1"
                     /db_xref="CCDS:CCDS17965.1"
                     /db_xref="GeneID:12448"
                     /db_xref="MGI:MGI:1329034"
                     /translation="MSRRSSRLQAKQHAQPNQPDSPQETQIIQAKKRKTAQDVKKRKE
                     EITKKHQYEIRNCWPPVLSGGISPCIIIETPHKEIGTSDFSRFTNYRFKNLFINPSPL
                     PDLSWACSQEVWQNMLQKENRYVHDKHFQVLHSDLEPQMRSILLDWLLEVCEVYTLHR
                     ETFYLAQDFFDRFMLTQKDVNKNMLQLIGITSLFIASKLEEIYAPKLQEFAYVTDGAC
                     SEVDILKMELNILKALKWELCPVTVISWLNLFLQVDAVKDVPKVLLPQYSQETFIQIA
                     QLLDLCILAIDSLEFQYRILAAAALCHFTSIEVVKKASGLEWDDISECVDWMVPFVSV
                     VKSVSPVKLKTFKKIPMEDRHNIQTHTNYLALLNEVNYVNIYRKGGQLSPVCNGGIMT
                     PPKSTEKPPGKH"
     exon            232..328
                     /gene="Ccne2"
                     /inference="alignment:Splign:2.1.0"
     exon            329..382
                     /gene="Ccne2"
                     /inference="alignment:Splign:2.1.0"
     exon            383..534
                     /gene="Ccne2"
                     /inference="alignment:Splign:2.1.0"
     exon            535..670
                     /gene="Ccne2"
                     /inference="alignment:Splign:2.1.0"
     exon            671..817
                     /gene="Ccne2"
                     /inference="alignment:Splign:2.1.0"
     exon            818..913
                     /gene="Ccne2"
                     /inference="alignment:Splign:2.1.0"
     exon            914..1048
                     /gene="Ccne2"
                     /inference="alignment:Splign:2.1.0"
     exon            1049..1160
                     /gene="Ccne2"
                     /inference="alignment:Splign:2.1.0"
     exon            1161..1318
                     /gene="Ccne2"
                     /inference="alignment:Splign:2.1.0"
     exon            1319..3113
                     /gene="Ccne2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggagacttgg ggttccccac cccagccctc ccaaggcctc tgccaaaacg cggagccgaa
       61 ccgtagcctg acactccgag atctaagagc caccgtgagg gggcccggcg cgaactggaa
      121 ggcgtgcggg agcctgtggt gggcaaccag catgggggag gagcctctga gccgtgcagc
      181 cgcggcgcgc gcagaggttt catagtcctt gaagagaatg tcaagacgca gtagccgttt
      241 acaagctaag caacatgccc agcccaacca gccagactct ccgcaagaaa cccagataat
      301 tcaggccaag aagagaaaaa cagcacagga tgtcaaaaaa agaaaagagg agatcaccaa
      361 gaagcatcag tatgagatta ggaattgttg gccacctgta ctgtctggag gaatcagccc
      421 ttgcattatc attgaaacac cccataaaga aataggaaca agtgacttct ctagatttac
      481 aaattacaga tttaaaaatc tttttattaa tccctcacct ctgccagatt taagctgggc
      541 atgttcacag gaggtttggc aaaacatgtt acaaaaggaa aacagatacg tgcatgacaa
      601 acattttcaa gttctgcatt ctgacctgga accacagatg aggtcaatac ttttagactg
      661 gcttttagag gtttgtgaag tatacactct tcatagggag acattttacc ttgcccaaga
      721 cttttttgac agatttatgt tgacacaaaa ggatgtaaat aaaaatatgc ttcaactcat
      781 tgggattacc tcattgttca ttgcttccaa acttgaggaa atctacgctc ctaaactcca
      841 agagtttgct tacgtcactg atggtgcttg cagtgaagta gatatcttaa agatggaact
      901 caatatatta aaggctttaa aatgggaact ttgtccagta acagtcatct cctggttgaa
      961 tctttttctt caagttgatg ctgttaaaga tgttcctaag gttcttctac ctcaatattc
     1021 tcaggagacg ttcatccaga tagctcagct tttagatctg tgcattctag ccatcgactc
     1081 tttagaattt caatacagaa ttctggctgc tgccgcctta tgtcatttta cctccattga
     1141 agtggttaag aaagcttcag gtttggaatg ggatgacatc tcggaatgtg tagactggat
     1201 ggtgcctttt gttagtgttg taaaaagtgt gagtccagtg aagctgaaga cttttaagaa
     1261 gatacccatg gaagatagac acaatatcca gacacacaca aattatttgg ctttgctgaa
     1321 tgaagtaaac tatgtgaaca tctacagaaa aggagggcag ctgtcaccag tgtgtaatgg
     1381 aggcattatg acaccaccaa agagtactga aaaaccacca ggaaaacact gaagttaaca
     1441 acctggaatt gaacaaataa tggatagttt catataaatg agttttacag aaaagtagtg
     1501 ctgtaactat ccttgtctaa ggagttacac tgccattctt ttacttaaaa actatatcaa
     1561 tttggcacta aatgcctagg atgcacaaaa tcctgggttc aatccccagc actacaaaag
     1621 gaaacaaaac aaaaacttca aaaaattggc actaaagaag tatttcctat aaaagagaac
     1681 ttgtttacaa aggtgacttc actcccaagg atagtggatg gaagccaaca atttaagcta
     1741 tagcagttgt ttctgtttgt tactgtgttt ctttaaaatt cagtgttact gtatttcttt
     1801 tgatgaacta ggaattttat cattggaata tggactaaac tagtgctacc ttaaaggata
     1861 cattagctga cacagaactt tgaatctaga ttttatattc ttaaattcct atactcttga
     1921 atggtgcaat ttgtttttga aaataaattt taagcttatt tacaaaggtt gttttgtaat
     1981 aaagtgacta atttatctaa agcagtttgt aacaaacgat aaaacttgaa ttttatgaat
     2041 ggtaaagttc aatctgtttt gaactagttt gtctgccttg ccatatttct taatcagtaa
     2101 ggcactgaac caaatgttta aactgtgctc taaatgggag aaccaaagaa attataaaca
     2161 agatataaat gctttggctt cttctactcg ggggttttac ttgatagaaa ggttgcttta
     2221 taatcttttt gtgtatcaca atttgggtaa aattaaacac tttttcaaac tatataagaa
     2281 agtcacttta ttgcacacta agatatctct aaggcgcttt atgtttgcaa aactggtggt
     2341 ccatttttaa gccccatatt atgagatgag gactgtgtca acatgaaaaa actttaacat
     2401 atgacctaaa ctattttctt atggcagaaa atattaaatg tatacttact cctagaaatt
     2461 tatttattta aacttgctgt atatagaata gctacttata cattaaatat tttaagttag
     2521 cctttgaaaa ggaaatttgg gcctaaaaaa gttaatttca ttagaaaaaa aatggtacca
     2581 ggcatgaacc ttgtctctct ttgaagaaat tataaactat tgttaagata tgaagttttt
     2641 gtataatttg tttataaact aatttgtttc agtttgtttt ggtctaaaaa gaaaacacca
     2701 ctaaattgta catatgtatt atataaactt aatcttttaa tactgtttac ttttagccca
     2761 ctgtttaaaa aataaaattg aaaaaaaatt aactaactgc ttaaaagtaa agttttgcca
     2821 ttgcttgtag aaacttcttt ttccttctct gtgctgccag ctgtaatact tcttcagggt
     2881 tgcttgcatt caattctgtt tggccaatgg ctttgatctt aaaacagaaa agtgttatta
     2941 gaagtttgac tgaaaaaaat tgtcacagta gtacacataa ctcaaagtta aagttaacta
     3001 aatcaaatta aaaactacag aaaaaaatgg catcacattg atccactttt agtatggtta
     3061 cctggaggga catttagtta cactaaataa atttctgtat gcttatgtga ttg
//
