LOCUS       NM_007632               1992 bp    mRNA    linear   ROD 17-DEC-2024
DEFINITION  Mus musculus cyclin D3 (Ccnd3), transcript variant 1, mRNA.
ACCESSION   NM_007632 XM_001003930 XM_001003934 XM_001003940 XM_001003943
VERSION     NM_007632.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1992)
  AUTHORS   Littlejohn,R., Zambrano-Carrasco,J., Zou,J., Yao,Y., Kim,I.M.,
            Zhou,J., Li,J. and Su,H.
  TITLE     Inhibition of cardiomyocyte neddylation impairs embryonic cardiac
            morphogenesis
  JOURNAL   J Mol Cell Cardiol 197, 40-44 (2024)
   PUBMED   39437885
REFERENCE   2  (bases 1 to 1992)
  AUTHORS   Caria,C.A., Faa,V., Porcu,S., Marongiu,M.F., Poddie,D., Perseu,L.,
            Meloni,A., Vaccargiu,S. and Ristaldi,M.S.
  TITLE     Post-GWAS Validation of Target Genes Associated with HbF and HbA2
            Levels
  JOURNAL   Cells 13 (14), 1185 (2024)
   PUBMED   39056767
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1992)
  AUTHORS   Culberson,E.J., Shields,K.C., Glynn,R.A., Allyn,B.M., Hayer,K.E.
            and Bassing,C.H.
  TITLE     The Cyclin D3 Protein Enforces Monogenic TCRbeta Expression by
            Mediating TCRbeta Protein-Signaled Feedback Inhibition of Vbeta
            Recombination
  JOURNAL   J Immunol 212 (4), 534-540 (2024)
   PUBMED   38117277
  REMARK    GeneRIF: The Cyclin D3 Protein Enforces Monogenic TCRbeta
            Expression by Mediating TCRbeta Protein-Signaled Feedback
            Inhibition of Vbeta Recombination.
REFERENCE   4  (bases 1 to 1992)
  AUTHORS   Munoz-Gallardo,M.D.M., Garcia-Padilla,C., Vicente-Garcia,C.,
            Carvajal,J., Arenega,A. and Franco,D.
  TITLE     miR-195b is required for proper cellular homeostasis in the elderly
  JOURNAL   Sci Rep 14 (1), 810 (2024)
   PUBMED   38191655
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1992)
  AUTHORS   Katano,W., Mori,S., Sasaki,S., Tajika,Y., Tomita,K., Takeuchi,J.K.
            and Koshiba-Takeuchi,K.
  TITLE     Sall1 and Sall4 cooperatively interact with Myocd and SRF to
            promote cardiomyocyte proliferation by regulating CDK and cyclin
            genes
  JOURNAL   Development 150 (24) (2023)
   PUBMED   38014633
REFERENCE   6  (bases 1 to 1992)
  AUTHORS   Medema,R.H., Herrera,R.E., Lam,F. and Weinberg,R.A.
  TITLE     Growth suppression by p16ink4 requires functional retinoblastoma
            protein
  JOURNAL   Proc Natl Acad Sci U S A 92 (14), 6289-6293 (1995)
   PUBMED   7603984
REFERENCE   7  (bases 1 to 1992)
  AUTHORS   Ravnik,S.E., Rhee,K. and Wolgemuth,D.J.
  TITLE     Distinct patterns of expression of the D-type cyclins during
            testicular development in the mouse
  JOURNAL   Dev Genet 16 (2), 171-178 (1995)
   PUBMED   7537638
REFERENCE   8  (bases 1 to 1992)
  AUTHORS   Xiong,Y., Menninger,J., Beach,D. and Ward,D.C.
  TITLE     Molecular cloning and chromosomal mapping of CCND genes encoding
            human D-type cyclins
  JOURNAL   Genomics 13 (3), 575-584 (1992)
   PUBMED   1386336
REFERENCE   9  (bases 1 to 1992)
  AUTHORS   Inaba,T., Matsushime,H., Valentine,M., Roussel,M.F., Sherr,C.J. and
            Look,A.T.
  TITLE     Genomic organization, chromosomal localization, and independent
            expression of human cyclin D genes
  JOURNAL   Genomics 13 (3), 565-574 (1992)
   PUBMED   1386335
REFERENCE   10 (bases 1 to 1992)
  AUTHORS   Matsushime,H., Roussel,M.F., Ashmun,R.A. and Sherr,C.J.
  TITLE     Colony-stimulating factor 1 regulates novel cyclins during the G1
            phase of the cell cycle
  JOURNAL   Cell 65 (4), 701-713 (1991)
   PUBMED   1827757
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY142612.1, M86183.1, AK210362.1, AK159503.1 and BQ033424.1.
            
            On Feb 21, 2007 this sequence version replaced NM_007632.1.
            
            Transcript Variant: This variant (1) differs in the 5' UTR,
            compared to variant 3. Variant 1 encodes the same protein as
            variant 3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC004076.1, AK168290.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-105               BY142612.1         2-106
            106-1067            M86183.1           1-962
            1068-1385           AK210362.1         83-400
            1386-1974           AK159503.1         1312-1900
            1975-1992           BQ033424.1         1-18                c
FEATURES             Location/Qualifiers
     source          1..1992
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 23.37 cM"
     gene            1..1992
                     /gene="Ccnd3"
                     /gene_synonym="9230106B05Rik"
                     /note="cyclin D3"
                     /db_xref="GeneID:12445"
                     /db_xref="MGI:MGI:88315"
     exon            1..386
                     /gene="Ccnd3"
                     /gene_synonym="9230106B05Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             189..1067
                     /gene="Ccnd3"
                     /gene_synonym="9230106B05Rik"
                     /codon_start=1
                     /product="G1/S-specific cyclin-D3"
                     /protein_id="NP_031658.1"
                     /db_xref="CCDS:CCDS28850.1"
                     /db_xref="GeneID:12445"
                     /db_xref="MGI:MGI:88315"
                     /translation="MELLCCEGTRHAPRAGPDPRLLGDQRVLQSLLRLEERYVPRASY
                     FQCVQKEIKPHMRKMLAYWMLEVCEEQRCEEDVFPLAMNYLDRYLSCVPTRKAQLQLL
                     GTVCLLLASKLRETTPLTIEKLCIYTDQAVAPWQLREWEVLVLGKLKWDLAAVIAHDF
                     LALILHRLSLPSDRQALVKKHAQTFLALCATDYTFAMYPPSMIATGSIGAAVLGLGAC
                     SMSADELTELLAGITGTEVDCLRACQEQIEAALRESLREAAQTAPSPVPKAPRGSSSQ
                     GPSQTSTPTDVTAIHL"
     exon            387..602
                     /gene="Ccnd3"
                     /gene_synonym="9230106B05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            603..762
                     /gene="Ccnd3"
                     /gene_synonym="9230106B05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            763..899
                     /gene="Ccnd3"
                     /gene_synonym="9230106B05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            900..1980
                     /gene="Ccnd3"
                     /gene_synonym="9230106B05Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1961..1966
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ccnd3"
                     /gene_synonym="9230106B05Rik"
                     /note="hexamer: AATAAA"
     polyA_site      1980
                     /gene="Ccnd3"
                     /gene_synonym="9230106B05Rik"
                     /note="major polyA site"
ORIGIN      
        1 atcgtcgcga ggggcggggc gcctgtcagg gaagcggtgc gcgcgggtgg cgggcgggct
       61 ggggcttctc cgcacagtgc cagcgccagc gccagacccg cccgcacccc gcgctctccc
      121 tcacgcgcgt cgcttctcct aggactcgct aacccgcact cttgctctca cccgtgagcc
      181 atcgcaggat ggagctgctg tgttgcgagg gcacccggca cgcgccccgg gccgggcccg
      241 acccgcggct gcttggggac cagcgtgtcc tgcagagttt actccgcctg gaggagcgct
      301 acgtgccgcg agcctcctac ttccagtgcg tgcaaaagga gatcaagccg cacatgcgga
      361 agatgctggc atactggatg ctggaggtgt gtgaggagca gcgctgcgag gaggatgtct
      421 tccctctggc tatgaactac ctggatcgct acctgtcctg cgtccccacc cgaaaggcgc
      481 aattgcagct tctaggtacc gtctgcctgt tgctggcctc caagctgcgc gaaaccacgc
      541 ccctgactat tgagaagctt tgcatctata cggaccaggc tgtggctcca tggcagttgc
      601 gggagtggga ggtgctggtc ctggggaagc tcaagtggga cctggctgcc gtgattgcgc
      661 acgacttcct ggccttgatt ctgcaccgcc tgtctctgcc cagtgaccgg caggctttgg
      721 tcaaaaagca tgcccagacc tttttggccc tctgtgctac agattacacc tttgcgatgt
      781 atcctccatc catgatcgcc acaggcagca ttggggcagc cgtgctaggc ctaggcgcct
      841 gctctatgtc tgcggatgag ctcacagagt tgctggccgg gatcacaggc actgaagtgg
      901 actgcctgcg agcctgccag gaacagatcg aagctgccct cagggagagc ctcagggaag
      961 ctgctcagac agcccccagc ccagtgccca aagccccccg gggctctagc agccaggggc
     1021 ccagtcagac cagcactccc acagatgtca cagccattca cctgtagctt gagacaggcc
     1081 ctctcaggcc accaagcaga ggaggggccc ctgccacccc ctccctgcct ctagaacaat
     1141 ccatgctata tctgaagccc gaggggggct ctccttcccc ctcacaaagc ccaaggggcc
     1201 aggtcctgcc tatccccaca gtgtgcacta aggggttgca tggtcatgag gggcgtcttc
     1261 atggccagtc agctcctctt ccttcccact caaccagctt ggctgtcctg ggccatgatg
     1321 gtcagagaaa tacaaacagg taaaatccac acaccagcat ttcttttgag tccctcttct
     1381 gtccggggct ccaaccttct cagttgccaa aacgccccag taccttccaa aggtgttggc
     1441 ccttgcaggc tccttcgggc atcccgatag aagcttatga ggagctgccc tagatggcct
     1501 ctgtgtaatc cgtactccag ctgctcttag agggaacagc ctaggctttg gccagagcaa
     1561 gaacccatac actgttgctt tgcttgctgc ttagcttctg tgattgtggg gtcttaaggg
     1621 tgccgtggtc attttaattt attgctttga atacaactgt aagagggtac agtgaggcct
     1681 gtaccccaca agtggtggta accctggcgg ttgctctttc cctcccttct tcccctctgc
     1741 tactgctttg tggcccagga gctgctacag cctgggatgg gggtcacgcc ttcctctcct
     1801 cacccctcca cctcatcttc atcagagcag ggttaggttg ggatggatcg atgccgtgga
     1861 ggtgacagag ctatctggag agagggcaag ccctagggtc acaggtcttt cctcgggcca
     1921 caaggtttgg gctggtggcc catttctatc atgctgcctt aataaagatt tcggaataaa
     1981 aaaaaaaaaa aa
//
