LOCUS       NM_009829               5772 bp    mRNA    linear   ROD 17-SEP-2024
DEFINITION  Mus musculus cyclin D2 (Ccnd2), mRNA.
ACCESSION   NM_009829
VERSION     NM_009829.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5772)
  AUTHORS   Butts,J.C., Wu,S.R., Durham,M.A., Dhindsa,R.S., Revelli,J.P.,
            Ljungberg,M.C., Saulnier,O., McLaren,M.E., Taylor,M.D. and
            Zoghbi,H.Y.
  TITLE     A single-cell transcriptomic map of the developing Atoh1 lineage
            identifies neural fate decisions and neuronal diversity in the
            hindbrain
  JOURNAL   Dev Cell 59 (16), 2171-2188 (2024)
   PUBMED   39106860
REFERENCE   2  (bases 1 to 5772)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 5772)
  AUTHORS   Pastor-Alonso,O., Syeda Zahra,A., Kaske,B., Garcia-Moreno,F.,
            Tetzlaff,F., Bockelmann,E., Grunwald,V., Martin-Suarez,S.,
            Riecken,K., Witte,O.W., Encinas,J.M. and Urbach,A.
  TITLE     Generation of adult hippocampal neural stem cells occurs in the
            early postnatal dentate gyrus and depends on cyclin D2
  JOURNAL   EMBO J 43 (3), 317-338 (2024)
   PUBMED   38177500
REFERENCE   4  (bases 1 to 5772)
  AUTHORS   Munoz-Gallardo,M.D.M., Garcia-Padilla,C., Vicente-Garcia,C.,
            Carvajal,J., Arenega,A. and Franco,D.
  TITLE     miR-195b is required for proper cellular homeostasis in the elderly
  JOURNAL   Sci Rep 14 (1), 810 (2024)
   PUBMED   38191655
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5772)
  AUTHORS   Bosze,B., Suarez-Navarro,J., Cajias,I., Brzezinski Iv,J.A. and
            Brown,N.L.
  TITLE     Notch pathway mutants do not equivalently perturb mouse embryonic
            retinal development
  JOURNAL   PLoS Genet 19 (9), e1010928 (2023)
   PUBMED   37751417
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5772)
  AUTHORS   Xiong,Y., Menninger,J., Beach,D. and Ward,D.C.
  TITLE     Molecular cloning and chromosomal mapping of CCND genes encoding
            human D-type cyclins
  JOURNAL   Genomics 13 (3), 575-584 (1992)
   PUBMED   1386336
REFERENCE   7  (bases 1 to 5772)
  AUTHORS   Inaba,T., Matsushime,H., Valentine,M., Roussel,M.F., Sherr,C.J. and
            Look,A.T.
  TITLE     Genomic organization, chromosomal localization, and independent
            expression of human cyclin D genes
  JOURNAL   Genomics 13 (3), 565-574 (1992)
   PUBMED   1386335
REFERENCE   8  (bases 1 to 5772)
  AUTHORS   Kiyokawa,H., Busquets,X., Powell,C.T., Ngo,L., Rifkind,R.A. and
            Marks,P.A.
  TITLE     Cloning of a D-type cyclin from murine erythroleukemia cells
  JOURNAL   Proc Natl Acad Sci U S A 89 (6), 2444-2447 (1992)
   PUBMED   1372445
REFERENCE   9  (bases 1 to 5772)
  AUTHORS   Tremblay,P.J., Kozak,C.A. and Jolicoeur,P.
  TITLE     Identification of a novel gene, Vin-1, in murine leukemia
            virus-induced T-cell leukemias by provirus insertional mutagenesis
  JOURNAL   J Virol 66 (3), 1344-1353 (1992)
   PUBMED   1738193
  REMARK    Erratum:[J Virol 1992 Aug;66(8):5176]
REFERENCE   10 (bases 1 to 5772)
  AUTHORS   Matsushime,H., Roussel,M.F., Ashmun,R.A. and Sherr,C.J.
  TITLE     Colony-stimulating factor 1 regulates novel cyclins during the G1
            phase of the cell cycle
  JOURNAL   Cell 65 (4), 701-713 (1991)
   PUBMED   1827757
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY161742.1, AK147345.1 and CAAA01200960.1.
            
            On Nov 5, 2005 this sequence version replaced NM_009829.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK147345.1, BC049086.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-41                BY161742.1         1-41
            42-2716             AK147345.1         2-2676
            2717-5772           CAAA01200960.1     6921-9976
FEATURES             Location/Qualifiers
     source          1..5772
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 61.92 cM"
     gene            1..5772
                     /gene="Ccnd2"
                     /gene_synonym="2600016F06Rik; cD2; Vin-1; Vin1"
                     /note="cyclin D2"
                     /db_xref="GeneID:12444"
                     /db_xref="MGI:MGI:88314"
     exon            1..467
                     /gene="Ccnd2"
                     /gene_synonym="2600016F06Rik; cD2; Vin-1; Vin1"
                     /inference="alignment:Splign:2.1.0"
     CDS             276..1145
                     /gene="Ccnd2"
                     /gene_synonym="2600016F06Rik; cD2; Vin-1; Vin1"
                     /codon_start=1
                     /product="G1/S-specific cyclin-D2"
                     /protein_id="NP_033959.1"
                     /db_xref="CCDS:CCDS20564.1"
                     /db_xref="GeneID:12444"
                     /db_xref="MGI:MGI:88314"
                     /translation="MELLCCEVDPVRRAVPDRNLLEDRVLQNLLTIEERYLPQCSYFK
                     CVQKDIQPYMRRMVATWMLEVCEEQKCEEEVFPLAMNYLDRFLAGVPTPKTHLQLLGA
                     VCMFLASKLKETIPLTAEKLCIYTDNSVKPQELLEWELVVLGKLKWNLAAVTPHDFIE
                     HILRKLPQQKEKLSLIRKHAQTFIALCATDFKFAMYPPSMIATGSVGAAICGLQQDDE
                     VNTLTCDALTELLAKITHTDVDCLKACQEQIEALLLNSLQQFRQEQHNAGSKSVEDPD
                     QATTPTDVRDVDL"
     exon            468..683
                     /gene="Ccnd2"
                     /gene_synonym="2600016F06Rik; cD2; Vin-1; Vin1"
                     /inference="alignment:Splign:2.1.0"
     exon            684..843
                     /gene="Ccnd2"
                     /gene_synonym="2600016F06Rik; cD2; Vin-1; Vin1"
                     /inference="alignment:Splign:2.1.0"
     exon            844..992
                     /gene="Ccnd2"
                     /gene_synonym="2600016F06Rik; cD2; Vin-1; Vin1"
                     /inference="alignment:Splign:2.1.0"
     exon            993..5772
                     /gene="Ccnd2"
                     /gene_synonym="2600016F06Rik; cD2; Vin-1; Vin1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2044..2049
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ccnd2"
                     /gene_synonym="2600016F06Rik; cD2; Vin-1; Vin1"
                     /note="hexamer: AAGAAA"
     polyA_site      2053
                     /gene="Ccnd2"
                     /gene_synonym="2600016F06Rik; cD2; Vin-1; Vin1"
                     /note="major polyA site"
     polyA_site      2067
                     /gene="Ccnd2"
                     /gene_synonym="2600016F06Rik; cD2; Vin-1; Vin1"
     regulatory      2112..2117
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ccnd2"
                     /gene_synonym="2600016F06Rik; cD2; Vin-1; Vin1"
                     /note="hexamer: TATAAA"
     polyA_site      2133
                     /gene="Ccnd2"
                     /gene_synonym="2600016F06Rik; cD2; Vin-1; Vin1"
     regulatory      2587..2592
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ccnd2"
                     /gene_synonym="2600016F06Rik; cD2; Vin-1; Vin1"
                     /note="hexamer: AGTAAA"
     polyA_site      2609
                     /gene="Ccnd2"
                     /gene_synonym="2600016F06Rik; cD2; Vin-1; Vin1"
     polyA_site      4036
                     /gene="Ccnd2"
                     /gene_synonym="2600016F06Rik; cD2; Vin-1; Vin1"
     regulatory      4687..4692
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ccnd2"
                     /gene_synonym="2600016F06Rik; cD2; Vin-1; Vin1"
                     /note="hexamer: AAGAAA"
     polyA_site      4709
                     /gene="Ccnd2"
                     /gene_synonym="2600016F06Rik; cD2; Vin-1; Vin1"
     polyA_site      5272
                     /gene="Ccnd2"
                     /gene_synonym="2600016F06Rik; cD2; Vin-1; Vin1"
ORIGIN      
        1 tgcctgagcg agagaggaga gcgagctgag gagagccggg cagttcggag ggaaggaccg
       61 gtgcgagtca ggcggccctt gaggctccgc tcgcccacct tccactcttc tctctctctc
      121 tccctctctc tctttgccat ttctttcctc tcccaaatct cccattcagc caaaggaagg
      181 aggtaaggga agcactcccc gacccccccg cacctccaaa aaataataat aataaaaaaa
      241 atttacagtc gggaccgagt ggtggccggc tggctatgga gctgctgtgc tgcgaggtgg
      301 acccggtccg cagggccgtg ccggaccgca acctgctgga agaccgcgtt ctgcagaacc
      361 tgttgaccat cgaggagcgc tacctcccgc agtgttccta tttcaagtgc gtgcagaagg
      421 acatccaacc gtacatgcgc aggatggtgg ccacctggat gctagaggtc tgtgaggaac
      481 aaaagtgtga agaagaggtc tttcctctgg ccatgaatta cctggaccgt ttcttggctg
      541 gagtcccgac tcctaagacc catcttcagc tcctgggtgc agtgtgcatg ttcctagctt
      601 ccaagctgaa agagaccatc ccgctgactg cggaaaagct gtgcatttac accgacaact
      661 ctgtgaagcc ccaggagctg ctggagtggg aactggtagt gttgggtaag ctgaagtgga
      721 acctggccgc agtcacccct cacgacttca ttgagcacat ccttcgcaag ctgccccagc
      781 aaaaggagaa gctgtccctg atccgcaagc atgcgcagac cttcatcgct ctgtgcgcta
      841 ccgacttcaa gtttgccatg tacccgccgt cgatgattgc aactggaagc gtgggagcag
      901 ccatctgtgg gcttcagcag gatgatgaag tgaacacact cacgtgtgat gccctgacag
      961 agctgctggc caagatcacc cacactgatg tggattgtct caaagcctgc caggagcaaa
     1021 tcgaagctct gctgctgaac agcctgcagc agttccgtca agagcagcat aacgccggat
     1081 ccaagtctgt ggaagatccg gaccaagcca ccacccctac agacgtgcgg gatgttgacc
     1141 tgtgaggaag ccattcgggc ggcaagagag aggcgtgttc gtcatctgct agccccttct
     1201 ctctctagtt atgtcttgtt ctttgtgttt ttaggatgaa acttcaaaaa agaaaaaaaa
     1261 aaaacaaaaa acaaaaacaa aatctgcccc cacctagatc ctatttaaag gtcttttaga
     1321 agtgagagga aaaggccgta tagttgtaac gcatgtggtg cctgttcaaa gtcctgcata
     1381 aggggatccc tgtacactcg aaccgttatt atttgatgat gtaaaagtca tagtgagatg
     1441 cttacaggag aacccgcaga ctagctagag agtgtgcgta cctgcaacat gggaacgaat
     1501 tagaggagac tgtcttttgt gcttgtgacc tagtgcatat gcccccttta gtagaattgc
     1561 aaggaaccgt gggtgccagg accgcatgag tagtttgcaa agcagtgaac ccaaggagga
     1621 atcagaaacg agaagggaca tgccggggag gttgcgcaaa accacccaac cacatgactg
     1681 aaccattttg gatgtaagaa gcgccttgat gcctcaccac gtgttcccaa gactgagcgt
     1741 ccgggtctct ccgtcgcata ctcttgctga ctaaagtagc tgctacctaa gggatatgtc
     1801 ttttgccagt tggacacagg tgaacggctc ctaagtctca tgtttggtga atttgggctt
     1861 ctacttccaa acatggttca ttgtagatgt attttactgt tatctgatgg agggaattcg
     1921 ctatgggcca tgaccaaaac gcatctaaat gggggcagat ggagaccata gacggaatct
     1981 aaaacaaagc tgccttgtgt aagggaagag ggtgaggtga tctttaatcc ccttgttaag
     2041 aaaaagaaaa aaagaaacta cccctaactt ttggtgctga ttagcatgtc tggtccactg
     2101 tttaactttg ttataaacca ttccattaga aaagcacttt gaaaattttg ggggagggtg
     2161 gggtgggata tgggatggtt tatgcaaatc atgttgaata cgccttcctc ctttgcccct
     2221 ccccttcctg accctcgtcc agttactgtt catttctgga gtctgatgtt ctggtaccca
     2281 gctctggtgt ccctgccagg gctgagaaag ccctctgctg atatcctcat cccagcattc
     2341 ttcggaaaac ctgtcaacag aggtctaaag cattgtgatg gcttagaagg attgaatccc
     2401 cgtctatgtt tttctccttt ggacatggaa agaaaggtta cttctgatgc acaggctgaa
     2461 catcagggtg tggcattttg gtcccttttc cgttttttgt ttgtttgttt gtttgtttgt
     2521 aattttagtg caaagttgta ttcattgtac ttgaagaccc ccctctccca cttcttggag
     2581 acagtcagta aacagaagtg ggagccacag ttggtttggt tttgttttgt ttttttttgt
     2641 tttttttttt ttgcacaatt ataattgaca ggttatgaag ctatttgtta aaatatctgc
     2701 tttgtttttt tttttttgag aaaagatcag aacagggctg ctttgaagag ttatacacag
     2761 gttctgcctt gtttcacagt gtgagggttg aagatggaga aacatctaag ggtctcttat
     2821 ctttcatttt ttcttttgtt ctgtttatta ttattatttt tcgctgctaa gaagctaaga
     2881 tcgttcaccc ccattcacat taacagtacc tagctgtaat gtttcacggt gtgctgctat
     2941 tttagaaaca ttgttataat atattatttt actgcttaaa tttcaagtcc cgaggtagat
     3001 ggtcgagaga cgagttctct gtactggaaa agccttttcc tctgtccctg tccttctggt
     3061 agcatcgatg ggctgcgttg cgtttggttc cgtttggttc cttttcttcc gtgcctcttc
     3121 attaccaggt tttctttcct cctctgacca cattcttcaa agagagtatt ctttacctca
     3181 ggtttactgg acaaaaacaa aacaaaacaa aaccaatagt gataacaatg tacttctttt
     3241 cgttttccta atacctcaca gctataccgg atctgtttgg aaggccgctg gcacgaggca
     3301 cagggcaggc agaagacagg aactggacat cctccttgat agaaagcagg agaaacctga
     3361 ccccagagtc tcaggccagg ggtcttctct gtcttgaaga ttgccaggct cccctttgac
     3421 gcaggctccc ttcttatgat agaagacagt gacgaagggc tcctctaccc aaggcagata
     3481 ctcatcaaac acagacagtg gactaggtca gcctgatttg catgcgtgca ccagggtctg
     3541 caatgaagaa ttctggcaga cagttaggag accctccctc catcttgtag cccattcaga
     3601 cacaggactt tcctcttcat ggggtccctt catcatgaac attgaccagt ttccttcttg
     3661 gcatctatac cccaacttcg gatggcctcc gaagtcttcc taggactgag tctggttggt
     3721 gctgagtcta cagcacacgt ggatgatatt cctttctcct tctcttgtcc tctgcagtct
     3781 acagtgacag gcaagtgctg tgcgtggcca ggttgtctgt gtgtagcatt gaatggcttc
     3841 agggtttgga tcccgttgag tggggcaagg taggaggccc aagttgaatg agtctggaat
     3901 gcaagttgaa agaagggaga ggctgtttct gtggtctcgg gtgtatttag gaaggattgg
     3961 gacttggtga gttagcgaga ccctaaattc taggggcttt gtggtaggac ggtgggtgat
     4021 ggtttgggaa gtttgagaga gaaaacggga gcagcctgca gctagccagt gtttatccag
     4081 agctcacgca ctgcacagca cactcttctg gtccttaagg gaccccacag aacttgacag
     4141 acacactccc ttgagttctt gggcaacttg ggtacctgat gagtggcctt tgagcttaac
     4201 tgaaacattg aatgaaggaa gctgacacac aaggggagag gcaggttact atctgcccct
     4261 ccatccctct tacctggaac ctaagacact cttcctgttt gccttccttg gagcctagtg
     4321 gaacgagtcc tgtagagtgg ccattctgcc tgctcctcac ttacacaaag gaagggagcc
     4381 tggattcctt ggtgaccaat accttctgct tagatgtggg tctccttggt agtatttctg
     4441 tctcagaggg gtataaacga ccccaaggat ttcagcttgc tctccccaag ccccttcgta
     4501 tcctacagaa ggggttgcag attctggtct ttttctgcct tgctaatgat ctcttctttg
     4561 tttctaattt gtcattgttg tttgtttttg tttgttcttg ttttttttct ccatcagtgg
     4621 gggctaagtc gttcccccag cctgccaaat tttgatcctt ccctgttttg accaaatcct
     4681 aggggaaaga aaccctagta tgccaaaaat aatatgctaa gcataaggag attcataatg
     4741 gttcctaaga accaggcagc ctgtgagtgg tgagctgctt ctagatggga cagcttgtag
     4801 aggctgcttt ggtttgaact gtccccagga caccacggga aagcagagcc cgtcatatag
     4861 gttgctagct ttaaggtgca tgcctactga cacgggactc ctctctagca gccaggctgg
     4921 gggtacatgt agcacccctg gatcccatct tgttgctagc agggtaagtg acccctcaga
     4981 gggagcttaa gagctttcct atagtctagc tctttgggga cccaccagac tgtgccttgg
     5041 gaattatagg agcaacaggc taagacaggg tggctttcac aaagaaggca gaggagcttt
     5101 gtctccatga ggacagggct gggaggacca cacttgtccc tgtgtcctgg acagtggtgt
     5161 gggaactgga ggtagcaatc agaagtctaa gtaagccagc tgacctctaa gcccaaagga
     5221 ctcccccttg cttaccttag acagtccaac cttgggaata gctttaaaaa ggggaattaa
     5281 tactgagaca gtgaagtccc cttaagccga caagccctcc ataggtgcac accgcacaca
     5341 taggcttctc tcagtgcaga ctccaggtgg tggtcaacag ctgcggcatg cttatctatt
     5401 tgtacgaaat agtgtaggga agccccagga ggtgttatag cttccatata ccatgtggct
     5461 tttgatgttt ctggattttc aacagcacaa aagagtcctc gagccggaac atgcgctact
     5521 ccgattttaa acgtggctgg gctgtgagac ccgttcttgg ctctggtttt acgaagccat
     5581 caatacatac acacccttga tggagctgca gatccgttcc ttttcctgca gcccacttgt
     5641 gggggaaaag tgccttactg acttacagta gccactcagt ttcaacaggt gcctatcttt
     5701 gacaaaaaaa aaccacaaaa aacaaaaaaa aaaaaaacaa aaaaaaaaac agaaaagaaa
     5761 aaaaacgtta aa
//
