LOCUS       NM_007631               3702 bp    mRNA    linear   ROD 14-JAN-2025
DEFINITION  Mus musculus cyclin D1 (Ccnd1), transcript variant 2, mRNA.
ACCESSION   NM_007631 XM_001002530 XM_001002537
VERSION     NM_007631.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3702)
  AUTHORS   Xu,X., Fang,M., Chen,L., Huang,H., Dai,Z.M., Yang,J. and Qiu,M.
  TITLE     Nzf2 promotes oligodendrocyte differentiation and regeneration via
            repressing HDAC1-mediated histone deacetylation
  JOURNAL   Sci Adv 10 (50), eadf8405 (2024)
   PUBMED   39671488
REFERENCE   2  (bases 1 to 3702)
  AUTHORS   Liu,L., Jiang,Q., Du,C., Yang,T., Zhou,L., Chen,J., Gu,L., Wang,Q.,
            Wang,Z., Wang,H. and Wang,L.
  TITLE     Ankrd1 regulates endogenous cardiac regeneration in mice by
            modulating cyclin D1
  JOURNAL   Eur J Pharmacol 983, 177005 (2024)
   PUBMED   39299480
  REMARK    GeneRIF: Ankrd1 regulates endogenous cardiac regeneration in mice
            by modulating cyclin D1.
REFERENCE   3  (bases 1 to 3702)
  AUTHORS   Omura,S., Ogawa,R., Kawachi,T., Ogawa,A., Arai,Y., Takayama,N.,
            Masui,A., Kondo,K., Sugimoto,H., Shinohara,H.M., Takahashi,T.,
            Maeda,H. and Ohyama,K.
  TITLE     Olig2+/NG2+/BLBP+ astrocyte progenitors: a novel component of the
            neurovascular unit in the developing mouse hippocampus
  JOURNAL   Front Cell Neurosci 18, 1464402 (2024)
   PUBMED   39484182
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3702)
  AUTHORS   Nedomova,M., Haberecht-Muller,S., Moller,S., Venz,S.,
            Prochazkova,M., Prochazka,J., Sedlak,F., Chawengsaksophak,K.,
            Hammer,E., Kasparek,P., Adamek,M., Sedlacek,R., Konvalinka,J.,
            Kruger,E. and Grantz Saskova,K.
  TITLE     DDI2 protease controls embryonic development and inflammation via
            TCF11/NRF1
  JOURNAL   iScience 27 (10), 110893 (2024)
   PUBMED   39328932
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3702)
  AUTHORS   Zhu,S., Huo,S., Wang,Z., Huang,C., Li,C., Song,H., Yang,X., He,R.,
            Ding,C., Qiu,M. and Zhu,X.J.
  TITLE     Follistatin controls the number of murine teeth by limiting
            TGF-beta signaling
  JOURNAL   iScience 27 (9), 110785 (2024)
   PUBMED   39286503
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3702)
  AUTHORS   Lammie,G.A., Smith,R., Silver,J., Brookes,S., Dickson,C. and
            Peters,G.
  TITLE     Proviral insertions near cyclin D1 in mouse lymphomas: a parallel
            for BCL1 translocations in human B-cell neoplasms
  JOURNAL   Oncogene 7 (12), 2381-2387 (1992)
   PUBMED   1461646
REFERENCE   7  (bases 1 to 3702)
  AUTHORS   Lanahan,A., Williams,J.B., Sanders,L.K. and Nathans,D.
  TITLE     Growth factor-induced delayed early response genes
  JOURNAL   Mol Cell Biol 12 (9), 3919-3929 (1992)
   PUBMED   1508193
REFERENCE   8  (bases 1 to 3702)
  AUTHORS   Xiong,Y., Menninger,J., Beach,D. and Ward,D.C.
  TITLE     Molecular cloning and chromosomal mapping of CCND genes encoding
            human D-type cyclins
  JOURNAL   Genomics 13 (3), 575-584 (1992)
   PUBMED   1386336
REFERENCE   9  (bases 1 to 3702)
  AUTHORS   Inaba,T., Matsushime,H., Valentine,M., Roussel,M.F., Sherr,C.J. and
            Look,A.T.
  TITLE     Genomic organization, chromosomal localization, and independent
            expression of human cyclin D genes
  JOURNAL   Genomics 13 (3), 565-574 (1992)
   PUBMED   1386335
REFERENCE   10 (bases 1 to 3702)
  AUTHORS   Motokura,T., Bloom,T., Kim,H.G., Juppner,H., Ruderman,J.V.,
            Kronenberg,H.M. and Arnold,A.
  TITLE     A novel cyclin encoded by a bcl1-linked candidate oncogene
  JOURNAL   Nature 350 (6318), 512-515 (1991)
   PUBMED   1826542
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC161763.3.
            
            On Mar 27, 2020 this sequence version replaced NM_007631.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.3007870.1, AK164997.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-336               AC161763.3         74279-74614
            337-552             AC161763.3         76008-76223
            553-712             AC161763.3         76657-76816
            713-861             AC161763.3         79946-80094
            862-3702            AC161763.3         81339-84179
FEATURES             Location/Qualifiers
     source          1..3702
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 88.92 cM"
     gene            1..3702
                     /gene="Ccnd1"
                     /gene_synonym="bcl-1; cD1; CycD1; Cyl-1; PRAD1"
                     /note="cyclin D1"
                     /db_xref="GeneID:12443"
                     /db_xref="MGI:MGI:88313"
     exon            1..336
                     /gene="Ccnd1"
                     /gene_synonym="bcl-1; cD1; CycD1; Cyl-1; PRAD1"
                     /inference="alignment:Splign:2.1.0"
     CDS             139..1026
                     /gene="Ccnd1"
                     /gene_synonym="bcl-1; cD1; CycD1; Cyl-1; PRAD1"
                     /note="isoform 2 is encoded by transcript variant 2;
                     G1/S-specific cyclin-D1"
                     /codon_start=1
                     /product="G1/S-specific cyclin-D1 isoform 2"
                     /protein_id="NP_031657.1"
                     /db_xref="CCDS:CCDS22055.1"
                     /db_xref="GeneID:12443"
                     /db_xref="MGI:MGI:88313"
                     /translation="MEHQLLCCEVETIRRAYPDTNLLNDRVLRAMLKTEETCAPSVSY
                     FKCVQKEIVPSMRKIVATWMLEVCEEQKCEEEVFPLAMNYLDRFLSLEPLKKSRLQLL
                     GATCMFVASKMKETIPLTAEKLCIYTDNSIRPEELLQMELLLVNKLKWNLAAMTPHDF
                     IEHFLSKMPEADENKQTIRKHAQTFVALCATDVKFISNPPSMVAAGSVVAAMQGLNLG
                     SPNNFLSCYRTTHFLSRVIKCDPDCLRACQEQIEALLESSLRQAQQNVDPKATEEEGE
                     VEEEAGLACTPTDVRDVDI"
     exon            337..552
                     /gene="Ccnd1"
                     /gene_synonym="bcl-1; cD1; CycD1; Cyl-1; PRAD1"
                     /inference="alignment:Splign:2.1.0"
     exon            553..712
                     /gene="Ccnd1"
                     /gene_synonym="bcl-1; cD1; CycD1; Cyl-1; PRAD1"
                     /inference="alignment:Splign:2.1.0"
     exon            713..861
                     /gene="Ccnd1"
                     /gene_synonym="bcl-1; cD1; CycD1; Cyl-1; PRAD1"
                     /inference="alignment:Splign:2.1.0"
     exon            862..3702
                     /gene="Ccnd1"
                     /gene_synonym="bcl-1; cD1; CycD1; Cyl-1; PRAD1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3682..3687
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ccnd1"
                     /gene_synonym="bcl-1; cD1; CycD1; Cyl-1; PRAD1"
                     /note="hexamer: AATAAA"
     polyA_site      3702
                     /gene="Ccnd1"
                     /gene_synonym="bcl-1; cD1; CycD1; Cyl-1; PRAD1"
                     /note="major polyA site"
ORIGIN      
        1 agagggctgt cggcgcagta gcagagagct acagactccg cgcgctccgg agaccggcag
       61 tacagcgcga ggcagcgcgc gtcagcagcc gccaccggag cccaaccgag accacagccc
      121 tccccagacg gccgcgccat ggaacaccag ctcctgtgct gcgaagtgga gaccatccgc
      181 cgcgcgtacc ctgacaccaa tctcctcaac gaccgggtgc tgcgagccat gctcaagacg
      241 gaggagacct gtgcgccctc cgtatcttac ttcaagtgcg tgcagaagga gattgtgcca
      301 tccatgcgga aaatcgtggc cacctggatg ctggaggtct gtgaggagca gaagtgcgaa
      361 gaggaggtct tcccgctggc catgaactac ctggaccgct tcctgtccct ggagcccttg
      421 aagaagagcc gcctgcagct gctgggggcc acctgcatgt tcgtggcctc taagatgaag
      481 gagaccattc ccttgactgc cgagaagttg tgcatctaca ctgacaactc tatccggccc
      541 gaggagctgc tgcaaatgga actgcttctg gtgaacaagc tcaagtggaa cctggccgcc
      601 atgactcccc acgatttcat cgaacacttc ctctccaaaa tgccagaggc ggatgagaac
      661 aagcagacca tccgcaagca tgcacagacc tttgtggccc tctgtgccac agatgtgaag
      721 ttcatttcca acccaccctc catggtagct gctgggagcg tggtggctgc gatgcaaggc
      781 ctgaacctgg gcagccccaa caacttcctc tcctgctacc gcacaacgca ctttctttcc
      841 agagtcatca agtgtgaccc ggactgcctc cgtgcctgcc aggaacagat tgaagccctt
      901 ctggagtcaa gcctgcgcca ggcccagcag aacgtcgacc ccaaggccac tgaggaggag
      961 ggggaagtgg aggaagaggc tggtctggcc tgcacgccca ccgacgtgcg agatgtggac
     1021 atctgagggc caccgggcag gcgggagcca ccaagtagtg gcacccgcaa agaggaagga
     1081 gccagcccgg gtgctcctga cgacgtcccc cttggggaca tgttgttacc agaagaggaa
     1141 gttttgttct ctttgttggt tgtttttcct taatctttct cctttctatc tgatttaagc
     1201 aaaagagaaa aaaatatctg aaagctgtct taaagagaga gagagagaga tagaatctgc
     1261 atcaccctga gagtagggag ccagggggtg ctacaaaaat agaattctgt accccagtaa
     1321 tcaactagtt ttctattaat gtgcttgtct gttctaagag taggattaac acaggggaag
     1381 tcttgagaag gagttttgat tcttttatat gtttttaaaa aaaagcttaa gaaacattgc
     1441 tttaaaaagg aaggaaaaaa aatacagcaa accattgtta aagtagaaga gtttttaggt
     1501 tgagaaatgt actctgcttt gctgaaaagc cacagcttag gccctcagcc tcactccctg
     1561 gcttgctcag tgcctacagc cctgttacct gatacctgtg ctttatccca ggggtgggca
     1621 gacctcttaa ccttatagat ggtcagtgcg acctctagtg gtctcatggc gtgtggcaca
     1681 acccccctcc ccagggctca gcttaatgtg ccctctcccc ccaacaacct gcaggttcac
     1741 agcaccagcc acacagcggt agggatgaaa tagtgacata atatattcta tttttgtaac
     1801 cttcctattt tgtagctctg tttagagaga tgctggtttt tgcctgaagg ccctgcagcc
     1861 tgcccacatc aggttaaacc cacagctttt gtgtgtggtt tgttttgttg tgttttcttt
     1921 ctctatgttc caaaaccatt ccatttcaaa gcacttttgg tcagctagct ggaggcagtg
     1981 ttgctggtgt gtgttggggg gaggggttct aatggaatgg atggggatgt ccacacacgc
     2041 attcagatgg ctgtacaaca ggttgtaggg ctggtagtat gaggtgcttg ggaagttttg
     2101 ttgggtcaag aagagagaac tctgttctcg caccaccggg atctgtcctg caaagttgaa
     2161 gggatccttt ggtgccagct ggtgtttgga agtaggaacc atgatggcat tacctggaca
     2221 aggagattgg ggacaactct taagtctcac acaggaggct tttaaacact aaaatgtcta
     2281 atttatactt aaggctacag aagagtattt atgggaaagg ctgcccatga ccagtgtgac
     2341 tcaaagcaat gtgatctccc ttgattcaaa cgcacacctc tgccctgctg gagaaggttt
     2401 agggccatgt ctgagagatt ggtctttcat tgggcaacgg gggggggggg ggggtcctta
     2461 aaaaaaaaaa accacaaaga cagagatttg gtctgcttga ctttcccaac ccaattggcc
     2521 ccattggaga gccatccaaa ctgaggaaaa ttaggggact ccaaaagagt ttgattctgg
     2581 cacattcttg ccgctgcccc caagttaaca acagtaggta atttgcacac ctctggctct
     2641 gtgcctttct attaggactt tttggcagaa ggtggagagc gggaggctta agaggggatg
     2701 tgagggaaga ggtgaaggtg ggaccacatg ggacaggcca cggctcctct catggcgctg
     2761 ctaccgatga ctcccaggat cccagacgtt cagaaccaga ttctcattgc tttgtatctt
     2821 tcacgttgtt ttcgctgcta ttggagggtc agttttgttt tgttttgttt tacaatgtca
     2881 gactgccatg ttcaagtttt aatttcctca tagagtgtat ttacagatgc ccttttttgt
     2941 actttttttt ttaattgtga tctattttgg cttaatgtga ttaccgctgt attccaaaaa
     3001 aaaaaaaaaa acaggttcct gttcacaata cctcatgtat catctagcca tgcacgagcc
     3061 tggcaggcag gtgggcggtc tgcctccagg gatcctggga ccctgatggc gatcgtcctg
     3121 tcatgctggg cccttcattt gatctgggac atagcatcac agcagtcagg gcacctggat
     3181 tgttctgtta tcgatattgt ttcttgtagc ggcctgttgt gcatgccacc atgctgctgg
     3241 cccgggggga tttgctctga gtctccggtg catcatttaa tctgttaggt tctagtgttc
     3301 cgtcttgttt tgtgttaatt acagcattgt gctaatgtaa agactctgcc tttgcgaagc
     3361 cagctgcagt gctgtaggcc cccaagttcc ctagcaagct gccaaaccaa aacgggcacc
     3421 accagctcag ctgaggcatc ccagccaggc aggacccttg agggccgctg tatccatggt
     3481 gatggggtga ggttttggcc aaaaggccaa agactggtgg tgggtccacg gaatctgccc
     3541 tgtgacatga aaggctttga ggggctctgg ctggtggcca ggttggcttt ttgtatttct
     3601 ggttgacaca ccatggcgct tcccagcaca gacatgtgac cagcatggtc caggaaaaaa
     3661 aaaaagacaa aaaatctaga aaataaaatt ggtaaaatct ca
//
