LOCUS       NM_016746               3391 bp    mRNA    linear   ROD 05-AUG-2023
DEFINITION  Mus musculus cyclin C (Ccnc), transcript variant 1, mRNA.
ACCESSION   NM_016746
VERSION     NM_016746.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3391)
  AUTHORS   Song Z, Xiaoli AM, Li Y, Siqin G, Wu T, Strich R, Pessin JE and
            Yang F.
  TITLE     The conserved Mediator subunit cyclin C (CCNC) is required for
            brown adipocyte development and lipid accumulation
  JOURNAL   Mol Metab 64, 101548 (2022)
   PUBMED   35863637
REFERENCE   2  (bases 1 to 3391)
  AUTHORS   Stieg DC, Cooper KF and Strich R.
  TITLE     The extent of cyclin C promoter occupancy directs changes in
            stress-dependent transcription
  JOURNAL   J Biol Chem 295 (48), 16280-16291 (2020)
   PUBMED   32934007
  REMARK    GeneRIF: The extent of cyclin C promoter occupancy directs changes
            in stress-dependent transcription.
REFERENCE   3  (bases 1 to 3391)
  AUTHORS   Lynch CJ, Bernad R, Martinez-Val A, Shahbazi MN, Nobrega-Pereira S,
            Calvo I, Blanco-Aparicio C, Tarantino C, Garreta E, Richart-Gines
            L, Alcazar N, Grana-Castro O, Gomez-Lopez G, Aksoy I, Munoz-Martin
            M, Martinez S, Ortega S, Prieto S, Simboeck E, Camasses A,
            Stephan-Otto Attolini C, Fernandez AF, Sierra MI, Fraga MF, Pastor
            J, Fisher D, Montserrat N, Savatier P, Munoz J, Zernicka-Goetz M
            and Serrano M.
  TITLE     Global hyperactivation of enhancers stabilizes human and mouse
            naive pluripotency through inhibition of CDK8/19 Mediator kinases
  JOURNAL   Nat Cell Biol 22 (10), 1223-1238 (2020)
   PUBMED   32989249
REFERENCE   4  (bases 1 to 3391)
  AUTHORS   Ponce JM, Coen G, Spitler KM, Dragisic N, Martins I, Hinton A Jr,
            Mungai M, Tadinada SM, Zhang H, Oudit GY, Song LS, Li N, Sicinski
            P, Strack S, Abel ED, Mitchell C, Hall DD and Grueter CE.
  TITLE     Stress-Induced Cyclin C Translocation Regulates Cardiac
            Mitochondrial Dynamics
  JOURNAL   J Am Heart Assoc 9 (7), e014366 (2020)
   PUBMED   32248761
  REMARK    GeneRIF: Stress-Induced Cyclin C Translocation Regulates Cardiac
            Mitochondrial Dynamics.
REFERENCE   5  (bases 1 to 3391)
  AUTHORS   Jezek J, Chang KT, Joshi AM and Strich R.
  TITLE     Mitochondrial translocation of cyclin C stimulates intrinsic
            apoptosis through Bax recruitment
  JOURNAL   EMBO Rep 20 (9), e47425 (2019)
   PUBMED   31385392
REFERENCE   6  (bases 1 to 3391)
  AUTHORS   Taniwaki T, Haruna K, Nakamura H, Sekimoto T, Oike Y, Imaizumi T,
            Saito F, Muta M, Soejima Y, Utoh A, Nakagata N, Araki M, Yamamura K
            and Araki K.
  TITLE     Characterization of an exchangeable gene trap using pU-17 carrying
            a stop codon-beta geo cassette
  JOURNAL   Dev Growth Differ 47 (3), 163-172 (2005)
   PUBMED   15840001
REFERENCE   7  (bases 1 to 3391)
  AUTHORS   Malik S, Guermah M, Yuan CX, Wu W, Yamamura S and Roeder RG.
  TITLE     Structural and functional organization of TRAP220, the
            TRAP/mediator subunit that is targeted by nuclear receptors
  JOURNAL   Mol Cell Biol 24 (18), 8244-8254 (2004)
   PUBMED   15340084
  REMARK    Erratum:[Mol Cell Biol. 2022 Nov 17;42(11):e0035922. PMID:
            36255214]
REFERENCE   8  (bases 1 to 3391)
  AUTHORS   Kozar K, Ciemerych MA, Rebel VI, Shigematsu H, Zagozdzon A,
            Sicinska E, Geng Y, Yu Q, Bhattacharya S, Bronson RT, Akashi K and
            Sicinski P.
  TITLE     Mouse development and cell proliferation in the absence of
            D-cyclins
  JOURNAL   Cell 118 (4), 477-491 (2004)
   PUBMED   15315760
REFERENCE   9  (bases 1 to 3391)
  AUTHORS   Kohn KW.
  TITLE     Molecular interaction map of the mammalian cell cycle control and
            DNA repair systems
  JOURNAL   Mol Biol Cell 10 (8), 2703-2734 (1999)
   PUBMED   10436023
  REMARK    Review article
REFERENCE   10 (bases 1 to 3391)
  AUTHORS   Araki K, Imaizumi T, Sekimoto T, Yoshinobu K, Yoshimuta J, Akizuki
            M, Miura K, Araki M and Yamamura K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK037957.1, BC120649.1 and AL772187.6.
            
            [WARNING] On Oct 18, 2023 this sequence was replaced by
            NM_016746.5.
            
            On Mar 12, 2014 this sequence version replaced NM_016746.3.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC100396.1, U62638.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-73                AK037957.1         2-74
            74-2450             BC120649.1         1-2377
            2451-3391           AL772187.6         32676-33616
FEATURES             Location/Qualifiers
     source          1..3391
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 8.86 cM"
     gene            1..3391
                     /gene="Ccnc"
                     /gene_synonym="CG1C"
                     /note="cyclin C"
                     /db_xref="GeneID:51813"
                     /db_xref="MGI:MGI:1858199"
     exon            1..215
                     /gene="Ccnc"
                     /gene_synonym="CG1C"
                     /inference="alignment:Splign:2.1.0"
     CDS             184..1035
                     /gene="Ccnc"
                     /gene_synonym="CG1C"
                     /note="isoform 1 is encoded by transcript variant 1;
                     dJ199J3.4 (cyclin C)"
                     /codon_start=1
                     /product="cyclin-C isoform 1"
                     /protein_id="NP_058026.2"
                     /db_xref="CCDS:CCDS17998.1"
                     /db_xref="GeneID:51813"
                     /db_xref="MGI:MGI:1858199"
                     /translation="MAGNFWQSSHYLQWILDKQDLLKERQKDLKFLSEEEYWKLQIFF
                     TNVIQALGEHLKLRQQVIATATVYFKRFYARYSLKSIDPVLMAPTCVFLASKVEEFGV
                     VSNTRLIAATTSVLKTRFSYAFPKEFPYRMNHILECEFYLLELMDCCLIVYHPYRPLL
                     QYVQDMGQEDVLLPLAWRIVNDTYRTDLCLLYPPFMIALACLHVACVVQQKDARQWFA
                     ELSVDMEKILEIIRVILKLYEQWKNFDERKEMATILSKMPKPKPPPNSEGEQGPNGSQ
                     NSSYSQS"
     exon            216..322
                     /gene="Ccnc"
                     /gene_synonym="CG1C"
                     /inference="alignment:Splign:2.1.0"
     exon            323..407
                     /gene="Ccnc"
                     /gene_synonym="CG1C"
                     /inference="alignment:Splign:2.1.0"
     exon            408..477
                     /gene="Ccnc"
                     /gene_synonym="CG1C"
                     /inference="alignment:Splign:2.1.0"
     exon            478..529
                     /gene="Ccnc"
                     /gene_synonym="CG1C"
                     /inference="alignment:Splign:2.1.0"
     exon            530..585
                     /gene="Ccnc"
                     /gene_synonym="CG1C"
                     /inference="alignment:Splign:2.1.0"
     exon            586..621
                     /gene="Ccnc"
                     /gene_synonym="CG1C"
                     /inference="alignment:Splign:2.1.0"
     exon            622..713
                     /gene="Ccnc"
                     /gene_synonym="CG1C"
                     /inference="alignment:Splign:2.1.0"
     exon            714..781
                     /gene="Ccnc"
                     /gene_synonym="CG1C"
                     /inference="alignment:Splign:2.1.0"
     exon            782..861
                     /gene="Ccnc"
                     /gene_synonym="CG1C"
                     /inference="alignment:Splign:2.1.0"
     exon            862..980
                     /gene="Ccnc"
                     /gene_synonym="CG1C"
                     /inference="alignment:Splign:2.1.0"
     exon            981..3391
                     /gene="Ccnc"
                     /gene_synonym="CG1C"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctcagtgtt gtcgaccggc gtcaaggcga cgagggtgct gttctcttcc tccggctgcg
       61 gtggctgtgg agttcagccc agccagtctg gtaggagcac agtcgtccgg actgtgtcta
      121 tggtcgctcc gcgggccgct ttgctggctg gtgcatttgt atcagggcaa gcagtattat
      181 tccatggcag ggaacttctg gcagagctcc cactatttgc agtggatttt ggataaacaa
      241 gatctgttga aagagcgcca aaaggaccta aagtttctct cagaagagga gtattggaag
      301 ttacaaatat tttttacaaa tgttatccaa gcattaggtg aacatcttaa attaagacaa
      361 caagttattg ctactgctac agtctatttc aagagattct atgctaggta ttctctgaaa
      421 agtatagatc ctgtattaat ggcgcctaca tgtgtgtttc tggcatccaa agtagaggaa
      481 tttggtgttg tctcaaatac aagattgatt gctgctacta cttctgtatt aaaaactaga
      541 ttttcatatg cttttccaaa ggaatttcct tacaggatga atcatatact agaatgtgaa
      601 ttttacctct tagaattaat ggactgttgc ttgatagtgt atcatcctta tagacctttg
      661 ctccagtatg tgcaggacat gggccaggaa gacgtgctgc ttccccttgc atggaggata
      721 gtgaatgata cctacaggac ggatctctgt ctgctgtacc ctccgttcat gatcgcttta
      781 gcttgcctac atgtagcctg tgtcgtacaa cagaaagatg ctagacagtg gtttgcagaa
      841 ctttctgtgg atatggagaa gattttggaa ataatcaggg ttattttaaa actgtatgag
      901 cagtggaaga attttgatga gagaaaagag atggcaacta ttcttagtaa gatgccgaaa
      961 ccaaaaccac ctccaaacag tgaaggtgag cagggtccaa atggaagtca gaactctagc
     1021 tacagccaat cttaaaacac cctgaagaat cccgtagtgg accacttgga agtaaagcat
     1081 tggacagttt gagtaatgtc ttcattggaa gcagatgcaa atgaatagct tgtttctgtc
     1141 aagcatattg ggaattgact taattttcac aaaataaggt tttttcctaa cttgatttag
     1201 tgtgtaattt attaatgctt aattacaaaa tttagtaagg ctctaaagga acctatagcc
     1261 atacacagac atttcagggt taacctctct tacatacaca tatgtatata gacacatact
     1321 aatactggtt tttgattaga taattgaagg gtttttttta attaataata ataacttttt
     1381 attaagtcag gaaacatgaa atgtcatttg ttgaaatttt tctttcagca ttgagggacc
     1441 aaaagaggac ataaaaagtc aataaaacta cccccagccc agttaaattt taaaactgga
     1501 tataagaaat taaatcttag aaaatcctta gaaggtttta gaaatgataa ttacagtttg
     1561 agggagatta atcaagaact tacttatttt aaaattgatt gtatttaata ctttttgtat
     1621 cattacagaa gatactggcc cagcctatca aaaagtgcaa tatatatata gcatactttg
     1681 acattttaaa ggttggattg acttactagc tgttttgaaa acctaaaaga aaaggttatt
     1741 tgcaactaat ttatagttaa attagtttaa cttgattaaa cacttaaggt aaaatttggt
     1801 gaaattttaa tgtttaatct gtcctgaaaa ttttttatga gacatataca cccggtttaa
     1861 ttttatgttt tattgtgaac taacatatgt acagcaagta ttctaaatca ggaaggaacc
     1921 tagtcaggtt ttagaccagt gagattctta attctcatgg gtatagactt cagaataaat
     1981 gttacatttg tgggacttca taaattaatt aattttcttc agactcaaag ggagaagaat
     2041 aaataaagct tggagtaatg agatattatt gtgtagtttt gcacctttta aaaaataaat
     2101 catgaaaaaa attactaagt gttgacttcc tggttaaaat tggaagaata aaagttaagt
     2161 ttttcaggta tattaactaa tgtcttgaat tcctgttgct aagtttgact taggttctct
     2221 gagaatcttt gtgcgtgtta aattagagcc ctaaactctg taaagaggtg atttttgtat
     2281 agtttatgaa tagattgtga ggaaggttct gcttcctatg gggaatcaga tgcaggtgtg
     2341 ctgaaaaaga gacttacatt ggtacaaaca tggactctcc taaggccgta taaggctaag
     2401 taacaaacaa acagaggaac aaacaggctc tccccgaact ccacttggat gcttggtaat
     2461 tgatttgctt atcccagccg ttaactatag ttttatcttc aagctttttt aaatccagtt
     2521 tcttttttca gatttttttt ttttttttgc tttattattt tctttgcaaa tgctcttgtg
     2581 gatgattaag actttgcaaa agcagacaaa gccgtgaaat agatctccat gtgtgtatgc
     2641 tctagcctca gccattactg attcatagcc agtttcacct taatgtaaac ttccacacca
     2701 gtctccagct catacattat cttgaagaaa attctagata tatcatttta cccatacata
     2761 atttcatact gctaataggt gaaataatta tttactatta tattaaaatt ctcaattccc
     2821 tgaacattgc agagcattct gtattcattt ataaatcctt ttaggtttag attcatggat
     2881 tattcctcca tgctataaaa aacattccct gttttcattt cttcatgtat taagtttccc
     2941 atagcctaag ttttactgtg agcatcttta gcatgccatt tagcgagggt ttttctcctt
     3001 tgtatttctg taaattgata attgaatatg aaggctgatc acaccgagat tctttttgtt
     3061 ttggctagac tactgtaggg tggccatctc ttgtattaat cagcacatag tggctgttgc
     3121 tgtcctcatt tatgacaagt actgtttcag aatcagtcag tcttaggcac actgtccagt
     3181 ctcatagcca ccagccactt agggctgaac agttactatg tggcttgtct gaatgcagat
     3241 atgctataaa tgtgcaaaca tgttgggttt caggtactta ttaatataaa acaaaataat
     3301 gttaaaaatc tcaatttgtt tataaccatt atgtgtttta aatgataata ttttggatac
     3361 atagaattaa ataaaacatt attaaaattt t
//
