LOCUS       NM_183015               4591 bp    mRNA    linear   ROD 12-JUN-2024
DEFINITION  Mus musculus cyclin B3 (Ccnb3), mRNA.
ACCESSION   NM_183015
VERSION     NM_183015.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4591)
  AUTHORS   Bouftas,N., Schneider,L., Halder,M., Demmig,R., Baack,M.,
            Cladiere,D., Walter,M., Al Abdallah,H., Kleinhempel,C.,
            Messaritaki,R., Muller,J., Passarelli,F., Wehrle,P., Heim,A.,
            Wassmann,K. and Mayer,T.U.
  TITLE     Cyclin B3 implements timely vertebrate oocyte arrest for
            fertilization
  JOURNAL   Dev Cell 57 (19), 2305-2320 (2022)
   PUBMED   36182686
REFERENCE   2  (bases 1 to 4591)
  AUTHORS   Chotiner,J.Y., Leu,N.A., Xu,Y. and Wang,P.J.
  TITLE     Recurrent pregnancy loss in mice lacking the X-linked Ccnb3
            genedagger
  JOURNAL   Biol Reprod 106 (3), 382-384 (2022)
   PUBMED   34850816
  REMARK    GeneRIF: Recurrent pregnancy loss in mice lacking the X-linked
            Ccnb3 genedagger.
            GeneRIF: Our findings underscore the requirement for CCNB3 in
            female meiosis and suggest that ZGA-specific functions of CCNB3
            observed in invertebrate species are not likely conserved in
            mammals. The Ccnb3-deficient mouse model is similar to a human
            infertility condition - recurrent pregnancy loss (RPL).
REFERENCE   3  (bases 1 to 4591)
  AUTHORS   Nakano,T., Aochi,H., Hirasaki,M., Takenaka,Y., Fujita,K.,
            Tamura,M., Soma,H., Kamezawa,H., Koizumi,T., Shibuya,H.,
            Inomata,R., Okuda,A., Murakoshi,T., Shimada,A. and Inoue,I.
  TITLE     Effects of Ppargamma1 deletion on late-stage murine embryogenesis
            and cells that undergo endocycle
  JOURNAL   Dev Biol 478, 222-235 (2021)
   PUBMED   34246625
REFERENCE   4  (bases 1 to 4591)
  AUTHORS   He,Y., Chen,Q., Dai,J., Cui,Y., Zhang,C., Wen,X., Li,J., Xiao,Y.,
            Peng,X., Liu,M., Shen,B., Sha,J., Hu,Z., Li,J. and Shu,W.
  TITLE     Single-cell RNA-Seq reveals a highly coordinated transcriptional
            program in mouse germ cells during primordial follicle formation
  JOURNAL   Aging Cell 20 (7), e13424 (2021)
   PUBMED   34174788
REFERENCE   5  (bases 1 to 4591)
  AUTHORS   Meng,T.G., Lei,W.L., Li,J., Wang,F., Zhao,Z.H., Li,A., Wang,Z.B.,
            Sun,Q.Y. and Ou,X.H.
  TITLE     Degradation of Ccnb3 is essential for maintenance of MII arrest in
            oocyte
  JOURNAL   Biochem Biophys Res Commun 521 (1), 265-269 (2020)
   PUBMED   31640856
  REMARK    GeneRIF: The results indicate that Ccnb3 plays a critical
            regulatory role in MII arrest and exit in mouse oocytes.
REFERENCE   6  (bases 1 to 4591)
  AUTHORS   Shi,B., Xue,J., Zhou,J., Kasowitz,S.D., Zhang,Y., Liang,G.,
            Guan,Y., Shi,Q., Liu,M., Sha,J., Huang,X. and Wang,P.J.
  TITLE     MORC2B is essential for meiotic progression and fertility
  JOURNAL   PLoS Genet 14 (1), e1007175 (2018)
   PUBMED   29329290
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 4591)
  AUTHORS   Soh,Y.Q.S., Mikedis,M.M., Kojima,M., Godfrey,A.K., de Rooij,D.G.
            and Page,D.C.
  TITLE     Meioc maintains an extended meiotic prophase I in mice
  JOURNAL   PLoS Genet 13 (4), e1006704 (2017)
   PUBMED   28380054
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 4591)
  AUTHORS   Zhang,T., Qi,S.T., Huang,L., Ma,X.S., Ouyang,Y.C., Hou,Y., Shen,W.,
            Schatten,H. and Sun,Q.Y.
  TITLE     Cyclin B3 controls anaphase onset independent of spindle assembly
            checkpoint in meiotic oocytes
  JOURNAL   Cell Cycle 14 (16), 2648-2654 (2015)
   PUBMED   26125114
  REMARK    GeneRIF: Depletion of cyclin B3 inhibits metaphase-anaphase
            transition as indicated by a well-sustained MI spindle and cyclin
            B1 expression in meiotic oocytes.
REFERENCE   9  (bases 1 to 4591)
  AUTHORS   Lozano,J.C., Verge,V., Schatt,P., Juengel,J.L. and Peaucellier,G.
  TITLE     Evolution of cyclin B3 shows an abrupt three-fold size increase,
            due to the extension of a single exon in placental mammals,
            allowing for new protein-protein interactions
  JOURNAL   Mol Biol Evol 29 (12), 3855-3871 (2012)
   PUBMED   22826462
REFERENCE   10 (bases 1 to 4591)
  AUTHORS   Nguyen,T.B., Manova,K., Capodieci,P., Lindon,C., Bottega,S.,
            Wang,X.Y., Refik-Rogers,J., Pines,J., Wolgemuth,D.J. and Koff,A.
  TITLE     Characterization and expression of mammalian cyclin b3, a
            prepachytene meiotic cyclin
  JOURNAL   J Biol Chem 277 (44), 41960-41969 (2002)
   PUBMED   12185076
  REMARK    GeneRIF: cloning of a partial cDNA and localized mRNA to leptotene
            and zygotene spermatocytes
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL671962.5.
            
            On Feb 3, 2022 this sequence version replaced NM_183015.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ555464.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849382 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-86                AL671962.5         186708-186793       c
            87-127              AL671962.5         183867-183907       c
            128-261             AL671962.5         175929-176062       c
            262-351             AL671962.5         170741-170830       c
            352-464             AL671962.5         165160-165272       c
            465-783             AL671962.5         154956-155274       c
            784-3492            AL671962.5         152150-154858       c
            3493-3606           AL671962.5         150372-150485       c
            3607-3699           AL671962.5         140649-140741       c
            3700-3837           AL671962.5         135537-135674       c
            3838-3993           AL671962.5         131408-131563       c
            3994-4143           AL671962.5         130554-130703       c
            4144-4274           AL671962.5         125389-125519       c
            4275-4591           AL671962.5         124789-125105       c
FEATURES             Location/Qualifiers
     source          1..4591
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 3.13 cM"
     gene            1..4591
                     /gene="Ccnb3"
                     /note="cyclin B3"
                     /db_xref="GeneID:209091"
                     /db_xref="MGI:MGI:2183443"
     exon            1..86
                     /gene="Ccnb3"
                     /inference="alignment:Splign:2.1.0"
     exon            87..127
                     /gene="Ccnb3"
                     /inference="alignment:Splign:2.1.0"
     exon            128..261
                     /gene="Ccnb3"
                     /inference="alignment:Splign:2.1.0"
     CDS             166..4356
                     /gene="Ccnb3"
                     /codon_start=1
                     /product="G2/mitotic-specific cyclin-B3"
                     /protein_id="NP_898836.2"
                     /db_xref="CCDS:CCDS29961.1"
                     /db_xref="GeneID:209091"
                     /db_xref="MGI:MGI:2183443"
                     /translation="MPPPLLPKRSKLETEKAQSNKITPREEQQSEKIGKSNHAASSSS
                     SSTQGAVKRRSVFEDVTNASHSQCVQSKEDNIELKSHVSKRTKKGVGEVTQKKIKSSK
                     MGHVTSLSNMEKEFILDIPNKPKTLTTEEPSVFQKTLVLNEEPATKETCLMRKTLKSC
                     AFHQETLLMEKPLTLLVETEDYNEFDTELMTSKKKDKPEDPTIIEEMTDLKKSVIRKV
                     TLTSSPLWLKNKHVVQEEKPVIQEKSSFKKISLVSNVVTTKEKPPVKKPHFRKKKPTT
                     EMKSLLQEPSLEEKYNTQEDASILKKPQVLQENTNNKDATLTEPVTFKGKHSANEATH
                     TKKPSSSKNNPDPQGKGTNLRPLRVHPVTYENEPMSSKKSTTKKKDSHFHGPSVLPDK
                     HSPQMEVSTVKKSLALPNPTTEEKMLHFPVATVLEKQHNMGEAPCLKKPSPLRKQQQL
                     PKRRRFFSNSAVQETVIRKPLFFKMSTTEKDPPSQWPSALPKKHISPGELSKQKKQHV
                     SPKHNMEEDSQCWLDSAFKKQLSREEPASTHTPLKLEMQQAITKETGFHLRNPLVLPT
                     VTSEAKSLTKEPPSFREQNTSLLKRKSTTHTITLQQAQSEWQEMTDEDRNLFSIKPGS
                     HRKEPIPEFLQNPLPPNENCLISQKLSHSMPFASQKTTSQERAHRKESVASNDDKNFF
                     SQDLFSPFSSADEDTLKFHKSLDFQEQVDRKNDSHKKMFDSQDSVSEEESFLRKLFCK
                     DRCSSTEELSQERTVALEQEFLLIKILNENTSSDVDEPLSHQSPHIQNHSDTTKEALE
                     ASEALEAPEALETLEALVASEDLEEPLNILEELSTENMVALMKMLVTEDESTKDSFSG
                     NYTAAREAHAEKSLSLEETSINEAATLKESLSSQEKHRAELVTVLKELLVLMKNPSLK
                     RVALAFQENPSNNVETLLREVLALVENSTADESTLQEKPSTKTDVTPKELLALEENSS
                     NKKANPMDSLSFDHKPDTEMGEIARMVLTDEEYNIDTLYERVLALSQGLIAADQLSFT
                     DLQNFEETKIVDEEEFFKSFLVFENKNSPNMSSNAFESRTDNSSAIMPSSKAFNPVEN
                     SNPYVSSSKSFKSTLGAKETEITIQDDSDSLERIEKEGQDPLLNTIYAKDVFNYLKER
                     EEKFLVQKYMDGQMELTSDMRAILVDWLVEIQGSFQMTHETLYLAVKIMDLYLMKAQC
                     KKNHLQLLGSTTYMIAAKFEESYPPSLSEFLFICEDMYEKSDMVSLESSILQTLNFDI
                     NIPTAYNFLRRYASCIHASMKTLTLSRFICEMTLQEYEYIEERPSKLAAASFILALYM
                     RNLSNCVPTLEYFTGYKMAELHILVRKLNHLLNFRSHSILKNVFEKYSEETYFEVAKI
                     PPLSKQDLENLLNCALFH"
     exon            262..351
                     /gene="Ccnb3"
                     /inference="alignment:Splign:2.1.0"
     exon            352..464
                     /gene="Ccnb3"
                     /inference="alignment:Splign:2.1.0"
     exon            465..783
                     /gene="Ccnb3"
                     /inference="alignment:Splign:2.1.0"
     exon            784..3492
                     /gene="Ccnb3"
                     /inference="alignment:Splign:2.1.0"
     exon            3493..3606
                     /gene="Ccnb3"
                     /inference="alignment:Splign:2.1.0"
     exon            3607..3699
                     /gene="Ccnb3"
                     /inference="alignment:Splign:2.1.0"
     exon            3700..3837
                     /gene="Ccnb3"
                     /inference="alignment:Splign:2.1.0"
     exon            3838..3993
                     /gene="Ccnb3"
                     /inference="alignment:Splign:2.1.0"
     exon            3994..4143
                     /gene="Ccnb3"
                     /inference="alignment:Splign:2.1.0"
     exon            4144..4274
                     /gene="Ccnb3"
                     /inference="alignment:Splign:2.1.0"
     exon            4275..4591
                     /gene="Ccnb3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4571..4576
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ccnb3"
                     /note="hexamer: AATAAA"
     polyA_site      4591
                     /gene="Ccnb3"
                     /note="major polyA site"
ORIGIN      
        1 agttactaga agctcacgcg cggaggcggt tatgccgcga ggccggccgt tactccgttg
       61 ctgaggccgt tatgctaaga cagacgatgc cttggaactg gagttacagg cagttgtgag
      121 ttgtcatctc tatcttggag gaaacactgc tgaatctgca taaagatgcc accaccacta
      181 ctacccaaaa gatccaaact ggagactgag aaggctcagt ctaacaagat cacacctaga
      241 gaggagcagc aatctgaaaa gattggaaag agtaaccatg cagcatcttc atcttcatct
      301 tcaactcaag gcgcagtaaa gaggagatca gtgtttgaag atgtaactaa tgcatctcat
      361 agtcaatgtg tccagtcaaa ggaagacaat atagagctta aaagccatgt ttccaaaagg
      421 acaaagaagg gagttggtga agttactcag aaaaaaataa aaagttctaa gatggggcat
      481 gttacttcac tgtcaaacat ggagaaagag tttattctgg atatacccaa caagcctaaa
      541 acactaacta ctgaggaacc atctgtcttt caaaagacat tagttttaaa tgaggagcct
      601 gctactaaag agacatgcct tatgaggaag acattaaaga gttgtgcatt tcatcaggag
      661 acacttctaa tggagaagcc actaaccttg ctggtggaga ctgaagatta caatgagttt
      721 gatacagaac tgatgacttc taaaaagaag gataaacctg aagatccaac catcattgag
      781 gagatgactg atttgaagaa gtctgttatt aggaaggtga cgctcacctc aagcccatta
      841 tggttaaaga ataaacatgt tgttcaagaa gagaaacctg tgattcagga gaagagttca
      901 ttcaagaaga tatcattagt atcaaatgtg gtgactacta aagagaagcc accagtcaaa
      961 aagccacatt tcaggaaaaa aaagcctacc actgagatga agtctttgtt acaggagcca
     1021 tcactggaag agaaatataa tactcaagaa gatgcaagca tcttgaagaa gccacaggtg
     1081 ttacaagaga atacaaataa caaagatgct actttaacag agccagttac ttttaaaggg
     1141 aaacatagtg ccaatgaagc aacccataca aagaagccat cctcttctaa aaataatcct
     1201 gaccctcagg gaaaaggcac taatttgagg ccactaagag ttcatccagt cacctatgaa
     1261 aatgagccaa tgtcctctaa gaagtcaact actaagaaga aagattccca tttccatggg
     1321 ccatctgtac tgccagacaa gcatagccct caaatggagg tgtccactgt gaaaaaatcc
     1381 ctggctctgc caaatcctac cactgaggag aagatgttac attttccagt agctacagtt
     1441 ttggagaagc agcataacat gggcgaggcc ccttgcctga agaagccctc acctttaagg
     1501 aagcagcagc agctccctaa aagaagacgt ttcttcagta actctgcagt acaagaaaca
     1561 gtcattcgca agccattgtt ctttaagatg tctaccactg agaaagatcc cccttcccag
     1621 tggccatctg cactgccaaa gaagcatatc agtcctgggg aattgtccaa acagaagaag
     1681 cagcatgtct caccaaagca taacatggag gaggactcac agtgttggtt agattcagct
     1741 tttaagaaac agctcagcag ggaggagcca gcctccaccc atacgccttt aaagttagag
     1801 atgcagcagg ctattactaa agagacaggg ttccatttga gaaacccact agtattacca
     1861 acagtcactt cagaagcaaa gtcactgact aaggagcctc catcctttag ggaacaaaat
     1921 acatctttac tgaaaagaaa gagtactact cacacaataa ccttacagca agcacagtca
     1981 gagtggcagg aaatgacaga tgaagacaga aatttgtttt ctataaagcc tggatcacat
     2041 aggaaggaac ctatacctga gttccttcag aatccattgc caccaaatga aaattgctta
     2101 atttcacaaa aactatccca ctcaatgcca tttgcctcac agaagaccac cagtcaagaa
     2161 agagcacata ggaaggaatc ggtggcttca aatgatgaca agaacttctt ctcgcaggac
     2221 ctattttctc ctttcagttc tgctgatgaa gatacattga aattccataa gtctttggac
     2281 tttcaagagc aggttgatag aaaaaatgac tcccacaaaa aaatgtttga ctcccaggac
     2341 agtgtttccg aagaagagtc ctttttaaga aagctatttt gtaaggacag atgctcctct
     2401 actgaagaat taagccaaga gaggactgtt gctctggaac aggaattcct cttaataaaa
     2461 atattgaatg agaataccag tagtgatgtt gatgagcctc ttagtcatca gtcacctcat
     2521 attcagaacc attctgacac tacgaaggag gccttggagg cctcagaagc cttggaggcc
     2581 ccagaagcct tggagacctt agaagccttg gtggcctcag aagacttgga ggaacctcta
     2641 aacattttag aagaactcag cactgagaat atggttgccc tcatgaagat gttggtcaca
     2701 gaagatgagt ctactaagga ttcttttagc gggaattaca ctgctgccag ggaagctcat
     2761 gctgagaaat ccttgtcctt ggaagagacc agcatcaatg aagcggcaac tttgaaggag
     2821 tccttatctt cacaggagaa gcacagagct gagctggtga ctgttctgaa ggagctactt
     2881 gttttaatga agaatcccag tctgaagagg gtggccttag cgtttcagga gaatccatct
     2941 aataacgtag agactctctt gagggaagta ttggcattgg tggagaactc tacagctgac
     3001 gaatctactc tgcaggagaa acctagcact aaaacagatg ttaccccaaa ggaactattg
     3061 gccttggaag agaattccag caataaaaag gcaaacccca tggactcttt atcctttgat
     3121 cataagcctg acactgagat gggtgaaata gccagaatgg tattaactga tgaagagtac
     3181 aacatagata ccctgtatga gagagtatta gcactgagtc agggactcat tgctgcagac
     3241 cagttgtcct ttacagatct acagaatttt gaagagacta aaattgttga tgaagaggaa
     3301 tttttcaaat cattccttgt ctttgaaaat aagaatagcc ctaatatgtc cagcaatgct
     3361 tttgaatcca gaacagacaa ttccagtgct atcatgccaa gttcaaaggc attcaatcct
     3421 gtcgagaact ccaacccata tgtgtctagt tccaaaagct ttaagtcaac tctgggtgca
     3481 aaagaaactg agataaccat acaggatgac agtgacagcc tggaaagaat tgaaaaggaa
     3541 ggccaagatc cattattgaa cactatatat gccaaagacg tcttcaatta cttgaaagaa
     3601 agagaggaaa agttcctagt tcagaaatac atggatgggc agatggaact caccagtgat
     3661 atgagagcca ttcttgtgga ctggttggtg gagatacagg gatcctttca gatgacccat
     3721 gagaccctgt atttggcagt gaagataatg gatctctacc taatgaaggc acaatgcaag
     3781 aagaatcatc tacaactcct tggttccact acttacatga ttgcagccaa atttgaggaa
     3841 tcctatcccc cttctctgtc agagttcctg ttcatttgtg aagatatgta tgaaaagagt
     3901 gatatggtat ctttggaaag cagcatcctg caaactctca actttgacat caatattccc
     3961 acagcatata attttctgcg tagatatgct tcgtgcatcc atgctagcat gaagacacta
     4021 accttatccc gcttcatctg tgagatgacc ctgcaagaat atgagtatat tgaagagagg
     4081 ccttcaaagc tagctgcagc ctctttcatc ttggccctct atatgaggaa tctcagcaat
     4141 tgtgttccta cactggaata tttcactggg tacaagatgg cagaactcca tatcttggtc
     4201 aggaagttaa accatttgct gaacttccga tcccatagta tcctcaagaa tgtgtttgag
     4261 aagtattctg aagagaccta ctttgaagtc gccaaaatcc ctcctttgag caagcaagat
     4321 ctagagaatc ttttgaattg tgcattattc cactgaggac ctctgacagc agttgtcagg
     4381 gctgggcaga aataccaata gtatgaattt attcatttat cttatgcatg aagtttccct
     4441 attgttaact tttcattaat atttttcctc tctttatttt cctaaactga tagttatgga
     4501 accttaaaaa tcttgaaatt acttttatga aagaagagaa attgttttgt tatatttgtt
     4561 taaaaaattt aataaaatac aatggttact a
//
