LOCUS       NM_007630               1541 bp    mRNA    linear   ROD 24-SEP-2024
DEFINITION  Mus musculus cyclin B2 (Ccnb2), mRNA.
ACCESSION   NM_007630
VERSION     NM_007630.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1541)
  AUTHORS   Kang,H.S., Grimm,S.A., Liao,X.H. and Jetten,A.M.
  TITLE     GLIS3 expression in the thyroid gland in relation to TSH signaling
            and regulation of gene expression
  JOURNAL   Cell Mol Life Sci 81 (1), 65 (2024)
   PUBMED   38281222
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1541)
  AUTHORS   Yao,X., Wang,C., Yu,W., Sun,L., Lv,Z., Xie,X., Tian,S., Yan,L.,
            Li,L. and Liu,J.
  TITLE     BCAS2 regulates oocyte meiotic prophase I by participating in mRNA
            alternative splicing
  JOURNAL   FASEB J 38 (1), e23361 (2024)
   PUBMED   38085152
REFERENCE   3  (bases 1 to 1541)
  AUTHORS   Cho,K.W., Andrade,M., Bae,S., Kim,S., Eyun Kim,J., Jang,E.Y.,
            Lee,S., Husain,A., Sutliff,R.L., Calvert,J.W., Park,C. and
            Yoon,Y.S.
  TITLE     Polycomb Group Protein CBX7 Represses Cardiomyocyte Proliferation
            Through Modulation of the TARDBP/RBM38 Axis
  JOURNAL   Circulation 147 (24), 1823-1842 (2023)
   PUBMED   37158107
REFERENCE   4  (bases 1 to 1541)
  AUTHORS   Xiao,Y., Ma,J., Guo,C., Liu,D., Pan,J. and Huang,X.
  TITLE     Cyclin B2 overexpression promotes tumour growth by regulating
            jagged 1 in hepatocellular carcinoma
  JOURNAL   Aging (Albany NY) 14 (6), 2855-2867 (2022)
   PUBMED   35349480
  REMARK    GeneRIF: Cyclin B2 overexpression promotes tumour growth by
            regulating jagged 1 in hepatocellular carcinoma.
REFERENCE   5  (bases 1 to 1541)
  AUTHORS   Akagawa,R., Nabeshima,Y.I. and Kawauchi,T.
  TITLE     Alternative Functions of Cell Cycle-Related and DNA Repair Proteins
            in Post-mitotic Neurons
  JOURNAL   Front Cell Dev Biol 9, 753175 (2021)
   PUBMED   34746147
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1541)
  AUTHORS   Kohn,K.W.
  TITLE     Molecular interaction map of the mammalian cell cycle control and
            DNA repair systems
  JOURNAL   Mol Biol Cell 10 (8), 2703-2734 (1999)
   PUBMED   10436023
  REMARK    Review article
REFERENCE   7  (bases 1 to 1541)
  AUTHORS   Brandeis,M., Rosewell,I., Carrington,M., Crompton,T., Jacobs,M.A.,
            Kirk,J., Gannon,J. and Hunt,T.
  TITLE     Cyclin B2-null mice develop normally and are fertile whereas cyclin
            B1-null mice die in utero
  JOURNAL   Proc Natl Acad Sci U S A 95 (8), 4344-4349 (1998)
   PUBMED   9539739
REFERENCE   8  (bases 1 to 1541)
  AUTHORS   Zhao,J., Nornes,H.O. and Neuman,T.
  TITLE     Expression of Rb, E2F1, cdc2, and D, and B cyclins in developing
            spinal cord
  JOURNAL   Neurosci Lett 190 (1), 49-52 (1995)
   PUBMED   7624053
REFERENCE   9  (bases 1 to 1541)
  AUTHORS   Chapman,D.L. and Wolgemuth,D.J.
  TITLE     Isolation of the murine cyclin B2 cDNA and characterization of the
            lineage and temporal specificity of expression of the B1 and B2
            cyclins during oogenesis, spermatogenesis and early embryogenesis
  JOURNAL   Development 118 (1), 229-240 (1993)
   PUBMED   8375336
REFERENCE   10 (bases 1 to 1541)
  AUTHORS   Hanley-Hyde,J., Mushinski,J.F., Sadofsky,M., Huppi,K., Krall,M.,
            Kozak,C.A. and Mock,B.
  TITLE     Expression of murine cyclin B1 mRNAs and genetic mapping of related
            genomic sequences
  JOURNAL   Genomics 13 (4), 1018-1030 (1992)
   PUBMED   1387105
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY300844.1, AK076122.1 and AA033463.1.
            
            On Jan 31, 2006 this sequence version replaced NM_007630.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X66032.1, AK076122.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-39                BY300844.1         4-42
            40-1430             AK076122.1         34-1424
            1431-1541           AA033463.1         320-430
FEATURES             Location/Qualifiers
     source          1..1541
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 39.53 cM"
     gene            1..1541
                     /gene="Ccnb2"
                     /gene_synonym="CycB2"
                     /note="cyclin B2"
                     /db_xref="GeneID:12442"
                     /db_xref="MGI:MGI:88311"
     exon            1..138
                     /gene="Ccnb2"
                     /gene_synonym="CycB2"
                     /inference="alignment:Splign:2.1.0"
     CDS             115..1311
                     /gene="Ccnb2"
                     /gene_synonym="CycB2"
                     /codon_start=1
                     /product="G2/mitotic-specific cyclin-B2"
                     /protein_id="NP_031656.2"
                     /db_xref="CCDS:CCDS23320.1"
                     /db_xref="GeneID:12442"
                     /db_xref="MGI:MGI:88311"
                     /translation="MALLRRPTVSSDLKNIDTEVIPKAKSHVTIRRAVLEEIGNKVRN
                     RTTQVAKKPQNTKVPALPTKVTNVNKQPKPTASVKPVQMEALAPKDRPPAPEDVSMKE
                     ESLCQAFSDALLCKIEDIDNEDRENPQLCSDYVKDIYQYLRQLEVLQSINPHFLDGRD
                     INGRMRAILVDWLVQVHSKFRLLQETLYMCIAIMDRFLQAQLVCRKKLQLVGITALLL
                     ASKYEEMFSPNIEDFVYITDNAYTSSQIREMETLILKELKFELGRPLPLHFLRRASKA
                     GEVDVEQHTLAKYLMELTLVDYDMVHYHPSQVAAAASCLSQKVLGQGKWNLKQQYYTG
                     YMESEVLEVMQHMAKNVVKVNDNRTKFIAVKNKYASSRLLKISTIPQLNSKIIKDLAS
                     PLLGSP"
     exon            139..267
                     /gene="Ccnb2"
                     /gene_synonym="CycB2"
                     /inference="alignment:Splign:2.1.0"
     exon            268..381
                     /gene="Ccnb2"
                     /gene_synonym="CycB2"
                     /inference="alignment:Splign:2.1.0"
     exon            382..552
                     /gene="Ccnb2"
                     /gene_synonym="CycB2"
                     /inference="alignment:Splign:2.1.0"
     exon            553..711
                     /gene="Ccnb2"
                     /gene_synonym="CycB2"
                     /inference="alignment:Splign:2.1.0"
     exon            712..948
                     /gene="Ccnb2"
                     /gene_synonym="CycB2"
                     /inference="alignment:Splign:2.1.0"
     exon            949..1089
                     /gene="Ccnb2"
                     /gene_synonym="CycB2"
                     /inference="alignment:Splign:2.1.0"
     exon            1090..1200
                     /gene="Ccnb2"
                     /gene_synonym="CycB2"
                     /inference="alignment:Splign:2.1.0"
     exon            1201..1541
                     /gene="Ccnb2"
                     /gene_synonym="CycB2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1417..1422
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ccnb2"
                     /gene_synonym="CycB2"
                     /note="hexamer: AATAAA"
     polyA_site      1443
                     /gene="Ccnb2"
                     /gene_synonym="CycB2"
                     /note="major polyA site"
ORIGIN      
        1 ggtatttgaa tcgcggaccg ggcggtggac gcggagcggc ggggccctga ccctcccaac
       61 ggtgtcgcag accggagtgg ctgtgcctcg tccgcacttg ccagggcggc cctcatggcg
      121 ctgctccgac gcccgacggt gtccagtgat ttgaagaata ttgacacaga agttattcct
      181 aaagccaaga gccatgtgac tatccggcgg gcagttttag aagaaattgg aaataaagtt
      241 agaaacagaa ccactcaggt ggcgaagaaa cctcagaaca ccaaagtacc agctctgccc
      301 accaaagtga caaatgtcaa caagcagccg aaacccacag cctctgtgaa accagtgcag
      361 atggaggcgc tagctcccaa ggatcgtcct cccgcccctg aggatgtctc catgaaggaa
      421 gagagcctct gccaagcttt ctctgatgct ctgctctgca agatcgagga catagataac
      481 gaggacaggg agaaccctca gctctgcagt gactacgtga aggacatcta ccagtacctc
      541 aggcagcttg aggttttaca gtccattaat ccacacttct tagatggaag agatataaat
      601 ggacgtatgc gtgccatcct ggtggactgg ctggtccaag tccattccaa gtttcggctt
      661 ctgcaggaaa ctctgtacat gtgcattgcc atcatggacc ggttcctgca ggctcagctg
      721 gtctgccgga agaaactgca gctggtcggg atcacagctc tgctcctggc ttccaaatat
      781 gaggagatgt tttctccaaa tatcgaagac tttgtttata tcacagataa tgcttacacc
      841 agttcccaaa tccgagaaat ggagactctg attttgaaag agttgaaatt tgagttgggc
      901 cgacctttgc cacttcactt cttaaggcga gcctcaaaag ccggagaggt ggatgttgaa
      961 cagcacactt tagccaagta cctgatggag ctgacgctcg tcgactatga catggtgcac
     1021 taccatcctt ctcaggtggc agccgctgcc tcttgcctgt ctcagaaggt gctgggccaa
     1081 ggaaaatgga atttgaagca gcagtattac acaggctaca tggagagtga agtcctggaa
     1141 gtcatgcagc acatggccaa gaacgttgtg aaagtcaatg acaaccgtac caagttcatc
     1201 gctgtcaaga acaagtatgc cagcagcaga ctcctgaaga tcagcacgat ccctcagctg
     1261 aactccaaaa tcatcaaaga cctggcctcc cctctgctgg gcagccccta gacactggac
     1321 tgccatcctg cgcttctcag atcctgtatg tattttattc tagtttacat cacaaacctc
     1381 ttctcaaact cattttctaa ttgtgtattg atgaaaaata aagctattga ttttcttata
     1441 ctatcctgtg tatgtttgta tactctacac tgaagaaatg tagaatggcc tacaataact
     1501 ctgctctgta ttgaaggaaa ataaagctat tgatctactt a
//
