LOCUS       NM_001111119            1508 bp    mRNA    linear   ROD 25-FEB-2025
DEFINITION  Mus musculus cyclin B1 interacting protein 1 (Ccnb1ip1), mRNA.
ACCESSION   NM_001111119 XM_139038
VERSION     NM_001111119.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1508)
  AUTHORS   Ito,M., Yun,Y., Kulkarni,D.S., Lee,S., Sandhu,S., Nunez,B., Hu,L.,
            Lee,K., Lim,N., Hirota,R.M., Prendergast,R., Huang,C., Huang,I. and
            Hunter,N.
  TITLE     Distinct and interdependent functions of three RING proteins
            regulate recombination during mammalian meiosis
  JOURNAL   Proc Natl Acad Sci U S A 122 (2), e2412961121 (2025)
   PUBMED   39761402
REFERENCE   2  (bases 1 to 1508)
  AUTHORS   Zhang,X., He,H., Yu,H., Teng,X., Wang,Z., Li,C., Li,J., Yang,H.,
            Shen,J., Wu,T., Zhang,F., Zhang,Y. and Wu,Q.
  TITLE     Maternal RNA transcription in Dlk1-Dio3 domain is critical for
            proper development of the mouse placental vasculature
  JOURNAL   Commun Biol 7 (1), 363 (2024)
   PUBMED   38521877
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1508)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 1508)
  AUTHORS   Huang,T., Wu,X., Wang,S., Bao,Z., Wan,Y., Wang,Z., Li,M., Yu,X.,
            Lv,Y., Liu,Z., Chen,X., Chan,W.Y., Gao,F., Lu,G., Chen,Z.J. and
            Liu,H.
  TITLE     SPIDR is required for homologous recombination during mammalian
            meiosis
  JOURNAL   Nucleic Acids Res 51 (8), 3855-3868 (2023)
   PUBMED   36938872
REFERENCE   5  (bases 1 to 1508)
  AUTHORS   Felipe-Medina,N., Caburet,S., Sanchez-Saez,F., Condezo,Y.B., de
            Rooij,D.G., Gomez-H,L., Garcia-Valiente,R., Todeschini,A.L.,
            Duque,P., Sanchez-Martin,M.A., Shalev,S.A., Llano,E., Veitia,R.A.
            and Pendas,A.M.
  TITLE     A missense in HSF2BP causing primary ovarian insufficiency affects
            meiotic recombination by its novel interactor C19ORF57/BRME1
  JOURNAL   Elife 9, e56996 (2020)
   PUBMED   32845237
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1508)
  AUTHORS   Wang,K., Wang,M., Tang,D., Shen,Y., Miao,C., Hu,Q., Lu,T. and
            Cheng,Z.
  TITLE     The role of rice HEI10 in the formation of meiotic crossovers
  JOURNAL   PLoS Genet 8 (7), e1002809 (2012)
   PUBMED   22792078
REFERENCE   7  (bases 1 to 1508)
  AUTHORS   Strong,E.R. and Schimenti,J.C.
  TITLE     Evidence Implicating CCNB1IP1, a RING Domain-Containing Protein
            Required for Meiotic Crossing Over in Mice, as an E3 SUMO Ligase
  JOURNAL   Genes (Basel) 1 (3), 440-451 (2010)
   PUBMED   21779533
REFERENCE   8  (bases 1 to 1508)
  AUTHORS   Kumar,R., Bourbon,H.M. and de Massy,B.
  TITLE     Functional conservation of Mei4 for meiotic DNA double-strand break
            formation from yeasts to mice
  JOURNAL   Genes Dev 24 (12), 1266-1280 (2010)
   PUBMED   20551173
  REMARK    GeneRIF: Mei4 and Rec114, are evolutionarily conserved in most
            eukaryotes and Mei4(-/-) mice are deficient in meiotic DSB
            formation, thus showing the functional conservation of Mei4 in mice
REFERENCE   9  (bases 1 to 1508)
  AUTHORS   Ward,J.O., Reinholdt,L.G., Motley,W.W., Niswander,L.M.,
            Deacon,D.C., Griffin,L.B., Langlais,K.K., Backus,V.L.,
            Schimenti,K.J., O'Brien,M.J., Eppig,J.J. and Schimenti,J.C.
  TITLE     Mutation in mouse hei10, an e3 ubiquitin ligase, disrupts meiotic
            crossing over
  JOURNAL   PLoS Genet 3 (8), e139 (2007)
   PUBMED   17784788
  REMARK    GeneRIF: Cloning and characterization of the mei4 ortholog of Hei10
            (also known as Gm288 in mouse) demonstrates a novel link between
            cell cycle regulation and mismatch repair during prophase I.
REFERENCE   10 (bases 1 to 1508)
  AUTHORS   Ward,J.O., Reinholdt,L.G., Hartford,S.A., Wilson,L.A., Munroe,R.J.,
            Schimenti,K.J., Libby,B.J., O'Brien,M., Pendola,J.K., Eppig,J. and
            Schimenti,J.C.
  TITLE     Toward the genetics of mammalian reproduction: induction and
            mapping of gametogenesis mutants in mice
  JOURNAL   Biol Reprod 69 (5), 1615-1625 (2003)
   PUBMED   12855593
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC027184.15.
            
            On Dec 11, 2007 this sequence version replaced XM_139038.5.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189685.158902.1,
                                           SRR5189676.108631.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-93                AC027184.15        131608-131700
            94-410              AC027184.15        133462-133778
            411-744             AC027184.15        135030-135363
            745-1508            AC027184.15        137324-138087
FEATURES             Location/Qualifiers
     source          1..1508
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 26.25 cM"
     gene            1..1508
                     /gene="Ccnb1ip1"
                     /gene_synonym="Gm288; Hei10; mei4"
                     /note="cyclin B1 interacting protein 1"
                     /db_xref="GeneID:239083"
                     /db_xref="MGI:MGI:2685134"
     exon            1..93
                     /gene="Ccnb1ip1"
                     /gene_synonym="Gm288; Hei10; mei4"
                     /inference="alignment:Splign:2.1.0"
     exon            94..410
                     /gene="Ccnb1ip1"
                     /gene_synonym="Gm288; Hei10; mei4"
                     /inference="alignment:Splign:2.1.0"
     CDS             114..944
                     /gene="Ccnb1ip1"
                     /gene_synonym="Gm288; Hei10; mei4"
                     /EC_number="2.3.2.27"
                     /note="RING-type E3 ubiquitin transferase CCNB1IP1"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase CCNB1IP1"
                     /protein_id="NP_001104589.1"
                     /db_xref="CCDS:CCDS49477.1"
                     /db_xref="GeneID:239083"
                     /db_xref="MGI:MGI:2685134"
                     /translation="MSLCEDMLLCNYRKCRIKLSGYAWVTACSHIFCDQHGSGEFSRS
                     PAICPACNSTLSGKLDIVRTELSPSEEYKAMVLAGLRPEVVLDISSRALAFWTYQVHQ
                     ERLYQEYNFSKAENHLKQMEKMYMQQIQSKNIELTSMKGEVISMKKVLEEYKKKFSDI
                     SEKLMERNRQYQKLQGLYDSLRLRNITIASQEGSLEPGMIPQSGVFGFPPGNNSKFSL
                     DHIPVGNQGGGDEDVQFRPFFVCSPTAPEPINNFFSFASPSHEAEQQVCSRAFKAKRI
                     "
     exon            411..744
                     /gene="Ccnb1ip1"
                     /gene_synonym="Gm288; Hei10; mei4"
                     /inference="alignment:Splign:2.1.0"
     exon            745..1508
                     /gene="Ccnb1ip1"
                     /gene_synonym="Gm288; Hei10; mei4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1485..1490
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ccnb1ip1"
                     /gene_synonym="Gm288; Hei10; mei4"
                     /note="hexamer: AATAAA"
     polyA_site      1507
                     /gene="Ccnb1ip1"
                     /gene_synonym="Gm288; Hei10; mei4"
                     /note="major polyA site"
ORIGIN      
        1 aggccttgcg caccacgcat gcgccctggc ggcttggcca cgcgaaatct gtcttgagtg
       61 gaggatcgac acctttactt taccttgttg cagggttctt ttggagattc gccatgtctt
      121 tgtgtgaaga catgctgctt tgcaattatc ggaagtgtcg gatcaagctc tctggttatg
      181 cttgggtcac tgcctgttct cacatcttct gcgatcagca cggcagcggg gagttcagtc
      241 gttcaccagc gatctgtcct gcttgcaaca gtaccctttc tggaaagcta gatattgttc
      301 gaacagaact cagtccatca gaggagtaca aagctatggt attggcaggg cttcgcccag
      361 aggttgtttt ggacattagc tcccgggcat tggccttctg gacataccag gtacaccagg
      421 agcgtctcta tcaagagtat aatttcagca aggccgagaa ccacttaaaa cagatggaga
      481 agatgtatat gcagcaaata cagagcaaga atatagaatt gacctctatg aaaggggagg
      541 ttatttccat gaagaaagtt ctagaagaat acaagaaaaa gtttagtgac atctctgaaa
      601 aacttatgga gcgtaatcgc cagtaccaaa agctccaagg cctttatgat agccttaggc
      661 taagaaatat cactatcgcc agccaagaag gctccctgga accaggtatg atcccgcagt
      721 ctggagtctt tggcttccca ccagggaata actcaaagtt ttctttggac catataccag
      781 ttggaaatca aggtggtgga gatgaagatg ttcagttcag accatttttt gtgtgttctc
      841 ccacagcgcc tgaacccatt aacaacttct ttagttttgc atctccaagc catgaagcag
      901 agcagcaagt ctgcagcagg gcctttaaag caaaaagaat ttagctcatt tttcattcct
      961 gcatccctga gttctcttca catttcgacc ttagaagaag ttggcttgca gtagggcgtg
     1021 tggcttcctg tttggtttct tgattgttag cttagggcat gggcatttca tgaatctcag
     1081 tctctacgtt tgtcattgct cacacaatca cattgttgca cagatcctga ttcagaccaa
     1141 gctgtgttta tgctcataga agcctcagtg ttatgtttcc ctggagcttt ggattgattc
     1201 taccgtgttt atgttaaatg tgtgcattga tttttctctg ctagtatatt tctgtaaaaa
     1261 taatggtctt ggaaaatgat ggccaaaaat gatagtcttg gaaaatggtg gctttccatt
     1321 aacatgtatt ttaacagtca tgtattttca tttgtgttac tttgttttgg aggtgcactt
     1381 atgccagtga atgaatgtgc aatttgatgc atatgaattg tttatatgta aaaataattt
     1441 atactgataa agttatttgt tgatttcatt gttatttgtt tcaaaataaa actgcttctt
     1501 tacttttt
//
